Multigenerational exposure to genistein does not increase bone mineral density in rats

Bone

Volumn 37, Issue 5, 2005, Pages 720-727

  Hotchkiss, Charlotte E ^a   Weis, Connie ^a   Blaydes, Betty ^a   Newbold, Retha ^a   Delclos, K Barry ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Bone development; Bone mineral density; Endocrine disruptors; Genistein; Rat

Indexed keywords

ALKALINE PHOSPHATASE; GENISTEIN; PYRIDINOLINE;

ANIMAL EXPERIMENT; ARTICLE; AUTOPSY; BONE DENSITY; BONE DEVELOPMENT; BONE MINERAL; CONCEPTION; CONTROLLED STUDY; CORTICAL BONE; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR; LUMBAR VERTEBRA; MALE; NONHUMAN; PERINATAL PERIOD; RAT; SEX ROLE; WEANING;

AGING; ALKALINE PHOSPHATASE; AMINO ACIDS; ANIMALS; BODY WEIGHT; BONE DENSITY; BONE DEVELOPMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FEMUR; GENISTEIN; GROWTH INHIBITORS; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 26944486624     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2005.06.005     Document Type: Article

References (69)

1. NIH Consensus Development Panel on Osteoporosis Prevention D, Therapy Osteoporosis prevention, diagnosis, and therapy JAMA 285 2001 785 795
2. R.D. Wasnich Epidemiology of osteoporosis M.J. Favus M.J. Favus Primer on the metabolic bone diseases and disorders of mineral metabolism Fourth ed. 1999 Lippincott Williams and Wilkins Philadelphia, PA 257 259
3. J.J.B. Anderson, and S.C. Garner The effects of phytoestrogens on bone Nutr. Res. 17 1997 1617 1632
4. W. Wuttke, H. Jarry, S. Westphalen, V. Christoffel, and D. Seidlova-Wuttke Phytoestrogens for hormone replacement therapy? J. Steroid Biochem. Mol. Biol. 83 2003 133 147
5. B.H. Arjmandi, E.A. Lucas, and D.A. Khalil One year soy protein supplementation has positive effects on bone formation markers but not bone density in postmenopausal women Nutr. J. 4 2005 8
6. D. Carusi Phytoestrogens as hormone replacement therapy: an evidence-based approach Prim. Care Update Ob Gyns 7 2000 253 259
7. J.A. Eden Managing the menopause: phyto-oestrogens or hormone replacement therapy? Ann. Med. 33 2001 4 6
8. K.D. Setchell, and E. Lydeking-Olsen Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies Am. J. Clin. Nutr. 78 2003 593S 609S
9. D.L. Alekel, A.S. Germain, and C.T. Peterson Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women Am. J. Clin. Nutr. 72 2000 844 852
10. S.M. Potter, J.A. Baum, and H. Teng Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women Am. J. Clin. Nutr. 68 1998 1375S 1379S
11. P.B. Clifton-Bligh, R.J. Baber, G.R. Fulcher, M.L. Nery, and T. Moreton The effect of isoflavones extracted from red clover (Rimostil) on lipid and bone metabolism Menopause 8 2001 259 265
12. N. Morabito, A. Crisafulli, and C. Vergara Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: a randomized double-blind placebo-controlled study J. Bone Miner. Res. 17 2002 1904 1912
13. L.M. Chiechi, G. Secreto, and M. D'Amore Efficacy of a soy rich diet in preventing postmenopausal osteoporosis: the Menfis randomized trial Maturitas 42 2002 295 300
14. Y.M. Chen, S.C. Ho, S.S. Lam, S.S. Ho, and J.L. Woo Soy isoflavones have a favorable effect on bone loss in Chinese postmenopausal women with lower bone mass: a double-blind, randomized, controlled trial J. Clin. Endocrinol. Metab. 88 2003 4740 4747
