메뉴 건너뛰기




Volumn 30, Issue 6-7, 2005, Pages 909-919

Cellular stress reactions as putative cholinergic links in Alzheimer's disease

Author keywords

Acetylcholinesterase; Alternative splicing; Alzheimer's disease; Cellular stress

Indexed keywords

ACETYLCHOLINESTERASE; CALCIUM;

EID: 26244455579     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-005-6963-8     Document Type: Article
Times cited : (25)

References (71)
  • 1
    • 0034329742 scopus 로고    scopus 로고
    • Apoptosis in neurodegenerative disorders
    • M. P. Mattson 2000 Apoptosis in neurodegenerative disorders Nat. Rev. Mol. Cell Biol. 1 120 129
    • (2000) Nat. Rev. Mol. Cell Biol. , vol.1 , pp. 120-129
    • Mattson, M.P.1
  • 2
    • 2642567691 scopus 로고    scopus 로고
    • Cholinergic activity and amyloid precursor protein processing in aging and Alzheimer's disease
    • X. Zhang 2004 Cholinergic activity and amyloid precursor protein processing in aging and Alzheimer's disease Curr. Drug Targets CNS Neurol. Disord. 3 137 152
    • (2004) Curr. Drug Targets CNS Neurol. Disord. , vol.3 , pp. 137-152
    • Zhang, X.1
  • 3
    • 5344277556 scopus 로고    scopus 로고
    • Deciphering the molecular basis of memory failure in Alzheimer's disease
    • D. M. Walsh D. J. Selkoe 2004 Deciphering the molecular basis of memory failure in Alzheimer's disease Neuron 44 181 93
    • (2004) Neuron , vol.44 , pp. 181-93
    • Walsh, D.M.1    Selkoe, D.J.2
  • 4
    • 0042433479 scopus 로고    scopus 로고
    • The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: Recent challenges and their implications for novel drug development
    • A. V. Terry J. J. Buccafusco 2003 The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: Recent challenges and their implications for novel drug development J. Pharmacol. Exp. Ther. 306 821 827
    • (2003) J. Pharmacol. Exp. Ther. , vol.306 , pp. 821-827
    • Terry, A.V.1    Buccafusco, J.J.2
  • 5
    • 0028790904 scopus 로고
    • Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice
    • I. Gordon E. Grauer I. Genis E. Sehayek D. M. Michaelson 1995 Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice Neurosci. Lett. 199 1 4
    • (1995) Neurosci. Lett. , vol.199 , pp. 1-4
    • Gordon, I.1    Grauer, E.2    Genis, I.3    Sehayek, E.4    Michaelson, D.M.5
  • 6
    • 12144286749 scopus 로고    scopus 로고
    • Decreased level of brain acetylcholine and memory disturbance in APPsw mice
    • Y. Ikarashi 2004 Decreased level of brain acetylcholine and memory disturbance in APPsw mice Neurobiol. Aging 25 483 490
    • (2004) Neurobiol. Aging , vol.25 , pp. 483-490
    • Ikarashi, Y.1
  • 7
    • 0034524262 scopus 로고    scopus 로고
    • In-vivo measurements of regional acetylcholine esterase activity in degenerative dementia: Comparison with blood flow and glucose metabolism
    • K. Herholz 2000 In-vivo measurements of regional acetylcholine esterase activity in degenerative dementia: Comparison with blood flow and glucose metabolism J. Neural Transm. 107 1457 1468
    • (2000) J. Neural Transm. , vol.107 , pp. 1457-1468
    • Herholz, K.1
  • 8
    • 1642451941 scopus 로고    scopus 로고
    • In vivo study of acetylcholine esterase in basal forebrain, amygdala, and cortex in mild to moderate Alzheimer disease
    • K. Herholz 2004 In vivo study of acetylcholine esterase in basal forebrain, amygdala, and cortex in mild to moderate Alzheimer disease Neuroimage 21 136 143
    • (2004) Neuroimage , vol.21 , pp. 136-143
    • Herholz, K.1
  • 9
    • 0037234423 scopus 로고    scopus 로고
    • The role of acetylcholinesterase in the pathogenesis of Alzheimer's disease
    • T. M. Rees S. Brimijoin 2003 The role of acetylcholinesterase in the pathogenesis of Alzheimer's disease Drugs Today (Barc.) 39 75 83
    • (2003) Drugs Today (Barc.) , vol.39 , pp. 75-83
    • Rees, T.M.1    Brimijoin, S.2
  • 11
    • 0037332298 scopus 로고    scopus 로고
    • Phenolic antioxidants attenuate hippocampal neuronal cell damage against kainic acid induced excitotoxicity
    • M. S. Parihar T. Hemnani 2003 Phenolic antioxidants attenuate hippocampal neuronal cell damage against kainic acid induced excitotoxicity J. Biosci. 28 121 128
    • (2003) J. Biosci. , vol.28 , pp. 121-128
    • Parihar, M.S.1    Hemnani, T.2
  • 12
    • 85047693458 scopus 로고    scopus 로고
    • Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: Cause or effect?
