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Volumn 129, Issue 10, 2005, Pages 1299-1310

Myelodysplastic syndromes: Clinicopathologic features, pathobiology, and molecular pathogenesis

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GROWTH FACTOR;

EID: 26044469886     PISSN: 00039985     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (30)

References (163)
  • 2
    • 0031906395 scopus 로고    scopus 로고
    • Pathogenesis, etiology and epidemiology of myelodysplastic syndromes
    • Aul C, Bowen DT, Yoshida Y. Pathogenesis, etiology and epidemiology of myelodysplastic syndromes. Haematologica. 1998;83:71-86.
    • (1998) Haematologica , vol.83 , pp. 71-86
    • Aul, C.1    Bowen, D.T.2    Yoshida, Y.3
  • 3
    • 0030018549 scopus 로고    scopus 로고
    • Pathogenesis, biology, and management of myelodysplastic syndromes in children
    • Haas OA, Gadner H. Pathogenesis, biology, and management of myelodysplastic syndromes in children. Semin Hematol. 1996;33:225-235.
    • (1996) Semin Hematol , vol.33 , pp. 225-235
    • Haas, O.A.1    Gadner, H.2
  • 5
    • 0025950902 scopus 로고
    • Congenital myelodysplasia: A newly described disease entity?
    • McMullin MF, Chisholm M, Hows JM. Congenital myelodysplasia: a newly described disease entity? Br J Haematol. 1991;79:340-342.
    • (1991) Br J Haematol , vol.79 , pp. 340-342
    • McMullin, M.F.1    Chisholm, M.2    Hows, J.M.3
  • 6
    • 0019952276 scopus 로고
    • Proposals for the classification of the myelodysplastic syndromes
    • Bennett JM, Catovsky D, Daniel MT, et al. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol. 1982;51:189-199.
    • (1982) Br J Haematol , vol.51 , pp. 189-199
    • Bennett, J.M.1    Catovsky, D.2    Daniel, M.T.3
  • 7
    • 0034585827 scopus 로고    scopus 로고
    • The World Health Organization classification of neoplasms of the hematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November, 1997
    • Harris NL, Jaffe ES, Diebold J, et al. The World Health Organization classification of neoplasms of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November, 1997. Hematol J. 2000;1:53-66.
    • (2000) Hematol J , vol.1 , pp. 53-66
    • Harris, N.L.1    Jaffe, E.S.2    Diebold, J.3
  • 8
    • 0036786901 scopus 로고    scopus 로고
    • The World Health Organization (WHO) classification of the myeloid neoplasms
    • Vardiman JW, Harris NL, Brunning RD. The World Health Organization (WHO) classification of the myeloid neoplasms [see comment]. Blood 2002;100: 2292-2302.
    • (2002) Blood , vol.100 , pp. 2292-2302
    • Vardiman, J.W.1    Harris, N.L.2    Brunning, R.D.3
  • 9
    • 0030897009 scopus 로고    scopus 로고
    • International scoring system for evaluating prognosis in myelodysplastic syndromes
    • Greenberg P, Cox C, LeBeau MM, et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood. 1997;89:2079-2088.
    • (1997) Blood , vol.89 , pp. 2079-2088
    • Greenberg, P.1    Cox, C.2    Lebeau, M.M.3
  • 10
    • 3042821845 scopus 로고    scopus 로고
    • Novel therapies for myelodysplastic syndromes
    • Faderl S, Kantarjian HM. Novel therapies for myelodysplastic syndromes. Cancer. 2004;101:226-241.
    • (2004) Cancer , vol.101 , pp. 226-241
    • Faderl, S.1    Kantarjian, H.M.2
  • 12
    • 0037252540 scopus 로고    scopus 로고
    • Recent progress in the treatment of myelodysplastic syndrome in adult patients
    • Erba HP. Recent progress in the treatment of myelodysplastic syndrome in adult patients. Curr Opin Oncol. 2003;15:1-9.
    • (2003) Curr Opin Oncol , vol.15 , pp. 1-9
    • Erba, H.P.1
  • 14
    • 5744248237 scopus 로고    scopus 로고
    • DNA methyltransferase inhibitors in myelodysplastic syndrome
    • Silverman LR. DNA methyltransferase inhibitors in myelodysplastic syndrome. Best Pract Res Clin Haematol. 2004;17:585-594.
    • (2004) Best Pract Res Clin Haematol , vol.17 , pp. 585-594
    • Silverman, L.R.1
  • 15
    • 0036902962 scopus 로고    scopus 로고
    • DNA methylation and demethylating drugs in myelodysplastic syndromes and secondary leukemias
    • Leone G, Teofili L, Voso MT, Lubbert M. DNA methylation and demethylating drugs in myelodysplastic syndromes and secondary leukemias. Haematologica. 2002;87:1324-1341.
    • (2002) Haematologica , vol.87 , pp. 1324-1341
    • Leone, G.1    Teofili, L.2    Voso, M.T.3    Lubbert, M.4
  • 16
    • 0038470905 scopus 로고    scopus 로고
    • Molecular mechanisms of myelodysplastic syndrome
    • Hirai H. Molecular mechanisms of myelodysplastic syndrome. Jpn J Clin Oncol. 2003;33:153-160.
    • (2003) Jpn J Clin Oncol , vol.33 , pp. 153-160
    • Hirai, H.1
  • 17
    • 0035380289 scopus 로고    scopus 로고
    • Clonality in the myelodysplastic syndromes
    • Boultwood J, Wainscoat JS. Clonality in the myelodysplastic syndromes. Int J Hematol. 2001;73:411-415.
    • (2001) Int J Hematol , vol.73 , pp. 411-415
    • Boultwood, J.1    Wainscoat, J.S.2
  • 18
    • 0031933804 scopus 로고    scopus 로고
    • X-inactivation analysis in the 1990s: Promise and potential problems
    • Busque L, Gilliland DG. X-inactivation analysis in the 1990s: promise and potential problems. Leukemia. 1998;12:128-135.
    • (1998) Leukemia , vol.12 , pp. 128-135
    • Busque, L.1    Gilliland, D.G.2
  • 19
    • 0031951725 scopus 로고    scopus 로고
    • Clonal development of myeloproliferative disorders: Clues to hematopoietic differentiation and multistep pathogenesis of cancer
    • Raskind WH, Steinmann L, Najfeld V. Clonal development of myeloproliferative disorders: clues to hematopoietic differentiation and multistep pathogenesis of cancer. Leukemia. 1998;12:108-116.
    • (1998) Leukemia , vol.12 , pp. 108-116
    • Raskind, W.H.1    Steinmann, L.2    Najfeld, V.3
  • 20
    • 0031869587 scopus 로고    scopus 로고
    • Patients with high-risk myelodysplastic syndrome can have polyclonal or clonal haemopoiesis in complete haematological remission
    • Delforge M, Demuynck H, Verhoef G, et al. Patients with high-risk myelodysplastic syndrome can have polyclonal or clonal haemopoiesis in complete haematological remission. Br J Haematol. 1998;102:486-494.
    • (1998) Br J Haematol , vol.102 , pp. 486-494
    • Delforge, M.1    Demuynck, H.2    Verhoef, G.3
  • 22
    • 0027289648 scopus 로고
    • Myelodysplastic syndromes: From morphology to molecular biology, part I: Classification, natural history and cell biology of myelodysplasia
    • Yoshida Y, Stephenson J, Mufti GJ. Myelodysplastic syndromes: from morphology to molecular biology, part I: classification, natural history and cell biology of myelodysplasia. Int J Hematol. 1993;57:87-97.
    • (1993) Int J Hematol , vol.57 , pp. 87-97
    • Yoshida, Y.1    Stephenson, J.2    Mufti, G.J.3
  • 24
    • 0034048199 scopus 로고    scopus 로고
    • Myelodysplastic syndrome and aplastic anemia: Diagnostic and conceptual uncertainties
    • Barrett J. Myelodysplastic syndrome and aplastic anemia: diagnostic and conceptual uncertainties. Leuk Res. 2000;24:595-596.
    • (2000) Leuk Res , vol.24 , pp. 595-596
    • Barrett, J.1
  • 25
    • 0037031289 scopus 로고    scopus 로고
    • Antithymocyte globulin for treatment of the bone marrow failure associated with myelodysplastic syndromes
    • Molldrem JJ, Leifer E, Bahceci E, et al. Antithymocyte globulin for treatment of the bone marrow failure associated with myelodysplastic syndromes. Ann Intern Med. 2002;137:156-163.
