One year soy protein supplementation has positive effects on bone formation markers but not bone density in postmenopausal women

Nutrition Journal

Volumn 4, Issue , 2005, Pages

  Arjmandi, Bahram H ^a   Lucas, Edralin A ^a   Khalil, Dania A ^a   Devareddy, Latha ^a   Smith, Brenda J ^a   McDonald, Jennifer ^a   Arquitt, Andrea B ^a   Payton, Mark E ^a   Mason, Claudia ^a  

^a OKLAHOMA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; ALKALINE PHOSPHATASE BONE ISOENZYME; BIOLOGICAL MARKER; DEOXYPYRIDINOLINE; OSTEOCALCIN; SOMATOMEDIN C; SOYBEAN PROTEIN;

ADULT; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; BLOOD ANALYSIS; BONE DENSITY; BONE METABOLISM; BONE MINERAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DUAL ENERGY X RAY ABSORPTIOMETRY; ENZYME ACTIVITY; FEMALE; HIP; HUMAN; LONG TERM CARE; LUMBAR SPINE; LUMBAR VERTEBRA; MEASUREMENT; OSSIFICATION; OSTEOLYSIS; OUTCOMES RESEARCH; POSTMENOPAUSE; PROTEIN DIET; PROTEIN INTAKE; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; URINALYSIS; URINARY EXCRETION;

ABSORPTIOMETRY, PHOTON; ALKALINE PHOSPHATASE; AMINO ACIDS; BIOLOGICAL MARKERS; BODY MASS INDEX; BONE DENSITY; CALCIUM; DIET; DIET RECORDS; DIETARY CARBOHYDRATES; DIETARY PROTEINS; DOUBLE-BLIND METHOD; ENERGY INTAKE; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; LUMBAR VERTEBRAE; MIDDLE AGED; NUTRITIONAL PHYSIOLOGICAL PHENOMENA; OSTEOCALCIN; OSTEOGENESIS; PELVIC BONES; POSTMENOPAUSE; QUESTIONNAIRES; SOYBEAN PROTEINS;

EID: 17844379469     PISSN: 14752891     EISSN: 14752891     Source Type: Journal    
DOI: 10.1186/1475-2891-4-8     Document Type: Article

References (65)

