Distribution and expression of cyclooxygenase (COX) isoenzymes, their physiological roles, and the categorization of nonsteroidal anti-inflammatory drugs (NSAIDs)

American Journal of Medicine

Volumn 107, Issue 6 SUPPL. 1, 1999, Pages 11-16

  Wallace, John L ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5 (4 FLUOROPHENYL) 1 [(4 METHYLSULFONYL)PHENYL] 3 TRIFLUOROMETHYLPYRAZOLE; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ETODOLAC; IBUPROFEN; INDOMETACIN; ISOENZYME; MELOXICAM; MESSENGER RNA; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NAPROXEN; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTACYCLIN; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; ROFECOXIB; THROMBOXANE B2;

ANIMAL MODEL; BACTERIAL INFECTION; BLOOD PRESSURE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFICACY; DRUG SCREENING; DRUG SPECIFICITY; ENZYME HISTOCHEMISTRY; ENZYME INDUCTION; GASTROINTESTINAL TRACT; HELICOBACTER PYLORI; HUMAN; HUMAN TISSUE; IN VITRO STUDY; INFLAMMATION; KIDNEY; MACULA DENSA; MOUSE; MUCOSA INFLAMMATION; NONHUMAN; OVARY; OVULATION; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; RAT; SODIUM RESTRICTION; ULCER HEALING; UTERUS;

EID: 0033404030     PISSN: 00029343     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0002-9343(99)00363-0     Document Type: Conference Paper

References (41)