15. C.S. Hsu, W.W. Shen, Y.M. Hsueh, and S.L. Yeh Soy isoflavone supplementation in postmenopausal women. Effects on plasma lipids, antioxidant enzyme activities and bone density J. Reprod. Med. 46 2001 221 226
16. C. Atkinson, J.E. Compston, N.E. Day, M. Dowsett, and S.A. Bingham The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial Am. J. Clin. Nutr. 79 2004 326 333
17. J.C. Gallagher, R. Satpathy, K. Rafferty, and V. Haynatzka The effect of soy protein isolate on bone metabolism Menopause 11 2004 290 298
18. S. Kreijkamp-Kaspers, L. Kok, and D.E. Grobbee Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: a randomized controlled trial JAMA 292 2004 65 74
19. M. Mori, T. Aizawa, M. Tokoro, T. Miki, and Y. Yamori Soy isoflavone tablets reduce osteoporosis risk factors and obesity in middle-aged Japanese women Clin. Exp. Pharmacol. Physiol. 31 2004 S39 S41
20. L.S. Harkness, K. Fiedler, A.R. Sehgal, D. Oravec, and E. Lerner Decreased bone resorption with soy isoflavone supplementation in postmenopausal women J. Women's Health (Larchmt) 13 2004 1000 1007
21. B.H. Arjmandi, R. Birnbaum, and N.V. Goyal Bone-sparing effect of soy protein in ovarian hormone-deficient rats is related to its isoflavone content Am. J. Clin. Nutr. 68 1998 1364S 1368S
22. B.H. Arjmandi, M.J. Getlinger, and N.V. Goyal Role of soy protein with normal or reduced isoflavone content in reversing bone loss induced by ovarian hormone deficiency in rats Am. J. Clin. Nutr. 68 1998 1358S 1363S
23. T. Uesugi, T. Toda, K. Tsuji, and H. Ishida Comparative study on reduction of bone loss and lipid metabolism abnormality in ovariectomized rats by soy isoflavones, daidzein, genistein, and glycitin Biol. Pharm. Bull. 24 2001 368 372
24. Y. Ishimi, C. Miyaura, and M. Ohmura Selective effects of genistein, a soybean isoflavone, on B-lymphopoiesis and bone loss caused by estrogen deficiency Endocrinology 140 1999 1893 1900
25. M. Lieberherr, G. Cournot, and S.P. Robins Guidelines for using in vitro methods to study the effects of phyto-oestrogens on bone Br. J. Nutr. 89 2003 S59 S73
26. F. Branca Dietary phyto-oestrogens and bone health Proc. Nutr. Soc. 62 2003 877 887
27. C.H. Turner, R.K. Roeder, and A. Wieczorek Variability in skeletal mass, structure, and biomechanical properties among inbred strains of rats J. Bone Miner. Res. 16 2001 1532 1539
28. J.E. Compston Sex steroids and bone Physiol. Rev. 81 2001 419 447
29. A. Morishima, M.M. Grumbach, E.R. Simpson, C. Fisher, and K. Qin Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens J. Clin. Endocrinol. Metab. 80 1995 3689 3698
30. E.P. Smith, J. Boyd, and G.R. Frank Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man N. Engl. J. Med. 331 1994 1056 1061
31. C. Carani, K. Qin, and M. Simoni Effect of testosterone and estradiol in a man with aromatase deficiency N. Engl. J. Med. 337 1997 91 95
32. S. Migliaccio, R.R. Newbold, B.C. Bullock, J.A. McLachlan, and K.S. Korach Developmental exposure to estrogens induces persistent changes in skeletal tissue Endocrinology 130 1992 1756 1758
33. S. Migliaccio, R.R. Newbold, and B.C. Bullock Alterations of maternal estrogen levels during gestation affect the skeleton of female offspring Endocrinology 137 1996 2118 2125