1. National Osteoporosis Foundation America's Bone Health: The State of Osteoporosis and Low Bone Mass. .
2. Gambacciani M, Ciaponi M: Postmenopausal osteoporosis management. Current Opinion in Obstetrics & Gynecology 2000, 12:189-197.
3. Scheiber MD, Rebar RW: Isoflavones and postmenopausal bone health: a viable alternative to estrogen therapy? Menopause 1999, 6:233-241.
4. Branca F: Physical activity, diet and skeletal health. Public Health Nutr 1999, 2:391-396.
5. Heaney RP: Calcium, dairy products and osteoporosis. J Am Coll Nutr 2000, 19(2 Suppl):83S-99S.
6. Fitzpatrick LA: Phytoestrogens - mechanism of action and effect on bone markers and bone mineral density. Endocrinol Metab Clin North Am 2003, 32:233-252.
7. Setchell KD, Lydeking-Olsen E: Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies. Am J Clin Nutr 2003, 78:593S-609S.
8. Arjmandi BH, Smith BJ: Soy isoflavones' osteoprotective role in postmenopausal women: mechanism of action. J Nutr Biochem 2002, 13:130-137.
9. Adams C, Cannell S: Women's beliefs about "natural" hormones and natural hormone replacement therapy. Menopause 2001, 8:433-440.
10. Cassidy A: Dietary phytoestrogens and bone health. J Br Menopause Soc 2003, 9:17-21.
11. Weaver CM, Liebman M: Biomarkers of bone health appropriate for evaluating functional foods designed to reduce risk of osteoporosis. Br J Nutr 2002, 88(Suppl 2):S225-S232.
12. Valtuena S, Cashman K, Robins SP, Cassidy A, Kardinaal A, Branca F: Investigating the role of natural phyto-oestrogens on bone health in postmenopausal women. Br J Nutr 2003, 89(Suppl 1):S87-S99.
13. Del Mar CB, Glasziou PP, Spinks AB, Sanders SL: Natural remedies for osteoporosis in postmenopausal women. Med J Aust 2002, 176:182-183.
14. Setchell KD: Soy isoflavones - benefits and risks from nature's selective estrogen receptor modulators: (SERMs). J Am Coll Nutr 2001, 20:354S-362S.
15. Brzezinski A, Debi A: Phytoestrogens: the "natural" selective estrogen receptor modulators? Eur J Obstet Gynecol Reprod Biol 1999, 85:47-51.
16. Adlercreutz H, Mazur W: Phyto-oestrogens and Western diseases. Ann Med 1997, 29:95-1201.
17. Scwartz AV, Kelsey JL, Maggi S, Tuttleman M, et al.: International variation in the incidence of hip fractures: cross-national project on osteoporosis for the World Health Organization Program for research on aging. Osteopor Int 1999, 9:242-253.
18. Chen Z, Zheng W, Custer LJ, et al.: Usual dietary consumption of soy foods and its correlation with the excretion rate of isoflavonoids in overnight urine samples among Chinese women in Shanghai. Nutr Cancer 1999, 33:82-87.
19. Ho SC, Woo J, Lam S, Chen Y, Sham A, Lau J: Soy protein consumption and bone mass in early postmenopausal Chinese women. Osteoporos Int 2003, 14:835-842.
20. Arjmandi BH, Birnbaum R, Goyal NV, Getlinger MJ, Juma S, Alekel L, et al.: Bone-sparing effect of soy protein in ovarian hormonedeficient rats is related to its isoflavone content. Am J Clin Nutr 1998, 68:1364S-1368S.
21. Arjmandi BH, Getlinger MJ, Goyal NV, Alekel L, Hasler CM, Juma S, et al.: Role of soy protein with normal or reduced isoflavone content in reversing bone loss induced by ovarian hormone deficiency in rats. Am J Clin Nutr 1998, 68:1358S-1363S.
22. Picherit C, Chanteranne B, Bennetau-Pelissero C, Davicco MJ, Lebecque P, Barlet JP, et al.: Dose-dependent bone-sparing effects of dietary isoflavones in the ovariectomised rat. Br J Nutr 2001, 85:307-316.
23. Picherit C, Coxam V, Bennetau-Pelissero C, Kati-Coulibaly S, Davicco MJ, Lebecque P, et al.: Daidzein is more efficient than genistein in preventing ovariectomy-induced bone loss in rats. J Nutr 2000, 130:1675-1681.
