메뉴 건너뛰기




Volumn 13, Issue 1, 2004, Pages 53-58

Connective tissue growth factor and renal diseases: Some answers, more questions

Author keywords

CCN2; Connective tissue growth factor; Kidney; Mesangial cells; Renal diseases

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; SCLEROPROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 4043089953     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-200401000-00008     Document Type: Review
Times cited : (47)

References (82)
  • 1
    • 0035068590 scopus 로고    scopus 로고
    • Transforming growth factor-beta(1) and myofibroblasts: A potential pathway towards renal scarring in human glomerular disease
    • Goumenos DS, Tsamandas AC, Oldroyd S, et al. Transforming growth factor-beta(1) and myofibroblasts: a potential pathway towards renal scarring in human glomerular disease. Nephron 2001; 87:240-248.
    • (2001) Nephron , vol.87 , pp. 240-248
    • Goumenos, D.S.1    Tsamandas, A.C.2    Oldroyd, S.3
  • 2
    • 0030419494 scopus 로고    scopus 로고
    • Molecular insights into renal interstitial fibrosis
    • Eddy AA. Molecular insights into renal interstitial fibrosis. J Am Soc Nephrol 1996; 7:2495-2508.
    • (1996) J Am Soc Nephrol , vol.7 , pp. 2495-2508
    • Eddy, A.A.1
  • 3
    • 0031050172 scopus 로고    scopus 로고
    • Interstitial myofibroblasts: Predictors of progression in membranous nephropathy
    • Roberts IS, Burrows C, Shanks JH, et al. Interstitial myofibroblasts: predictors of progression in membranous nephropathy. J Clin Pathol 1997; 50:123-127.
    • (1997) J Clin Pathol , vol.50 , pp. 123-127
    • Roberts, I.S.1    Burrows, C.2    Shanks, J.H.3
  • 4
    • 0036786834 scopus 로고    scopus 로고
    • TGF-beta signaling in renal disease
    • Bottinger EP, Bitzer M. TGF-beta signaling in renal disease. J Am Soc Nephrol 2002; 13:2600-2610.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 2600-2610
    • Bottinger, E.P.1    Bitzer, M.2
  • 5
    • 0034970113 scopus 로고    scopus 로고
    • In vitro evidence for differential involvement of CTGF, TGFbeta, and PDGF-BB in mesangial response to injury
    • Blom IE, van Dijk AJ, Wieten L, et al. In vitro evidence for differential involvement of CTGF, TGFbeta, and PDGF-BB in mesangial response to injury. Nephrol Dial Transplant 2001; 16:1139-1148.
    • (2001) Nephrol Dial Transplant , vol.16 , pp. 1139-1148
    • Blom, I.E.1    Van Dijk, A.J.2    Wieten, L.3
  • 6
    • 0037229290 scopus 로고    scopus 로고
    • Tubular epithelial-myofibroblast transdifferentiation mechanisms in proximal tubule cells
    • Lan HY. Tubular epithelial-myofibroblast transdifferentiation mechanisms in proximal tubule cells. Curr Opin Nephrol Hypertens 2003; 12:25-29. This is an up-to-date review on mechanisms of tubular epithelial-myofibroblast transdifferentiation.
    • (2003) Curr Opin Nephrol Hypertens , vol.12 , pp. 25-29
    • Lan, H.Y.1
  • 7
    • 0029737102 scopus 로고    scopus 로고
    • Expression of extracellular matrix molecules in human mesangial cells in response to prolonged hyperglycaemia
    • Wahab NA, Harper K, Mason RM. Expression of extracellular matrix molecules in human mesangial cells in response to prolonged hyperglycaemia. Biochem J 1996; 316:985-992.
    • (1996) Biochem J , vol.316 , pp. 985-992
    • Wahab, N.A.1    Harper, K.2    Mason, R.M.3
  • 8
    • 0026557672 scopus 로고
    • Production of extracellular matrix by glomerular epithelial cells is regulated by transforming growth factor-beta 1
    • Nakamura T, Miller D, Ruoslahti E, et al. Production of extracellular matrix by glomerular epithelial cells is regulated by transforming growth factor-beta 1. Kidney Int 1992; 41:1213-1221.
    • (1992) Kidney Int , vol.41 , pp. 1213-1221
    • Nakamura, T.1    Miller, D.2    Ruoslahti, E.3
  • 9
    • 0027414896 scopus 로고
    • Role of proteoglycans and cytoskeleton in the effects of TGF-beta 1 on renal proximal tubule cells
    • Humes HD, Nakamura T, Cieslinski DA, et al. Role of proteoglycans and cytoskeleton in the effects of TGF-beta 1 on renal proximal tubule cells. Kidney Int 1993; 43:575-584.
