Effect of neonatal exposure to diethylstilbestrol and tamoxifen on pelvis and femur in male mice

Anatomical Record

Volumn 244, Issue 3, 1996, Pages 416-422

  Fukazawa, Yugo ^a   Nobata, Sigenori ^a   Katoh, Miho ^a   Tanaka, Masami ^b   Kobayashi, Sinji ^b   Ohta, Yasuhiko ^c   Hayashi, Yokichi ^d   Iguchi, Taisen ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c TOTTORI UNIVERSITY   (Japan)

^d NAGANO COLLEGE OF NURSING   (Japan)

Author keywords

Diethylstilbestrol; Femur; Mouse; Neonatal treatment; Pelvis; Tamoxifen

Indexed keywords

CALCIUM; DIETHYLSTILBESTROL; PHOSPHORUS; TAMOXIFEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE LEVEL; CALCIUM BONE LEVEL; FEMUR; GENITAL MALFORMATION; MOUSE; NONHUMAN; OSTEOBLAST; PELVIS; PRIORITY JOURNAL;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; BONE DENSITY; DIETHYLSTILBESTROL; ESTROGEN ANTAGONISTS; ESTROGENS, NON-STEROIDAL; FEMUR; MALE; MICE; MICE, INBRED C57BL; PELVIC BONES; TAMOXIFEN; TESTOSTERONE;

EID: 0030061119     PISSN: 0003276X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0185(199603)244:3<416::AID-AR12>3.0.CO;2-S     Document Type: Article

References (46)

