Oncostatin M, a Cytokine Released by Activated Mononuclear Cells, Induces Epithelial Cell-Myofibroblast Transdifferentiation via Jak/Stat Pathway Activation

Journal of the American Society of Nephrology

Volumn 15, Issue 1, 2004, Pages 21-32

  Nightingale, Joanna ^a   Patel, Sharmila ^a   Suzuki, Naotaka ^a   Buxton, Roger ^b   Takagi, Ken Ichro ^a   Suzuki, Jun ^c   Sumi, Yoshihiko ^c   Imaizumi, Atsushi ^c   Mason, Roger M ^d   Zhang, Zhi ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^c TEIJIN LTD   (Japan)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTIN; BIOLOGICAL MARKER; CELL PROTEIN; COLLAGEN TYPE 1; CYTOKERATIN 19; CYTOKINE; EDOXUDINE; ENZYME INHIBITOR; FIBRONECTIN; JANUS KINASE; JANUS KINASE 2; MESSENGER RNA; ONCOSTATIN M; PROTEIN SUBUNIT; STAT PROTEIN; UVOMORULIN;

ARTICLE; CELL DIFFERENTIATION; CELL INTERACTION; CELL LEVEL; CELL TRANSFORMATION; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE RELEASE; DNA MICROARRAY; DOWN REGULATION; ENZYME ACTIVATION; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; INFLAMMATORY INFILTRATE; KIDNEY FIBROSIS; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE EPITHELIUM; MOLECULAR GENETICS; MONONUCLEAR CELL; MYOFIBROBLAST; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UNINDEXED SEQUENCE; UPREGULATION;

EID: 9144254680     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ASN.0000102479.92582.43     Document Type: Article

References (32)