    • D. W. Dickson 2004 Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: Cause or effect? J. Clin. Invest. 114 23 7
    • (2004) J. Clin. Invest. , vol.114 , pp. 23-7
    • Dickson, D.W.1
  • 13
    • 0035818998 scopus 로고    scopus 로고
    • Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP
    • A. Kamal A. Almenar-Queralt J. F. LeBlanc E. A. Roberts L. S. Goldstein 2001 Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP Nature 414 643 648
    • (2001) Nature , vol.414 , pp. 643-648
    • Kamal, A.1    Almenar-Queralt, A.2    Leblanc, J.F.3    Roberts, E.A.4    Goldstein, L.S.5
  • 14
    • 0034703981 scopus 로고    scopus 로고
    • Analysis of Galpha protein recognition profiles of angiotensin II receptors using chimeric Galpha proteins
    • H. Sasamura 2000 Analysis of Galpha protein recognition profiles of angiotensin II receptors using chimeric Galpha proteins Mol. Cell. Endocrinol. 170 113 121
    • (2000) Mol. Cell. Endocrinol. , vol.170 , pp. 113-121
    • Sasamura, H.1
  • 15
    • 0038322593 scopus 로고    scopus 로고
    • Gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins
    • D. M. Walsh 2003 gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins Biochemistry 42 6664 6673
    • (2003) Biochemistry , vol.42 , pp. 6664-6673
    • Walsh, D.M.1
  • 16
    • 0036830947 scopus 로고    scopus 로고
    • Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease
    • F. M. LaFerla 2002 Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease Nat. Rev. Neurosci. 3 862 872
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 862-872
    • Laferla, F.M.1
  • 17
    • 0038607071 scopus 로고    scopus 로고
    • Gamma-secretase activity is associated with a conformational change of nicastrin
    • K. Shirotani 2003 Gamma-secretase activity is associated with a conformational change of nicastrin J. Biol. Chem. 278 16474 16477
    • (2003) J. Biol. Chem. , vol.278 , pp. 16474-16477
    • Shirotani, K.1
  • 18
    • 0037022644 scopus 로고    scopus 로고
    • Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate
    • W. P. Esler 2002 Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate Proc. Natl. Acad. Sci. USA 99 2720 2725
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 2720-2725
    • Esler, W.P.1
  • 19
    • 0037435604 scopus 로고    scopus 로고
    • Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s)
    • W. T. Kimberly 2003 Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s) Biochemistry 42 137 144
    • (2003) Biochemistry , vol.42 , pp. 137-144
    • Kimberly, W.T.1
  • 20
    • 0344237127 scopus 로고    scopus 로고
    • Calcium orchestrates apoptosis
    • M. P. Mattson S. L. Chan 2003 Calcium orchestrates apoptosis Nat. Cell Biol. 5 1041 1043
    • (2003) Nat. Cell Biol. , vol.5 , pp. 1041-1043
    • Mattson, M.P.1    Chan, S.L.2
  • 21
    • 0242570611 scopus 로고    scopus 로고
    • ApoE isoforms affect neuronal N-methyl-D-aspartate calcium responses and toxicity via receptor-mediated processes
    • Z. Qiu K. A. Crutcher B. T. Hyman G. W. Rebeck 2003 ApoE isoforms affect neuronal N-methyl-D-aspartate calcium responses and toxicity via receptor-mediated processes Neuroscience 122 291 303
    • (2003) Neuroscience , vol.122 , pp. 291-303
    • Qiu, Z.1    Crutcher, K.A.2    Hyman, B.T.3    Rebeck, G.W.4
  • 22
    • 3142718813 scopus 로고    scopus 로고
    • Gene expression profiling in fetal, aged, and Alzheimer hippocampus: A continuum of stress-related signaling
    • W. J. Lukiw 2004 Gene expression profiling in fetal, aged, and Alzheimer hippocampus: A continuum of stress-related signaling Neurochem. Res. 29 1287 1297