    • (1993) Kidney Int , vol.43 , pp. 575-584
    • Humes, H.D.1    Nakamura, T.2    Cieslinski, D.A.3
  • 10
    • 0028109801 scopus 로고
    • Transforming growth factor beta in tissue fibrosis
    • Border WA, Noble NA. Transforming growth factor beta in tissue fibrosis. N Engl J Med 1994; 331:1286-1292.
    • (1994) N Engl J Med , vol.331 , pp. 1286-1292
    • Border, W.A.1    Noble, N.A.2
  • 11
    • 0028175467 scopus 로고
    • Transforming growth factor-beta 1 stimulates glomerular mesangial cell synthesis of the 72-kd type IV collagenase
    • Marti HP, Lee L, Kashgarian M, Lovett DH. Transforming growth factor-beta 1 stimulates glomerular mesangial cell synthesis of the 72-kd type IV collagenase. Am J Pathol 1994; 144:82-94.
    • (1994) Am J Pathol , vol.144 , pp. 82-94
    • Marti, H.P.1    Lee, L.2    Kashgarian, M.3    Lovett, D.H.4
  • 12
    • 0037373094 scopus 로고    scopus 로고
    • CTGF mediates TGF-beta-induced fibronectin matrix deposition by upregulating active alpha5beta1 integrin in human mesangial cells
    • Weston BS, Wahab NA, Mason RM. CTGF mediates TGF-beta-induced fibronectin matrix deposition by upregulating active alpha5beta1 integrin in human mesangial cells. J Am Soc Nephrol 2003; 14:601-610. This study demonstrates that CTGF is a mediator of TGF-β profibrotic action and that activation of cell-surface integrins is important for matrix deposition.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 601-610
    • Weston, B.S.1    Wahab, N.A.2    Mason, R.M.3
  • 13
    • 0030030447 scopus 로고    scopus 로고
    • Expression of transforming growth factor-beta isoforms in human glomerular diseases
    • Yamamoto T, Noble NA, Cohen AH, et al. Expression of transforming growth factor-beta isoforms in human glomerular diseases. Kidney Int 1996; 49:461-469.
    • (1996) Kidney Int , vol.49 , pp. 461-469
    • Yamamoto, T.1    Noble, N.A.2    Cohen, A.H.3
  • 14
    • 0034604110 scopus 로고    scopus 로고
    • Role of transforming growth factor beta in human disease
    • Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor beta in human disease. N Engl J Med 2000; 342:1350-1358.
    • (2000) N Engl J Med , vol.342 , pp. 1350-1358
    • Blobe, G.C.1    Schiemann, W.P.2    Lodish, H.F.3
  • 15
    • 0028953768 scopus 로고
    • Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions
    • Sanderson N, Factor V, Nagy P, et al. Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions. Proc Natl Acad Sci U S A 1995; 92:2572-2576.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 2572-2576
    • Sanderson, N.1    Factor, V.2    Nagy, P.3
  • 16
    • 0030975645 scopus 로고    scopus 로고
    • TGF-beta in kidney fibrosis: A target for gene therapy
    • Border WA, Noble NA. TGF-beta in kidney fibrosis: a target for gene therapy. Kidney Int 1997; 51:1388-1396.
    • (1997) Kidney Int , vol.51 , pp. 1388-1396
    • Border, W.A.1    Noble, N.A.2
  • 17
    • 0029924637 scopus 로고    scopus 로고
    • Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice
    • Sharma K, Jin Y, Guo J, Ziyadeh FN. Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice. Diabetes 1996; 45:522-530.
    • (1996) Diabetes , vol.45 , pp. 522-530
    • Sharma, K.1    Jin, Y.2    Guo, J.3    Ziyadeh, F.N.4
  • 18
    • 10144227768 scopus 로고    scopus 로고
    • Inhibition of TGF-beta 1 expression by antisense oligonucleotides suppressed extracellular matrix accumulation in experimental glomerulonephritis
    • Akagi Y, Isaka Y, Arai M, et al. Inhibition of TGF-beta 1 expression by antisense oligonucleotides suppressed extracellular matrix accumulation in experimental glomerulonephritis. Kidney Int 1996; 50:148-155.
    • (1996) Kidney Int , vol.50 , pp. 148-155
    • Akagi, Y.1    Isaka, Y.2    Arai, M.3
  • 19
    • 0031441041 scopus 로고    scopus 로고
    • Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor beta receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]- anthracene
    • Bottinger EP, Jakubczak JL, Haines DC, et al. Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor beta receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene. Cancer Res 1997; 57:5564-5570.
    • (1997) Cancer Res , vol.57 , pp. 5564-5570
    • Bottinger, E.P.1    Jakubczak, J.L.2    Haines, D.C.3
  • 20
    • 0027229995 scopus 로고
    • Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair
    • Igarashi A, Okochi H, Bradham DM, et al. Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair. Mol Biol Cell 1993; 4:637-645.
    • (1993) Mol Biol Cell , vol.4 , pp. 637-645
    • Igarashi, A.1    Okochi, H.2    Bradham, D.M.3
  • 21
    • 0029808645 scopus 로고    scopus 로고
    • A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene
    • Grotendorst GR, Okochi H, Hayashi N. A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene. Cell Growth Differ 1996; 7:469-480.