    • (2002) Ann Intern Med , vol.137 , pp. 156-163
    • Molldrem, J.J.1    Leifer, E.2    Bahceci, E.3
  • 26
    • 15844405224 scopus 로고    scopus 로고
    • Novel insights into the biology of myelodysplastic syndromes: Excessive apoptosis and the role of cytokines
    • Raza A, Mundle S, Shetty V, et al. Novel insights into the biology of myelodysplastic syndromes: excessive apoptosis and the role of cytokines. Int J Hematol. 1996;63:265-278.
    • (1996) Int J Hematol , vol.63 , pp. 265-278
    • Raza, A.1    Mundle, S.2    Shetty, V.3
  • 28
    • 0033967640 scopus 로고    scopus 로고
    • A hypothesis for the pathogenesis of myelodysplastic syndromes: Implications for new therapies
    • Rosenfeld C, List A. A hypothesis for the pathogenesis of myelodysplastic syndromes: implications for new therapies. Leukemia. 2000;14:2-8.
    • (2000) Leukemia , vol.14 , pp. 2-8
    • Rosenfeld, C.1    List, A.2
  • 29
    • 0029068868 scopus 로고
    • Myelodysplastic(preleukemia) syndromes: The bone marrow factory failure problem
    • quiz 677
    • Hoagland HC. Myelodysplastic(preleukemia) syndromes: the bone marrow factory failure problem. Mayo Clin Proc. 1995;70:673-676; quiz 677.
    • (1995) Mayo Clin Proc , vol.70 , pp. 673-676
    • Hoagland, H.C.1
  • 30
    • 0036848438 scopus 로고    scopus 로고
    • More cell death in refractory anemia with excess blasts in transformation than in acute myeloid leukemia
    • Huh YO, Jilani I, Estey E, et al. More cell death in refractory anemia with excess blasts in transformation than in acute myeloid leukemia. Leukemia. 2002; 16:2249-2252.
    • (2002) Leukemia , vol.16 , pp. 2249-2252
    • Huh, Y.O.1    Jilani, I.2    Estey, E.3
  • 31
    • 0031444395 scopus 로고    scopus 로고
    • Understanding the myelodysplastic syndromes
    • Kouides PA, Bennett JM. Understanding the myelodysplastic syndromes. Oncologist. 1997;2:389-401.
    • (1997) Oncologist , vol.2 , pp. 389-401
    • Kouides, P.A.1    Bennett, J.M.2
  • 32
    • 0022804866 scopus 로고
    • Myelodysplastic syndromes: Natural history and features of prognostic importance
    • Mufti GJ, Galton DA. Myelodysplastic syndromes: natural history and features of prognostic importance. Clin Haematol. 1986;15:953-971.
    • (1986) Clin Haematol , vol.15 , pp. 953-971
    • Mufti, G.J.1    Galton, D.A.2
  • 33
    • 0035146787 scopus 로고    scopus 로고
    • Excessive apoptosis in low risk myelodysplastic syndromes (MDS)
    • Parker JE, Mufti GJ. Excessive apoptosis in low risk myelodysplastic syndromes (MDS). Leuk Lymphoma. 2000;40:1-24.
    • (2000) Leuk Lymphoma , vol.40 , pp. 1-24
    • Parker, J.E.1    Mufti, G.J.2
  • 34
    • 0034551738 scopus 로고    scopus 로고
    • The role of apoptosis, proliferation, and the Bcl-2-related proteins in the myelodysplastic syndromes and acute myeloid leukemia secondary to MDS
    • Parker JE, Mufti GJ, Rasool F, Mijovic A, Devereux S, Pagliuca A. The role of apoptosis, proliferation, and the Bcl-2-related proteins in the myelodysplastic syndromes and acute myeloid leukemia secondary to MDS. Blood. 2000;96: 3932-3938.
    • (2000) Blood , vol.96 , pp. 3932-3938
    • Parker, J.E.1    Mufti, G.J.2    Rasool, F.3    Mijovic, A.4    Devereux, S.5    Pagliuca, A.6
  • 35
    • 0032848438 scopus 로고    scopus 로고
    • Apoptosis in patients with myelodysplastic syndromes: Differential involvement of marrow cells in 'good' versus 'poor' prognosis patients and correlation with apoptosis-related genes
    • Tsoplou P, Kouraklis-Symeonidis A, Thanopoulou E, Zikos P, Orphanos V, Zoumbos NC. Apoptosis in patients with myelodysplastic syndromes: differential involvement of marrow cells in 'good' versus 'poor' prognosis patients and correlation with apoptosis-related genes. Leukemia. 1999;13:1554-1563.
    • (1999) Leukemia , vol.13 , pp. 1554-1563
    • Tsoplou, P.1    Kouraklis-Symeonidis, A.2    Thanopoulou, E.3    Zikos, P.4    Orphanos, V.5    Zoumbos, N.C.6
  • 36
    • 0032437584 scopus 로고    scopus 로고
    • 'Low-risk' myelodysplastic syndrome is associated with excessive apoptosis and an increased ratio of pro- Versus anti-apoptotic bcl-2-related proteins
    • Parker JE, Fishlock KL, Mijovic A, Czepulkowski B, Pagliuca A, Mufti GJ. 'Low-risk' myelodysplastic syndrome is associated with excessive apoptosis and an increased ratio of pro- versus anti-apoptotic bcl-2-related proteins. Br J Haematol. 1998;103:1075-1082.
    • (1998) Br J Haematol , vol.103 , pp. 1075-1082
    • Parker, J.E.1    Fishlock, K.L.2    Mijovic, A.3    Czepulkowski, B.4    Pagliuca, A.5    Mufti, G.J.6
  • 37
    • 0032171391 scopus 로고    scopus 로고
    • Bcl-2 expression by myeloid precursors in myelodysplastic syndromes: Relation to disease progression
    • Davis RE, Greenberg PL. Bcl-2 expression by myeloid precursors in myelodysplastic syndromes: relation to disease progression. Leuk Res. 1998;22:767-777.
    • (1998) Leuk Res , vol.22 , pp. 767-777
    • Davis, R.E.1    Greenberg, P.L.2
  • 38
    • 0033387759 scopus 로고    scopus 로고
    • Apoptosis, bcl-2 expression and p53 accumulation in myelodysplastic syndrome, myelodysplastic-syndrome-derived acute myelogenous leukemia and de novo acute myelogenous leukemia
    • Kurotaki H, Tsushima Y, Nagai K, Yagihashi S. Apoptosis, bcl-2 expression and p53 accumulation in myelodysplastic syndrome, myelodysplastic-syndrome- derived acute myelogenous leukemia and de novo acute myelogenous leukemia. Acta Haematol. 2000;102:115-123.
    • (2000) Acta Haematol , vol.102 , pp. 115-123
    • Kurotaki, H.1    Tsushima, Y.2    Nagai, K.3    Yagihashi, S.4
  • 39
    • 0029957664 scopus 로고    scopus 로고
    • Altered oncoprotein expression and apoptosis in myelodysplastic syndrome marrow cells
    • Rajapaksa R, Ginzton N, Rott LS, Greenberg PL. Altered oncoprotein expression and apoptosis in myelodysplastic syndrome marrow cells. Blood. 1996; 88:4275-4287.
    • (1996) Blood , vol.88 , pp. 4275-4287
    • Rajapaksa, R.1    Ginzton, N.2    Rott, L.S.3    Greenberg, P.L.4
  • 40
    • 0036113177 scopus 로고    scopus 로고
    • Expression and prognostic significance of Bcl-2 family proteins in myelodysplastic syndromes
    • Boudard D, Vasselon C, Bertheas MF, et al. Expression and prognostic significance of Bcl-2 family proteins in myelodysplastic syndromes. Am J Hematol. 2002;70:115-125.
    • (2002) Am J Hematol , vol.70 , pp. 115-125
    • Boudard, D.1    Vasselon, C.2    Bertheas, M.F.3
  • 41
    • 5744243856 scopus 로고    scopus 로고
    • Pathobiology, classification, and diagnosis of myelodysplastic syndrome
    • Mufti GJ. Pathobiology, classification, and diagnosis of myelodysplastic syndrome. Best Practice Clin Haematol. 2004;17:543-557.
    • (2004) Best Practice Clin Haematol , vol.17 , pp. 543-557
    • Mufti, G.J.1
  • 44
    • 0023607867 scopus 로고
    • The 5q-abnormality
    • Nimer SD, Golde DW. The 5q-abnormality. Blood. 1987;70:1705-1712.
    • (1987) Blood , vol.70 , pp. 1705-1712
    • Nimer, S.D.1    Golde, D.W.2
  • 45
    • 0027315865 scopus 로고
    • Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases
    • Le Beau MM, Espinosa R III, Neuman WL, et al. Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases. Proc Natl Acad Sci U S A. 1993;90:5484-5488.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 5484-5488
    • Le Beau, M.M.1    Espinosa III, R.2    Neuman, W.L.3
  • 46
    • 0027465728 scopus 로고
    • Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia
    • Willman CL, Sever CE, Pallavicini MG, et al. Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia. Science. 1993;259:968-971.