24. Fanti P, Monier-Faugere MC, Geng Z, Schmidt J, Morris PE, Cohen D, et al.: The phytoestrogen genistein reduces bone loss in shortterm ovariectomized rats. Osteoporos Int 1998, 8:274-281.
25. Arjmandi BH, Alekel L, Hollis BW, Amin D, Stacewicz-Sapuntzakis M, Guo P, et al.: Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis. J Nutr 1996, 126:161-167.
26. Harrison E, Adjei A, Ameho C, Yamamoto S, Kono S: The effect of soybean protein on bone loss in a rat model of postmenopausal osteoporosis. J Nutr Sci Vitaminol (Tokyo) 1998, 44:257-268.
27. Dalais FS, Rice GE, Wahlqvist ML, Grehan M, Murkies AL, Medley G, et al.: Effects of dietary phytoestrogens in postmenopausal women. Climacteric 1998, 1:124-129.
28. Potter SM, Baum JA, Teng H, Stillman RJ, Shay NF, Erdman JW Jr: Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am J Clin Nutr 1998, 68:1375S-1379S.
29. Alekel DL, Germain AS, Peterson CT, Hanson KB, Stewart JW, Toda T: Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am J Clin Nutr 2000, 72:844-852.
30. Vitolins M, Anthony M, Lenschik L, Bland DR, Burke GL: Does soy protein and its isoflavones prevent bone loss in peri- and postmenopausal women? Results of a two year randomized clinical trial. J Nutr 2002, 132:582S.
31. Kreijkamp-Kaspers S, Kok L, Grobbee DE, de Haan EHF, Aleman A, Lampe J, van der Schouw YT: Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women. JAMA 2004, 292:65-74.
32. Gallagher JC, Satpathy R, Rafferty K, Haynatzka V: The effect of soy protein isolate on bone metabolism. Menopause 2004, 11:290-298.
33. Leydeking-Olsen E, Jensen JBE, Setchell KD, Jensen TH: Soymilk or progesterone for the prevention of bone loss. A 2 year randomized, placebo-controlled trial. Eur J Nutr 2004, 12:12.
34. Chiechi LM, Secreto G, D'Amore M, Fanelli M, Venturelli E, Cantatore F, et al.: Efficacy of a soy rich diet in preventing postmenopausal osteoporosis: the Menfis randomized trial. Maturitas 2002, 42:295-300.
35. United States Food and Drug Administration: Food Labeling: Health Claims; Soy Protein and Coronary Heart Disease; Final Rule. Federal Register 64 FR 57699 October 26 1999.
36. Arjmandi BH, Khan DA, Juma S, Drum ML, Abdul Kadir KB, Venatesh S, et al.: Whole flaxseed consumption lowers serum LDL - cholestrol and lipoprotein(a) concentrations in postmenopausal women. Nutr Res 1998, 18:1203-1214.
37. Arjmandi BH, Juma S, Lucas EA, Wei L, Venkatesh S, Khan DA: Flaxseed supplementation positively influence bone metabolism in postmenopausal women. JANA 1998, 1:27-32.
38. Garnero P, Delmas PD: Assessment of the serum levels of bone alkaline phosphatase with a new immunoradiometric assay in patients with metabolic bone disease. J Clin Endocrinol Metab 1993, 77:1046-1053.
39. Robins SP, Woitge H, Hesley R, Ju J, Seyedin S, Seibel MJ: Direct, enzyme-linked immunoassay for urinary deoxypyridinoline as a specific marker for measuring bone resorption. J Bone Miner Res 1994, 9:1643-1649.
40. Baird DD, Umbach DM, Lansdell L, Hughes CL, Setchell KD, Weinberg CR, et al.: Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women. J Clin Endocrinol Metab 1995, 80:1685-1690.
41. Duncan AM, Underhill KE, Xu X, Lavalleur J, Phipps WR, Kurzer MS: Modest hormonal effects of soy isoflavones in postmenopausal women. J Clin Endocrinol Metab 1999, 84:3479-3484.
42. Xu X, Duncan AM, Wangen KE, Kurzer MS: Soy consumption alters endogenous estrogen metabolism in postmenopausal women. Cancer Epidemiol Biomarkers Prev 2000, 9:781-786.
43. Tham DM, Gardner CD, Haskell WL: Clinical review 97: Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence. J Clin Endocrinol Metab 1998, 83:2223-2235.
44. Yamamoto S, Sobue T, Kobayashi M, Sasaki S, Tsugane S: Soy, isoflavones, and breast cancer risk in Japan. J Natl Cancer Inst 2003, 95:906-913.
