Fibroblast growth factor-10 attenuates H2O2-induced alveolar epithelial cell DNA damage: Role of MAPK activation and DNA repair

American Journal of Respiratory Cell and Molecular Biology

Volumn 31, Issue 1, 2004, Pages 107-113

  Upadhyay, Daya ^b   Bundesmann, Michael ^b   Panduri, Vijayalakshmi ^b   Correa Meyer, Eduardo ^b   Kamp, David W ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

APHIDICOLIN; BINDING PROTEIN; DNA DIRECTED DNA POLYMERASE ALPHA; DNA DIRECTED DNA POLYMERASE DELTA; DNA DIRECTED DNA POLYMERASE EPSILON; ETHIDIUM BROMIDE; FIBROBLAST GROWTH FACTOR 10; FORSKOLIN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGENIC AGENT; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN INHIBITOR; RAF PROTEIN; RAS PROTEIN; SH3 BINDING PEPTIDE; SOS PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL REGENERATION; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; ELUTION; ENZYME ACTIVATION; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL TYPE 2; LUNG ALVEOLUS EPITHELIUM; LUNG DEVELOPMENT; NONHUMAN; OXIDATIVE STRESS; PROTEIN PHOSPHORYLATION; RAT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL LINE; DNA DAMAGE; DNA REPAIR; DNA-DIRECTED DNA POLYMERASE; ENZYME INHIBITORS; FIBROBLAST GROWTH FACTOR 10; FIBROBLAST GROWTH FACTORS; GRB2 ADAPTOR PROTEIN; HUMANS; HYDROGEN PEROXIDE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; OXIDANTS; OXIDATIVE STRESS; PROTEINS; PROTO-ONCOGENE PROTEINS C-RAF; PULMONARY ALVEOLI; PULMONARY FIBROSIS; RAS PROTEINS; RATS; RESPIRATORY MUCOSA;

ANIMALIA; BRONCHUS;

EID: 3042795814     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2003-0064OC     Document Type: Article

References (27)