    • (1993) Science , vol.259 , pp. 968-971
    • Willman, C.L.1    Sever, C.E.2    Pallavicini, M.G.3
  • 47
    • 0029821113 scopus 로고    scopus 로고
    • Cytogenetic and molecular delineation of a region of chromosome 7 commonly deleted in malignant myeloid diseases
    • Le Beau MM, Espinosa R III, Davis EM, Eisenbart JD, Larson RA, Green ED. Cytogenetic and molecular delineation of a region of chromosome 7 commonly deleted in malignant myeloid diseases. Blood. 1996;88:1930-1935.
    • (1996) Blood , vol.88 , pp. 1930-1935
    • Le Beau, M.M.1    Espinosa III, R.2    Davis, E.M.3    Eisenbart, J.D.4    Larson, R.A.5    Green, E.D.6
  • 48
    • 0025046596 scopus 로고
    • Chromosome aberrations and prognostic factors in therapy-related myelodysplasia and acute nonlymphocytic leukemia
    • Pedersen-Bjergaard J, Philip P, Larsen SO, Jensen G, Byrsting K. Chromosome aberrations and prognostic factors in therapy-related myelodysplasia and acute nonlymphocytic leukemia. Blood. 1990;76:1083-1091.
    • (1990) Blood , vol.76 , pp. 1083-1091
    • Pedersen-Bjergaard, J.1    Philip, P.2    Larsen, S.O.3    Jensen, G.4    Byrsting, K.5
  • 49
    • 0026525853 scopus 로고
    • Chromosomal loss and deletion are the most common mechanisms for loss of heterozygosity from chromosomes 5 and 7 in malignant myeloid disorders
    • Neuman WL, Rubin CM, Rios RB, et al. Chromosomal loss and deletion are the most common mechanisms for loss of heterozygosity from chromosomes 5 and 7 in malignant myeloid disorders. Blood. 1992;79:1501-1510.
    • (1992) Blood , vol.79 , pp. 1501-1510
    • Neuman, W.L.1    Rubin, C.M.2    Rios, R.B.3
  • 50
    • 0028210052 scopus 로고
    • Mutations in the ras proto-oncogenes in patients with myelodysplastic syndromes
    • Neubauer A, Greenberg P, Negrin R, Ginzton N, Liu E. Mutations in the ras proto-oncogenes in patients with myelodysplastic syndromes. Leukemia. 1994;8:638-641.
    • (1994) Leukemia , vol.8 , pp. 638-641
    • Neubauer, A.1    Greenberg, P.2    Negrin, R.3    Ginzton, N.4    Liu, E.5
  • 51
    • 0024380306 scopus 로고
    • Mechanisms of ras mutation in myelodysplastic syndrome
    • Yunis JJ, Boot AJ, Mayer MG, Bos JL. Mechanisms of ras mutation in myelodysplastic syndrome. Oncogene. 1989;4:609-614.
    • (1989) Oncogene , vol.4 , pp. 609-614
    • Yunis, J.J.1    Boot, A.J.2    Mayer, M.G.3    Bos, J.L.4
  • 52
    • 17344371122 scopus 로고    scopus 로고
    • RAS, FMS and p53 mutations and poor clinical outcome in myelodysplasias: A 10-year follow-up
    • Padua RA, Guinn BA, Al-Sabah AI, et al. RAS, FMS and p53 mutations and poor clinical outcome in myelodysplasias: a 10-year follow-up. Leukemia. 1998; 12:887-892.
    • (1998) Leukemia , vol.12 , pp. 887-892
    • Padua, R.A.1    Guinn, B.A.2    Al-Sabah, A.I.3
  • 53
    • 0023934849 scopus 로고
    • Mutation of Ki-ras and N-ras oncogenes in myelodysplastic syndromes
    • Lyons J, Janssen JW, Bartram C, Layton M, Mufti GJ. Mutation of Ki-ras and N-ras oncogenes in myelodysplastic syndromes. Blood. 1988;71:1707-1712.
    • (1988) Blood , vol.71 , pp. 1707-1712
    • Lyons, J.1    Janssen, J.W.2    Bartram, C.3    Layton, M.4    Mufti, G.J.5
  • 54
    • 0027181645 scopus 로고
    • N-ras mutations are associated with poor prognosis and increased risk of leukemia in myelodysplastic syndrome
    • Paquette RL, Landaw EM, Pierre RV, et al. N-ras mutations are associated with poor prognosis and increased risk of leukemia in myelodysplastic syndrome. Blood. 1993;82:590-599.
    • (1993) Blood , vol.82 , pp. 590-599
    • Paquette, R.L.1    Landaw, E.M.2    Pierre, R.V.3
  • 55
    • 0024376173 scopus 로고
    • ras oncogenes in human cancer: A review
    • Bos JL. ras oncogenes in human cancer: a review. Cancer Res. 1989;49: 4682-4689.
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 56
    • 0024222881 scopus 로고
    • The N-ras oncogene in myelodysplastic syndrome and leukemia
    • Hirai H, Ishikawa F. The N-ras oncogene in myelodysplastic syndrome and leukemia. Nippon Ketsueki Gakkai Zasshi. 1988;51:1463-1470.
    • (1988) Nippon Ketsueki Gakkai Zasshi , vol.51 , pp. 1463-1470
    • Hirai, H.1    Ishikawa, F.2
  • 57
    • 7444254061 scopus 로고    scopus 로고
    • CSF-1 regulation of the wandering macrophage: Complexity in action
    • Pixley FJ, Stanley ER. CSF-1 regulation of the wandering macrophage: complexity in action. Trends Cell Biol. 2004;14:628-638.
    • (2004) Trends Cell Biol , vol.14 , pp. 628-638
    • Pixley, F.J.1    Stanley, E.R.2
  • 58
    • 0023698917 scopus 로고
    • Differential processing of colony-stimulating factor 1 precursors encoded by two human cDNAs
    • Rettenmier CW, Roussel MF. Differential processing of colony-stimulating factor 1 precursors encoded by two human cDNAs. Mol Cell Biol. 1988;8:5026-5034.
    • (1988) Mol Cell Biol , vol.8 , pp. 5026-5034
    • Rettenmier, C.W.1    Roussel, M.F.2
  • 59
    • 0025276780 scopus 로고
    • Mutation of the human FMS gene (M-CSF receptor) in myelodysplastic syndromes and acute myeloid leukemia
    • Tobal K, Pagliuca A, Bhatt B, Bailey N, Layton DM, Mufti GJ. Mutation of the human FMS gene (M-CSF receptor) in myelodysplastic syndromes and acute myeloid leukemia. Leukemia. 1990;4:486-489.
    • (1990) Leukemia , vol.4 , pp. 486-489
    • Tobal, K.1    Pagliuca, A.2    Bhatt, B.3    Bailey, N.4    Layton, D.M.5    Mufti, G.J.6
  • 60
    • 0022312004 scopus 로고
    • Expression of the human c-fms proto-oncogene in hematopoietic cells and its deletion in the 5q- Syndrome
    • Nienhuis AW, Bunn HF, Turner PH, et al. Expression of the human c-fms proto-oncogene in hematopoietic cells and its deletion in the 5q- syndrome. Cell. 1985;42:421-428.
    • (1985) Cell , vol.42 , pp. 421-428
    • Nienhuis, A.W.1    Bunn, H.F.2    Turner, P.H.3
  • 62
    • 0030612423 scopus 로고    scopus 로고
    • Hypermethylation of the p15INK4B gene in myelodysplastic syndromes
    • Uchida T, Kinoshita T, Nagai H, et al. Hypermethylation of the p15INK4B gene in myelodysplastic syndromes. Blood. 1997;90:1403-1409.
    • (1997) Blood , vol.90 , pp. 1403-1409
    • Uchida, T.1    Kinoshita, T.2    Nagai, H.3
  • 63
    • 0033624862 scopus 로고    scopus 로고
    • Methylation status of the p15INK4B gene in hematopoietic progenitors and peripheral blood cells in myelodysplastic syndromes
    • Aoki E, Uchida T, Ohashi H, et al. Methylation status of the p15INK4B gene in hematopoietic progenitors and peripheral blood cells in myelodysplastic syndromes. Leukemia. 2000;14:586-593.