    • (2004) Neurochem. Res. , vol.29 , pp. 1287-1297
    • Lukiw, W.J.1
  • 23
    • 1842831135 scopus 로고    scopus 로고
    • Endoplasmic reticulum Ca(2+) homeostasis and neuronal death
    • A. Verkhratsky E. C. Toescu 2003 Endoplasmic reticulum Ca(2+) homeostasis and neuronal death J. Cell Mol. Med. 7 351 361
    • (2003) J. Cell Mol. Med. , vol.7 , pp. 351-361
    • Verkhratsky, A.1    Toescu, E.C.2
  • 24
    • 3042631024 scopus 로고    scopus 로고
    • Gene regulation and DNA damage in the ageing human brain
    • T. Lu 2004 Gene regulation and DNA damage in the ageing human brain Nature 429 883 891
    • (2004) Nature , vol.429 , pp. 883-891
    • Lu, T.1
  • 25
    • 0035744704 scopus 로고    scopus 로고
    • The molecular biology of memory storage: A dialog between genes and synapses
    • E. R. Kandel 2001 The molecular biology of memory storage: A dialog between genes and synapses Biosci. Rep. 21 565 611
    • (2001) Biosci. Rep. , vol.21 , pp. 565-611
    • Kandel, E.R.1
  • 26
    • 3142755799 scopus 로고    scopus 로고
    • Combinatorial complexity of 5' alternative acetylcholinesterase transcripts and protein products
    • E. Meshorer 2004 Combinatorial complexity of 5' alternative acetylcholinesterase transcripts and protein products J. Biol. Chem. 279 29740 29751
    • (2004) J. Biol. Chem. , vol.279 , pp. 29740-29751
    • Meshorer, E.1
  • 27
    • 11144355172 scopus 로고    scopus 로고
    • Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study
    • E. H. Sklan 2004 Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study Proc. Natl. Acad. Sci. USA 101 5512 5517
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 5512-5517
    • Sklan, E.H.1
  • 28
    • 0037718047 scopus 로고    scopus 로고
    • Pre-mRNA splicing modulations in senescence
    • E. Meshorer H. Soreq 2002 Pre-mRNA splicing modulations in senescence Aging Cell 1 10 16
    • (2002) Aging Cell , vol.1 , pp. 10-16
    • Meshorer, E.1    Soreq, H.2
  • 29
    • 1842375103 scopus 로고    scopus 로고
    • The amyloid beta-protein of Alzheimer's disease increases acetylcholinesterase expression by increasing intracellular calcium in embryonal carcinoma P19 cells
    • G. Sberna J. Saez-Valero K. Beyreuther C. L. Masters D. H. Small 1997 The amyloid beta-protein of Alzheimer's disease increases acetylcholinesterase expression by increasing intracellular calcium in embryonal carcinoma P19 cells J. Neurochem. 69 1177 1184
    • (1997) J. Neurochem. , vol.69 , pp. 1177-1184
    • Sberna, G.1    Saez-Valero, J.2    Beyreuther, K.3    Masters, C.L.4    Small, D.H.5
  • 30
    • 0347479362 scopus 로고    scopus 로고
    • Acetylcholinesterase induces the expression of the beta-amyloid precursor protein in glia and activates glial cells in culture
    • R. von Bernhardi G. Ramirez G. V. De Ferrari N. C. Inestrosa 2003 Acetylcholinesterase induces the expression of the beta-amyloid precursor protein in glia and activates glial cells in culture Neurobiol. Dis. 14 447 457
    • (2003) Neurobiol. Dis. , vol.14 , pp. 447-457
    • Von Bernhardi, R.1    Ramirez, G.2    De Ferrari, G.V.3    Inestrosa, N.C.4
  • 31
    • 0035048978 scopus 로고    scopus 로고
    • Compensatory mechanisms enhance hippocampal acetylcholine release in transgenic mice expressing human acetylcholinesterase
    • C. Erb 2001 Compensatory mechanisms enhance hippocampal acetylcholine release in transgenic mice expressing human acetylcholinesterase J. Neurochem. 77 638 646
    • (2001) J. Neurochem. , vol.77 , pp. 638-646
    • Erb, C.1
  • 32
    • 0036014116 scopus 로고    scopus 로고
    • Upregulation of neuronal nicotinic receptor subunits alpha4, beta2, and alpha7 in transgenic mice overexpressing human acetylcholinesterase