    • (1996) Cell Growth Differ , vol.7 , pp. 469-480
    • Grotendorst, G.R.1    Okochi, H.2    Hayashi, N.3
  • 22
    • 0027219381 scopus 로고
    • The modular architecture of a new family of growth regulators related to connective tissue growth factor
    • Bork P. The modular architecture of a new family of growth regulators related to connective tissue growth factor. FEBS Lett 1993; 327:125-130.
    • (1993) FEBS Lett , vol.327 , pp. 125-130
    • Bork, P.1
  • 23
    • 0033405368 scopus 로고    scopus 로고
    • Immunohistochemical localization of connective tissue growth factor (CTGF) in the mouse embryo between days 7.5 and 14.5 of gestation
    • Surveyor GA, Brigstock DR. Immunohistochemical localization of connective tissue growth factor (CTGF) in the mouse embryo between days 7.5 and 14.5 of gestation. Growth Factors 1999; 17:115-124.
    • (1999) Growth Factors , vol.17 , pp. 115-124
    • Surveyor, G.A.1    Brigstock, D.R.2
  • 24
    • 0038001571 scopus 로고    scopus 로고
    • CTGF expression during mouse embryonic development
    • Friedrichsen S, Heuer H, Christ S, et al. CTGF expression during mouse embryonic development. Cell Tissue Res 2003; 312:175-188. This study discusses the importance of CTGF during development, and shows that CTGF is expressed in the cardiovascular system, around bone and cartilage, and in maturing layer-VII neurons.
    • (2003) Cell Tissue Res , vol.312 , pp. 175-188
    • Friedrichsen, S.1    Heuer, H.2    Christ, S.3
  • 25
    • 0038093327 scopus 로고    scopus 로고
    • Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development
    • Ivkovic S, Yoon BS, Popoff SN, et al. Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development 2003; 130:2779-2791.
    • (2003) Development , vol.130 , pp. 2779-2791
    • Ivkovic, S.1    Yoon, B.S.2    Popoff, S.N.3
  • 26
    • 0037683425 scopus 로고    scopus 로고
    • Recombinant connective tissue growth factor modulates porcine skin fibroblast gene expression
    • Wang JF, Olson ME, Ball DK, et al. Recombinant connective tissue growth factor modulates porcine skin fibroblast gene expression. Wound Repair Regen 2003; 11:220-229. This the first study on CTGF knockout mice.
    • (2003) Wound Repair Regen , vol.11 , pp. 220-229
    • Wang, J.F.1    Olson, M.E.2    Ball, D.K.3
  • 27
    • 0031959237 scopus 로고    scopus 로고
    • Expression of connective tissue growth factor in human renal fibrosis
    • Ito Y, Aten J, Bende RJ, et al. Expression of connective tissue growth factor in human renal fibrosis. Kidney Int 1998; 53:853-861.
    • (1998) Kidney Int , vol.53 , pp. 853-861
    • Ito, Y.1    Aten, J.2    Bende, R.J.3
  • 28
    • 0035476418 scopus 로고    scopus 로고
    • Role of connective tissue growth factor in the pathogenesis of diabetic nephropathy
    • Wahab NA, Yevdokimova N, Weston BS, et al. Role of connective tissue growth factor in the pathogenesis of diabetic nephropathy. Biochem J 2001; 359:77-87.
    • (2001) Biochem J , vol.359 , pp. 77-87
    • Wahab, N.A.1    Yevdokimova, N.2    Weston, B.S.3
  • 29
    • 0035190222 scopus 로고    scopus 로고
    • Glomerular mRNAs in human type 1 diabetes: Biochemical evidence for microalbuminuria as a manifestation of diabetic nephropathy
    • Adler SG, Kang SW, Feld S, et al. Glomerular mRNAs in human type 1 diabetes: biochemical evidence for microalbuminuria as a manifestation of diabetic nephropathy. Kidney Int 2001; 60:2330-2336.
    • (2001) Kidney Int , vol.60 , pp. 2330-2336
    • Adler, S.G.1    Kang, S.W.2    Feld, S.3
  • 30
    • 0035127214 scopus 로고    scopus 로고
    • Kinetics of connective tissue growth factor expression during experimental proliferative glomerulonephritis
    • Ito Y, Goldschmeding R, Bende R, et al. Kinetics of connective tissue growth factor expression during experimental proliferative glomerulonephritis. J Am Soc Nephrol 2001; 12:472-484.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 472-484
    • Ito, Y.1    Goldschmeding, R.2    Bende, R.3
  • 31
    • 0034219152 scopus 로고    scopus 로고
    • Connective tissue growth factor expression in the rat remnant kidney model and association with tubular epithelial cells undergoing transdifferentiation
    • Frazier KS, Paredes A, Dube P, et al. Connective tissue growth factor expression in the rat remnant kidney model and association with tubular epithelial cells undergoing transdifferentiation. Vet Pathol 2000; 37:328-335.
