Fluoxetine-resistant mutants in C. elegans define a novel family of transmembrane proteins

Molecular Cell

Volumn 4, Issue 2, 1999, Pages 143-152

  Choy, Robert K M ^a   Thomas, James H ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOXETINE; MEMBRANE PROTEIN;

ALLELE; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; GENE SEQUENCE; GENETIC SCREENING; MOLECULAR CLONING; MULTIGENE FAMILY; MUTANT; NEUROMUSCULAR FUNCTION; NONHUMAN; NUCLEOTIDE SEQUENCE;

EID: 0033180210     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80362-7     Document Type: Article

References (41)

1. Alfonso, A., Grundahl, K., Duerr, J.S., Han, H.P., and Rand, J.B. (1993). The Caenorhabditis elegans unc-17 gene: A putative vesicular acetylcholine transporter. Science 261, 617-619.
2. Alfonso, A., Grundahl, K., McManus, J.R., and Rand, J.B. (1994). Cloning and characterization of the choline acetyltransferase structural gene (cha-1) from C. elegans. J. Neurosci. 14, 2290-2300.
3. Allain, H., Masson, A.V., Bentue-Ferrer, D., Toulouse, P., and Lecoz, F. (1995). Delay in the effect of antidepressive agents: Pharmacologic approach. Encephale 21 S2, 9-15.
4. Avery, L., and Horvitz, H.R. (1990). Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans. J. Exp. Zool. 253, 263-270.
5. Bargmann, C.I. (1998). Neurobiology of the C. elegans genome. Science 282, 2028-2033.
6. Brenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94.
7. Chalfie, M., Tu, Y., Euskirchen, G., Ward, W.W., and Prasher, D.C. (1994). Green fluorescent protein as a marker for gene expression. Science 263, 802-805.
8. Clark, S.G., Lu, X., and Horvitz, H.R. (1994). The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins. Genetics 137, 987-997.
9. Dahl, L.E., Lundin, L., le Fevre Honoré, P., and Dencker, S.J. (1982). Antidepressant effect of femoxetine and desipramine and relationship to the concentration of amine metabolites in cerebrospinal fluid. A double-blind evaluation. Acta Psychiatr. Scand. 66, 9-17.
10. Defrance, R., Marey, C., and Kamoun, A. (1988). Antidepressant and anxiolytic activities of tianeptine: An overview of clinical trials. Clin. Neuropharmacol. 11, Suppl. 2, S74-S82.
11. Duerr, J.S., Frisby, D.L., Gaskin, J., Duke, A., Asermely, K., Huddleston, D., Eiden, L.E., and Rand, J.B. (1999). The cat-1 gene of Caenorhabditis elegans encodes a vesicular monoamine transporter required for specific monoamine-dependent behaviors. J. Neurosci. 19, 72-84.
12. Fleming, J.T., Squire, M.D., Barnes, T.M., Tornoe, C., Matsuda, K., Ahnn, J., Fire, A., Sulston, J.E., Barnard, E.A., Sattelle, D.B., and Lewis, J.A. (1997). Caenorhabditis elegans levamisole resistance genes lev-1, unc-29, and unc-38 encode functional nicotinic acetylcholine receptor subunits. J. Neurosci. 17, 5843-5857.
13. Goldstein, G.W., and Betz, A.L. (1986). The blood-brain barrier. Sci. Am. 255, 74-83.
14. Hyttel, J. (1994). Pharmacological characterization of selective serotonin reuptake inhibitors (SSRIs). Int. Clin. Psychopharmacol. 9, Suppl. 1, 19-26.
15. Johnson, C.D., and Stretton, A.O. (1985). Localization of choline acetyltransferase within identified motoneurons of the nematode Ascaris. J. Neurosci. 5, 1984-1992.
16. Kimble, J., and Sharrock, W.J. (1983). Tissue-specific synthesis of yolk proteins in Caenorhabditis elegans. Dev. Biol. 96, 189-196.
17. Kornhuber, J., Retz, W., and Riederer, R. (1995). Slow accumulation of psychotropic substances in the human brain. Relationship to therapeutic latency of neuroleptic and antidepressant drugs? J. Neural Transm. Suppl. 46, 315-323.
18. Kyte, J., and Doolittle, R.F. (1982). A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157, 105-132.
19. Lewis, J.A., Wu, C.H., Berg, H., and Levine, J.H. (1980a). The genetics of levamisole resistance in the nematode Caenorhabditis elegans. Genetics 95, 905-928.
