Soy Isoflavones Have a Favorable Effect on Bone Loss in Chinese Postmenopausal Women with Lower Bone Mass: A Double-Blind, Randomized, Controlled Trial

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 10, 2003, Pages 4740-4747

  Chen, Yu Ming ^a,b   Ho, Suzanne C ^a,c   Lam, Silvia S H ^a   Ho, Susan S S ^a   Woo, Jean L F ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b SUN YAT SEN UNIVERSITY   (China)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; COLECALCIFEROL; ISOFLAVONE; PLACEBO; STARCH;

AGED; ARTICLE; BONE DENSITY; BONE MASS; BONE MINERAL; CHINESE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; HIP; HUMAN; MAJOR CLINICAL STUDY; OSTEOLYSIS; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SOYBEAN; SPINE;

ASIAN CONTINENTAL ANCESTRY GROUP; BONE DENSITY; DOUBLE-BLIND METHOD; FEMALE; HUMANS; ISOFLAVONES; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL; PATIENT COMPLIANCE; SOYBEAN PROTEINS;

ANIMALIA; GLYCINE MAX;

EID: 0242288698     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-030290     Document Type: Article

References (46)

1. Adlercreutz H, Mazur W 1997 Phyto-oestrogens and Western diseases. Ann Med 29:95-120
2. Tham DM, Gardner CD, Haskell WL 1998 Clinical review 97: Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence. J Clin Endocrinol Metab 83:2223-2235
3. Glazier MG, Bowman MA 2001 A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy. Arch Intern Med 161:1161-1172
4. Anderson JJ, Garner SC 1998 Phytoestrogens and bone. Bailliere Clin Endocrinol Metab 12:543-557
5. Arjmandi BH, Smith BJ 2002 Soy isoflavones' osteoprotective role in postmenopausal women: mechanism of action. J Nutr Biochem 13:130-137
6. Ishimi Y, Miyaura C, Ohmura M, Onoe Y, Sato T, Uchiyama Y, Ito M, Wang X, Suda T, Ikegami S 1999 Selective effects of genistein, a soybean isoflavone, on B-lymphopoiesis and bone loss caused by estrogen deficiency. Endocrinology 140:1893-1900
7. Picherit C, Coxam V, Bennetau-Pelissero C, Kati-Coulibaly S, Davicco MJ, Lebecque P, Barlet JP 2000 Daidzein is more efficient than genistein in preventing ovariectomy-induced bone loss in rats. J Nutr 130:1675-1681
8. Horiuchi T, Onouchi T, Takahashi M, Ito H, Orimo H 2000 Effect of soy protein on bone metabolism in postmenopausal Japanese women. Osteoporos Int 11:721-724
9. Greendale GA, FitzGerald G, Huang MH, Sternfeld B, Gold E, Seeman T, Sherman S, Sowers M 2002 Dietary soy isoflavones and bone mineral density: results from the study of women's health across the nation. Am J Epidemiol 155:746-754
10. Mei J, Yeung SS, Kung AW 2001 High dietary phytoestrogen intake is associated with higher bone mineral density in postmenopausal but not premenopausal women. J Clin Endocrinol Metab 86:5217-5221
11. Alekel DL, Germain AS, Peterson CT, Hanson KB, Stewart JW, Toda T 2000 Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am J Clin Nutr 72:844-852
12. Dalais FS, Rice GF, Wahlqvist ML, Grehan M, Murkies AL, Medley G, Ayton R, Strauss BJG 1998 Effects of dietary phytoestrogens in postmenopausal women. Climacteric 1:124-129
13. Potter SM, Baum JA, Teng H, Stillman RJ, Shay NF, Erdman Jr JW 1998 Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am J Clin Nutr 68:1375S-1379S
14. Clifton-Bligh PB, Baber RJ, Fulcher GR, Nery ML, Moreton T 2001 The effect of isoflavones extracted from red clover (Rimostil) on lipid and bone metabolism. Menopause 8:259-265
15. Hsu CS, Shen WW, Hsueh YM, Yeh SL 2001 Soy isoflavone supplementation in postmenopausal women. Effects on plasma lipids, antioxidant enzyme activities and bone density. J Reprod Med 46:221-226
16. Gallagher JC, Rafferty K, Haynatzka V, Wilson M 1999 Effect of soy protein on bone metabolism [Abstract]. J Nutr 130:667s
17. Arjmandi BH, Khalil DA, Smith BJ, Lucas EA, Juma S, Payton ME, Wild RA 2003 Soy protein has a greater effect on bone in postmenopausal women not on hormone replacement therapy, as evidenced by reducing bone resorption and urinary calcium excretion. J Clin Endocrinol Metab 88:1048-1054
18. SPSS Staff 2001 SPSS base 11.0 for Windows user's guide. Clifton, NJ: Prentice Hall
19. Ho SC, Leung PC, Swaminathan R, Chan C, Chan SS, Fan YK, Lindsay R 1994 Determinants of bone mass in Chinese women aged 21-40 years. II. Pattern of dietary calcium intake and association with bone mineral density. Osteoporos Int 4:167-175