    • (2000) Leukemia , vol.14 , pp. 586-593
    • Aoki, E.1    Uchida, T.2    Ohashi, H.3
  • 64
    • 0035134705 scopus 로고    scopus 로고
    • Methylation of the p15(INK4B) gene in myelodysplastic syndrome: It can be detected early at diagnosis or during disease progression and is highly associated with leukaemic transformation
    • Tien HF, Tang JH, Tsay W, et al. Methylation of the p15(INK4B) gene in myelodysplastic syndrome: it can be detected early at diagnosis or during disease progression and is highly associated with leukaemic transformation. Br J Haematol. 2001;112:148-154.
    • (2001) Br J Haematol , vol.112 , pp. 148-154
    • Tien, H.F.1    Tang, J.H.2    Tsay, W.3
  • 65
    • 0035976892 scopus 로고    scopus 로고
    • Interaction of EVI with cAMP-responsive element-binding protein-binding protein (CBP) and p300/ CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in colocalization in nuclear speckles
    • Chakraborty S, Senyuk V, Sitailo S, Chi Y, Nucifora G. Interaction of EVI with cAMP-responsive element-binding protein-binding protein (CBP) and p300/ CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in colocalization in nuclear speckles. J Biol Chem. 2001;276:44936-44943.
    • (2001) J Biol Chem , vol.276 , pp. 44936-44943
    • Chakraborty, S.1    Senyuk, V.2    Sitailo, S.3    Chi, Y.4    Nucifora, G.5
  • 66
    • 0029919477 scopus 로고    scopus 로고
    • Chromosomal abnormalities and oncogenes
    • Mitani K. Chromosomal abnormalities and oncogenes. Int J Hematol. 1996;63:81-93.
    • (1996) Int J Hematol , vol.63 , pp. 81-93
    • Mitani, K.1
  • 67
    • 10544235446 scopus 로고    scopus 로고
    • Expression of the zinc finger gene EVI-1 in ovarian and other cancers
    • Brooks DJ, Woodward S, Thompson FH, et al. Expression of the zinc finger gene EVI-1 in ovarian and other cancers. Br J Cancer. 1996;74:1518-1525.
    • (1996) Br J Cancer , vol.74 , pp. 1518-1525
    • Brooks, D.J.1    Woodward, S.2    Thompson, F.H.3
  • 68
    • 0030320739 scopus 로고    scopus 로고
    • Abnormal expression of Evi-1 gene: In human leukemias
    • Ogawa S, Mitani K, Kurokawa M, et al. Abnormal expression of Evi-1 gene: in human leukemias. Human Cell. 1996;9:323-332.
    • (1996) Human Cell , vol.9 , pp. 323-332
    • Ogawa, S.1    Mitani, K.2    Kurokawa, M.3
  • 69
    • 0032723317 scopus 로고    scopus 로고
    • Forced expression of the leukemia-associated gene EVI1 in ES cells: A model for myeloid leukemia with 3q26 rearrangements
    • Sitailo S, Sood R, Barton K, Nucifora G. Forced expression of the leukemia-associated gene EVI1 in ES cells: a model for myeloid leukemia with 3q26 rearrangements. Leukemia. 1999;13:1639-1645.
    • (1999) Leukemia , vol.13 , pp. 1639-1645
    • Sitailo, S.1    Sood, R.2    Barton, K.3    Nucifora, G.4
  • 70
    • 0026599120 scopus 로고
    • Expression of the Evi-1 zinc finger gene in 32Dc13 myeloid cells blocks granulocytic differentiation in response to granulocyte colony-stimulating factor
    • Morishita K, Parganas E, Matsugi T, Ihle JN. Expression of the Evi-1 zinc finger gene in 32Dc13 myeloid cells blocks granulocytic differentiation in response to granulocyte colony-stimulating factor. Mol Cell Biol. 1992;12:183-189.
    • (1992) Mol Cell Biol , vol.12 , pp. 183-189
    • Morishita, K.1    Parganas, E.2    Matsugi, T.3    Ihle, J.N.4
  • 71
    • 0027267480 scopus 로고
    • Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming gene
    • Kreider BL, Orkin SH, Ihle JN. Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming gene. Proc Natl Acad Sci U S A. 1993;90:6454-6258.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 6454-16258
    • Kreider, B.L.1    Orkin, S.H.2    Ihle, J.N.3
  • 72
    • 0028943758 scopus 로고
    • Dual functions of the AML1/Evi-1 chimeric protein in the mechanism of leukemogenesis in t(3;21) leukemias
    • Tanaka T, Mitani K, Kurokawa M, et al. Dual functions of the AML1/Evi-1 chimeric protein in the mechanism of leukemogenesis in t(3;21) leukemias. Mol Cell Biol. 1995;15:2383-2392.
    • (1995) Mol Cell Biol , vol.15 , pp. 2383-2392
    • Tanaka, T.1    Mitani, K.2    Kurokawa, M.3
  • 73
    • 0036843363 scopus 로고    scopus 로고
    • Analysis of CHK2 in patients with myelodysplastic syndromes
    • Aktas D, Arno MJ, Rassool F, Mufti GJ. Analysis of CHK2 in patients with myelodysplastic syndromes. Leuk Res. 2002;26:985-987.
    • (2002) Leuk Res , vol.26 , pp. 985-987
    • Aktas, D.1    Arno, M.J.2    Rassool, F.3    Mufti, G.J.4
  • 74
    • 0035126617 scopus 로고    scopus 로고
    • Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemias
    • Hofmann WK, Miller CW, Tsukasaki K, et al. Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemias. Leuk Res. 2001;25:333-338.
    • (2001) Leuk Res , vol.25 , pp. 333-338
    • Hofmann, W.K.1    Miller, C.W.2    Tsukasaki, K.3
  • 75
    • 0032888458 scopus 로고    scopus 로고
    • Study of p53 in elderly patients with myelodysplastic syndromes by immunohistochemistry and DNA analysis
    • Kikukawa M, Aoki N, Sakamoto Y, Mori M. Study of p53 in elderly patients with myelodysplastic syndromes by immunohistochemistry and DNA analysis. Am J Pathol. 1999;155:717-721.
    • (1999) Am J Pathol , vol.155 , pp. 717-721
    • Kikukawa, M.1    Aoki, N.2    Sakamoto, Y.3    Mori, M.4
  • 76
    • 9144254581 scopus 로고    scopus 로고
    • Expression analyses identify MLL as a prominent target of 11q23 amplification and support an etiologic role for MLL gain of function in myeloid malignancies
    • Poppe B, Vandesompele J, Schoch C, et al. Expression analyses identify MLL as a prominent target of 11q23 amplification and support an etiologic role for MLL gain of function in myeloid malignancies. Blood. 2004;103:229-235.
    • (2004) Blood , vol.103 , pp. 229-235
    • Poppe, B.1    Vandesompele, J.2    Schoch, C.3
  • 77
    • 0030819858 scopus 로고    scopus 로고
    • Expression mapping of adhesion receptor genes during differentiation of individual hematopoietic precursors
    • Voura EB, Billia F, Iscove NN, Hawley RG. Expression mapping of adhesion receptor genes during differentiation of individual hematopoietic precursors. Exp Hematol. 1997;25:1172-1179.
    • (1997) Exp Hematol , vol.25 , pp. 1172-1179
    • Voura, E.B.1    Billia, F.2    Iscove, N.N.3    Hawley, R.G.4
  • 78
    • 0036236034 scopus 로고    scopus 로고
    • In vitro characterization of hematopoietic microenvironment cells from patients with myelodysplastic syndrome
    • Flores-Figueroa E, Gutierrez-Espindola G, Montesinos JJ, Arana-Trejo RM, Mayani H. In vitro characterization of hematopoietic microenvironment cells from patients with myelodysplastic syndrome [see comment]. Leuk Res. 2002;26: 677-686.
    • (2002) Leuk Res , vol.26 , pp. 677-686
    • Flores-Figueroa, E.1    Gutierrez-Espindola, G.2    Montesinos, J.J.3    Arana-Trejo, R.M.4    Mayani, H.5
  • 80
    • 10144232108 scopus 로고    scopus 로고
    • Indication of an involvement of interleukin-1 beta converting enzyme-like protease in intramedullary apoptotic cell death in the bone marrow of patients with myelodysplastic syndromes
    • Mundle SD, Venugopal P, Cartlidge JD, et al. Indication of an involvement of interleukin-1 beta converting enzyme-like protease in intramedullary apoptotic cell death in the bone marrow of patients with myelodysplastic syndromes. Blood. 1996;88:2640-2647.
    • (1996) Blood , vol.88 , pp. 2640-2647
    • Mundle, S.D.1    Venugopal, P.2    Cartlidge, J.D.3
  • 81
    • 0027362667 scopus 로고
    • Investigation of the subcellular distribution of the bcl-2 oncoprotein: Residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes
    • Krajewski S, Tanaka S, Takayama S, Schibler MJ, Fenton W, Reed JC. Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res. 1993;53:4701-4714.