    • M. M. Svedberg 2002 Upregulation of neuronal nicotinic receptor subunits alpha4, beta2, and alpha7 in transgenic mice overexpressing human acetylcholinesterase J. Mol. Neurosci. 18 211 22
    • (2002) J. Mol. Neurosci. , vol.18 , pp. 211-22
    • Svedberg, M.M.1
  • 33
    • 0033063505 scopus 로고    scopus 로고
    • Anticholinesterases induce multigenic transcriptional feedback response suppressing cholinergic neurotransmission
    • D. Kaufer A. Friedman S. Seidman H. Soreq 1999 Anticholinesterases induce multigenic transcriptional feedback response suppressing cholinergic neurotransmission Chem. Biol. Interact. 119-120 349 360
    • (1999) Chem. Biol. Interact. , vol.119-120 , pp. 349-360
    • Kaufer, D.1    Friedman, A.2    Seidman, S.3    Soreq, H.4
  • 34
    • 0037127007 scopus 로고    scopus 로고
    • Alternative splicing and neuritic mRNA translocation under long-term neuronal hypersensitivity
    • E. Meshorer 2002 Alternative splicing and neuritic mRNA translocation under long-term neuronal hypersensitivity Science 295 508 512
    • (2002) Science , vol.295 , pp. 508-512
    • Meshorer, E.1
  • 36
    • 22144436584 scopus 로고    scopus 로고
    • Memory deficits correlating with acetylcholinesterase splice shift and amyloid burden in doubly transgenic mice
    • in press
    • Rees, T. M., et al. Memory deficits correlating with acetylcholinesterase splice shift and amyloid burden in doubly transgenic mice. Current Alzheimer Research, in press (2005).
    • (2005) Current Alzheimer Research
    • Rees, T.M.1
  • 37
    • 0043037253 scopus 로고    scopus 로고
    • Endoplasmic reticulum: A primary target in various acute disorders and degenerative diseases of the brain
    • W. Paschen 2003 Endoplasmic reticulum: A primary target in various acute disorders and degenerative diseases of the brain Cell Calcium 34 365 383
    • (2003) Cell Calcium , vol.34 , pp. 365-383
    • Paschen, W.1
  • 38
    • 0034889904 scopus 로고    scopus 로고
    • Changes in the phosphorylation of initiation factor eIF-2alpha, elongation factor eEF-2 and p70 S6 kinase after transient focal cerebral ischaemia in mice
    • S. Althausen 2001 Changes in the phosphorylation of initiation factor eIF-2alpha, elongation factor eEF-2 and p70 S6 kinase after transient focal cerebral ischaemia in mice J. Neurochem. 78 779 787
    • (2001) J. Neurochem. , vol.78 , pp. 779-787
    • Althausen, S.1
  • 39
    • 0031081340 scopus 로고    scopus 로고
    • The ER-overload response: Activation of NF-kappa B
    • H. L. Pahl P. A. Baeuerle 1997 The ER-overload response: Activation of NF-kappa B Trends Biochem. Sci. 22 63 67
    • (1997) Trends Biochem. Sci. , vol.22 , pp. 63-67
    • Pahl, H.L.1    Baeuerle, P.A.2
  • 40
    • 0033634641 scopus 로고    scopus 로고
    • Perk is essential for translational regulation and cell survival during the unfolded protein response
    • H. P. Harding Y. Zhang A. Bertolotti H. Zeng D. Ron 2000 Perk is essential for translational regulation and cell survival during the unfolded protein response Mol. Cell 5 897 904
    • (2000) Mol. Cell , vol.5 , pp. 897-904
    • Harding, H.P.1    Zhang, Y.2    Bertolotti, A.3    Zeng, H.4    Ron, D.5
  • 41
    • 0032525990 scopus 로고    scopus 로고
    • Stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
    • W. Tirasophon A. A. Welihinda R. J. A. Kaufman 1998 stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells Genes Dev. 12 1812 1824
    • (1998) Genes Dev. , vol.12 , pp. 1812-1824
    • Tirasophon, W.1    Welihinda, A.A.2    Kaufman, R.J.A.3
  • 42
