Factors produced by activated leukocytes alter renal epithelial cell differentiation

Kidney International

Volumn 56, Issue 4, 1999, Pages 1266-1269

  Healy, Edel ^a   Leonard, Martin ^a   Madrigal Estebas, Laura ^a   O'Farrelly, Cliona ^a   Watson, Alan J ^a   Ryan, Michael P ^a,b  

^a ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

End stage renal failure; Fibrosis; Inflammation; Proximal tubule cells; Tubulointerstitial disease

Indexed keywords

CELL ADHESION MOLECULE; CHEMOKINE; CYTOKINE; EPIDERMAL GROWTH FACTOR; GROWTH FACTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TRANSFORMING GROWTH FACTOR BETA; VASCULAR CELL ADHESION MOLECULE 1;

CELL DIFFERENTIATION; CONFERENCE PAPER; DISEASE COURSE; HUMAN; HUMAN CELL; KIDNEY EPITHELIUM; KIDNEY FAILURE; KIDNEY FIBROSIS; LEUKOCYTE; NEPHRITIS; PHENOTYPE; PRIORITY JOURNAL;

EID: 0032824512     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1999.00694.x     Document Type: Conference Paper

References (17)

1. PlCIILER R, GlACHELLI C, YOUNG B, ALPERS CE, COUSER WG, JOHNSON RJ: The pathogenesis of tubulointersititial disease associated with glomerulonephritis: The glomerular cytokine theory. Miner Electrolyte Metab 21:317-327, 1995
2. JOHNSON RJ: Cytokines, growth factors and renal injury: Where do we go now? Kidney Int 52:S2-S6, 1997
3. PAPAYIANNI A: Cytokines, growth factors, and other inflammatory mediators in glomerulonephritis. Renal Fail 18:725-740, 1996
4. SCIIENA FP, GESUALDO L, GRANDALIANO G, MONTINARO V: Progression of renal damage in human glomerulonephritides: Is there sleight of hand in winning the game. Kidney Int 52:1439-1457,1997
5. REMUZZI G, RUGGENENTI P, BENIGNI A: Understanding the nature of renal disease progression. Kidney Int 51:2-15, 1997
6. GERRITSMA JSJ, VAN KOOTEN C, GERRITSEN AF, VAN Es LA, DAIIA MR: Transforming growth factor β-1 regulates chemokine and complement production by human proximal tubular epithelial cells. Kidney lut 53:609-616, 1998
7. MULLER GA, SCHETTLER V, MULLER CA, STRUTZ F: Prevention of progression of renal fibrosis: How far are we? Kidney Int 49 (Suppl):S75-S82, 1996
8. RYAN MJ, JOHNSON G, KIRK J, FUERESTENBERG SM, ZAGER RA, TOROK-STORB B: HK-2: An immortalized proximal tubule epithelial cell line from normal adult human kidney. Kidney Int 45:48-57, 1994
9. HAY ED: Epithelial-mesenchymal transitions. Semin Dev Biol 1:347-356, 1996
10. STRUTZ F, MULLER G, NEILSON EG: Transdifferentiation: A new angle on renal fibrosis. Exp Neplirol 4:267-270, 1996
11. HAY ED, ZUK A: Transformations between epithelium and mesenchyme, normal, pathological and experimentally induced. Am J Kidney Dis 26:678-690, 1995
12. STRUTZ F, OKADA H, Lo C, DANOFF T, CARONE R, TOMASZEWSKI J, NEILSON E: Identification and characterisation of a fibroblast marker: Fspl. J Cell Biol 130:393-405, 1995
13. OKADA H, DANOFF T, KALLURI R, NEILSON G: Early role of FSP1 in epithelial-mesenchymal transformation. AmJPIiysiol273:F563-F574, 1997
14. SCHRAMEK H, FEIFEL E, HEALY E, POLLACK V: Constitutively active mutant of the mitogen-activated protein kinase kinase MEK-1 induces epithelial dedifferentiation and growth inhibition in Madin-Darby Canine Kidney-C7 cells. / Biol Chem 272:11426-11433, 1997
15. NEILSON EG, JIMINEZ SA, PHILLIPS MS: Cell mediated immunity in interstitial nephritis. III. T lymphocyte-mediated fibroblast proliferation and collagen synthesis. / Iinmunol 125:1708-1714, 1982
16. LEETW, PARK JK, AHN JH, IHM CG, KIM MJ: Role of mononuclear cells of IgA Nephropathy on ICAM-1 expression in mesangial cells. Korean J Intern Med 13:27-32, 1998
17. TAYLOR CT, MURPHY A, KELLEHER D, BAIRD AW: Changes in barrier function of a model intestinal epithelium by intraepithelial lymphocytes require new protein synthesis by epithelial cells. Gut 40:634-642, 1997