Is COX-2 inhibition a panacea for cancer prevention?

International Journal of Cancer

Volumn 94, Issue 5, 2001, Pages 613-614

  Vainio, Harri ^a  

^a INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

Carcinogenesis; Cycloocygenase 2; Cyclooxygenase deficient mice; Nonsteroidal anti inflammatory agent; Prostaglandins

Indexed keywords

CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT;

ANTINEOPLASTIC ACTIVITY; CANCER; CANCER PREVENTION; CANCER SURVIVAL; CARCINOGENESIS; COLORECTAL CARCINOMA; GENETIC PREDISPOSITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; STOMACH ULCER; TRANSGENIC MOUSE;

ANIMALS; ANTICARCINOGENIC AGENTS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; HUMANS; ISOENZYMES; MEMBRANE PROTEINS; MICE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES;

EID: 0035546011     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.1518     Document Type: Short Survey

References (20)

1. Aspirin use and colorectal cancer: Post-trial follow up data from Physicians' Health Study
2. Cyclooxygenase-deficient mice. A summary of their characteristics and susceptibilities to inflammation and carcinogenesis
3. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
4. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
5. Cyclooxygenase in biology and disease
6. Barrett's oesophagus, oesophageal cancer and colon cancer: An explanation of the association and cancer chemopreventive potential of non-steroidal anti-inflammatory drugs
7. Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck
8. A selective cyclooxygenase 2 inhibitor suppresses the growth of H-ras-transformed rat intestinal epithelial cells
9. Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)
10. Cyclooxygenase-1 and -2 deficiency decrease spontaneous intestinal adenomas in the Min mouse
11. Over-expression of cyclooxygenase (Cox)-2 is sufficient to induce tumorigenesis in transgenic mice
12. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis
13. Multiagent chemopreventive agent combinations
14. New paradigms for cancer prevention
15. Effect of alpha-difluoromethylornithine on rectal mucosal levels of polyamines in a randomized, double-blinded trial for colon cancer prevention
16. Cloning and characterization of a growth factor-inducible cyclooxygenase gene from rat intestinal epithelial cells
17. Combinatorial chemoprevention of intestinal metaplasia
18. Enhanced antitumor activity by co-administration of celecoxib and the chemotherapeutic agents cyclophosphamide and 5-FU
19. Preferential enhancement of tumor radioresponse by a cyclooxygenase-2 inhibitor