Terphenyl cyclooxygenase-2 (COX-2) inhibitors: Optimization of the central ring and o-biphenyl analogs

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 7, 1999, Pages 919-924

  Pinto, Donald J P ^a   Batt, Douglas G ^a   Pitts, William J ^a   Petraitis, Joseph J ^a   Orwat, Michael J ^a   Wang, Shuaige ^a   Jetter, James W ^a   Sherk, Susan R ^a   Houghton, Gregory C ^a   Copeland, Robert A ^a   Covington, Maryanne B ^a   Trzaskos, James M ^a   Magolda, Ronald L ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; ROFECOXIB;

ARTICLE; DRUG HALF LIFE; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; NUCLEAR MAGNETIC RESONANCE; SYNTHESIS;

CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; ISOENZYMES; MOLECULAR STRUCTURE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 0033526093     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00105-5     Document Type: Article

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