The role of acetylcholinesterase in the pathogenesis of Alzheimer's disease

Drugs of Today

Volumn 39, Issue 1, 2003, Pages 75-83

  Rees, Tina M ^a   Brimijoin, Stephen ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; CHOLINE; CHOLINESTERASE INHIBITOR; DONEPEZIL; GALANTAMINE; HUPERZINE A; NEUROTRANSMITTER; PEPTIDE; RIVASTIGMINE; TACRINE;

ALZHEIMER DISEASE; CHOLINERGIC NERVE CELL; DRUG STRUCTURE; HISTOCHEMISTRY; HUMAN; NEUROPROTECTION; NEUROTRANSMISSION; NONHUMAN; PALLIATIVE THERAPY; PROTEIN PROCESSING; REVIEW; SENILE PLAQUE; SYMPTOM; SYNAPSE;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; ANIMALS; CHOLINESTERASE INHIBITORS; HUMANS;

EID: 0037234423     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.2003.39.1.740206     Document Type: Review

References (39)

1. Arendt, T., Bigl, V., Tennstedt, A., Arendt, A. Neuronal loss in different parts of the nucleus basalis is related to neuritic plaque formation in cortical target areas in Alzheimer's disease. Neurosci 1985, 14: 1-14.
2. Summers, W.K., Majovski, L.V., Marsh, G.M., Tachiki, K., Kling, A. Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type. N Engl J Med 1986, 315: 1241-5.
3. Doody, R.S., Dunn, J.K., Clark, C.M. et al. Chronic donepezil treatment is associated with slowed cognitive decline in Alzheimer's disease. Dement Geriat Cogn Disord 2001, 12: 295-300.
4. Doody, R., Pratt, R., Perdomo, C. Clinical benefits of donepezil: Results from a long-term phase III extension trial. Neurology 1999, 52: A174.
5. Geula, C., Mesulam, M.-M. Cholinesterases and the pathology of Alzheimer disease. Alz Dis Assoc Disord 1995, 9: 23-8.
6. Moran, M.A., Mufson, E.J., Gomez-Ramos, P. Colocalization of cholinesterases with β-amyloid protein in aged and Alzheimer's brains. Acta Neurpathol 1993, 85: 362-9.
7. Tago, H., McGeer, P.L., McGeer, E.G. Acetylcholinesterase fibers and the development of senile plaques. Brain Res 1987, 406: 363-9.
8. Holtzman, D.M., Fagan, A.M., Mackey, B. et al. Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model. Ann Neurol 2000, 47: 739-47.
9. Alvarez, A., Bronfman, F., Perez, C.A., Vicente, M., Garrido, J., Inestrosa, N.C. Acetylcholinesterase, a senile plaque component, affects the fibrillogenesis of amyloid-β peptides. Neurosci Lett 1995, 201: 49-52.
10. Alvarez, A., Alarcon, R., Opazo, C. et al. Stable complexes involving acetylcholinesterase and amyloid-β peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils. J Neurosci 1998, 18: 3213-23.
11. Inestrosa, N.C., Alvarez, A., Perez, C.A. et al. Acetylcholineslerase accelerates assembly of amyloid-β peptides into Alzheimer's fibrils: Possible role of the peripheral site of the enzyme. Neuron 1996, 16: 881-91.
12. Reyes, A.E., Perez, D.R., Alvarez, A. et al. A monoclonal antibody against acetylcholinesterase inhibits the formation of amyloid fibrils induced by the enzyme. Biochem Biophys Res Comm 1997, 232: 652-5.
13. DeFerrari, G.V., Canales, M.A., Shin, I., Weiner, L.M., Silman, I., Inestrosa, N.C. A structural motif of acetylcholinesterase that promotoes amyloid β-peptide fibril formation. Biochem 2001, 40: 10447-57.
14. Inestrosa, N.C., Alvarez, A., Godoy, J., Reyes, A., DeFerrari, G.V. Acetylcholinesterase-amyloid-β peptide interaction and wnt signaling involvement in aβ neurotoxicity. Acta Neurol Scand 2000, 176: 53-9.
15. Bourne, Y., Taylor, P., Bougis, P.E., Marchot, P. Crystal structure of mouse acetylcholinesterase. A peripheral site-occluding loop in a tetrameric assembly. J Biol Chem 1999, 274: 2963-70.
16. Brimijoin, S., Koenigsberger, C. Cholinesterases in neural development: New findings and toxicologic implications. Environ Health Perspect 1999, 107: 59-64.
17. Soreq, H., Seidman, S. Acetylcholinesterase New roles for an old actor. Nat Rev Neurosci 2001, 2: 294-302.
18. Stedman, E., Stedman, L. The relative choline-esterase activities of serum and corpuscles from the blood of certain species. Biochem J 1935, 29: 2107-11.
