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Volumn 20, Issue SUPPL. 12, 2005, Pages

Alpha-synuclein transgenic mice: Relevance to multiple system atrophy

Author keywords

Glial cytoplasmic inclusion; Multiple system atrophy; Oligodendrocyte; Synuclein; Transgenic mouse

Indexed keywords

ALPHA 1B ADRENERGIC RECEPTOR; ALPHA SYNUCLEIN; MUTANT PROTEIN; PROTEASOME; PROTEIN KINASE; SERINE; TAU PROTEIN; UBIQUITIN;

EID: 26444544352     PISSN: 08853185     EISSN: None     Source Type: Journal    
DOI: 10.1002/mds.20542     Document Type: Article
Times cited : (13)

References (39)
  • 1
    • 0036150971 scopus 로고    scopus 로고
    • The synucleins
    • REVIEWS3002
    • George JM. The synucleins. Genome Biol 2002;3:REVIEWS3002.
    • (2002) Genome Biol. , vol.3
    • George, J.M.1
  • 2
    • 0037067993 scopus 로고    scopus 로고
    • Differential localization of α-, β- and γ-synucleins in the rat CNS
    • Li J-Y, Jensen PH, Dahlström A. Differential localization of α-, β- and γ-synucleins in the rat CNS. Neuroscience 2002;113:463-478.
    • (2002) Neuroscience , vol.113 , pp. 463-478
    • Li, J.-Y.1    Jensen, P.H.2    Dahlström, A.3
  • 3
    • 0035951869 scopus 로고    scopus 로고
    • A hydrophobic stretch of 12 amino acid residues in the middle of α-synuclein is essential for filament assembly
    • Giasson BI, Murray IVJ, Trojanowski JQ, Lee VM-Y. A hydrophobic stretch of 12 amino acid residues in the middle of α-synuclein is essential for filament assembly. J Biol Chem 2001; 276:2380-2386.
    • (2001) J. Biol. Chem. , vol.276 , pp. 2380-2386
    • Giasson, B.I.1    Murray, I.V.J.2    Trojanowski, J.Q.3    Lee, V.M.-Y.4
  • 4
    • 0035191413 scopus 로고    scopus 로고
    • Selective insolubility of α-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model
    • Kahle PJ, Neumann M, Ozmen L, et al. Selective insolubility of α-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model. Am J Pathol 2001;159:2215-2225.
    • (2001) Am. J. Pathol. , vol.159 , pp. 2215-2225
    • Kahle, P.J.1    Neumann, M.2    Ozmen, L.3
  • 5
    • 0035950270 scopus 로고    scopus 로고
    • β-Synuclein inhibits α-synuclein aggregation. A possible role as an anti-parkinsonian factor
    • Hashimoto M, Rockenstein E, Mante M, Mallory M, Masliah E. β-Synuclein inhibits α-synuclein aggregation. A possible role as an anti-parkinsonian factor. Neuron 2001;32:213-223.
    • (2001) Neuron , vol.32 , pp. 213-223
    • Hashimoto, M.1    Rockenstein, E.2    Mante, M.3    Mallory, M.4    Masliah, E.5
  • 6
    • 0037023699 scopus 로고    scopus 로고
    • Biophysical properties of the synucleins and their propensities to fibrillate: Inhibition of α-synuclein assembly by β- and γ-synucleins
    • Uversky VN, Li J, Souillac P, et al. Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of α-synuclein assembly by β- and γ-synucleins. J Biol Chem 2002; 277:11970-11978.
    • (2002) J. Biol. Chem. , vol.277 , pp. 11970-11978
    • Uversky, V.N.1    Li, J.2    Souillac, P.3
  • 7
    • 0037426346 scopus 로고    scopus 로고
    • β-synuclein inhibits formation of α-synuclein protofibrils: A possible therapeutic strategy against Parkinson's disease
    • Park JY, Lansbury PT Jr. β-synuclein inhibits formation of α-synuclein protofibrils: a possible therapeutic strategy against Parkinson's disease. Biochemistry 2003;42:3696-3700.
    • (2003) Biochemistry , vol.42 , pp. 3696-3700
    • Park, J.Y.1    Lansbury Jr., P.T.2
  • 8
    • 0027489773 scopus 로고
    • Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease
    • Uéda K, Fukushima H, Masliah E, et al. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc Natl Acad Sci U S A 1993;90:11282-11286.