1. Arai, Y., Mori, T., Suzuki, Y., and Bern, H.A. 1983 Long-term effects of perinatal exposure to sex steroids and diethylstilbestrol on the reproductive system of male animals. Int. Rev. Cytol., 84:235-268.
2. Chenu, C., Pfeilschifter, J. P., Mundy, G., and Roodman, G. 1988 Transforming growth factor beta inhibits formation of osteoclast-like cells in long-term human marrow cultures. Proc. Natl. Acad. Sci. U.S.A., 85:5683-5691.
3. Bern, H. A., and Talamantes, F. J. 1981 Neonatal mouse models and their relation to disease in the human female. In: Developmental Effects of Diethylstilbestrol (DES) in Pregnancy. Herbst, A.L. and Bern, H.A. (eds.) Thieme-Stratton, New York, pp. 129-147.
4. Centrella, M., and Canalis, E. 1985 Local regulators of skeletal growth: A perspective. Endocr. Rev., 6:544-554.
5. Chenu, C., Pfeilschifter, J. P., Mundy, G., and Roodman, G. 1988 Transforming growth factor beta inhibits formation of osteoclast-like cells in long-term human marrow cultures. Proc. Natl. Acad. Sci. U.S.A., 85.5683-5691.
6. Eriksen, E. F., Colvard, D. S., Berg, N. J., Graham, M. L., Mann, K. G., Spelsberg, T. C., and Riggs, B. L. 1988 Evidence of estrogen receptors in normal human osteoblast-like cells. Science, 241:84-86.
7. Forsberg, J.-G. 1979 Developmental mechanism of estrogen-induced irreversible changes in the mouse cervical epithelium. Natl. Cancer Inst. Monogr., 51:41-56.
8. Forsberg, J. G., Tenenbaum, A., Rydberg, C., and Sernvi, S. 1985 Ovarian structure and function in neonatally estrogen treated mice. In: International Symposium on Estrogens in the Environment. McLachlan, J.A. (ed.) Elsevier, New York, pp. 327-346.
9. Hansson, L. I., Menander-Sellman, K., Stenstrom, A., and Thorngren, K.-G. 1972 Rate of normal longitudinal bone growth in the rat. Calcif. Tissue Res., 10:238-251.
10. Herbst, A. L. and Bern, H. A. 1981 Developmental Effects of Diethylstilbestrol (DES) in Pregnancy. Thieme-Stratton, New York.
11. Herbst, A. L., Ulfelder, H., and Poskanzer, D. C. 1971 Association of maternal stilbestrol therapy with tumor appearance in young woman. New Engl. J. Med., 284:878-881.
12. Iguchi, T. 1985 Occurrence of polyovular follices in ovaries of mice treated neonatally with diethylstilbestrol. Proc. Jpn. Acad., 61: 288-291.
13. Iguchi, T. 1992 Cellular effects of early exposure to sex hormones and antihormones. Int. Rev. Cytol., 139:1-57.
14. Iguchi, T., Irisawa, S., Uesugi, Y., Kusunoki, S., and Takasugi, N. 1990 Abnormal development of the os penis in male mice treated neonatally with tamoxifen. Acta Anat., 139:201-208.
15. Iguchi, T., Ostrander, P., L., Mills, K. T., and Bern, H. A. 1985 Induction of abnormal epithelial changes by estrogen in neonatal mouse vaginal transplant. Cancer Res., 45:5688-5693.
16. Iguchi, T., Takase, M., and Takasugi, N. 1986 Development of vaginal adenosis-like lesions and uterine epithelial stratification in mice exposed perinatally to diethylstilbestrol. Proc. Soc. Exp. Biol. Med., 181:59-65.
17. Iguchi, T., Irisawa, S., Uchima, F. D. A., and Takasugi. N. 1988 Permanent chondrification in the pelvis and occurrence of hernias in mice treated neonatally with tamoxifen. Reprod. Toxieol., 2:127-134.
18. Iguchi, T., Irisawa, S., Fukazawa, Y., Uesugi, Y., and Takasugi, N. 1989 Morphometric analysis of the development of sexual dimorphism of the mouse pelvis. Anat. Rec., 224:490-494.
19. Ikeda, T., Shigeno, C., Kasai, R., Okumura, H., Ohta, S., Kohno, H., Konishi, J., and Yamamoto, T. 1993 Ovariectomy decreases the mRNA level of TGF-β1 and increases the mRNA level of osteocalcin in rat tibia in vivo. J. Bone Miner. Res., 8:S-283.
20. Jones, L. A. 1980 Long-term effects of neonatal administration of estrogen and progesterone alone or in combination on male BALB/c and BALB/cfC3H mice. Proc. Soc. Exp. Biol. Med., 165: 17-25.
21. Kazama, T., Mamada, K., Ito, J., Osawa, S., and Yonemitsu, H. 1990 The colorimetric determination of serum calcium with methylxylenol blue. Jpn. J. Med. Technol., 39:1820-1826.
22. Komm, B. S., Terpening, C. M., Benz, D. J., Graeme, K .A , Gallegos, A., Korc, M., Greene, G. L., O'Malley, B. W., and Haussler, M. R. 1988 Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells. Science, 241:81-84.
23. 2 administration prevents bone loss induced by orchidectomy in rats. J. Bone Mineral Res. 10:66-73.
24. McLachlan, J. A. 1979 Transplacental effects of diethylstilbestrol in mice. Natl. Cancer Inst. Monogr., 51:67-72.
25. McLachlan, J. A., Newbold, R. R., and Bullock, B. 1975 Reproductive tract lesions in male mice exposed prenatally to diethylstilbestrol. Science, 190:991-992.
26. Migliaccio, S., Newbold, R. R., Bullock, B., McLachlan, J. A., and Korach, K. S. 1992 Developmental exposure to estrogens induced persistent changes in skeletal tissue. Endocrinology, 130:1756-1758.
27. Mori, T. and Iguchi, T. 1988 Long-term effects of perinatal treatment with sex steroids and related substances on reproductive organs of female mice. In Toxicity of Hormones in Prenatal Life. Mori, T. and Nagasawa, H. (eds.), CRC Press, Florida, pp. 63-80.
28. Mori, T. and Nagasawa, H. 1988 Toxicity of Hormones in Perinatal Life, CRC Press, Florida.
29. Ohta, Y., Uesugi, Y., and Iguchi, T. 1993 Steroid synthesis in testicular and ovarian homogenates from adult mice treated neonatally with diethylstilbestrol. Med. Sci. Res., (in press).
30. Pfeilschifter, J. P., Seyedin, S., and Mundy, G. R. 1988 Transforming growth factor beta inhibits bone resorption in fetal rat long bone cultures. J. Clin. Invest., 82:680-690.
31. Ryan, K. J., Naftolin, F., Reddy, V., Flores, F., and Petro, Z. 1972 Estrogen formation in the brain. Am. J. Obstet. Gynecol., 114: 454-460.
32. Takasugi, N. 1963 Vaginal cornification in persistent-estrous mice. Endocrinology, 72:607-619.
33. Takasugi, N. 1971 Testicular damages in neonatally estrogenized adult mice. Endocrinol. Jpn., 17:277-281.
34. Takasugi, N. 1976 Cytological basis for permanent vaginal changes in mice treated neonatally with steroid hormones. Int. Rev. Cytol., 44:193-224.
35. Takasugi, N. 1979 Development of permanently proliferated and cornified vaginal epithelium in mice treated neonatally with steroid hormones and the implication in tumorigenesis. Natl. Cancer. Inst. Monogr., 51:57-66.
36. Takasugi, N., and Bern, H. A. 1964 Tissue changes in mice with persistent vaginal cornification induced by early postnatal treatment with estrogen. J. Natl. Cancer Inst., 33:855-865.
37. Takasugi, N., Bern, H. A., and DeOme, K. B. 1962 Persistent vaginal cornification in mice. Science, 138:438.
38. Takasugi, N., Tanaka, M., and Kato, C. 1983 Effects of continuous intravenous infusion of diethylstilbestrol into pregnant mice on fetus: Testicular morphology at fetal and postnatal period. Endocrinol. Jpn., 30:35-42.
39. Taussky, H. H., and Shorr, E. 1953 A microcolorimetric method for the determination of inorganic phosphorus. J. Biol. Chem., 202: 675-685.
40. Turner, R. T., Riggs, B. L., and Spelsberg, T. C. 1994 Skeletal effects of estrogen. Endocr. Rev., 15:275-300.
41. Uesugi, Y., Ohta, Y., Asashima, M., and Iguchi, T. 1992a Comparative study of sexual dimorphism of the innominate bone in rodents and amphibians. Anat. Rec., 234:432-437.
42. Uesugi, Y., Taguchi, O., Noumura, T., and Iguchi, T. 1992b Effects of sex steroids on the development of sexual dimorphism in mouse innominate bone. Anat. Rec., 234:541-548.
43. Uesugi, Y., Sato, T., and Iguchi, T. 1993 Morphometric analysis of the pelvis in mice treated neonatally with tamoxifen. Anat. Rec., 235: 126-130.
44. Vanderschueren, D., Van Herck, E., Suiker, A. M. H., Visser, W. J., Schot, L. P. C., and Bouillon, R. 1992 Bone and mineral metabolism in aged male rats: Short and long term effects of androgen deficiency. Endocrinology, 130:2906-2916.
45. Westerlind, K. C., Wakley, G. K., and Turner, R. T. 1993 Two days of reloading following spaceflight does not restore normal gene expression of bone matrix proteins and growth factors. J. Bone Miner. Res., 8:S-281.
46. Whedon, G. D., and Heaney, R. P. 1993 Effects of physical inactivity, paralysis, and weightlessness. In: Bone, Vol. 7. B.K. Hall, ed. CRC Press, Boca Raton, FL, pp. 57-77.