20. Lewis, J.A., Wu, C.H., Levine, J.H., and Berg, H. (1980b). Levamisole-resistant mutants of the nematode Caenorhabditis elegans appear to lack pharmacological acetylcholine receptors. Neuroscience 5, 967-989.
21. Livingstone, D. (1991). Studies on the unc-31 Gene of Caenorhabditis Elegans. PhD dissertation, University of Cambridge, Cambridge, United Kingdom.
22. Maes, M., and Meltzer, H.Y. (1995). The serotonin hypothesis of major depression. In Psychopharmacology: The Fourth Generation Of Progress, F.E. Bloom and D.J. Kupfer, eds. (New York, NY: Raven Press), pp. 933-944.
23. Malagié, I., Trillat, A.C., Jacquot, C., and Gardier, A.M. (1995). Effects of acute fluoxetine on extracellular serotonin levels in the raphe: An in vivo microdialysis study. Eur. J. Pharmacol. 286, 213-217.
24. Mello, C.C., Kramer, J.M., Stinchcomb, D., and Ambros, V. (1991). Efficient gene transfer in C. elegans: Extrachromosomal maintenance and integration of transforming sequences. EMBO J. 10, 3959-3970.
25. Mocaër, E., Rettori, M.C., and Kamoun, A. (1988). Pharmacological antidepressive effects and tianeptine-induced 5-HT uptake increase. Clin. Neuropharmacol. 11, Suppl. 2, S32-S42.
26. Nguyen, M., Alfonso, A., Johnson, C.D., and Rand, J.B. (1995). Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase. Genetics 140, 527-535.
27. Nielsen, H., Engelbrecht, J., Brunak, S., and von Heijne, G. (1997). Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. Protein Eng. 10, 1-6.
28. Nonet, M.L., Grundahl, K., Meyer, B.J., and Rand, J.B. (1993). Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin. Cell 73, 1291-1305.
29. Preskorn, S.H. (1995). Comparison of the tolerability of bupropion, fluoxetine, imipramine, nefazodone, paroxetine, sertraline and venlafaxine. J. Clin. Psychiatry 56, Suppl. 6, 12-21.
30. Rand, J.B., and Nonet, M.L. (1997). Synaptic transmission. In C. Elegans II, D.L. Riddle, T. Blumenthal, B.J. Meyer, and J.R. Priess, eds. (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press), pp. 611-644.
31. Riesenman, C. (1995). Antidepressant drug interactions and the Cytochrome P450 system: A critical appraisal. Pharmacotherapy 15, Suppl. 6, 84S-99S.
32. Saifee, O., Wei, L. and Nonet, M.L. (1998). The Caenorhabditis elegans unc-64 locus encodes a syntaxin that interacts genetically with synaptobrevin. Mol. Biol. Cell. 9, 1235-1252.
33. Shreffler, W., Magardino, T., Shekdar, K., and Wolinsky, E. (1995). The unc-8 and sup-40 genes regulate ion channel function in Caenorhabditis elegans motorneurons. Genetics 139, 1261-1272.
34. Sonnhammer, E.L., von Heijne, G., and Krogh, A. (1998). A hidden Markov model for predicting transmembrane helices in protein sequences. Intel. Syst. Mol. Biol. 6, 175-182.
35. Soroko, F.E., Mehta, N.B., Maxwell, R.A., Ferris, R.M., and Schroeder, D.H. (1977). Bupropion hydrochloride ((±) α-t-butylamino-3-chloroproiophenone HCI): A novel antidepressant agent. J. Pharm. Pharmacol. 29, 767-770.
36. Stretton, A.O., Fishpool, R.M., Southgate, E., Donmoyer, J.E., Walrond, J.P., Moses, J.E., and Kass, I.S. (1978). Structure and physiological activity of the motoneurons of the nematode Ascaris. Proc. Natl. Acad. Sci. USA 75, 3493-3497.
37. Trent, C., Tsung, N., and Horvitz, H.R. (1983). Egg-laying defective mutants of the nematode Caenorhabditis elegans. Genetics 104, 619-647.
38. Walent, J.H., Porter, B.W., and Martin, T.F. (1992). A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells. Cell 70, 765-775.
39. Weinshenker, D., Garriga, G., and Thomas, J.H. (1995). Genetic pharmacological analysis of neurotransmitters controlling egg laying in C. elegans. J. Neurosci. 15, 6975-6985.
40. White, J.G., Southgate, E., Thomson, J.N., and Brenner, S. (1976). The structure of the ventral nerve cord of Caenorhabditis elegans. Philos. Trans. R. Soc. Lond. B Biol. Sci. 275, 327-348
41. Wong, D.T., Bymaster, F.P., and Engleman, E.A. (1995). Prozac (fluoxetine, lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: Twenty years since its first publication. Life Sci. 57, 411-441.