    • (1993) Cancer Res , vol.53 , pp. 4701-4714
    • Krajewski, S.1    Tanaka, S.2    Takayama, S.3    Schibler, M.J.4    Fenton, W.5    Reed, J.C.6
  • 83
    • 0026565933 scopus 로고
    • bcl-2 proto-oncogene expression in normal and neoplastic human myeloid cells
    • Delia D, Aiello A, Soligo D, et al. bcl-2 proto-oncogene expression in normal and neoplastic human myeloid cells. Blood. 1992;79:1291-1298.
    • (1992) Blood , vol.79 , pp. 1291-1298
    • Delia, D.1    Aiello, A.2    Soligo, D.3
  • 84
    • 0027246692 scopus 로고
    • Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and -defective myeloid leukemic cells
    • Lotem J, Sachs L. Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and -defective myeloid leukemic cells. Cell Growth Differ. 1993;4:41-47.
    • (1993) Cell Growth Differ , vol.4 , pp. 41-47
    • Lotem, J.1    Sachs, L.2
  • 85
    • 0025937489 scopus 로고
    • Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis
    • Askew DS, Ashmun RA, Simmons BC, Cleveland JL. Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene. 1991;6:1915-1922.
    • (1991) Oncogene , vol.6 , pp. 1915-1922
    • Askew, D.S.1    Ashmun, R.A.2    Simmons, B.C.3    Cleveland, J.L.4
  • 86
    • 0028169245 scopus 로고
    • p53 expression in myeloid cells of myelodysplastic syndrome: Association with evolution of overt leukemia
    • Kitagawa M, Yoshida S, Kuwata T, Tanizawa T, Kamiyama R. p53 expression in myeloid cells of myelodysplastic syndrome: association with evolution of overt leukemia. Am J Pathol. 1994;145:338-344.
    • (1994) Am J Pathol , vol.145 , pp. 338-344
    • Kitagawa, M.1    Yoshida, S.2    Kuwata, T.3    Tanizawa, T.4    Kamiyama, R.5
  • 87
    • 0027257672 scopus 로고
    • Growth factors and angiogenesis
    • Schott RJ, Morrow LA. Growth factors and angiogenesis. Cardiovasc Res. 1993;27:1155-1161.
    • (1993) Cardiovasc Res , vol.27 , pp. 1155-1161
    • Schott, R.J.1    Morrow, L.A.2
  • 88
    • 0032753447 scopus 로고    scopus 로고
    • Angiogenesis in myelodysplastic syndromes
    • Pruneri G, Bertolini F, Soligo D, et al. Angiogenesis in myelodysplastic syndromes. Br J Cancer. 1999;81:1398-1401.
    • (1999) Br J Cancer , vol.81 , pp. 1398-1401
    • Pruneri, G.1    Bertolini, F.2    Soligo, D.3
  • 89
    • 5744230824 scopus 로고    scopus 로고
    • Modulation of angiogenesis in patients with myelodysplastic syndrome
    • Estey EH. Modulation of angiogenesis in patients with myelodysplastic syndrome. Best Pract Res Clin Haematol. 2004;17:623-639.
    • (2004) Best Pract Res Clin Haematol , vol.17 , pp. 623-639
    • Estey, E.H.1
  • 90
    • 0033806603 scopus 로고    scopus 로고
    • The thin red line: Angiogenesis in normal and malignant hematopoiesis
    • Bertolini F, Mancuso P, Gobbi A, Pruneri G. The thin red line: angiogenesis in normal and malignant hematopoiesis. Exp Hematol. 2000;28:993-1000.
    • (2000) Exp Hematol , vol.28 , pp. 993-1000
    • Bertolini, F.1    Mancuso, P.2    Gobbi, A.3    Pruneri, G.4
  • 91
    • 0033763986 scopus 로고    scopus 로고
    • Angiogenesis and angiogenic mediators in haematological malignancies
    • Mangi MH, Newland AC. Angiogenesis and angiogenic mediators in haematological malignancies. Br J Haematol. 2000;111:43-51.
    • (2000) Br J Haematol , vol.111 , pp. 43-51
    • Mangi, M.H.1    Newland, A.C.2
  • 92
    • 0034125929 scopus 로고    scopus 로고
    • Current status of antiangiogenic factors
    • Talks KL, Harris AL. Current status of antiangiogenic factors. Br J Haematol. 2000;109:477-489.
    • (2000) Br J Haematol , vol.109 , pp. 477-489
    • Talks, K.L.1    Harris, A.L.2
  • 93
    • 0030920373 scopus 로고    scopus 로고
    • Markers of tumor angiogenesis: Clinical applications in prognosis and anti-angiogenic therapy
    • Fox SB, Harris AL. Markers of tumor angiogenesis: clinical applications in prognosis and anti-angiogenic therapy. Invest New Drugs. 1997;15:15-28.
    • (1997) Invest New Drugs , vol.15 , pp. 15-28
    • Fox, S.B.1    Harris, A.L.2
  • 94
    • 17944378995 scopus 로고    scopus 로고
    • Prognostic evaluation of the microvascular network in myelodysplastic syndromes
    • Korkolopoulou P, Apostolidou E, Pavlopoulos PM, et al. Prognostic evaluation of the microvascular network in myelodysplastic syndromes. Leukemia. 2001;15:1369-1376.
    • (2001) Leukemia , vol.15 , pp. 1369-1376
    • Korkolopoulou, P.1    Apostolidou, E.2    Pavlopoulos, P.M.3
  • 95
    • 0035708042 scopus 로고    scopus 로고
    • Angiogenesis in acute myeloid leukemia and myelodysplastic syndrome
    • Albitar M. Angiogenesis in acute myeloid leukemia and myelodysplastic syndrome. Acta Haematol. 2001;106:170-176.
    • (2001) Acta Haematol , vol.106 , pp. 170-176
    • Albitar, M.1
  • 96
    • 0034665786 scopus 로고    scopus 로고
    • Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes
    • Aguayo A, Kantarjian H, Manshouri T, et al. Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes. Blood. 2000;96:2240-2245.
    • (2000) Blood , vol.96 , pp. 2240-2245
    • Aguayo, A.1    Kantarjian, H.2    Manshouri, T.3
  • 97
    • 17244381021 scopus 로고    scopus 로고
    • The role of the tumor microenvironment in hematological malignancies and implication for therapy
    • Zhou J, Mauerer K, Farina L, Gribben JG. The role of the tumor microenvironment in hematological malignancies and implication for therapy. Front Biosci. 2005;10:1581-1596.
    • (2005) Front Biosci , vol.10 , pp. 1581-1596
    • Zhou, J.1    Mauerer, K.2    Farina, L.3    Gribben, J.G.4
  • 98
    • 0032846420 scopus 로고    scopus 로고
    • SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor
    • Marchetto S, Fournier E, Beslu N, et al. SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor. Leukemia. 1999; 13:1374-1382.
    • (1999) Leukemia , vol.13 , pp. 1374-1382
    • Marchetto, S.1    Fournier, E.2    Beslu, N.3
  • 99
    • 0033020705 scopus 로고    scopus 로고
    • Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Crb2 and She in Baf3/ Flt3 cells
    • Zhang S, Mantel C, Broxmeyer HE. Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Crb2 and She in Baf3/ Flt3 cells. J Leukoc Biol. 1999;65:372-380.
    • (1999) J Leukoc Biol , vol.65 , pp. 372-380
    • Zhang, S.1    Mantel, C.2    Broxmeyer, H.E.3
  • 100
    • 0029294896 scopus 로고
    • Biology and potential clinical applications of flt3 ligand
    • Lyman SD, Williams DE. Biology and potential clinical applications of flt3 ligand. Curr Opin Hematol. 1995;2:177-181.
    • (1995) Curr Opin Hematol , vol.2 , pp. 177-181
    • Lyman, S.D.1    Williams, D.E.2
  • 101
    • 16944366584 scopus 로고    scopus 로고
    • Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia
    • Horiike S, Yokota S, Nakao M, et al. Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia. Leukemia. 1997;11:1442-1446.
    • (1997) Leukemia , vol.11 , pp. 1442-1446
    • Horiike, S.1    Yokota, S.2    Nakao, M.3
  • 102
    • 16944365287 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies: A study on a large series of patients and cell lines
    • Yokota S, Kiyoi H, Nakao M, et al. Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies: a study on a large series of patients and cell lines. Leukemia. 1997;11:1605-1609.
    • (1997) Leukemia , vol.11 , pp. 1605-1609
    • Yokota, S.1    Kiyoi, H.2    Nakao, M.3
  • 103
    • 0035871889 scopus 로고    scopus 로고
    • Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
    • Yamamoto Y, Kiyoi H, Nakano Y, et al. Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood. 2001; 97:2434-2439.