    • (2000) Vet Pathol , vol.37 , pp. 328-335
    • Frazier, K.S.1    Paredes, A.2    Dube, P.3
  • 32
    • 0033957976 scopus 로고    scopus 로고
    • Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis
    • Riser BL, Denichilo M, Cortes P, et al. Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis. J Am Soc Nephrol 2000; 11:25-38.
    • (2000) J Am Soc Nephrol , vol.11 , pp. 25-38
    • Riser, B.L.1    Denichilo, M.2    Cortes, P.3
  • 33
    • 0036892894 scopus 로고    scopus 로고
    • Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine
    • Twigg SM, Cao Z, MCLennan SV, et al. Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine. Endocrinology 2002; 143:4907-4915.
    • (2002) Endocrinology , vol.143 , pp. 4907-4915
    • Twigg, S.M.1    Cao, Z.2    McLennan, S.V.3
  • 34
    • 0037233530 scopus 로고    scopus 로고
    • Mechanisms of irbesartan on in prevention of renal lesion in streptozotocin-induced diabetic rats
    • •] provide the first evidence that CTGF mediates the profibrotic effects of angiotensin II.
    • (2003) Acta Pharmacol Sin , vol.24 , pp. 67-73
    • Liu, B.C.1    Chen, Q.2    Luo, D.D.3
  • 35
    • 0034951422 scopus 로고    scopus 로고
    • Connective tissue growth factor in tubulointerstitial injury of diabetic nephropathy
    • Wang S, Denichilo M, Brubaker C, et al. Connective tissue growth factor in tubulointerstitial injury of diabetic nephropathy. Kidney Int 2001; 60:96-105.
    • (2001) Kidney Int , vol.60 , pp. 96-105
    • Wang, S.1    Denichilo, M.2    Brubaker, C.3
  • 36
    • 0034870254 scopus 로고    scopus 로고
    • Expression of connective tissue growth factor in human renal fibroblasts: Regulatory roles of RhoA and cAMP
    • Heusinger-Ribeiro J, Eberlein M, Wahab NA, et al. Expression of connective tissue growth factor in human renal fibroblasts: regulatory roles of RhoA and cAMP. J Am Soc Nephrol 2001; 12:1853-1861.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 1853-1861
    • Heusinger-Ribeiro, J.1    Eberlein, M.2    Wahab, N.A.3
  • 37
    • 0037405422 scopus 로고    scopus 로고
    • BMP7 antagonizes TGF-beta-dependent fibrogenesis in mesangial cells
    • Wang S, Hirschberg R. BMP7 antagonizes TGF-beta-dependent fibrogenesis in mesangial cells. Am J Physiol Renal Physiol 2003; 284:F1006-F1013.
    • (2003) Am J Physiol Renal Physiol , vol.284
    • Wang, S.1    Hirschberg, R.2
  • 38
    • 0033605162 scopus 로고    scopus 로고
    • Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells
    • Murphy M, Godson C, Cannon S, et al. Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells. J Biol Chem 1999; 274:5830-5834.
    • (1999) J Biol Chem , vol.274 , pp. 5830-5834
    • Murphy, M.1    Godson, C.2    Cannon, S.3
  • 39
    • 0036783550 scopus 로고    scopus 로고
    • TGF-beta and CTGF have overlapping and distinct fibrogenic effects on human renal cells
    • Gore-Hyer E, Shegogue D, Markiewicz M, et al. TGF-beta and CTGF have overlapping and distinct fibrogenic effects on human renal cells. Am J Physiol Renal Physiol 2002; 283:F707-F716.
    • (2002) Am J Physiol Renal Physiol , vol.283
    • Gore-Hyer, E.1    Shegogue, D.2    Markiewicz, M.3
  • 40
    • 0038119587 scopus 로고    scopus 로고
    • Urinary CCN2 (CTGF) as a possible predictor of diabetic nephropathy: Preliminary report
    • Riser BL, Cortes P, Denichilo M, et al. Urinary CCN2 (CTGF) as a possible predictor of diabetic nephropathy: preliminary report. Kidney Int 2003; 64:451-458. This study provides a role for CTGF as a diagnostic marker of diabetic nephropathy.
    • (2003) Kidney Int , vol.64 , pp. 451-458
    • Riser, B.L.1    Cortes, P.2    Denichilo, M.3
  • 41
    • 0031225015 scopus 로고    scopus 로고
    • Connective tissue growth factor: A mediator of TGF-beta action on fibroblasts
    • Grotendorst GR. Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts [review]. Cytokine Growth Factor Rev 1997; 8:171-179.
    • (1997) Cytokine Growth Factor Rev , vol.8 , pp. 171-179
    • Grotendorst, G.R.1
  • 42
    • 0029808645 scopus 로고    scopus 로고
    • A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene
    • Grotendorst GR, Okochi H, Hayashi N. A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene. Cell Growth Differ 1996; 7:469-480.