    • (1993) Proc. Natl. Acad. Sci. U S A , vol.90 , pp. 11282-11286
    • Uéda, K.1    Fukushima, H.2    Masliah, E.3
  • 9
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the α-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos MH, Lavedan C, Leroy E, et al. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 1997;276:2045-2047.
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1    Lavedan, C.2    Leroy, E.3
  • 10
    • 0031990490 scopus 로고    scopus 로고
    • Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease
    • Krüger R, Kuhn W, Müller T, et al. Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nat Genet 1998;18: 106-108.
    • (1998) Nat. Genet. , vol.18 , pp. 106-108
    • Krüger, R.1    Kuhn, W.2    Müller, T.3
  • 12
    • 0035409575 scopus 로고    scopus 로고
    • Alpha-synuclein and neurodegenerative diseases
    • Goedert M. Alpha-synuclein and neurodegenerative diseases. Nat Rev Neurosci 2001;2:492-501.
    • (2001) Nat. Rev. Neurosci. , vol.2 , pp. 492-501
    • Goedert, M.1
  • 14
    • 0033973421 scopus 로고    scopus 로고
    • NACP/α-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brains
    • Wakabayashi K, Hayashi S, Yoshimoto M, Kudo H, Takahashi H. NACP/α-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brains. Acta Neuropathol (Berl) 2000;99:14-20.
    • (2000) Acta Neuropathol. (Berl.) , vol.99 , pp. 14-20
    • Wakabayashi, K.1    Hayashi, S.2    Yoshimoto, M.3    Kudo, H.4    Takahashi, H.5
  • 15
    • 0024843373 scopus 로고
    • Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome)
    • Papp MI, Kahn JE, Lantos PL. Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome). J Neurol Sci 1989;94:79-100.
    • (1989) J. Neurol. Sci. , vol.94 , pp. 79-100
    • Papp, M.I.1    Kahn, J.E.2    Lantos, P.L.3
  • 16
    • 0031715398 scopus 로고    scopus 로고
    • NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy
    • Arima K, Uéda K, Sunohara N, et al. NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy. Acta Neuropathol 1998;96:439-444.
    • (1998) Acta Neuropathol. , vol.96 , pp. 439-444
    • Arima, K.1    Uéda, K.2    Sunohara, N.3
  • 17
    • 0032584686 scopus 로고    scopus 로고
    • Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies
    • Spillantini MG, Crowther RA, Jakes R, Cairns NJ, Lantos PL, Goedert M. Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neurosci Lett 1998;251:205-208.
    • (1998) Neurosci. Lett. , vol.251 , pp. 205-208
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Cairns, N.J.4    Lantos, P.L.5    Goedert, M.6
  • 18
    • 0031715399 scopus 로고    scopus 로고
    • Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy
    • Wakabayashi K, Hayashi S, Kakita A, et al. Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy. Acta Neuropathol (Berl) 1998;96:445-452.
    • (1998) Acta Neuropathol. (Berl.) , vol.96 , pp. 445-452
    • Wakabayashi, K.1    Hayashi, S.2    Kakita, A.3
  • 19
    • 0031713491 scopus 로고    scopus 로고
    • Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α-synuclein
    • Tu P, Galvin JE, Baba M, et al. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α-synuclein. Ann Neurol 1998;44:415-422.
    • (1998) Ann. Neurol. , vol.44 , pp. 415-422
    • Tu, P.1    Galvin, J.E.2    Baba, M.3
  • 20
    • 0032833653 scopus 로고    scopus 로고
    • Widespread alterations of α-synuclein in multiple system atrophy
    • Dickson DW, Liu W-K, Hardy J, et al. Widespread alterations of α-synuclein in multiple system atrophy. Am J Pathol 1999;155: 1241-1251.
    • (1999) Am. J. Pathol. , vol.155 , pp. 1241-1251
    • Dickson, D.W.1    Liu, W.-K.2    Hardy, J.3
  • 21
    • 0033800039 scopus 로고    scopus 로고