    • 0037083755 scopus 로고    scopus 로고
    • IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response
    • K. Lee 2002 IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response Genes Dev. 16 452 466
    • (2002) Genes Dev. , vol.16 , pp. 452-466
    • Lee, K.1
  • 43
    • 0035966269 scopus 로고    scopus 로고
    • XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
    • H. Yoshida T. Matsui A. Yamamoto T. Okada K. Mori 2001 XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor Cell 107 881 891
    • (2001) Cell , vol.107 , pp. 881-891
    • Yoshida, H.1    Matsui, T.2    Yamamoto, A.3    Okada, T.4    Mori, K.5
  • 44
    • 0038446405 scopus 로고    scopus 로고
    • The unfolded protein response
    • C. Y. Liu R. J. Kaufman 2003 The unfolded protein response J. Cell Sci. 116 1861 1862
    • (2003) J. Cell Sci. , vol.116 , pp. 1861-1862
    • Liu, C.Y.1    Kaufman, R.J.2
  • 45
    • 0033258544 scopus 로고    scopus 로고
    • Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response
    • T. Katayama 1999 Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response Nat. Cell Biol. 1 479 485
    • (1999) Nat. Cell Biol. , vol.1 , pp. 479-485
    • Katayama, T.1
  • 46
    • 0034319169 scopus 로고    scopus 로고
    • Role of calcium in neuronal cell injury: Which subcellular compartment is involved?
    • W. Paschen 2000 Role of calcium in neuronal cell injury: which subcellular compartment is involved? Brain Res. Bull. 53 409 413
    • (2000) Brain Res. Bull. , vol.53 , pp. 409-413
    • Paschen, W.1
  • 47
    • 0041817715 scopus 로고    scopus 로고
    • Apoptosis induced by beta-amyloid25-35 in acetylcholinesterase- overexpressing neuroblastoma cells
    • H. Y. Zhang S. Brimijoin X. C. Tang 2003 Apoptosis induced by beta-amyloid25-35 in acetylcholinesterase-overexpressing neuroblastoma cells Acta Pharmacol. Sin. 24 853 858
    • (2003) Acta Pharmacol. Sin. , vol.24 , pp. 853-858
    • Zhang, H.Y.1    Brimijoin, S.2    Tang, X.C.3
  • 48
    • 4043104785 scopus 로고    scopus 로고
    • Overexpression of acetylcholinesterase inhibited cell proliferation and promoted apoptosis in NRK cells
    • Q. H. Jin H. Y. He Y. F. Shi H. Lu X. J. Zhang 2004 Overexpression of acetylcholinesterase inhibited cell proliferation and promoted apoptosis in NRK cells Acta. Pharmacol. Sin. 25 1013 1021
    • (2004) Acta. Pharmacol. Sin. , vol.25 , pp. 1013-1021
    • Jin, Q.H.1    He, H.Y.2    Shi, Y.F.3    Lu, H.4    Zhang, X.J.5
  • 49
    • 10844253547 scopus 로고    scopus 로고
    • Acetylcholinesterase plays a pivotal role in apoptosome formation
    • S. E. Park N. D. Kim Y. H. Yoo 2004 Acetylcholinesterase plays a pivotal role in apoptosome formation Cancer Res. 64 2652 2655
    • (2004) Cancer Res. , vol.64 , pp. 2652-2655
    • Park, S.E.1    Kim, N.D.2    Yoo, Y.H.3
  • 50
    • 0036024019 scopus 로고    scopus 로고
    • Induction of acetylcholinesterase expression during apoptosis in various cell types
    • X. J. Zhang 2002 Induction of acetylcholinesterase expression during apoptosis in various cell types Cell Death Differ. 9 790 800
    • (2002) Cell Death Differ. , vol.9 , pp. 790-800
    • Zhang, X.J.1
  • 51
    • 0036237097 scopus 로고    scopus 로고
    • Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells
    • L. Yang H. Y. He X. J. Zhang 2002 Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells Neurosci. Res. 42 261 268
    • (2002) Neurosci. Res. , vol.42 , pp. 261-268
    • Yang, L.1    He, H.Y.2    Zhang, X.J.3
  • 52
    • 0344441446 scopus 로고    scopus 로고
    • A peptide derived from acetylcholinesterase induces neuronal cell death: Characterisation of possible mechanisms