    • (1996) Cell Growth Differ , vol.7 , pp. 469-480
    • Grotendorst, G.R.1    Okochi, H.2    Hayashi, N.3
  • 43
    • 0035815683 scopus 로고    scopus 로고
    • CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling
    • Holmes A, Abraham DJ, Sa S, et al. CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling. J Biol Chem 2001; 276:10594-10601.
    • (2001) J Biol Chem , vol.276 , pp. 10594-10601
    • Holmes, A.1    Abraham, D.J.2    Sa, S.3
  • 44
    • 0034528616 scopus 로고    scopus 로고
    • Induction of connective tissue growth factor by activation of heptahelical receptors. Modulation by Rho proteins and the actin cytoskeleton
    • Hahn A, Heusinger-Ribeiro J, Lanz T, et al. Induction of connective tissue growth factor by activation of heptahelical receptors. Modulation by Rho proteins and the actin cytoskeleton. J Biol Chem 2000; 275:37429-37435.
    • (2000) J Biol Chem , vol.275 , pp. 37429-37435
    • Hahn, A.1    Heusinger-Ribeiro, J.2    Lanz, T.3
  • 45
    • 0034805654 scopus 로고    scopus 로고
    • Hydrogen peroxide is a novel inducer of connective tissue growth factor
    • Park SK, Kim J, Seomun Y, et al. Hydrogen peroxide is a novel inducer of connective tissue growth factor. Biochem Biophys Res Commun 2001; 284:966-971.
    • (2001) Biochem Biophys Res Commun , vol.284 , pp. 966-971
    • Park, S.K.1    Kim, J.2    Seomun, Y.3
  • 46
    • 0037047082 scopus 로고    scopus 로고
    • Prevention of accelerated atherosclerosis by angiotensin-converting enzyme inhibition in diabetic apolipoprotein E-deficient mice
    • Candido R, Jandeleit-Dahm KA, Cao Z, et al. Prevention of accelerated atherosclerosis by angiotensin-converting enzyme inhibition in diabetic apolipoprotein E-deficient mice. Circulation 2002; 106:246-253.
    • (2002) Circulation , vol.106 , pp. 246-253
    • Candido, R.1    Jandeleit-Dahm, K.A.2    Cao, Z.3
  • 47
    • 10744230225 scopus 로고    scopus 로고
    • Angiotensin II induces connective tissue growth factor gene expression via calcineurin-dependent pathways
    • •] provide the first evidence that CTGF mediates the profibrotic effects of angiotensin II.
    • (2003) Am J Pathol , vol.163 , pp. 355-366
    • Finckenberg, P.1    Inkinen, K.2    Ahonen, J.3
  • 48
    • 0037427505 scopus 로고    scopus 로고
    • Transcriptional profiling of gene expression patterns during sphingosine 1-phosphate-induced mesangial cell proliferation
    • Katsuma S, Hada Y, Shiojima S, et al. Transcriptional profiling of gene expression patterns during sphingosine 1-phosphate-induced mesangial cell proliferation. Biochem Biophys Res Commun 2003; 300:577-584.
    • (2003) Biochem Biophys Res Commun , vol.300 , pp. 577-584
    • Katsuma, S.1    Hada, Y.2    Shiojima, S.3
  • 49
    • 0034976494 scopus 로고    scopus 로고
    • Regulation of connective tissue growth factor (ccn2; ctgf) gene expression in human mesangial cells: Modulation by HMG CoA reductase inhibitors (statins)
    • Goppelt-Struebe M, Hahn A, Iwanciw D, et al. Regulation of connective tissue growth factor (ccn2; ctgf) gene expression in human mesangial cells: modulation by HMG CoA reductase inhibitors (statins). Mol Pathol 2001; 54:176-179.
    • (2001) Mol Pathol , vol.54 , pp. 176-179
    • Goppelt-Struebe, M.1    Hahn, A.2    Iwanciw, D.3
  • 50
    • 0035907365 scopus 로고    scopus 로고
    • Static pressure regulates connective tissue growth factor expression in human mesangial cells
    • Hishikawa K, Oemar BS, Nakaki T. Static pressure regulates connective tissue growth factor expression in human mesangial cells. J Biol Chem 2001; 276:16797-16803.
    • (2001) J Biol Chem , vol.276 , pp. 16797-16803
    • Hishikawa, K.1    Oemar, B.S.2    Nakaki, T.3
  • 51
    • 0036775477 scopus 로고    scopus 로고
    • Gene regulation of connective tissue growth factor: New targets for antifibrotic therapy?
    • Blom IE, Goldschmeding R, Leask A. Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy? Matrix Biol 2002; 21:473-482. This is a comprehensive review on the gene regulation of CTGF in different cell types.