34. S. Migliaccio, R.R. Newbold, and A. Teti Transient estrogen exposure of female mice during early development permanently affects osteoclastogenesis in adulthood Bone 27 2000 47 52
35. Y. Fukazawa, S. Nobata, and M. Katoh Effect of neonatal exposure to diethylstilbestrol and tamoxifen on pelvis and femur in male mice Anat. Rec. 244 1996 416 422
36. T. Nakamura, C.H. Turner, and T. Yoshikawa Do variations in hip geometry explain differences in hip fracture risk between Japanese and white Americans? J. Bone Miner. Res. 9 1994 1071 1076
37. A. Zittermann, J. Geppert, and S. Baier Short-term effects of high soy supplementation on sex hormones, bone markers, and lipid parameters in young female adults Eur. J. Nutr. 43 2004 100 108
38. K.E. Wangen, A.M. Duncan, and B.E. Merz-Demlow Effects of soy isoflavones on markers of bone turnover in premenopausal and postmenopausal women J. Clin. Endocrinol. Metab. 85 2000 3043 3048
39. H. Katsuyama, S. Ideguchi, and M. Fukunaga Promotion of bone formation by fermented soybean (Natto) intake in premenopausal women J. Nutr. Sci. Vitaminol. (Tokyo) 50 2004 114 120
40. J.J. Anderson, X. Chen, and A. Boass Soy isoflavones: no effects on bone mineral content and bone mineral density in healthy, menstruating young adult women after one year J. Am. Coll. Nutr. 21 2002 388 393
41. P.G. Giampietro, G. Bruno, and G. Furcolo Soy protein formulas in children: no hormonal effects in long-term feeding J. Pediatr. Endocrinol. Metab. 17 2004 191 196
42. K.B. Delclos, T.J. Bucci, and L.G. Lomax Effects of dietary genistein exposure during development on male and female CD (Sprague-Dawley) rats Reprod. Toxicol. 15 2001 647 663
43. H.C. Chang, M.I. Churchwell, K.B. Delclos, R.R. Newbold, and D.R. Doerge Mass spectrometric determination of genistein tissue distribution in diet-exposed Sprague-Dawley rats J. Nutr. 130 2000 1963 1970
44. D.R. Doerge, H.C. Chang, M.I. Churchwell, and C.L. Holder Analysis of soy isoflavone conjugation in vitro and in human blood using liquid chromatography-mass spectrometry Drug Metab. Dispos. 28 2000 298 307
45. D.R. Doerge, M.I. Churchwell, H.C. Chang, R.R. Newbold, and K.B. Delclos Placental transfer of the soy isoflavone genistein following dietary and gavage administration to Sprague Dawley rats Reprod. Toxicol. 15 2001 105 110
46. X.G. Cheng, G. Lowet, and S. Boonen Prediction of vertebral and femoral strength in vitro by bone mineral density measured at different skeletal sites J. Bone Miner. Res. 13 1998 1439 1443
47. E.N. Ebbesen, J.S. Thomsen, H. Beck-Nielsen, H.J. Nepper-Rasmussen, and L. Mosekilde Lumbar vertebral body compressive strength evaluated by dual-energy X-ray absorptiometry, quantitative computed tomography, and ashing Bone 25 1999 713 724
48. J.M. Gertner Childhood and adolescence M.J. Favus M.J. Favus Primer on the metabolic bone diseases and disorders of mineral metabolism Fourth ed. 1999 Lippincott Williams and Wilkins Philadelphia, PA 45 59
49. J.J. Anderson, W.W. Ambrose, and S.C. Garner Biphasic effects of genistein on bone tissue in the ovariectomized, lactating rat model Proc. Soc. Exp. Biol. Med. 217 1998 345 350
50. J. Wu, X.X. Wang, and M. Takasaki Cooperative effects of exercise training and genistein administration on bone mass in ovariectomized mice J. Bone Miner. Res. 16 2001 1829 1836