20. DHEW, Food, Agriculture Organization of the United Nations 1972 Food composition table for use in east Asia. DHEW Publication No. (NIH) 73-465. Bethesda, MD: National Institutes of Health
21. Wang GY 1991 Food composition tables (in Chinese). Beijing: People's Medical Publishing House
22. Ho SC, Chan SG, Yi Q, Wong E, Leung PC 2001 Soy intake and the maintenance of peak bone mass in Hong Kong Chinese women. J Bone Miner Res 16:1363-1369
23. Institue of Medicine 1997 Calcium. In: Institute of Medicine, ed. Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D and fluoride. Washington DC: National Academy Press; 71-145
24. Chinese Nutrition Society 2000 Chinese dietary reference intakes. Beijing: China Light Industry Press; 458-458
25. Lau EM, Suriwongpaisal P, Lee JK, Das DS, Festin MR, Saw SM, Khir A, Torralba T, Sham A, Sambrook P 2001 Risk factors for hip fracture in Asian men and women: the Asian osteoporosis study. J Bone Miner Res 16:572-580
26. Lau EM, Lynn H, Chan YH, Woo J 2002 Milk supplementation prevents bone loss in postmenopausal Chinese women over 3 years. Bone 31:536-540
27. Matkovic V, Heaney RP 1992 Calcium balance during human growth: evidence for threshold behavior. Am J Clin Nutr 55:992-996
28. Anderson JJ, Ambrose WW, Garner SC 1998 Biphasic effects of genistein on bone tissue in the ovariectomized, lactating rat model. Proc Soc Exp Biol Med 217:345-350
29. Arjmandi BH, Getlinger MJ, Goyal NV, Alekel L, Hasler CM, Juma S, Drum ML, Hollis BW, Kukreja SC 1998 Role of soy protein with normal or reduced isoflavone content in reversing bone loss induced by ovarian hormone deficiency in rats. Am J Clin Nutr 68:1358S-1363S
30. Rosen CJ, Wuster C 2003 Growth hormone rising: did we quit too quickly? J Bone Miner Res 18:406-409
31. Landin-Wilhelmsen K, Nilsson A, Bosaeus I, Bengtsson BA 2003 Growth hormone increases bone mineral content in postmenopausal osteoporosis: a randomized placebo-controlled trial. J Bone Miner Res 18:393-405
32. Boonen S, Lesaffre E, Dequeker J, Aerssens J, Nijs J, Pelemans W, Bouillon R 1996 Relationship between baseline insulin-like growth factor-I (IGF-1) and femoral bone density in women aged over 70 years: potential implications for the prevention of age-related bone loss. J Am Geriatr Soc 44:1301-1306
33. Sugimoto T, Nishiyama K, Kuribayashi F, Chihara K 1997 Serum levels of insulin-like growth factor (IGF) I, IGF-binding protein (IGFBP)-2, and IGFBP-3 in osteoporotic patients with and without spinal fractures. J Bone Miner Res 12:1272-1279
34. Brot C, Jensen LB, Sorensen OH 1997 Bone mass and risk factors for bone loss in perimenopausal Danish women. J Intern Med 242:505-511
35. Glauber HS, Vollmer WM, Nevitt MC, Ensrud KE, Orwoll ES 1995 Body weight versus body fat distribution, adiposity, and frame size as predictors of bone density. J Clin Endocrinol Metab 80:1118-1123
36. Ho SC, Chan SS, Woo J, Leung PC, Lau J 1995 Determinants of bone mass in the Chinese old-old population. Osteoporos Int 5:161-166
37. Ho SC, Leung PC 1995 Determinants of Peak bone mass in Chinese and Caucasian populations. Hong Kong Med J 1:38-42
38. King RA 1998 Daidzein conjugates are more bioavailable than genistein conjugates in rats. Am J Clin Nutr 68:1496S-1499S
39. Xu X, Wang HJ, Murphy PA, Cook L, Hendrich S 1994 Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women. J Nutr 124:825-832
40. Meema S, Meema HE 1976 Menopausal bone loss and estrogen replacement. Isr J Med Sci 12:601-606
41. Recker R, Lappe J, Davies K, Heaney R 2000 Characterization of perimenopausal bone loss: a prospective study. J Bone Miner Res 15:1965-1973
42. Dawson-Hughes B, Harris SS 2002 Calcium intake influences the association of protein intake with rates of bone loss in elderly men and women. Am J Clin Nutr 75:773-779
43. Munger RG, Cerhan JR, Chiu BC 1999 Prospective study of dietary protein intake and risk of hip fracture in postmenopausal women. Am J Clin Nutr 69:147-152
44. Sellmeyer DE, Stone KL, Sebastian A, Cummings SR 2001 A high ratio of dietary animal to vegetable protein increases the rate of bone loss and the risk of fracture in postmenopausal women. Study of Osteoporotic Fractures Research Group. Am J Clin Nutr 73:118-122
45. Heaney RP, Gallagher JC, Johnston CC, Neer R, Parfitt AM, Whedon GD 1982 Calcium nutrition and bone health in the elderly. Am J Clin Nutr 36: 986-1013
46. Dempster DW 2002 Bone remodeling. In: Coe FL, Favus MJ, eds. Disorders of bone and mineral metabolism, 2nd Ed. Philadelphia: Lippincott Williams & Wilkins; 315-344