    • (2002) Matrix Biol , vol.21 , pp. 473-482
    • Blom, I.E.1    Goldschmeding, R.2    Leask, A.3
  • 52
    • 0033003978 scopus 로고    scopus 로고
    • Involvement of cis-acting repressive element(s) in the 3-untranslated region of human connective tissue growth factor gene
    • Kubota S, Hattori T, Nakanishi T, et al. Involvement of cis-acting repressive element(s) in the 3-untranslated region of human connective tissue growth factor gene. FEBS Lett 1999; 450:84-88.
    • (1999) FEBS Lett , vol.450 , pp. 84-88
    • Kubota, S.1    Hattori, T.2    Nakanishi, T.3
  • 53
    • 0034638612 scopus 로고    scopus 로고
    • Characterization of a mouse ctgf 3-UTR segment that mediates repressive regulation of gene expression
    • Kondo S, Kubota S, Eguchi T, et al. Characterization of a mouse ctgf 3-UTR segment that mediates repressive regulation of gene expression. Biochem Biophys Res Commun 2000; 278:119-124.
    • (2000) Biochem Biophys Res Commun , vol.278 , pp. 119-124
    • Kondo, S.1    Kubota, S.2    Eguchi, T.3
  • 54
    • 0036087126 scopus 로고    scopus 로고
    • Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis
    • Yokoi H, Mukoyama M, Sugawara A, et al. Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis. Am J Physiol Renal Physiol 2002; 282:F933-F942.
    • (2002) Am J Physiol Renal Physiol , vol.282
    • Yokoi, H.1    Mukoyama, M.2    Sugawara, A.3
  • 55
    • 0032873465 scopus 로고    scopus 로고
    • Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: Down-regulation by cAMP
    • Duncan MR, Frazier KS, Abramson S, et al. Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP. FASEB J 1999; 13:1774-1786.
    • (1999) FASEB J , vol.13 , pp. 1774-1786
    • Duncan, M.R.1    Frazier, K.S.2    Abramson, S.3
  • 56
    • 0034817102 scopus 로고    scopus 로고
    • Role of connective tissue growth factor in profibrotic action of transforming growth factor-beta: A potential target for preventing renal fibrosis
    • Yokoi H, Sugawara A, Mukoyama M, et al. Role of connective tissue growth factor in profibrotic action of transforming growth factor-beta: a potential target for preventing renal fibrosis. Am J Kidney Dis 2001; 38 (Suppl 1):S134-S138.
    • (2001) Am J Kidney Dis , vol.38 , Issue.1 SUPPL.
    • Yokoi, H.1    Sugawara, A.2    Mukoyama, M.3
  • 57
    • 0031014983 scopus 로고    scopus 로고
    • Transforming growth factor beta induces anchorage-independent growth of NRK fibroblasts via a connective tissue growth factor-dependent signaling pathway
    • Kothapalli D, Frazier KS, Welply A, et al. Transforming growth factor beta induces anchorage-independent growth of NRK fibroblasts via a connective tissue growth factor-dependent signaling pathway. Cell Growth Differ 1997; 8:61-68.
    • (1997) Cell Growth Differ , vol.8 , pp. 61-68
    • Kothapalli, D.1    Frazier, K.S.2    Welply, A.3
  • 58
    • 0036786249 scopus 로고    scopus 로고
    • Connective tissue growth factor and regulation of the mesangial cell cycle: Role in cellular hypertrophy
    • Wahab NA, Weston BS, Roberts T, et al. Connective tissue growth factor and regulation of the mesangial cell cycle: role in cellular hypertrophy. J Am Soc Nephrol 2002; 13:2437-2445. This study provides the first evidence that CTGF mediates TGF-β-dependent induction of cellular hypertrophy.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 2437-2445
    • Wahab, N.A.1    Weston, B.S.2    Roberts, T.3
  • 59
    • 0346106235 scopus 로고    scopus 로고
    • The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells
    • 3 integrin.
    • (2002) J Biol Chem , vol.277 , pp. 44187-44194
    • Crean, J.K.1    Finlay, D.2    Murphy, M.3
  • 60
    • 0041842627 scopus 로고    scopus 로고
    • Cytoskeletal rearrangement and signal transduction in TGF-beta1-stimulated mesangial cell collagen accumulation
    • Hubchak SC, Runyan CE, Kreisberg JI, et al. Cytoskeletal rearrangement and signal transduction in TGF-beta1-stimulated mesangial cell collagen accumulation. J Am Soc Nephrol 2003; 14:1969-1980.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 1969-1980
    • Hubchak, S.C.1    Runyan, C.E.2    Kreisberg, J.I.3
  • 61
    • 0036481769 scopus 로고    scopus 로고
    • Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis
    • Inoki I, Shiomi T, Hashimoto G, et al. Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis. FASEB J 2002; 16:219-221.
    • (2002) FASEB J , vol.16 , pp. 219-221
    • Inoki, I.1    Shiomi, T.2    Hashimoto, G.3
  • 62
    • 0036051343 scopus 로고    scopus 로고
    • Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta
    • Abreu JG, Ketpura NI, Reversade B, et al. Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. Nat Cell Biol 2002; 4:599-604. This study provides the first evidence of the physical interaction between CTGF and TGF-β.
