NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy

Acta Neuropathologica

Volumn 96, Issue 5, 1998, Pages 439-444

  Arima, Kunimasa ^a,b   Uéda, Kenji ^a   Sunohara, Nobuhiko ^c   Arakawa, Kenji ^c   Hirai, Shigeo ^b,c   Nakamura, Minako ^a   Tonozuka Uehara, Haruko ^a   Kawai, Mitsuru ^b  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

^c National Center of Neurology and Psychiatry   (Japan)

Author keywords

Glial cytoplasmic inclusions; Multiple system atrophy; NACP; Neuronal cytoplasmic inclusions; Synuclein

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID PRECURSOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; ANTIBODY LABELING; ARTICLE; ATROPHY; CELL INCLUSION; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOELECTRON MICROSCOPY; IMMUNOREACTIVITY; MALE; NERVE CELL DEGENERATION; NERVE CELL MEMBRANE; OLIGODENDROGLIA; PONS; PRIORITY JOURNAL; SENILE PLAQUE;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INCLUSION BODIES; MALE; MICROSCOPY, IMMUNOELECTRON; MIDDLE AGED; MULTIPLE SYSTEM ATROPHY; NERVE TISSUE PROTEINS; NEUROFIBRILS; NEURONS; OLIGODENDROGLIA; PONS; RATS; SYNUCLEINS;

EID: 0031715398     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050917     Document Type: Article

References (16)

1. Arima K, Murayama S, Mukoyama M, Inose T (1992) Immunocytochemical and ultrastructural studies of neuronal and oligodendroglial cytoplasmic inclusions in multiple system atrophy. 1. Neuronal cytoplasmic inclusions. Acta Neuropathol 83: 453-460
2. Graham JC, Oppenheimer DR (1969) Orthostatic hypotension and nicotinic sensitivity in a case of multiple system atrophy. J Neurol Neurosurg Psychiatry 32: 28-34
3. Ishimaru H, Uéda K, Takahashi A, Maruyama Y (1998) Changes in presynaptic protein NACP/α-synuclein in an ischemic gerbil hippocampus. Brain Res 788: 311-314
4. Iwai A, Masliah E, Yoshimoto M, Ge N, Flanagan L, Rhoan de Silva HA, Kittel A, Saitoh T (1995) The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 14: 467-475
5. Jakes R, Spillantini MG, Goedert M (1994) Identification of two distinct synucleins from human brain. FEBS Lett 345: 27-32
6. Kato S, Nakamura H (1990) Cytoplasmic argyrophilic inclusions in neurons of pontine nuclei in patients with olivopontocerebellar atrophy: immunohistochemical and ultrastructural studies. Acta Neuropathol 79: 584-594
7. Maroteaux L, Scheller RH (1991) The rat brain synucleins; family of proteins transiently associated with neuronal membrane. Brain Res Mol Brain Res 11: 335-343
8. Maroteaux L, Campanelli JT, Scheller RH (1988) Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J Neurosci 8: 2804-2815
9. Masliah E, Iwai A, Mallory M, Uéda K, Saitoh T (1996) Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease. Am J Pathol 148: 201-210
10. Murayama S, Arima K, Nakazato Y, Satoh J, Oda M, Inose T (1992) Immunocytochemical and ultrastructural studies of neuronal and oligodendroglial cytoplasmic inclusions in multiple system atrophy. 2. Oligodendroglial cytoplasmic inclusions. Acta Neuropathol 84: 32-38
11. Nakazato Y, Yamazaki H, Hirato J, Ishida Y, Yamaguchi H (1989) Oligodendroglial microtubular tangles in olivopontocerebellar atrophy. J Neuropathol Exp Neurol 49: 521-530
12. Papp MI, Kahn JE, Lantos PL (1989) Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striate nigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome). J Neurol Sci 94: 79-100
13. Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL (1997) Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276: 2045-2047
14. Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M (1997) α-Synuclein in Lewy bodies. Nature 388: 839-840
15. Uéda K, Fukushima H, Masliah E, Xia Y, Iwai A, Yoshimoto M, Otero DA, Kondo J, Ihara Y, Saitoh T (1993) Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc Natl Acad Sci USA 90: 11282-11286
16. Uéda K, Saitoh T, Mori H (1994) Tissue-dependent alternative splicing of mRNA for NACP, the precursor of non-Aβ component of Alzheimer's disease amyloid. Biochem Biophys Res Commun 205: 1366-1372