    • T. Day S. A. Greenfield 2003 A peptide derived from acetylcholinesterase induces neuronal cell death: characterisation of possible mechanisms Exp. Brain Res. 153 334 342
    • (2003) Exp. Brain Res. , vol.153 , pp. 334-342
    • Day, T.1    Greenfield, S.A.2
  • 53
    • 2142652150 scopus 로고    scopus 로고
    • Elements of the C-terminal t peptide of acetylcholinesterase that determine amphiphilicity, homomeric and heteromeric associations, secretion and degradation
    • S. Belbeoc'h 2004 Elements of the C-terminal t peptide of acetylcholinesterase that determine amphiphilicity, homomeric and heteromeric associations, secretion and degradation Eur. J. Biochem. 271 1476 1487
    • (2004) Eur. J. Biochem. , vol.271 , pp. 1476-1487
    • Belbeoc'H, S.1
  • 54
    • 12344250822 scopus 로고    scopus 로고
    • Function of alternative splicing
    • S. Stamm 2005 Function of alternative splicing Gene 344C 1 20
    • (2005) Gene , vol.344 , pp. 1-20
    • Stamm, S.1
  • 55
    • 0345465663 scopus 로고    scopus 로고
    • Integration of endoplasmic reticulum signaling in health and disease
    • M. Aridor W. E. Balch 1999 Integration of endoplasmic reticulum signaling in health and disease Nat. Med. 5 745 751
    • (1999) Nat. Med. , vol.5 , pp. 745-751
    • Aridor, M.1    Balch, W.E.2
  • 56
    • 0033613147 scopus 로고    scopus 로고
    • A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
    • M. S. Brown J. L. Goldstein 1999 A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood Proc. Natl. Acad. Sci. USA 96 11041 11048
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 11041-11048
    • Brown, M.S.1    Goldstein, J.L.2
  • 57
    • 0035424456 scopus 로고    scopus 로고
    • CREating a SCAP-less liver keeps SREBPs pinned in the ER membrane and prevents increased lipid synthesis in response to low cholesterol and high insulin
    • T. F. Osborne 2001 CREating a SCAP-less liver keeps SREBPs pinned in the ER membrane and prevents increased lipid synthesis in response to low cholesterol and high insulin Genes Dev. 15 1873 1888
    • (2001) Genes Dev. , vol.15 , pp. 1873-1888
    • Osborne, T.F.1
  • 58
    • 0032454039 scopus 로고    scopus 로고
    • Effects of amyloid precursor protein derivatives and oxidative stress on basal forebrain cholinergic systems in Alzheimer's disease
    • M. P. Mattson W. A. Pedersen 1998 Effects of amyloid precursor protein derivatives and oxidative stress on basal forebrain cholinergic systems in Alzheimer's disease Int. J. Dev. Neurosci. 16 737 753
    • (1998) Int. J. Dev. Neurosci. , vol.16 , pp. 737-753
    • Mattson, M.P.1    Pedersen, W.A.2
  • 59
    • 0033605252 scopus 로고    scopus 로고
    • Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases
    • A. Weidemann 1999 Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases J. Biol. Chem. 274 5823 5829
    • (1999) J. Biol. Chem. , vol.274 , pp. 5823-5829
    • Weidemann, A.1
  • 60
    • 0034672421 scopus 로고    scopus 로고
    • Alzheimer's disease: A dysfunction of the amyloid precursor protein(1)
    • R. L. Neve D. L. McPhie Y. Chen 2000 Alzheimer's disease: a dysfunction of the amyloid precursor protein(1) Brain Res. 886 54 66
    • (2000) Brain Res. , vol.886 , pp. 54-66
    • Neve, R.L.1    McPhie, D.L.2    Chen, Y.3
  • 61
    • 0027381376 scopus 로고
    • Protease inhibitors and indolamines selectively inhibit cholinesterases in the histopathologic structures of Alzheimer's disease
    • C. I. Wright C. Geula M. M. Mesulam 1993 Protease inhibitors and indolamines selectively inhibit cholinesterases in the histopathologic structures of Alzheimer's disease Ann. NY Acad. Sci. 695 65 68