    • (2002) Nat Cell Biol , vol.4 , pp. 599-604
    • Abreu, J.G.1    Ketpura, N.I.2    Reversade, B.3
  • 63
    • 0031587828 scopus 로고    scopus 로고
    • The MAD-related protein smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling
    • Hayashi H, Abdollah S, Qiu Y, et al. The MAD-related protein smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell 1997; 89:1165-1173.
    • (1997) Cell , vol.89 , pp. 1165-1173
    • Hayashi, H.1    Abdollah, S.2    Qiu, Y.3
  • 64
    • 0036205654 scopus 로고    scopus 로고
    • Blockade of the effects of TGF-beta1 on mesangial cells by overexpression of Smad7
    • Chen R, Huang C, Morinelli TA, et al. Blockade of the effects of TGF-beta1 on mesangial cells by overexpression of Smad7. J Am Soc Nephrol 2002; 13:887-893.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 887-893
    • Chen, R.1    Huang, C.2    Morinelli, T.A.3
  • 65
    • 0033820374 scopus 로고    scopus 로고
    • Glucose stimulation of transforming growth factor-beta bioactivity in mesangial cells is mediated by thrombospondin-1
    • Poczatek MH, Hugo C, Darley-Usmar V, et al. Glucose stimulation of transforming growth factor-beta bioactivity in mesangial cells is mediated by thrombospondin-1. Am J Pathol 2000; 157:1353-1363.
    • (2000) Am J Pathol , vol.157 , pp. 1353-1363
    • Poczatek, M.H.1    Hugo, C.2    Darley-Usmar, V.3
  • 66
    • 0031586015 scopus 로고    scopus 로고
    • Cyr61 and Fisp12 are both ECM-associated signaling molecules: Activities, metabolism, and localization during development
    • Kireeva ML, Latinkic BV, Kolesnikova TV, et al. Cyr61 and Fisp12 are both ECM-associated signaling molecules: activities, metabolism, and localization during development. Exp Cell Res 1997; 233:63-77.
    • (1997) Exp Cell Res , vol.233 , pp. 63-77
    • Kireeva, M.L.1    Latinkic, B.V.2    Kolesnikova, T.V.3
  • 67
    • 0033541389 scopus 로고    scopus 로고
    • The CCN family of angiogenic regulators: The integrin connection
    • Lau LF, Lam SC. The CCN family of angiogenic regulators: the integrin connection. Exp Cell Res 1999; 248:44-57.
    • (1999) Exp Cell Res , vol.248 , pp. 44-57
    • Lau, L.F.1    Lam, S.C.2
  • 68
    • 0032913069 scopus 로고    scopus 로고
    • Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphav-beta3, promotes endothelial cell survival, and induces angiogenesis in vivo
    • Babic AM, Chen CC, Lau LF. Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphav-beta3, promotes endothelial cell survival, and induces angiogenesis in vivo. Mol Cell Biol 1999; 19:2958-2966.
    • (1999) Mol Cell Biol , vol.19 , pp. 2958-2966
    • Babic, A.M.1    Chen, C.C.2    Lau, L.F.3
  • 69
    • 0035971161 scopus 로고    scopus 로고
    • The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts
    • Chen CC, Chen N, Lau LF. The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts. J Biol Chem 2001; 276:10443-10452.
    • (2001) J Biol Chem , vol.276 , pp. 10443-10452
    • Chen, C.C.1    Chen, N.2    Lau, L.F.3
  • 70
    • 0037097845 scopus 로고    scopus 로고
    • Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): Immediate-early gene products expressed in atherosclerotic lesions
    • Schober JM, Chen N, Grzeszkiewicz TM, et al. Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions. Blood 2002; 99:4457-4465.
    • (2002) Blood , vol.99 , pp. 4457-4465
    • Schober, J.M.1    Chen, N.2    Grzeszkiewicz, T.M.3
  • 71
    • 0030754093 scopus 로고    scopus 로고
    • Purification and characterization of novel heparin-binding growth factor in uterine secretory fluids: Identification as heparin-regulated Mr 10,000 forms of connective tissue growth factor
    • Brigstock DR, Steffen CL, Kim GY, et al. Purification and characterization of novel heparin-binding growth factor in uterine secretory fluids: identification as heparin-regulated Mr 10,000 forms of connective tissue growth factor. J Biol Chem 1997; 272:20275-20282.
    • (1997) J Biol Chem , vol.272 , pp. 20275-20282
    • Brigstock, D.R.1    Steffen, C.L.2    Kim, G.Y.3
  • 72
    • 0029816069 scopus 로고    scopus 로고
    • Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation bt connective tissue growth factor
    • Frazier K, Williams S, Kothapalli D, et al. Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation bt connective tissue growth factor. J Invest Dermatol 1996; 107:404-411.