    • Immunohistochemical and biochemical studies demonstrate a distinct profile of α-synuclein permutations in multiple system atrophy
    • Duda JE, Giasson BI, Gur TL, et al. Immunohistochemical and biochemical studies demonstrate a distinct profile of α-synuclein permutations in multiple system atrophy. J Neuropathol Exp Neurol 2000;59:830-841.
    • (2000) J. Neuropathol. Exp. Neurol. , vol.59 , pp. 830-841
    • Duda, J.E.1    Giasson, B.I.2    Gur, T.L.3
  • 22
    • 0034602442 scopus 로고    scopus 로고
    • Oxidative damage linked to neurodegeneration by selective α-synuclein nitration in synucleinopathy lesions
    • Giasson BI, Duda JE, Murray IVJ, et al. Oxidative damage linked to neurodegeneration by selective α-synuclein nitration in synucleinopathy lesions. Science 2000;290:985-989.
    • (2000) Science , vol.290 , pp. 985-989
    • Giasson, B.I.1    Duda, J.E.2    Murray, I.V.J.3
  • 23
    • 0036174010 scopus 로고    scopus 로고
    • α-Synuclein is phosphorylated in synucleinopathy lesions
    • Fujiwara H, Hasegawa M, Dohmae N, et al. α-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 2002;4:160-164.
    • (2002) Nat. Cell. Biol. , vol.4 , pp. 160-164
    • Fujiwara, H.1    Hasegawa, M.2    Dohmae, N.3
  • 24
    • 2242472974 scopus 로고    scopus 로고
    • Phosphorylated α-synuclein is ubiquitinated in α-synucleinopathy lesions
    • Hasegawa M, Fujiwara H, Nonaka T, et al. Phosphorylated α-synuclein is ubiquitinated in α-synucleinopathy lesions. J Biol Chem 2002;277:49071-49076.
    • (2002) J. Biol. Chem. , vol.277 , pp. 49071-49076
    • Hasegawa, M.1    Fujiwara, H.2    Nonaka, T.3
  • 25
    • 0036326067 scopus 로고    scopus 로고
    • Structure/function of α-synuclein in health and disease: Rational development of animal models for Parkinson's and related diseases
    • Kahle PJ, Haass C, Kretzschmar HA, Neumann M. Structure/function of α-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases. J Neurochem 2002;82:449-457.
    • (2002) J. Neurochem. , vol.82 , pp. 449-457
    • Kahle, P.J.1    Haass, C.2    Kretzschmar, H.A.3    Neumann, M.4
  • 26
    • 0036605566 scopus 로고    scopus 로고
    • Differential neuropathological alterations in transgenic mice expressing α-synuclein from the platelet-derived growth factor and Thy-1 promoters
    • Rockenstein E, Mallory M, Hashimoto M, et al. Differential neuropathological alterations in transgenic mice expressing α-synuclein from the platelet-derived growth factor and Thy-1 promoters. J Neurosci Res 2002;68:568-578.
    • (2002) J. Neurosci. Res. , vol.68 , pp. 568-578
    • Rockenstein, E.1    Mallory, M.2    Hashimoto, M.3
  • 28
    • 0034280435 scopus 로고    scopus 로고
    • Subcellular localization of wild-type and Parkinson's disease-associated mutant α-synuclein in human and transgenic mouse brain
    • Kahle PJ, Neumann M, Ozmen L, et al. Subcellular localization of wild-type and Parkinson's disease-associated mutant α-synuclein in human and transgenic mouse brain. J Neurosci 2000;20:6365-6373.
    • (2000) J. Neurosci. , vol.20 , pp. 6365-6373
    • Kahle, P.J.1    Neumann, M.2    Ozmen, L.3
  • 29
    • 0036304315 scopus 로고    scopus 로고
    • Hyperphosphorylation and insolubility of α-synuclein in transgenic mouse oligodendrocytes
    • Kahle PJ, Neumann M, Ozmen L, et al. Hyperphosphorylation and insolubility of α-synuclein in transgenic mouse oligodendrocytes. EMBO Rep 2002;3:583-588.
    • (2002) EMBO Rep. , vol.3 , pp. 583-588
    • Kahle, P.J.1    Neumann, M.2    Ozmen, L.3
  • 30
    • 0031774904 scopus 로고    scopus 로고
    • The definition of multiple system atrophy: A review of recent developments