1. Papayianni A: Cytokines, growth factors, and other inflammatory mediators in glomerulonephritis. Renal Fail 18: 725-740, 1996
2. Schena FP, Gesualdo L, Grandaliano G, Montinaro V: Progression of renal damage in human glomerulonephritides: Is there sleight of hand in winning the game? Kidney Int 52: 1439-1457, 1997
3. Eddy AA: Molecular basis of renal fibrosis. Pediatr Nephrol 15: 290-301, 2000
4. Ng Y, Huang T, Yang W, Chen Z, Yang A, Mu W, Nikolic-Paterson DJ, Atkins RC, Lan HY: Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerslitial fibrosis in 5/6 nephrectomized rats. Kidney Int 54: 864-876, 1998
5. Yang J, Liu Y: Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol 159: 1465-1475, 2001
6. Vesey DA, Cheung CWY, Cuttle L, Endre Z, Gobe G, Johnson DW: Interleukin-1β induces human proximal tubule cell injury, α-smooth muscle actin expression and fibronectin production. Kidney Int 62: 31-40, 2002
7. Fan J, Ng Y, Hill PA, Nikolic-Paterson DJ, Mu W, Atkins RC, Lan HY: Transforming growth factor-β regulates tubular epithelial-myofibroblast trunsdifferentiation in vitro. Kidney Int 56: 1455-1467, 1999
8. Fan J, Huang X, Ng Y, Nikolic-Paterson DJ, Mu W, Atkins RC, Lan HY: Interleukin-1 induces tubular epithelial-myofibroblast transdifferentiation through a transforming growth factor-β1-dependent mechanism in vitro. Am J Kidney Dis 37: 820-831, 2001
9. Healy E, Leonard M, Madrigal-Estebas L, O'Farrelly C, Watson AJ, Ryan MP: Factors produced by activated leukocytes alter renal epithelial cell differentiation. Kidney Int 56: 1266-1269, 1999
10. Bridges CG, Taylor DL, Ahmed PS, Brennan TM, Hornsperger JM, Nave JE, Casara P, Tyms AS: MDL 74,968, a new acyclo-nucleotide analog: Against human immunodeficiency virus in vitro and in the hu-PBL-SCID.Beige mouse model of infection. Antimicrob Agems Chemother 40: 1072-1077, 1996
11. Zhang Z, Blake DR, Stevens CR, Kanezler JK, Winyard PG, Symons MCR, Benboubetra M, Harrison R: A reappraisal of xanthine dehydrogenase and oxidase in hypoxic reperfusion injury: A role of NADH as an electron donor. Free Radic Res 28: 151-164, 1998
12. Sasaki S, Bao Q, Hughes RC: Galectin-3 modulates rat mesangial cell proliferation and matrix synthesis during experimental glomerulonephritis induced by anti-Thy1.1 antibodies. J Pathol 187:481-489, 1999
13. Scaffidi AK, Mutsaers SE, Moodley YP, McAnultyy RJ, Laurent GJ, Thompson PJ. Knight DA: Oncostatin M stimulates proliferation, induces collagen production and inhibits apoptosis of human lung fibroblasts. Br J Pharmacol 136: 793-801, 2002
14. Li WQ, Dehnade F, Zafarrullah M: Oncostatin M-induced matrix metalloproteinases and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway. J Immunol 166: 3491-3498, 2001
15. Strutz F, Muller GA, Neilson EG: Transdifferentiation: A new angle on renal fibrosis. Exp Nephrol 4: 267-270, 1996
16. Rastaldi MP, Ferrario F, Giardino L, Dell'Antonio G, Grillo P, Strutz F, Muller GA, Colasanti G, D'Amico G: Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies. Kidney Int 62: 137-146, 2002
17. Yano N, Endoh M, Nomoto Y, Sakai H, Fadden K, Rifai A: Phenotypic characterization of cytokine expression in patients with IgA nephropathy. J Clin Immunol 17: 396-403, 1997
18. International Human Genome Sequencing Consortium: Initial sequencing and analysis of the human genome. Nature 405: 860-921, 2001
19. Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, et al.: The sequence of the human genome. Science 291: 1304-1351, 2001
20. Hay ED: An overview of epithelio-mesenchymal transformation. Acta Anat (Basel) 154: 8-20, 1995
21. Savagner P, Boyer B, Valles AM, Jouanneau J, Thiery JP: Modulations of the epithelial phenotype during embryogenesis and cancer progression. Cancer Treat Res 71: 29-249, 1994
22. Ewing CM, Ru N, Morton RA, Robinson JC, Wheelock MJ, Johnson KR, Barrett JC, Isaacs WB: Chromosome 5 suppresses tumorigenicity of PC3 prostate cancer cells: Correction with re-expression of α-catenin and restoration of E-cadherin function. Cancer Res 55: 4813-4817, 1995
23. Rose TM. Bruce AG: Oncostatin M is a member of a cytokine family that induces leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. Proc Natl Acad Sci USA 88: 8641-8645, 1991
24. Heinrich PC, Behrmann I, Muller-Newen G, Schaper F, Graevel L: Inteleukin-6-type cytokine signaling through the gp130/Jak/ STAT pathway. Biochem J 334: 297-314, 1998
25. Auernhammer CJ, Melmed S: Leukemia-inhibitory factor-neuroimmune modulator of endocrine function. Endocr Rev 21: 313-345, 2000
26. Blanchard F, Wang Y, Kinzie E, Duplomb L, Godard A, Baumann H: Oncostatin M regulates the synthesis and turnover of gp130, leukemia inhibitory factor receptor α, and oncostatin M receptor β by distinct mechanisms. J Biol Chem 276: 47038-47045, 2001
27. Ihn H, Tamaki K: Oncostatin M stimulates the growth of dermal fibroblasts via a mitogen-activated protein kinase-dependent pathway. J Immunol 165: 2149-2155, 2000
28. Schramek H, Feifel E, Healy E, Pollack V: Constitutively active mutant of the mitogen-activated protein kinase kinase MEK-1 induces epithelial dedifferentiation and growth inhibition in Madin-Darby canine kidney-C7 cells. J Biol Chem 272: 11426-11433, 1997
29. Hocevar BA, Brown TL, Howe PH: TGF-β induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway. EMBO J 18: 1345-1356, 1999
30. WAF1/CP1 by transforming growth factor-β. J Biol Chem 274: 35381-35387, 1999
31. Yue J, Mulder KM: Requirement of Ras/MAPK pathway activation by transforming growth factor β for transforming growth factor β1 production in a Smad-dependent pathway. J Biol Chem 275: 30765-30773, 2000
32. Zavadil J, Bitzer M, Liang D, Yang YC, Massimi A, Kneitz S, Piek E, Bottinger EP: Genetic programs of epithelial cell plasticity directed by transforming growth factor-β. Proc Natl Acad Sci USA 98: 6686-6691, 2001