    • (2001) Blood , vol.97 , pp. 2434-2439
    • Yamamoto, Y.1    Kiyoi, H.2    Nakano, Y.3
  • 104
    • 0032960181 scopus 로고    scopus 로고
    • Cancer epigenetics comes of age
    • Jones PA, Laird PW. Cancer epigenetics comes of age. Nat Genet. 1999; 21:163-167.
    • (1999) Nat Genet , vol.21 , pp. 163-167
    • Jones, P.A.1    Laird, P.W.2
  • 105
    • 0028074299 scopus 로고
    • DNA methylation and cancer
    • Laird PW, Jaenisch R. DNA methylation and cancer. Hum Mol Genet. 1994;3(review issue 1):1487-1495.
    • (1994) Hum Mol Genet , vol.3 , Issue.REVIEW ISSUE 1 , pp. 1487-1495
    • Laird, P.W.1    Jaenisch, R.2
  • 106
    • 0036022068 scopus 로고    scopus 로고
    • Genomewide DNA hypomethylation is associated with alterations on chromosome 8 in prostate carcinoma
    • Schulz WA, Elo JP, Florl AR, et al. Genomewide DNA hypomethylation is associated with alterations on chromosome 8 in prostate carcinoma. Genes Chromosomes Cancer. 2002;35:58-65.
    • (2002) Genes Chromosomes Cancer , vol.35 , pp. 58-65
    • Schulz, W.A.1    Elo, J.P.2    Florl, A.R.3
  • 107
    • 0023848637 scopus 로고
    • Reduced genomic 5-methylcytosine content in human colonic neoplasia
    • Feinberg AP, Gehrke CW, Kuo KC, Ehrlich M. Reduced genomic 5-methylcytosine content in human colonic neoplasia. Cancer Res. 1988;48:1159-1161.
    • (1988) Cancer Res , vol.48 , pp. 1159-1161
    • Feinberg, A.P.1    Gehrke, C.W.2    Kuo, K.C.3    Ehrlich, M.4
  • 109
    • 0037068353 scopus 로고    scopus 로고
    • DNA methylation in cancer: Too much, but also too little
    • Ehrlich M. DNA methylation in cancer: too much, but also too little. Oncogene. 2002;21:5400-5413.
    • (2002) Oncogene , vol.21 , pp. 5400-5413
    • Ehrlich, M.1
  • 110
    • 1242285594 scopus 로고    scopus 로고
    • Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue
    • Suter CM, Martin DI, Ward RL. Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue. Int J Colorectal Dis. 2004;19: 95-101.
    • (2004) Int J Colorectal Dis , vol.19 , pp. 95-101
    • Suter, C.M.1    Martin, D.I.2    Ward, R.L.3
  • 111
    • 0031025368 scopus 로고    scopus 로고
    • Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies
    • Herman JG, Civin CI, Issa JP, Collector MI, Sharkis SJ, Baylin SB. Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies. Cancer Res. 1997;57:837-841.
    • (1997) Cancer Res , vol.57 , pp. 837-841
    • Herman, J.G.1    Civin, C.I.2    Issa, J.P.3    Collector, M.I.4    Sharkis, S.J.5    Baylin, S.B.6
  • 112
    • 19044371573 scopus 로고    scopus 로고
    • p21(CIP1/WAF1/SDI1) hypermethylation: An exciting new lead in ALL biology
    • Boldt DH. p21(CIP1/WAF1/SDI1) hypermethylation: an exciting new lead in ALL biology. Blood. 2002;99:2283.
    • (2002) Blood , vol.99 , pp. 2283
    • Boldt, D.H.1
  • 113
    • 0036525616 scopus 로고    scopus 로고
    • 5′ CpC island hypermethylation is associated with transcriptional silencing of the p21 (CIP1/WAF1/ SDI1) gene and confers poor prognosis in acute lymphoblastic leukemia
    • Roman-Gomez J, Castillejo JA, Jimenez A, et al. 5′ CpC island hypermethylation is associated with transcriptional silencing of the p21 (CIP1/WAF1/ SDI1) gene and confers poor prognosis in acute lymphoblastic leukemia. Blood. 2002;99:2291-2296.
    • (2002) Blood , vol.99 , pp. 2291-2296
    • Roman-Gomez, J.1    Castillejo, J.A.2    Jimenez, A.3
  • 114
    • 0037625237 scopus 로고    scopus 로고
    • Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia
    • Shen L, Toyota M, Kondo Y, et al. Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia. Blood. 2003;101:4131-4136.
    • (2003) Blood , vol.101 , pp. 4131-4136
    • Shen, L.1    Toyota, M.2    Kondo, Y.3
  • 115
    • 0036785401 scopus 로고    scopus 로고
    • Aberrant DNA methylation of p57(KIP2) gene in the promoter region in lymphoid malignancies of B-cell phenotype
    • Li Y, Nagai H, Ohno T, et al. Aberrant DNA methylation of p57(KIP2) gene in the promoter region in lymphoid malignancies of B-cell phenotype. Blood. 2002;100:2572-2577.
    • (2002) Blood , vol.100 , pp. 2572-2577
    • Li, Y.1    Nagai, H.2    Ohno, T.3
  • 116
    • 0037842155 scopus 로고    scopus 로고
    • Cadherin-13, a mediator of calcium-dependent cell-cell adhesion, is silenced by methylation in chronic myeloid leukemia and correlates with pretreatment risk profile and cytogenetic response to interferon alfa
    • Roman-Gomez J, Castillejo JA, Jimenez A, et al. Cadherin-13, a mediator of calcium-dependent cell-cell adhesion, is silenced by methylation in chronic myeloid leukemia and correlates with pretreatment risk profile and cytogenetic response to interferon alfa. J Clin Oncol. 2003;21:1472-1479.
    • (2003) J Clin Oncol , vol.21 , pp. 1472-1479
    • Roman-Gomez, J.1    Castillejo, J.A.2    Jimenez, A.3
  • 118
    • 3543070093 scopus 로고    scopus 로고
    • Hypermethylation of 5′-region of the human calcitonin gene in leukemias: Structural features and diagnostic significance
    • Marinitch DV, Vorobyev IA, Holmes JA, et al. Hypermethylation of 5′-region of the human calcitonin gene in leukemias: structural features and diagnostic significance. Biochemistry (Mosc). 2004;69:340-349.
    • (2004) Biochemistry (Mosc) , vol.69 , pp. 340-349
    • Marinitch, D.V.1    Vorobyev, I.A.2    Holmes, J.A.3
  • 119
    • 0028832888 scopus 로고
    • Abnormal regional hypermethylation of the calcitonin gene in myelodysplastic syndromes
    • Dhodapkar M, Grill J, Lust JA. Abnormal regional hypermethylation of the calcitonin gene in myelodysplastic syndromes. Leuk Res. 1995;19:719-726.
    • (1995) Leuk Res , vol.19 , pp. 719-726
    • Dhodapkar, M.1    Grill, J.2    Lust, J.A.3
  • 121
    • 4444291401 scopus 로고    scopus 로고
    • DNA methylation as a therapeutic target in hematologic disorders: Recent results in older patients with myelodysplasia and acute myeloid leukemia
    • Ruter B, Wijermans PW, Lubbert M. DNA methylation as a therapeutic target in hematologic disorders: recent results in older patients with myelodysplasia and acute myeloid leukemia. Int J Hematol. 2004;80:128-135.
    • (2004) Int J Hematol , vol.80 , pp. 128-135
    • Ruter, B.1    Wijermans, P.W.2    Lubbert, M.3
  • 123
    • 0033046553 scopus 로고    scopus 로고
    • Cancer-specific region of hypermethylation identified within the HIC1 putative tumour suppressor gene in acute myeloid leukaemia
    • Melki JR, Vincent PC, Clark SJ. Cancer-specific region of hypermethylation identified within the HIC1 putative tumour suppressor gene in acute myeloid leukaemia. Leukemia. 1999;13:877-883.
    • (1999) Leukemia , vol.13 , pp. 877-883
    • Melki, J.R.1    Vincent, P.C.2    Clark, S.J.3
  • 124
    • 0033179375 scopus 로고    scopus 로고
    • Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia
    • Melki JR, Vincent PC, Clark SJ. Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia. Cancer Res. 1999;59:3730-3740.