19. Layer, P.G. Nonclassical roles of cholinesterases in the embryonic brain and possible links to Alzheimer disease. Alz Dis Assoc Disord 1995, 9: 29-36.
20. Brimijoin, S., Hammond, P. Transient expression of acetylcholinesterase messenger RNA and enzyme activity in developing rat thalamus studied by quantitative histochemistry and in situ hybidization. Neurosci 1996, 71: 555-65.
21. Robertson, R.T. A morphogenic role for transiently expressed acetylcholinesterase in developing thalamocortical systems? Neurosci Lett 1987, 75: 259-64.
22. Koenigsberger, C., Chiappa, S., Brimijoin, S. Neurite differentiation is modulated in neuroblastoma cells engineered for altered acetycholinesterase expression. J Neurochem 1997, 69: 1389-97.
23. Grifman, M., Galyam, N., Seidman, S., Soreq, H. Functional redundancy of acetylcholinesterase and neuroligin in mammalian neuritogenesis. Proc Natl Acad Sci 1998, 95: 13935-40.
24. Sharma, K.V., Koenigsberger, C., Brimijoin, S., Bigbee, J.W. Direct evidence for an adhesive function in the noncholinergic role of acetylcholinesterase in neurite outgrowth. J Neurosci Res 2001, 63: 165-757.
25. Darboux, I., Barthalay, Y., Piovant, M., Hipeau-Jacquotte, R. The structure-function relationships in Drosophila neurotactin show that cholinesterasic domains may have adhesive properties. EMBO J 1996, 15: 4835-43.
26. Beeri, R., Andres, C., Lev-Lehman, E. et al. Transgenic expression of human acetylcholinesterase induces progressive cognitive deterioration in mice. Curr Biol 1995, 5: 1063-71.
27. Hsiao, K.K., Borchelt, D.R., Olson, K., et al. Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins. Neuron 1995, 15: 1203-18.
28. Erb, C., Troost, J., Kopf, S. et al. Compensatory mechanisms enhance hippocampal acetylcholine release in transgenic mice expressing human acetylcholinesterase. J Neurochem 2001, 77: 638-46.
29. Mori, F., Lai, C.C., Fusi, F., Giacobini, E. Cholinesterase inhibitors increase secretion of amyloid precursor proteins in rat brain cortex. Neuroreport 1995, 6: 633-6.
30. Nordberg, A., Hellstrom-Lindahl, E., Lee, M. et al. Chronic nicotine treatment reduces β-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw). J Neurochem 2002, 81: 655-8.
31. Dineley, K.T., Westerman, M., Bui, D., Bell, K.S., Ashe, K.H., Sweatt, J.D. β-Amyloid activates the mitogen-activated protein kinase cascade via hippocampal α7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. J Neurosci 2001, 21: 4125-33.
32. Sberna, G., Saez-Valero, J., Li, Q.-X. et al. Acetylcholinesterase is increased in the brains of transgenic mice expressing the C-terminal fragment (ct100) of the β-amyloid protein precursor of Alzheimer's disease. J Neurochem 1998, 71: 723-31.
33. Sberna, G., Saez-Valero, J., Beyreuther, K., Masters, C.L., Small, D.H. The amyloid β-protein of Alzheimer's disease increases acetylcholinesterase expression by increasing intracellular calcium in embryonal carcinoma P19 cells. J Neurochem 1997, 69: 1177-84.
34. Lahiri, D.K., Lewis, S., Farlow, M. Tacrine alters the secretion of the β-amyloid precursor protein in cell lines. J Neurosci Res 1994, 37: 777-87.
35. Shaw, K.T.Y., Utsuki, T., Rogers, J. et al. Phenserine regulates translation of β-amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. Proc Natl Acad Sci 2001, 98: 7605-10.
36. Xiao, X.Q., Zhang, H.Y., Tang, X.C. Huperzine A attenuates amyloid β-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation. J Neurosci Res 2002, 67: 30-6.
37. Wang, L.M., Han, Y.F., Tang, X.C. Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats. Eur J Pharmacol 2000, 398: 65-72.
38. Zhang, H.Y., Liang, Y.Q., Tang, X.C., He, X.C., Bai, D.L. Stereoselectivities of enantiomers of Huperzine A in protection against β-amyloid 25-35 induced injury in PC12 and NG108-15 cells and cholinesterase inhibition in mice. Neurosci Lett 2002, 317: 143-6.
39. Wang, X.D., Zhang, J.M., Yang, H.H., Hu, G.Y. Modulation of NMDA receptor by Huperzine A in rat cerebral cortex. Acta Pharmacol Sin 1999, 20: 31-5.