Overexpression of the α(1B)-adrenergic receptor causes apoptotic neurodegeneration: Multiple system atrophy

Nature Medicine

Volumn 6, Issue 12, 2000, Pages 1388-1394

  Zuscik, Michael J ^a   Sands, Scott ^b   Ross, Sean A ^a   Waugh, David J J ^a   Gaivin, Robert J ^a   Morilak, David ^b   Perez, Dianne M ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b University of Texas Health Sciences Center ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [2 (4 HYDROXYPHENYL)ETHYLAMINOMETHYL]TETRALONE I 125; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1B ADRENERGIC RECEPTOR; CARBIDOPA PLUS LEVODOPA; LEVODOPA; RADIOLIGAND; TERAZOSIN; ADRENERGIC RECEPTOR ALPHA(1B); ALPHA 1 ADRENERGIC RECEPTOR;

ADOLESCENT; AGED; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; GENE OVEREXPRESSION; GRAND MAL EPILEPSY; LIGAND BINDING; MOTOR DYSFUNCTION; MOUSE; NERVE DEGENERATION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SHY DRAGER SYNDROME; TRANSGENIC MOUSE; AGE; ANIMAL; ATROPHY; BIOSYNTHESIS; BRAIN CORTEX; DEGENERATIVE DISEASE; GENETICS; HINDLIMB; PARKINSON DISEASE; PATHOLOGY; PHENOTYPE; SEIZURE; SUBSTANTIA NIGRA;

AGE FACTORS; ANIMALS; APOPTOSIS; ATROPHY; CEREBRAL CORTEX; HINDLIMB; MICE; MICE, TRANSGENIC; NEURODEGENERATIVE DISEASES; PARKINSON DISEASE; PHENOTYPE; RECEPTORS, ADRENERGIC, ALPHA-1; SEIZURES; SUBSTANTIA NIGRA;

EID: 0034353231     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/82207     Document Type: Article

References (30)

1. Cloning, cell-type specificity, and regulatory function of the mouse α(1B)-adrenergic receptor promoter
2. Constitutive activation of a single effector pathway: Evidence for multiple activation states of a G protein-coupled receptor
3. 1-adrenergic receptor activation
4. 1-adrenergic stimulation in relation to the behaviour stimulating effect of modafinil; studies with experimental animals
5. 1-adrenoceptors: Their role in the modulation of attention and memory formation
6. Genomic organization and expression of the human α(1B)-adrenergic receptor
7. Tyrosine hydroxylase and Parkinson's disease
8. 1-Adrenoceptors in the mammalian brain: Similar pharmacology but different distribution in rodents and primates
9. Expression of α(1b) adrenoceptor mRNA in corticotropin-releasing hormone-containing cells of the rat hypothalamus and its regulation by corticosterone
10. Extranuclear dendrites of locus coeruleus neurons: Activation by glutamate and modulation of activity by alpha adrenoceptors
11. Modulation of long-term synaptic depression in visual cortex by acetylcholine and norepinephrine
12. Noradrenergic modulation of cortical acetylcholine release is both direct and γ-aminobutyric acid-mediated
13. Excitatory amino acid-mediated cytotoxicity and calcium homeostasis in cultured neurons
14. Apoptosis mediated by activation of the G-protein coupled receptor for parathyroid hormone (PTH)/PTH-related protein (PTHrP)
15. Adrenergic receptors in Parkinson's disease
16. 1-Adrenergic, D1, and D2 receptors interactions in the prefrontal corte: Implications for the modality of action of different types of neuroleptics
17. Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors
18. Strychnine-induced seizures in mice: The role of noradrenaline
19. α-1 Adrenoceptors are decreased in human epileptic foci
20. Brain adrenoceptor binding sites in mice susceptible (DBA/2J) and resistant (C57 BI/6) to audiogenic seizures
21. Myocardial expression of a constitutively active a1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy
22. Transgenic mice with cardiac overexpression of a1B-adrenergic receptors
23. Decreased blood pressure response in mice deficient of the a1-badrenergic receptor
24. Genetic alteration of a2C-adrenoceptor expression in mice: Influence on locomotor, hypothermic and neurochemical effects of dexmedetomidine, a subtype-nonselective a2-adrenoceptor agonist
25. Gene substitution/knockout to delineate the role of a2-adrenoceptor subtypes in mediating central effects of catecholamines and imidazolines
26. Parkinsonism
27. Molecular cloning and expression of the cDNA for the hamster a1-adrenergic receptor
28. Distribution of a1A adrenergic receptor mRNA in the rat brain visualized by in situ hybridization
29. Quantitative comparison of immunohistochemical staining intensity in tissues fixed in formalin and Histochoice