    • (1996) J Invest Dermatol , vol.107 , pp. 404-411
    • Frazier, K.1    Williams, S.2    Kothapalli, D.3
  • 73
    • 0036345499 scopus 로고    scopus 로고
    • A role for CCN3 (NOV) in calcium signalling
    • Li CL, Martinez V, He B, et al. A role for CCN3 (NOV) in calcium signalling. Mol Pathol 2002; 55:250-261.
    • (2002) Mol Pathol , vol.55 , pp. 250-261
    • Li, C.L.1    Martinez, V.2    He, B.3
  • 74
    • 0032577910 scopus 로고    scopus 로고
    • Demonstration of receptors specific for connective tissue growth factor on a human chondrocytic cell line (HCS-2/8)
    • Nishida T, Nakanishi T, Shimo T, et al. Demonstration of receptors specific for connective tissue growth factor on a human chondrocytic cell line (HCS-2/8). Biochem Biophys Res Commun 1998; 247:905-909.
    • (1998) Biochem Biophys Res Commun , vol.247 , pp. 905-909
    • Nishida, T.1    Nakanishi, T.2    Shimo, T.3
  • 75
    • 0035798710 scopus 로고    scopus 로고
    • The low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor is a receptor for connective tissue growth factor
    • Segarini PR, Nesbitt JE, Li D, et al. The low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor is a receptor for connective tissue growth factor. J Biol Chem 2001; 276:40659-40667.
    • (2001) J Biol Chem , vol.276 , pp. 40659-40667
    • Segarini, P.R.1    Nesbitt, J.E.2    Li, D.3
  • 76
    • 0035476393 scopus 로고    scopus 로고
    • Uptake and intracellular transport of the connective tissue growth factor: A potential mode of action
    • Wahab NA, Brinkman H, Mason RM. Uptake and intracellular transport of the connective tissue growth factor: a potential mode of action. Biochem J 2001; 359:89-97.
    • (2001) Biochem J , vol.359 , pp. 89-97
    • Wahab, N.A.1    Brinkman, H.2    Mason, R.M.3
  • 77
    • 0034023127 scopus 로고    scopus 로고
    • Role of Ras and Mapks in TGFbeta signaling
    • Mulder KM. Role of Ras and Mapks in TGFbeta signaling. Cytokine Growth Factor Rev 2000; 11:23-35.
    • (2000) Cytokine Growth Factor Rev , vol.11 , pp. 23-35
    • Mulder, K.M.1
  • 78
    • 0032589970 scopus 로고    scopus 로고
    • TGF-β1 activates MAP kinase in human mesangial cells: A possible role in collagen expression
    • Hayashida T, Poncelet AC, Hubchak SC, et al. TGF-β1 activates MAP kinase in human mesangial cells: a possible role in collagen expression. Kidney Int 1999; 56:1710-1720.
    • (1999) Kidney Int , vol.56 , pp. 1710-1720
    • Hayashida, T.1    Poncelet, A.C.2    Hubchak, S.C.3
  • 79
    • 0033104505 scopus 로고    scopus 로고
    • TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway
    • Hocevar BA, Brown TL, Howe PH. TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway. EMBO J 1999; 18:1345-1356.
    • (1999) EMBO J , vol.18 , pp. 1345-1356
    • Hocevar, B.A.1    Brown, T.L.2    Howe, P.H.3
  • 80
    • 0037407520 scopus 로고    scopus 로고
    • Extracellular matrix metabolism in diabetic nephropathy
    • Mason RM, Wahab NA. Extracellular matrix metabolism in diabetic nephropathy. J Am Soc Nephrol 2003; 14:1358-1373. This review compiles the available data on ECM metabolism in the kidney cells and the role of both CTGF and TGF-β.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 1358-1373
    • Mason, R.M.1    Wahab, N.A.2
  • 81
    • 0037333862 scopus 로고    scopus 로고
    • Selective stimulation of collagen synthesis in the presence of costimulatory insulin signaling by connective tissue growth factor in scleroderma fibroblasts
    • Gore-Hyer E, Pannu J, Smith EA, et al. Selective stimulation of collagen synthesis in the presence of costimulatory insulin signaling by connective tissue growth factor in scleroderma fibroblasts. Arthritis Rheum 2003; 48:798-806.
    • (2003) Arthritis Rheum , vol.48 , pp. 798-806
    • Gore-Hyer, E.1    Pannu, J.2    Smith, E.A.3
  • 82
    • 0035088456 scopus 로고    scopus 로고
    • Thrombospondin-1 is the key activator of TGF-beta1 in human mesangial cells exposed to high glucose
    • Yevdokimova N, Wahab NA, Mason RM. Thrombospondin-1 is the key activator of TGF-beta1 in human mesangial cells exposed to high glucose. J Am Soc Nephrol 2001; 12:703-712.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 703-712
    • Yevdokimova, N.1    Wahab, N.A.2    Mason, R.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.