    • (1993) Ann. NY Acad. Sci. , vol.695 , pp. 65-68
    • Wright, C.I.1    Geula, C.2    Mesulam, M.M.3
  • 62
    • 0003356476 scopus 로고    scopus 로고
    • Role of the ErbB-4 carboxyl terminus in gamma-secretase cleavage
    • C. Y. Ni H. Yuan G. Carpenter 2003 Role of the ErbB-4 carboxyl terminus in gamma-secretase cleavage J. Biol. Chem. 278 4561 4565
    • (2003) J. Biol. Chem. , vol.278 , pp. 4561-4565
    • Ni, C.Y.1    Yuan, H.2    Carpenter, G.3
  • 63
    • 3042796016 scopus 로고    scopus 로고
    • Notch signaling in Drosophila long-term memory formation
    • X. Ge 2004 Notch signaling in Drosophila long-term memory formation Proc. Natl. Acad. Sci. U S A 101 10172 10176
    • (2004) Proc. Natl. Acad. Sci. U S a , vol.101 , pp. 10172-10176
    • Ge, X.1
  • 64
    • 11144354609 scopus 로고    scopus 로고
    • Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration
    • C. A. Saura 2004 Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration Neuron 42 23 36
    • (2004) Neuron , vol.42 , pp. 23-36
    • Saura, C.A.1
  • 65
    • 0141429160 scopus 로고    scopus 로고
    • A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations
    • P. Marambaud 2003 A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations Cell 114 635 645
    • (2003) Cell , vol.114 , pp. 635-645
    • Marambaud, P.1
  • 66
    • 0036592523 scopus 로고    scopus 로고
    • The significance of environmental factors in the etiology of Alzheimer's disease
    • W. B. Grant A. Campbell R. F. Itzhaki J. Savory 2002 The significance of environmental factors in the etiology of Alzheimer's disease J. Alzheimers Dis. 4 179 189
    • (2002) J. Alzheimers Dis. , vol.4 , pp. 179-189
    • Grant, W.B.1    Campbell, A.2    Itzhaki, R.F.3    Savory, J.4
  • 67
    • 2642543940 scopus 로고    scopus 로고
    • Neuroprotective properties of Bcl-w in Alzheimer disease
    • X. Zhu 2004 Neuroprotective properties of Bcl-w in Alzheimer disease J. Neurochem. 89 1233 1240
    • (2004) J. Neurochem. , vol.89 , pp. 1233-1240
    • Zhu, X.1
  • 68
    • 1242274383 scopus 로고    scopus 로고
    • Tumor necrosis factor death receptor signaling cascade is required for amyloid-beta-protein-induced neuron death
    • R. Li 2004 Tumor necrosis factor death receptor signaling cascade is required for amyloid-beta-protein-induced neuron death J. Neurosci. 24 1760 1771
    • (2004) J. Neurosci. , vol.24 , pp. 1760-1771
    • Li, R.1
  • 69
    • 1442323992 scopus 로고    scopus 로고
    • Long-lasting acetylcholinesterase splice variations in anticholinesterase-treated Alzheimer's disease patients
    • T. Darreh-Shori 2004 Long-lasting acetylcholinesterase splice variations in anticholinesterase-treated Alzheimer's disease patients J. Neurochem. 88 1102 1113
    • (2004) J. Neurochem. , vol.88 , pp. 1102-1113
    • Darreh-Shori, T.1
  • 70
    • 15244356627 scopus 로고    scopus 로고
    • Functional Manipulations of Acetylcholinesterase Splice Variants Highlight Alternative Splicing Contributions to Murine Neocortical Development
    • Dori 2004 Functional Manipulations of Acetylcholinesterase Splice Variants Highlight Alternative Splicing Contributions to Murine Neocortical Development Cerebral Cortex 15 419 430
    • (2004) Cerebral Cortex , vol.15 , pp. 419-430
    • Dori1
  • 71
    • 0035320772 scopus 로고    scopus 로고
    • Acetylcholinesterase - New roles for an old actor
    • H Soreq S. Seidman 2001 Acetylcholinesterase - new roles for an old actor Nat. Rev. Neurosci. 2 294 302
    • (2001) Nat. Rev. Neurosci. , vol.2 , pp. 294-302
    • Soreq, H.1    Seidman, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.