    • Lantos PL. The definition of multiple system atrophy: a review of recent developments. J Neuropathol Exp Neurol 1998;57:1099-1111.
    • (1998) J. Neuropathol. Exp. Neurol. , vol.57 , pp. 1099-1111
    • Lantos, P.L.1
  • 31
    • 0030722286 scopus 로고    scopus 로고
    • Expression of molecular chaperones and vesicle transport proteins in differentiating oligodendrocytes
    • Neri CL, Duchala CS, Macklin WB. Expression of molecular chaperones and vesicle transport proteins in differentiating oligodendrocytes. J Neurosci Res 1997;50:769-780.
    • (1997) J. Neurosci. Res. , vol.50 , pp. 769-780
    • Neri, C.L.1    Duchala, C.S.2    Macklin, W.B.3
  • 32
    • 0037466656 scopus 로고    scopus 로고
    • Initiation and synergistic fibrillization of tau and alpha-synuclein
    • Giasson BI, Forman MS, Higuchi M, et al. Initiation and synergistic fibrillization of tau and alpha-synuclein. Science 2003;300: 636-640.
    • (2003) Science , vol.300 , pp. 636-640
    • Giasson, B.I.1    Forman, M.S.2    Higuchi, M.3
  • 33
    • 0033819138 scopus 로고    scopus 로고
    • The pathogenesis of multiple system atrophy: Past, present, and future
    • Jaros E, Burn DJ. The pathogenesis of multiple system atrophy: past, present, and future. Mov Disord 2000;15:784-788.
    • (2000) Mov. Disord. , vol.15 , pp. 784-788
    • Jaros, E.1    Burn, D.J.2
  • 34
    • 0035108490 scopus 로고    scopus 로고
    • Co-localization of α-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration
    • Piao Y-S, Hayashi S, Hasegawa M, et al. Co-localization of α-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration. Acta Neuropathol (Berl) 2001;101:285-293.
    • (2001) Acta Neuropathol. (Berl.) , vol.101 , pp. 285-293
    • Piao, Y.-S.1    Hayashi, S.2    Hasegawa, M.3
  • 35
    • 0036934180 scopus 로고    scopus 로고
    • Mixed multiple system atrophy and progressive supranuclear palsy: A clinical and pathological report of one case
    • Takanashi M, Ohta S, Matsuoka S, Mori H, Mizuno Y. Mixed multiple system atrophy and progressive supranuclear palsy: a clinical and pathological report of one case. Acta Neuropathol (Berl) 2002;103:82-87.
    • (2002) Acta Neuropathol. (Berl.) , vol.103 , pp. 82-87
    • Takanashi, M.1    Ohta, S.2    Matsuoka, S.3    Mori, H.4    Mizuno, Y.5
  • 36
    • 18644371727 scopus 로고    scopus 로고
    • 1B-adrenergic receptor induces a synucleinopathy with excessive tyrosine nitration but decreased phosphorylation
    • 1B-adrenergic receptor induces a synucleinopathy with excessive tyrosine nitration but decreased phosphorylation. J Neurochem 2002; 83:623-634.
    • (2002) J. Neurochem. , vol.83 , pp. 623-634
    • Papay, R.1    Zuscik, M.J.2    Ross, S.A.3
  • 37
    • 0034353231 scopus 로고    scopus 로고
    • 1B-adrenergic receptor causes apoptotic neurodegeneration: Multiple system atrophy
    • 1B-adrenergic receptor causes apoptotic neurodegeneration: multiple system atrophy. Nat Med 2000;6:1388-1394.
    • (2000) Nat. Med. , vol.6 , pp. 1388-1394
    • Zuscik, M.J.1    Sands, S.2    Ross, S.A.3
  • 39
    • 15444376598 scopus 로고    scopus 로고
    • Mouse model of multiple system atrophy: α-synuclein expression in oligodendrocytes causes glial and neuronal degeneration
    • Yazawa I, Giasson BI, Sasaki R, Zhang B, Joyce S, Uryu K, Trojanowski JQ, Lee DH-Y. Mouse model of multiple system atrophy: α-synuclein expression in oligodendrocytes causes glial and neuronal degeneration. Neuron 2005;45:847.
    • (2005) Neuron , vol.45 , pp. 847
    • Yazawa, I.1    Giasson, B.I.2    Sasaki, R.3    Zhang, B.4    Joyce, S.5    Uryu, K.6    Trojanowski, J.Q.7    Lee, D.H.-Y.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.