    • (1999) Cancer Res , vol.59 , pp. 3730-3740
    • Melki, J.R.1    Vincent, P.C.2    Clark, S.J.3
  • 125
    • 7244237957 scopus 로고    scopus 로고
    • Aberrant methylation of multiple tumor suppressor genes in acute myeloid leukemia
    • Ekmekci CG, Gutierrez MI, Siraj AK, Ozbek U, Bhatia K. Aberrant methylation of multiple tumor suppressor genes in acute myeloid leukemia. Am J Hematol. 2004;77:233-240.
    • (2004) Am J Hematol , vol.77 , pp. 233-240
    • Ekmekci, C.G.1    Gutierrez, M.I.2    Siraj, A.K.3    Ozbek, U.4    Bhatia, K.5
  • 126
    • 0033973587 scopus 로고    scopus 로고
    • Active repression of methylated genes by the chromosomal protein MBD1
    • Ng HH, Jeppesen P, Bird A. Active repression of methylated genes by the chromosomal protein MBD1. Mol Cell Biol. 2000;20:1394-1406.
    • (2000) Mol Cell Biol , vol.20 , pp. 1394-1406
    • Ng, H.H.1    Jeppesen, P.2    Bird, A.3
  • 127
    • 0032871399 scopus 로고    scopus 로고
    • MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex
    • Ng HH, Zhang Y, Hendrich B, et al. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nat Genet. 1999;23:58-61.
    • (1999) Nat Genet , vol.23 , pp. 58-61
    • Ng, H.H.1    Zhang, Y.2    Hendrich, B.3
  • 128
    • 0031837109 scopus 로고    scopus 로고
    • Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
    • Jones PL, Veenstra GJ, Wade PA, et al. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat Genet. 1998;19:187-191.
    • (1998) Nat Genet , vol.19 , pp. 187-191
    • Jones, P.L.1    Veenstra, G.J.2    Wade, P.A.3
  • 129
    • 0031792779 scopus 로고    scopus 로고
    • Identification and characterization of a family of mammalian methyl-CpG binding proteins
    • Hendrich B, Bird A. Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol Cell Biol. 1998;18:6538-6547.
    • (1998) Mol Cell Biol , vol.18 , pp. 6538-6547
    • Hendrich, B.1    Bird, A.2
  • 130
    • 0342437491 scopus 로고    scopus 로고
    • MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin
    • Nan X, Campoy FJ, Bird A. MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Cell. 1997;88:471-481.
    • (1997) Cell , vol.88 , pp. 471-481
    • Nan, X.1    Campoy, F.J.2    Bird, A.3
  • 131
    • 0032459591 scopus 로고    scopus 로고
    • High-risk myelodysplastic syndromes and hypermethylation of the p15Ink4B gene
    • Uchida T, Kinoshita T, Hotta T, Murate T. High-risk myelodysplastic syndromes and hypermethylation of the p15Ink4B gene. Leuk Lymphoma. 1998;32: 9-18.
    • (1998) Leuk Lymphoma , vol.32 , pp. 9-18
    • Uchida, T.1    Kinoshita, T.2    Hotta, T.3    Murate, T.4
  • 132
    • 0032523011 scopus 로고    scopus 로고
    • Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression
    • Quesnel B, Guillerm G, Vereecque R, et al. Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression. Blood. 1998;91:2985-2990.
    • (1998) Blood , vol.91 , pp. 2985-2990
    • Quesnel, B.1    Guillerm, G.2    Vereecque, R.3
  • 133
    • 0142261186 scopus 로고    scopus 로고
    • Gene silencing of the p15/INK4B cell-cycle inhibitor by hypermethylation: An early or later epigenetic alteration in myelodysplastic syndromes?
    • Lubbert M. Gene silencing of the p15/INK4B cell-cycle inhibitor by hypermethylation: an early or later epigenetic alteration in myelodysplastic syndromes? Leukemia. 2003;17:1762-1764.
    • (2003) Leukemia , vol.17 , pp. 1762-1764
    • Lubbert, M.1
  • 134
    • 0030614715 scopus 로고    scopus 로고
    • The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2
    • Reynisdottir I, Massague J. The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2. Genes Dev. 1997;11:492-503.
    • (1997) Genes Dev , vol.11 , pp. 492-503
    • Reynisdottir, I.1    Massague, J.2
  • 135
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature. 1993;366:704-707.
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 136
    • 0028884312 scopus 로고
    • Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site
    • Li JM, Nichols MA, Chandrasekharan S, Xiong Y, Wang XF. Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site. J Biol Chem. 1995;270:26750-26753.
    • (1995) J Biol Chem , vol.270 , pp. 26750-26753
    • Li, J.M.1    Nichols, M.A.2    Chandrasekharan, S.3    Xiong, Y.4    Wang, X.F.5
  • 137
    • 0028168242 scopus 로고
    • p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest
    • Hannon GJ, Beach D. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature. 1994;371:257-261.
    • (1994) Nature , vol.371 , pp. 257-261
    • Hannon, G.J.1    Beach, D.2
  • 138
    • 0033233233 scopus 로고    scopus 로고
    • P15INK4b gene methylation and myelodysplastic syndromes
    • Quesnel B, Fenaux P. P15INK4b gene methylation and myelodysplastic syndromes. Leuk Lymphoma. 1999;35:437-443.
    • (1999) Leuk Lymphoma , vol.35 , pp. 437-443
    • Quesnel, B.1    Fenaux, P.2
  • 139
    • 0022572130 scopus 로고
    • The suppressive influences of human tumor necrosis factors on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia: Synergism of tumor necrosis factor and interferon-gamma
    • Broxmeyer HE, Williams DE, Lu L, et al. The suppressive influences of human tumor necrosis factors on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia: synergism of tumor necrosis factor and interferon-gamma. J Immunol. 1986;136:4487-4495.
    • (1986) J Immunol , vol.136 , pp. 4487-4495
    • Broxmeyer, H.E.1    Williams, D.E.2    Lu, L.3
  • 140
    • 0028353492 scopus 로고
    • The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death
    • Smith CA, Farrah T, Goodwin RG. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Cell. 1994;76:959-962.
    • (1994) Cell , vol.76 , pp. 959-962
    • Smith, C.A.1    Farrah, T.2    Goodwin, R.G.3
  • 141
    • 0028927607 scopus 로고
    • The Fas death factor
    • Nagata S, Golstein P. The Fas death factor. Science. 1995;267:1449-1456.
    • (1995) Science , vol.267 , pp. 1449-1456
    • Nagata, S.1    Golstein, P.2
  • 142
    • 0029016931 scopus 로고
    • Fas antigen expression on CD34+ human marrow cells is induced by interferon gamma and tumor necrosis factor alpha and potentiates cytokine-mediated hematopoietic suppression in vitro
    • Maciejewski J, Selleri C, Anderson S, Young NS. Fas antigen expression on CD34+ human marrow cells is induced by interferon gamma and tumor necrosis factor alpha and potentiates cytokine-mediated hematopoietic suppression in vitro. Blood. 1995;85:3183-3190.
    • (1995) Blood , vol.85 , pp. 3183-3190
    • Maciejewski, J.1    Selleri, C.2    Anderson, S.3    Young, N.S.4
  • 143
    • 0032694521 scopus 로고    scopus 로고
    • Induction of negative regulators of haematopoiesis in human bone marrow cells by HLA-DR cross-linking
    • Yamaguchi M, Nadler S, Lee JW, Deeg HJ. Induction of negative regulators of haematopoiesis in human bone marrow cells by HLA-DR cross-linking. Transpl Immunol. 1999;7:159-168.
    • (1999) Transpl Immunol , vol.7 , pp. 159-168
    • Yamaguchi, M.1    Nadler, S.2    Lee, J.W.3    Deeg, H.J.4
  • 144
    • 0037411227 scopus 로고    scopus 로고
    • Expression of TNF receptors and related signaling molecules in the bone marrow from patients with myelodysplastic syndromes
    • Sawanobori M, Yamaguchi S, Hasegawa M, et al. Expression of TNF receptors and related signaling molecules in the bone marrow from patients with myelodysplastic syndromes. Leuk Res. 2003;27:583-591.
    • (2003) Leuk Res , vol.27 , pp. 583-591
    • Sawanobori, M.1    Yamaguchi, S.2    Hasegawa, M.3
  • 145
    • 0031656518 scopus 로고    scopus 로고
    • A role for tumour necrosis factor-alpha, Fas and Fas-Ligand in marrow failure associated with myelodysplastic syndrome
    • Gersuk GM, Beckham C, Loken MR, et al. A role for tumour necrosis factor-alpha, Fas and Fas-Ligand in marrow failure associated with myelodysplastic syndrome. Br J Haematol 1998;103:176-188.