1. Kamp, D. W., V. A. Israbian, S. Preusen, C. X. Zhang, and S. A. Weitzman. 1995. Asbestos causes DNA strand breaks in cultured pulmonary epithelial cells: role of iron-catalyzed free radicals. Am. J. Physiol. 268:L471-L480.
2. 2 exposure. Am. J. Physiol. 275:L780-L787.
3. Deterding, R. R., A. M. Havill, T. Yano, S. C. Middleton, C. R. Jacoby, J. M. Shannon, W. S. Simonet, and R. J. Mason. 1997. Prevention of bleomycin-induced lung injury in rats by keratinocyte growth factor. Proc. Assoc. Am. Physicians 109:254-268.
4. Takeoka, M., W. F. Ward, N. Pollack, D. W. Kamp, and R. J. Panos. 1997. Keratinocyte growth factor facilitates repair of radiation-induced DNA damage in alveolar epithelial cells. Am. J. Physiol. 272:L1174-L1180.
5. Henle, E. S., and S. Linn. 1997. Formation, prevention, and repair of DNA damage by iron/hydrogen peroxide. J. Biol. Chem. 272:19095-19098.
6. Kinnula, V. L., J. D. Crapo, and K. O. Raivio. 1995. Generation and degradation of reactive oxygen metabolites in the lung. Lab. Invest. 73:3-19.
7. Schraufstater, I., D. B. Hinshaw, P. A. Hyslop, R. G. Spragg, and C. G. Cochrane. 1986. Oxidant injury of cells. DNA strand breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenosine dinucleotide. J. Clin. Invest. 77:1312-1320.
8. Gardner, A. M., F. Xu, C. Fady, F. J. Jacoby, D. C. Duffy, Y. Tu, and A. Lichtenstein. 1997. Apoptotic and nonapoptotic cytotoxicity induced by hydrogen peroxide. Free Radic. Biol. Med. 22:73-83.
9. Pastink, A., J. C. Eeken, and P. H. Lohman. 2001. Genomic integrity and the repair of double-strand DNA breaks. Mutat. Res. 480-481:37-50.
10. Ware, L. B., and M. A. Matthay. 2002. Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation and repair. Am. J. Physiol. 282:L924-L940.
11. Michelson, P. H., M. Tigue, R. J. Panos, and P. H. Sporn. 1999. Keratinocyte growth factor stimulates bronchial epithelial cell proliferation in vitro and in vivo. Am. J. Physiol. 277:L737-L742.
12. Waters, C. M., U. Savla, and R. J. Panos. 1997. Keratinocyte growth factor prevents hydrogen peroxide-induced increases in airway epithelial cell permeability. Am. J. Physiol 272:L681-L689.
13. Igarashi, M., P. W. Finch, and S. A. Aaronson. 1998. Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7). J. Biol. Chem. 273:1320-1325.
14. Mason, J., M. A. Rampy, K. McCormack-Shannon, K. Edeen, Z. Okoye, and J. M. Shannon. 1999. FGF-10 is a mitogen for adult rat type II cells. Am. J. Respir Crit. Care Med. 159:A172. (Abstr.)
15. Sekine, K., H. Ohuchi, M. Fujiwara, M. Yamasaki, T. Yoshizawa, T. Sato, N. Yagishita, D. Matsui, Y. Koga, N. Itoh, and S. Kato. 1999. Fgf10 is essential for limb and lung formation. Nat. Genet. 21:138-141.
16. Luo, Y., W. Lu, K. A. Mohamedali, J. H. Jang, R. B. Jones, J. L. Gabriel, M. Kan, and W. L. McKeehan. 1998. The glycine box: a determinant of specificity for fibroblast growth factor. Biochemistry 37:16506-16515.
17. Upadhyay, D., E. C. Meyer, J. I. Sznajder, and D. W. Kamp. 2003. FGF-10 attenuates cyclic stretch-induced alveolar epithelial cell DNA damage via MAPK/ERK pathway. Am. J. Physiol. Lung Cell. Mol. Physiol 284:L350-L359.
18. 2. Role in cell survival following oxidant injury. J. Biol. Chem. 271:4138-4142.
19. Buder-Hoffmann, S., C. Palmer, P. Vacek, D. Taatjes, and B. Mossman. 2001. Different accumulation of activated extracellular signal-regulated kinases (ERK 1/2) and role in cell-cycle alterations by epidermal growth factor, hydrogen peroxide, or asbestos in pulmonary epithelial cells. Am. J. Respir. Cell Mol Biol. 24:405-413.
20. Wu, M., Y. H. He, M. Kobune, Y. Xu, M. R. Kelley, and W. J. Martin II. 2002. Protection of human lung cells against hyperoxia using the DNA base excision repair genes hOgg1 and Fpg. Am. J. Respir. Crit Care Med. 166: 192-199.
21. Pardo, O. E., A. Arcaro, G. Salerno, S. Raguz, J. Downward, and M. J. Seckl. 2002. Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosis. J. Biol. Chem. 277:12040-12046.
22. Frank, G. D., M. Mifune, T. Inagami, M. Ohba, T. Sasaki, S. Higashiyama, P. J. Dempsey, and S. Eguchi. 2003. Distinct mechanisms of receptor and nonreceptor tyrosine kinase activation by reactive oxygen species in vascular smooth muscle cells: role of metalloprotease and protein kinase C-delta. Mol Cell Biol. 23:1581-1589.
23. Lim, L., V. V. Kalinichenko, J. A. Whitsett, and R. H. Costa. 2002. Fusion of lung lobes and vessels in mouse embryos heterozygous for the forkhead box f1 targeted allele. Am. J. Physiol. Lung Cell. Mol Physiol 282:L1012-L1022.
24. Panos, R. J., P. M. Bak, W. S. Simonet, J. S. Rubin, and L. J. Smith. 1995. Intratracheal instillation of keratinocyte growth factor decreases hyperoxia-induced mortality in rats. J. Clin. Invest. 96:2026-2033.
25. Frank, S., B. Munz, and S. Werner. 1997. The human homologue of a bovine non-selenium glutathione peroxidase is a novel keratinocyte growth factor-regulated gene. Oncogene 12:915-921.
26. Szebenyi, G., and J. F. Fallon. 1999. Fibroblast growth factors as multifunctional signaling factors. Int. Rev. Cytol. 185:45-106.
27. Tefft, D., M. Lee, S. Smith, D. L. Crowe, S. Bellusci, and D. Warburton. 2002. mSprouty2 inhibits FGF10-activated MAP kinase by differentially binding to upstream target proteins. Am. J. Physiol. Lung Cell. Mol. Physiol. 283: L700-L706.