51. Y. Duan, C.H. Turner, B.T. Kim, and E. Seeman Sexual dimorphism in vertebral fragility is more the result of gender differences in age-related bone gain than bone loss J. Bone Miner. Res. 16 2001 2267 2275
52. E. Seeman Pathogenesis of bone fragility in women and men Lancet 359 2002 1841 1850
53. E.S. Orwoll, and R.F. Klein Osteoporosis in men Endocr. Rev. 16 1995 87 116
54. C. Picherit, V. Coxam, and C. Bennetau-Pelissero Daidzein is more efficient than genistein in preventing ovariectomy-induced bone loss in rats J. Nutr. 130 2000 1675 1681
55. C. Picherit, C. Bennetau-Pelissero, and B. Chanteranne Soybean isoflavones dose-dependently reduce bone turnover but do not reverse established osteopenia in adult ovariectomized rats J. Nutr. 131 2001 723 728
56. M. Nakai, M. Black, E.H. Jeffery, and J.M. Bahr Dietary soy protein and isoflavones: no effect on the reproductive tract and minimal positive effect on bone resorption in the intact female Fischer 344 rat Food Chem. Toxicol. 43 2005 945 949
57. P. Fanti, M.C. Monier-Faugere, and Z. Geng The phytoestrogen genistein reduces bone loss in short-term ovariectomized rats Osteoporos. Int. 8 1998 274 281
58. C. Picherit, B. Chanteranne, and C. Bennetau-Pelissero Dose-dependent bone-sparing effects of dietary isoflavones in the ovariectomised rat Br. J. Nutr. 85 2001 307 316
59. B.H. Arjmandi, R. Birnbaum, and N.V. Goyal Bone-sparing effect of soy protein in ovarian hormone-deficient rats is related to its isoflavone content Am. J. Clin. Nutr. 68 1998 1364S 1368S
60. B.H. Arjmandi, M.J. Getlinger, and N.V. Goyal Role of soy protein with normal or reduced isoflavone content in reversing bone loss induced by ovarian hormone deficiency in rats Am. J. Clin. Nutr. 68 1998 1358S 1363S
61. E. Harrison, A. Adjei, C. Ameho, S. Yamamoto, and S. Kono The effect of soybean protein on bone loss in a rat model of postmenopausal osteoporosis J. Nutr. Sci. Vitaminol. (Tokyo) 44 1998 257 268
62. H. Ishida, T. Uesugi, and K. Hirai Preventive effects of the plant isoflavones, daidzin and genistin, on bone loss in ovariectomized rats fed a calcium-deficient diet Biol. Pharm. Bull. 21 1998 62 66
63. J.M. Bahr, M. Nakai, and A. Rivera Dietary soy protein and isoflavones: minimal beneficial effects on bone and no effect on the reproductive tract of sexually mature ovariectomized Sprague-Dawley rats Menopause 12 2005 165 173
64. P.D. Gluckman, and M.A. Hanson Living with the past: evolution, development, and patterns of disease Science 305 2004 1733 1736
65. C.L. Inman, G.L. Warren, H.A. Hogan, and S.A. Bloomfield Mechanical loading attenuates bone loss due to immobilization and calcium deficiency J. Appl. Physiol. 87 1999 189 195
66. V. Shen, X.G. Liang, and R. Birchman Short-term immobilization-induced cancellous bone loss is limited to regions undergoing high turnover and/or modeling in mature rats Bone 21 1997 71 78
67. J.R. Guthrie, L. Dennerstein, and J.D. Wark Risk factors for osteoporosis: a review Medscape Women's Health 5 2000 E1
68. T.A. Guise, and G.R. Mundy Physiological and pathological roles of parathyroid hormone-related peptide Curr. Opin. Nephrol. Hypertens. 5 1996 307 315
69. W. Rankin, V. Grill, and T.J. Martin Parathyroid hormone-related protein and hypercalcemia Cancer 80 1997 1564 1571