Short term immobilization-induced cancellous bone loss is limited to regions undergoing high turnover and/or modeling in mature rats

Bone

Volumn 21, Issue 1, 1997, Pages 71-78

  Shen, Victor ^a,b   Liang, X G ^a   Birchman, R ^a   Wu, D D ^a   Healy, D ^c   Lindsay, R ^a,b   Dempster, D W ^a,b  

^a HELEN HAYES HOSPITAL   (United States)

^b Columbia Univ Coll Phys Surgs ^*  (United States)

^c Helen Hayes Hospital ^*

Author keywords

Calcium deficiency; Histomorphometry; Immobilization; Osteoporosis; Ovariectomy; Risk factors

Indexed keywords

CALCIUM; ESTROGEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE ATROPHY; BONE EROSION; BONE MARROW; BONE TURNOVER; CALCIUM DEFICIENCY; CANCELLOUS BONE; CONTROLLED STUDY; DENERVATION; ESTROGEN DEFICIENCY; FEMALE; FIBULA; IMMOBILIZATION STRESS; NONHUMAN; OSSIFICATION; OSTEOLYSIS; OVARIECTOMY; RAT; RISK FACTOR; SKELETON; STATISTICAL ANALYSIS; TIBIA; TRABECULAR BONE;

EID: 0030872881     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(97)00070-7     Document Type: Article

References (21)

1. Bagi, C. M., Mecham, C., Weiss, J., and Miller, S. C. Comparative morphometric changes in rat cortical bone following ovariectomy and/or immobilization. Bone 14:877-883; 1993.
2. Bagi, C. M. and Miller, S. C. Comparison of osteopenic changes in cancellous bone induced by ovariectomy and/or immobilization in adult rats. Anat Record 239:243-254; 1994.
3. Dempster, D. W., Birchman, R., Xu, R., Lindsay, R., and Shen, V. Temporal changes in cancellous bone structure of rats immediately after ovariectomy. Bone 16:157-161; 1995.
4. Garrahan, N. J., Mellish, R. W. E., and Compston, J. E. A new method for the two-dimensional analysis of bone structure in human iliac crest biopsies. J Microsc 143:341-349; 1986.
5. Hodgkinson, A., Aaron, J. E., Horsman, A., McLachlan, M. S. F., and Nordin, B. E. C. Effect of oophorectomy and calcium deprivation on bone mass in the rat. Clin Sci Mol Med 54:439-446; 1978.
6. Jee, W. S. S., Wronski, T. J., Morey, E. R., and Kimmel, D. B. Effects of spaceflight on trabecular bone in rats. Am J Physiol 244:R310-R314; 1983.
7. Kalu, D. N., Liu, C. C., Hardin, R. R., and Hollis, B. W. The aged rat model of ovarian hormone deficiency bone loss. Endocrinol 124:7-16; 1989.
8. Ke, H. Z., Li, M., and Jee, W. S. S. Prostaglandin E2 prevents ovariectomy-induced cancellous bone loss in rats. Bone Miner 19:45-62; 1992.
9. Li, X. J., Jee, W. S. S., Chow, S. Y., and Woodbury, D. M. Adaptation of cancellous bone to aging and immobilization in the rat: a single photon absorptiometry and histomorphometry study. Anat Rec 227:12-14; 1990.
10. Lin, B. Y., Jee, W. S. S., Chen, M. M., Ma, Y. F., Ke, H. Z., and Li, X. J. Mechanical loading modified ovariectomy-induced cancellous bone loss. Bone Miner 25:199-210; 1994.
11. Morey, E. R. and Baylink, D. J. Inhibition of bone formation during spaceflight. Science 201:1138-1140; 1978.
12. Parfitt, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. A., Malluche, H., Meunier, P. J., Ott, S. M., and Recker, R. R. Bone histomorphometry: Standardization of nomenclature, symbols and units. J Bone Miner Res 2:595-610; 1987.
13. Shen, V., Birchman, R., Xu, R., Lindsay, R., and Dempster, D. W. Short-term changes in histomorphometric and biochemical turnover markers and bone mineral density in estrogen and/or dietary calcium deficient rats. Bone 16:149-156; 1995.
14. Thompson, D. D. and Rodan, G. A. Indomethacin inhibition of tenotomy-induced bone resorption in rats. J Bone Miner Res 3:409-414; 1988.
15. Turner, R. T. and Bell, N. H. The effects of immobilization on bone histomorphometry in rats. J Bone Miner Res 1:399-407; 1986.
16. Turner, R. T., Wakley, G. K., and Szukalski, B. Effects of gravitational and muscular loading on bone formation in growing rats. Physiologist 28:567-568; 1985.
17. Wark, J. D. Osteoporosis: pathogenesis, diagnosis, prevention and management. Balliere's Clin Endocrinol Metab 7:151-181; 1993.
18. Weinreb, M., Rodan, G. A., and Thompson, D. D. Immobilization-related bone loss in the rat is increased by calcium deficiency. Calcif Tiss Int 48:93-100; 1991.
19. Wronski, T. J., Cintron, M., and Dann, L. M. Temporal relationship between bone loss and increased bone turnover in ovariectomized rats. Calcif Tiss Int 43:179-183; 1988.
20. Wronski, T. J., Walsh, C. C., and Ignaszewski, L. A. Histological evidence for osteopenia and increased bone turnover in ovariectomized rats. Bone 7:119-123; 1986.
21. Yoshida, S., Yamamuro, T., Okumura, H., and Takahashi, H. Microstructural changes of osteopenic trabeculae in the rat. Bone 12:185-194; 1991.