45. Kritz-Silverstein D, Von Muhlen D, Barrett-Connor E, Bressel MA: Isoflavones and cognitive function in older women: the Soy and Postmenopausal Health In Aging: (SOPHIA) Study. Menopause 2003, 10:196-202.
46. Merz-Demlow BE, Duncan AM, Wangen KE, Xu X, Carr TP, Phipps WR, et al.: Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women. Am J Clin Nutr 2000, 71:1462-1469.
47. Messina M, Hughes C: Efficacy of soyfoods and soybean isoflavone supplements for alleviating menopausal symptoms is positively related to initial hot flush frequency. J Med Food 2003, 6:1-11.
48. Messina M: Soy, soy phytoestrogens: (isoflavones), and breast cancer. Am J Clin Nutr 1999, 70:574-575.
49. Messina MJ, Loprinzi CL: Soy for breast cancer survivors: a critical review of the literature. J Nutr 2001, 131:3095S-3108S.
50. Messina MJ: Emerging evidence on the role of soy in reducing prostate cancer risk. Nutr Rev 2003, 61:117-131.
51. Geinoz G, Rapin CH, Rizzoli R, Kraemer R, Buchs B, Slosman D, et al.: Relationship between bone mineral density and dietary intakes in the elderly. Osteoporos Int 1993, 3:242-248.
52. Hannan MT, Tucker KL, Dawson-Hughes B, Cupples LA, Felson DT, Kiel DP: Effect of dietary protein on bone loss in elderly men and women: the Framingham Osteoporosis Study. J Bone Miner Res 2000, 15:2504-2512.
53. Massey LK: Dietary animal and plant protein and human bone health: a whole foods approach. J Nutr 2003, 133:862S-865S.
54. Kerstetter JE, O'Brien KO, Insogna KL: Dietary protein, calcium metabolism, and skeletal homeostasis revisited. Am J Clin Nutr 2003, 78:584S-592S.
55. Kerstetter JE, O'Brien K, Insogna K: Dietary protein and intestinal calcium absorption. Am J Clin Nutr 2001, 73:990-992.
56. Chen YM, Ho SC, Lam SS, Ho SS, Woo JL: Beneficial effect of soy isoflavones on bone mineral content was modified by years since menopause, body weight, and calcium intake: a doubleblind, randomized, controlled trial. Menopause 2004, 11:246-254.
57. Morabito N, Crisafulli A, Vergara C, Gaudio A, Lasco A, Frisina N, et al.: Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: a randomized double-blind placebo-controlled study. J Bone Miner Res 2002, 17:1904-1912.
58. Clifton-Bligh PB, Baber RJ, Fulcher GR, Nery ML, Moreton T: The effect of isoflavones extracted from red clover: (Rimostil) on lipid and bone metabolism. Menopause 2001, 8:259-265.
59. Atkinson C, Compston JE, Day NE, Dowsett M, Bingham SA: The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2004, 79:326-333.
60. Lu LJW, Anderson KE, Grady JJ, Nagamani M: Chronic soy consumption influences serum levels of steroid and peptide hormones without uterine effects in postmenopausal women. J Nutr 2002, 132:615S.
61. Scheiber MD, Liu JH, Subbiah MT, Rebar RW, Setchell KD: Dietary inclusion of whole soy foods results in significant reductions in clinical risk factors for osteoporosis and cardiovascular disease in normal postmenopausal women. Menopause 2001, 8:384-392.
62. Arjmandi BH, Khalil DA, Smith BJ, Lucas EA, Juma S, Payton ME, et al.: Soy protein has a greater effect on bone in postmenopausal women not on hormone replacement therapy, as evidenced by reducing bone resorption and urinary calcium excretion. J Clin Endocrinol Metab 2003, 88:1048-1054.
63. Wong WW: Effects of soy isoflavones on blood lipids, blood pressure and biochemical markers of bone metabolism in postmenopausal women. J Nutr 2000, 130:686S.
64. Pansini F, Bonaccorsi G, Albertazzi P, et al.: Soy phytoestrogens and bone. Proceedings of the North American Menopause Society 1997:44.
65. Adlercreutz H, Hockerstedt K, Bannwart C, Bloigu S, Hamalainen E, Fotsis T, et al.: Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin: (SHBG). J Steroid Biochem 1987, 27:1135-1144.