    • (1998) Br J Haematol , vol.103 , pp. 176-188
    • Gersuk, G.M.1    Beckham, C.2    Loken, M.R.3
  • 147
    • 0030294026 scopus 로고    scopus 로고
    • Measurement of apoptosis, proliferation and three cytokines in 46 patients with myelodysplastic syndromes
    • Shetty V, Mundle S, Alvi S, et al. Measurement of apoptosis, proliferation and three cytokines in 46 patients with myelodysplastic syndromes. Leuk Res. 1996;20:891-900.
    • (1996) Leuk Res , vol.20 , pp. 891-900
    • Shetty, V.1    Mundle, S.2    Alvi, S.3
  • 148
    • 0029020851 scopus 로고
    • Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes
    • Raza A, Gezer S, Mundle S, et al. Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes. Blood. 1995;86:268-276.
    • (1995) Blood , vol.86 , pp. 268-276
    • Raza, A.1    Gezer, S.2    Mundle, S.3
  • 149
    • 0032933930 scopus 로고    scopus 로고
    • Biological characteristics of myelodysplastic syndrome patients who demonstrated high versus no intramedullary apoptosis
    • Dar S, Mundle S, Andric T, et al. Biological characteristics of myelodysplastic syndrome patients who demonstrated high versus no intramedullary apoptosis. Eur J Haematol. 1999;62:90-94.
    • (1999) Eur J Haematol , vol.62 , pp. 90-94
    • Dar, S.1    Mundle, S.2    Andric, T.3
  • 150
    • 0031464758 scopus 로고    scopus 로고
    • Overexpression of tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma by bone marrow cells from patients with myelodysplastic syndromes
    • Kitagawa M, Saito I, Kuwata T, et al. Overexpression of tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma by bone marrow cells from patients with myelodysplastic syndromes. Leukemia. 1997;11:2049-2054.
    • (1997) Leukemia , vol.11 , pp. 2049-2054
    • Kitagawa, M.1    Saito, I.2    Kuwata, T.3
  • 151
    • 0034022396 scopus 로고    scopus 로고
    • Negative regulators of hemopoiesis and stroma function in patients with myelodysplastic syndrome
    • Deeg HJ, Beckham C, Loken MR, et al. Negative regulators of hemopoiesis and stroma function in patients with myelodysplastic syndrome. Leuk Lymphoma. 2000;37:405-414.
    • (2000) Leuk Lymphoma , vol.37 , pp. 405-414
    • Deeg, H.J.1    Beckham, C.2    Loken, M.R.3
  • 152
    • 17544385520 scopus 로고    scopus 로고
    • Biological significance of proliferation, apoptosis, cytokines, and monocyte/macrophage cells in bone marrow biopsies of 145 patients with myelodysplastic syndrome
    • Allampallam K, Shetty V, Mundle S, et al. Biological significance of proliferation, apoptosis, cytokines, and monocyte/macrophage cells in bone marrow biopsies of 145 patients with myelodysplastic syndrome. Int J Hematol. 2002;75: 289-297.
    • (2002) Int J Hematol , vol.75 , pp. 289-297
    • Allampallam, K.1    Shetty, V.2    Mundle, S.3
  • 153
    • 0032944365 scopus 로고    scopus 로고
    • Biologic characteristics of 164 patients with myelodysplastic syndromes
    • Reza S, Dar S, Andric T, et al. Biologic characteristics of 164 patients with myelodysplastic syndromes. Leuk Lymphoma. 1999;33:281-287.
    • (1999) Leuk Lymphoma , vol.33 , pp. 281-287
    • Reza, S.1    Dar, S.2    Andric, T.3
  • 154
    • 10144248960 scopus 로고    scopus 로고
    • A paradigm shift in myelodysplastic syndromes
    • Raza A, Mundle S, Shetty V, et al. A paradigm shift in myelodysplastic syndromes. Leukemia. 1996;10:1648-1652.
    • (1996) Leukemia , vol.10 , pp. 1648-1652
    • Raza, A.1    Mundle, S.2    Shetty, V.3
  • 155
    • 0036826279 scopus 로고    scopus 로고
    • Suppression of antibody production by TNF-related apoptosis-inducing ligand (TRAIL)
    • Kayagaki N, Yamaguchi N, Abe M, et al. Suppression of antibody production by TNF-related apoptosis-inducing ligand (TRAIL). Cell Immunol. 2002; 219:82-91.
    • (2002) Cell Immunol , vol.219 , pp. 82-91
    • Kayagaki, N.1    Yamaguchi, N.2    Abe, M.3
  • 156
    • 0035892123 scopus 로고    scopus 로고
    • Expression of tumor necrosis factor-related apoptosis-inducing ligand, Apo2L, and its receptors in myelodysplastic syndrome: Effects on in vitro hemopoiesis
    • Zang DY, Goodwin RG, Loken MR, Bryant E, Deeg HJ. Expression of tumor necrosis factor-related apoptosis-inducing ligand, Apo2L, and its receptors in myelodysplastic syndrome: effects on in vitro hemopoiesis. Blood. 2001;98: 3058-3065.
    • (2001) Blood , vol.98 , pp. 3058-3065
    • Zang, D.Y.1    Goodwin, R.G.2    Loken, M.R.3    Bryant, E.4    Deeg, H.J.5
  • 157
    • 85009895235 scopus 로고    scopus 로고
    • TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors
    • Plasilova M, Zivny J, Jelinek J, et al. TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors. Leukemia. 2002;16: 67-73.
    • (2002) Leukemia , vol.16 , pp. 67-73
    • Plasilova, M.1    Zivny, J.2    Jelinek, J.3
  • 158
    • 0037111773 scopus 로고    scopus 로고
    • Characterization of gene expression of CD34+ cells from normal and myelodysplastic bone marrow
    • Hofmann WK, de Vos S, Komor M, Hoelzer D, Wachsman W, Koeffler HP. Characterization of gene expression of CD34+ cells from normal and myelodysplastic bone marrow. Blood. 2002;100:3553-3560.
    • (2002) Blood , vol.100 , pp. 3553-3560
    • Hofmann, W.K.1    De Vos, S.2    Komor, M.3    Hoelzer, D.4    Wachsman, W.5    Koeffler, H.P.6
  • 159
    • 10244227886 scopus 로고    scopus 로고
    • Distinctive gene expression profiles of CD34 cells from patients with myelodysplastic syndrome characterized by specific chromosomal abnormalities
    • Chen C, Zeng W, Miyazato A, et al. Distinctive gene expression profiles of CD34 cells from patients with myelodysplastic syndrome characterized by specific chromosomal abnormalities. Blood. 2004;104:4210-4218.
    • (2004) Blood , vol.104 , pp. 4210-4218
    • Chen, C.1    Zeng, W.2    Miyazato, A.3
  • 160
    • 0035880236 scopus 로고    scopus 로고
    • Identification of myelodysplastic syndrome-specific genes by DNA microarray analysis with purified hematopoietic stem cell fraction
    • Miyazato A, Ueno S, Ohmine K, et al. Identification of myelodysplastic syndrome-specific genes by DNA microarray analysis with purified hematopoietic stem cell fraction. Blood. 2001;98:422-427.
    • (2001) Blood , vol.98 , pp. 422-427
    • Miyazato, A.1    Ueno, S.2    Ohmine, K.3
  • 161
    • 2942563736 scopus 로고    scopus 로고
    • Gene expression profiling in the myelodysplastic syndromes using cDNA microarray technology
    • Pellagatti A, Esoof N, Watkins F, et al. Gene expression profiling in the myelodysplastic syndromes using cDNA microarray technology. Br J Haematol. 2004;125:576-583.
    • (2004) Br J Haematol , vol.125 , pp. 576-583
    • Pellagatti, A.1    Esoof, N.2    Watkins, F.3
  • 162
    • 0142215552 scopus 로고    scopus 로고
    • DNA microarray analysis of stage progression mechanism in myelodysplastic syndrome
    • Ueda M, Ota J, Yamashita Y, et al. DNA microarray analysis of stage progression mechanism in myelodysplastic syndrome. Br J Haematol. 2003;123: 288-296.
    • (2003) Br J Haematol , vol.123 , pp. 288-296
    • Ueda, M.1    Ota, J.2    Yamashita, Y.3
  • 163
    • 0033757263 scopus 로고    scopus 로고
    • Validation of the WHO proposals for a new classification of primary myelodysplastic syndromes: A retrospective analysis of 1600 patients
    • Germing U, Gattermann N, Strupp C, Aivado M, Aul C. Validation of the WHO proposals for a new classification of primary myelodysplastic syndromes: a retrospective analysis of 1600 patients. Leuk Res. 2000;24:983-992.
    • (2000) Leuk Res , vol.24 , pp. 983-992
    • Germing, U.1    Gattermann, N.2    Strupp, C.3    Aivado, M.4    Aul, C.5


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