Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 2, 2004, Pages 499-504

  Singh, Sunil K ^a   Reddy, P Ganapati ^a,b   Rao, K Srinivasa ^a   Lohray, Braj B ^a,c   Misra, P ^a   Rajjak, Shaikh A ^a   Rao, Yeleswarapu K ^a   Venkateswarlu, A ^a  

^a DR REDDY'S LABORATORIES LTD   (India)

^b INDIAN INSTITUTE OF TECHNOLOGY MADRAS   (India)

^c ZYDUS RESEARCH CENTRE   (India)

Author keywords

1,5 Diarylpyrazoles; Benzenesulfonamide; COX 2 inhibitors; Polar substitutions

Indexed keywords

CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; SULFONAMIDE;

ANIMAL CELL; ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; NONHUMAN; SUBSTITUTION REACTION;

EID: 0347360257     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.10.027     Document Type: Article

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