1. Flower RJ, Vane JR. Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamide-phenol). Nature. 1972;240:410-411.
2. Whittle BJR, Higgs GA, Eakins KE, et al. Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa. Nature. 1980;284:271-273.
3. Xie W, Chipman JG, Robertson DL, et al. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc Natl Acad Sci USA. 1991;88:2692-2696.
4. Mitchell JA, Adarasereenant P, Thiemermann C, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci USA. 1993;90:11693-11697.
5. Riendeau D, Percival MD, Boyce S, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997;121: 105-117.
6. Patrignani P, Panara MR, Greco A, et al. Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases. J Pharmacol Exp Ther. 1994;271:1705-1712.
7. Vane JR, Bakhle YS, Botting RM. Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol. 1998;38:97-120.
8. Penning TD, Talley JJ, Bertenshaw SR, et al. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methyl-phenyi)-3-(trifluoromethyl)-1 H-pyrazol-l-ylj berizenesulforiamide (SC-58635, celecoxib). J Med Chem. 1997;40:1347-1365.
9. McAdam BF, Catella-Lawson F, Mardini IA, Kapoor S, Lawson JA, Fitzgerald GA. Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. Proc Nat Acad Sci USA. 1999;96:272-277.
10. Dinchuk JE, Car BD, Focht RJ, et al. Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature. 1995;378:406-409.
11. Morham SG, Langenbach R, Loftin CD, et al. Prostaglandin synthase-2 gene disruption causes severe renal pathology in the mouse. Cell. 1995;83:473-482.
12. DuBois RN, Abramson SB, Crofford L, et al. Cyclooxygenase in biology and disease. FASEB J. 1998;12:1063-1073.
13. Harris RC, McKanna JA, Akai Y, et al. Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. J Clin Invest. 1994;94:2504-2510.
14. Harding P, Sigmon DH, Alfle ME, et al. Cyclooxygenase-2 mediates increased renal content induced by low-sodium diet. Hypertension. 1997;29:297-302.
15. Richards JS, Fitzpatrick SL, Clemens JW, et al. Ovarian cell differentiation: a cascade of multiple hormones, cellular signals, and regulated genes. Recent Prog Hormone Res. 1995;50:223-254.
16. Wong WYI, Richards JS. Induction of prostaglandin H synthase in rat preovulatory follicles by gonadotropin-releasing hormone. Endocrinology. 1992;130:3512-3521.
17. Sirois J, Simmons DL, Richards JS. Hormonal regulation of messenger ribonucleic acid encoding a novel isoform of prostaglandin endoperoxide H synthase in rat preovulatory follicles: induction in vivo and in vitro. J Biol Chem. 1992; 267:11586-11592.
18. Tsafriri A. Ovulation as a tissue remodelling process. Proteolysis and cumulus expansion. Adv Exp Med Biol. 1995; 377:121-140.
19. Chakraborty I, Das SK, Wang J, Dey SK. Developmental expression of the cyclooxygenase-1 and cyclooxygenase-2 (genes in the peri-implantation mouse uterus and their differential regulation by the blastocyst and ovarian steroids. J Mol Endocrinol. 1996;16:107-122.
20. Lim H, Paria BC, Das SK, et al. Multiple female reproductive failures in cyclooxygenase-2 deficient mice. Cell. 1997;91: 197-208.
21. Kargman S, Charleson S, Cartwright M, et al. Characterization of prostaglandin G / H synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts. Gastroenterology. 1996;111:448-454.
22. Jackson LM, Wu K, Mahida YR, et al. COX expression in human gastric mucosa infected with Helicobacter pylori constitutive or induced? Gastroenterology. 1998;114:A160. (Abstr.)
23. McLaughlan J, Seth R, Cole AT, et al. Increased inducible cyclooxygenase associated with treatment failure in ulcerative colitis. Gastroenterology. 1996;110:A964. (Abstr.)
24. Reuter BK, Asfaha S, Buret A, et al. Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2. J Clin Invest. 1996;98:2076-2085.
25. Mizuno H, Sakamoto C, Matsuda K. Induction of cyclooxygenase-2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology. 1997;112:387-397.
26. Armstrong CP, Blower AL. Non-steroidal anti-inflammatory drugs and life threatening complications of peptic ulceration. Gut. 1997;28:527-532.
27. Stadler P, Armstrong D, Margalith D, et al. Diclofenac delays healing of gastroduodenal mucosal lesions. Double-blind, placebo-controlled endoscopic study in healthy volunteers. Dig Dis Sci. 1991;36:594-600.
28. Schmassmann A, Peskar BM, Stettler C, et al. Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats. Br J Pharmacol. 1998;123:795-804.
29. Davies NM, Sharkey KA, Asfaha S, et al. Aspirin induces a rapid up-regulation of cyclooxygenase-2 expression in the rat stomach. Aliment Pharmacol Ther. 1997;11:1101-1108.
30. Sawaoka H, Tsuji S, Tsujii M, et al. Expression of cyclooxygenase-2 gene in gastric epithelium. J Clin Gastroenterol. 1997;25 (suppl 1):S105-S110.
31. Gretzer B, Ehrlich K, Maracic N, et al. Selective cyclooxygenase-2 inhibitors and their influence on the protective effect of a mild irritant in the rat stomach. Br J Pharmacol. 1998;123:927-935.
32. Nakatsugi S, Terada N, Yoshimura T, et al. Effects of nimesulide, a preferential cyclooxygenase-2 inhibitor, on carrageenan-induced pleurisy and stress-induced gastric lesions in rats. Prostaglandins Leukot Essent Fatty Acids. 1996;55:395-402.
33. Vane JR, Mitchell JA, Appleton I, et al. Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. Proc Natl Acad Sci USA. 1994;91:2046-2050.
34. Siegle I, Klein T, Backman JT, et al. Expression of cyclooxygenase-1 and cyclooxygenase-2 in human synovial tissue. Differential elevation of cyclooxygenase-2 in inflammatory joint diseases. Arthritis Rheum. 1998;41:122-129.
35. 2 formation in tissue from human colonic mucosa and chronic bursitis. Gastroenterology. 1998;114: A139. (Abstr.)
36. Seibert K, Zhang Y, Leahy K, et al. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Natl Acad Sci USA. 1994; 91:12013-12017.
37. Wallace JL, Bak A, McKnight W, et al. Cyclooxygenase-1 contributes to inflammatory responses in rats and mice: implications for GI toxicity. Gastroenterology. 1998;115: 101-109.
38. Smith CJ, Zhang Y, Koboldt CM, et al. Pharmacological analysis of cyclooxygenase-1 in inflammation. Proc Natl Acad Sci USA. 1999;95:13313-13318.
39. Langenbach R, Morham SG, Tiano HF, et al. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell. 1995;83:483-492.
40. Tomlinson A, Appleton I, Moore AR, et al. Cyclo-oxygenase and nitric oxide synthase isoforms in rat carrageenan-induced pleurisy. Br J Pharmacol. 1994;113:693-698.
41. Wallace JL, Chapman K, McKnight W. Limited anti-inflammatory efficacy of cyclooxygenase-2 inhibition in carrageenan-airpouch inflammation. Br J Pharmacol. 1999;126: 1200-1205.