Role of connective tissue growth factor in the pathogenesis of diabetic nephropathy

Biochemical Journal

Volumn 359, Issue 1, 2001, Pages 77-87

  Wahab, N A ^a   Yevdokimova, N ^a   Weston, B S ^a   Roberts, T ^a   Li, X J ^a   Brinkman, H ^a   Mason, R M ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Fibronectin; Fibrosis; Non obese diabetic mice; Plasminogen activator inhibitor 1

Indexed keywords

ANTIBODIES; BIOLOGICAL ORGANS; BIOSYNTHESIS; CELLS; GLUCOSE; PATHOLOGY; PATIENT TREATMENT; RNA;

CONNECTIVE TISSUE GROWTH FACTOR (CTGF);

TISSUE CULTURE;

ANTISENSE OLIGONUCLEOTIDE; CONNECTIVE TISSUE GROWTH FACTOR; EPITOPE; FIBRONECTIN; GLUCOSE; HYBRID PROTEIN; MESSENGER RNA; NEUTRALIZING ANTIBODY; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYCLONAL ANTIBODY; TRANSFORMING GROWTH FACTOR BETA1; COMPLEMENTARY DNA; IMMEDIATE EARLY PROTEIN; IMMUNOGLOBULIN G; SIGNAL PEPTIDE; TRANSFORMING GROWTH FACTOR BETA;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; GENETIC TRANSFECTION; GLOMERULUS; HUMAN; HUMAN TISSUE; MESANGIUM CELL; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN SECRETION; PROTEIN SYNTHESIS; ANIMAL; BIOPSY; CELL CULTURE; COMPARATIVE STUDY; DRUG EFFECT; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL DIABETES MELLITUS; GENE EXPRESSION REGULATION; KIDNEY; MESANGIUM; METABOLISM; MOLECULAR CLONING; MOUSE STRAIN; PATHOLOGY; PHYSIOLOGY; WESTERN BLOTTING;

ANIMAL; BIOPSY; BLOTTING, WESTERN; CELLS, CULTURED; CLONING, MOLECULAR; COMPARATIVE STUDY; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DNA, COMPLEMENTARY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBRONECTINS; GENE EXPRESSION REGULATION; GLOMERULAR MESANGIUM; GLUCOSE; HUMAN; IMMEDIATE-EARLY PROTEINS; IMMUNOENZYME TECHNIQUES; IMMUNOGLOBULIN G; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY; MICE; MICE, INBRED NOD; OLIGONUCLEOTIDES, ANTISENSE; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 0035476418     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3590077     Document Type: Article

References (48)

1. The effect of intensive treatment of diabetes on the development and progression of long-term complication in insulin-dependent diabetes mellitus
2. The tubulointerstitium in progressive diabetic kidney disease: More than an aftermath of glomerular injury?
3. High glucose induces the expression of connective tissue growth factor in human mesangial cells
4. Suppression subtractive hybridization identifies high glucose level as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells
5. The CCN family of angiogenic regulators: The integrin connection
6. Characterization of cell-associated and soluble forms of connective tissue growth factor (CTGF) produced by fibroblasts in vitro
7. Identification of glycosylated 38-kDa connective tissue growth factor (IGFBP-related protein 2) and proteolytic fragments in human biological fluids, and up-regulation of IGFBP-rP2 expression by TGF-β in Hs578T human breast cancer cells
8. Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein
9. Identification of a gene family regulated by transforming growth factor-β
10. Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair
11. Cloning of a mRNA preferentially expressed in chondrocytes by differential display-PCR from a human chondrocytic cell line that is identical with connective tissue growth factor (CTGF) mRNA
12. Dexamethasone is a novel potent inducer of connective tissue growth factor expression
13. Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1
14. Induction of connective tissue growth factor by activation of heptahelical receptors. Modulation by Rho proteins and the actin cytoskeleton
15. Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis
16. A novel transforming growth factor-β response element controls the expression of the connective tissue growth factor gene
17. Involvement of cis-acting responsive element(s) in the 3′-untranslated region of human connective tissue growth factor gene
18. Transforming growth factor β induces anchorage-independent growth of NRK fibroblasts via a connective tissue growth factor-dependent signaling pathway
19. Connective growth factor: A mediator of TGF-β action on fibroblasts
20. Connective tissue growth factor: A novel regulator of mucosal repair and fibrosis in inflammatory bowel disease
21. Significant correlation between connective tissue growth factor gene expression and skin sclerosis in tissue sections from patients with systemic sclerosis
22. Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis
23. Expression of connective tissue growth factor in human renal fibrosis
24. Connective tissue growth factor: Potential role in glomerulosclerosis and tubulointerstitial fibrosis
25. Expression of connective tissue growth factor in experimental rat and human liver fibrosis
26. Enhanced insulin-like growth factor binding protein-related protein 2 (connective tissue growth factor) expression in patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis
27. Expression of extracellular matrix molecules in human mesangial cells in response to prolonged hyperglycaemia
28. The decorin high glucose response element and mechanism of its activation in human mesangial cells
29. Stable cell lines of T-SV40 immortalized human glomerular mesangial cells
30. Cutting edge: Homologous recombination of the MHC class I K region defines new MHC-linked diabetogenic susceptibility gene(s) in nonobese diabetic mice
31. Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A β-chain or normal I-E α-chain
32. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
33. Glomerular lesions in nonobese diabetic mouse: Before and after the onset of hyperglycemia
34. Sequential effects of high glucose on mesangial cell transforming growth factor-β1 and fibronectin synthesis
35. Thrombospondin-1 is the key activator of TGFβ in human mesangial cells exposed to high glucose
36. Renal hypertrophy is associated with upregulation of TGF-β1 gene expression in diabetic BB rat and NOD mouse
37. Quantification of glomerular TGF-β1 mRNA in patients with diabetes mellitus
38. Modulation of neutral protease expression in human mesangial cells by hyperglycaemic culture
39. Activation of latent TGF-β1 by thrombospondin-1: Mechanisms and physiology
40. Direct binding of Smad3 and Smad4 to critical TGF-β-induced elements on the promoter of human plasminogen activator inhibitor-type 1 gene
41. Cooperative binding of Smad protein to two adjacent DNA elements in the plasminogen activator inhibitor-1 promoter mediates transforming growth factor β-induced smad-dependent transcription activation
42. Synergistic cooperation of TFE3 and smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene
43. TGFbeta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway
44. High glucose and TGF-β1 stimulate fibronectin gene expression through a cAMP response element
45. Phosphorylation of cAMP responsive element binding protein after treatment of mesangial cells with high glucose plus TGFβ or PMA
46. Transforming growth factor-β1 stimulates protein kinase A in mesangial cells
47. Type II transforming growth factor-β receptor as a tumor suppressor gene
48. Neutralization of TGF-β by anti-TGF-β antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice