High-Risk Myelodysplastic Syndromes and Hypermethylation of the p15Ink4B Gene

Leukemia and Lymphoma

Volumn 32, Issue 42006, 1998, Pages 9-18

  Uchida, Toshiki ^a   Kinoshita, Tomohiro ^a   Hotta, Tomomitsu ^b   Murate, Takashi ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Hypermethylation; Myelodysplastic syndromes; p15INK4B gene

Indexed keywords

PROTEIN P15;

ACUTE GRANULOCYTIC LEUKEMIA; CPG ISLAND; EXON; GENE INACTIVATION; HUMAN; METHYLATION; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; TUMOR SUPPRESSOR GENE;

ANIMALS; CARRIER PROTEINS; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASES; DISEASE PROGRESSION; DNA METHYLATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; MYELODYSPLASTIC SYNDROMES; NEOPLASMS; RISK FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 0032459591     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428199809059242     Document Type: Review

References (64)

1. Bird A. The essentials of DNA methylation. Cell 1992; 70: 5 – 8
2. Bird A. CpG-rich islands and the function of DNA methylation. Nature 1986; 321: 209 – 203
3. Li E., Beard C., Jaenisch R. Role for DNA methylation in genomic imprinting. Nature 1993; 366: 362 – 365
4. Pfeifer G. P., Steigerwald S. D., Mueller P. R., Wold B., Riggs A. D. Genomic sequencing and methylation analysis by ligation mediated PCR. Science 1989; 246: 810 – 813
5. Serrano M., Lee H. W., Chin L., Cordon-Cardo C., Beach D., Depinho R. A. Role of the INK4a locus in tumor suppression and cell mortality. Cell 1996; 85: 27 – 37
6. Counts J. L., Goodman J. I. Alterations in DNA methylation may play a variety of roles in carcinogenesis. Cell 1995; 83: 13 – 15
7. Jones P. A. DNA methylation errors and cancer. Cancer Res. 1996; 56: 2463 – 2467
8. Issa J. P. J., Baylin S. B., Herman J. G. DNA methylation changes in hematologic malignancies: biologic and clinical implications. Leukemia 1997; 11 (Supplement 1) S7 – S11
9. Sakai T., Toguchida J., Ohtani N., Yandell D. W., Rapaport J. M., Dryja T. P. Allele-specific hypermethylation of the retinoblastoma, tumor-suppressor gene. Am. J. Hum Genet. 1991; 48: 880 – 888
10. Herman J. G., Latif R, Weng Y., Lerman M. I., Zbar B., Liu S., Samid D., Duan D. S., Gnarra J. R., Linehan W. M., Baylin S. B. Silencing of the VHL, tumor-suppressor gene by DNA methylation in renal carcinoma. Proc. Natl. Acad. Sci. USA 1994; 91: 9700 – 9704
11. Merlo A., Herman J. G., Mao L., Lee D. J., Gabrielson E., Burger P. C, Baylin S. B., Sidransky D. CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1, in human cancers. Nature Med. 1995; 1: 686 – 692
12. Herman J. G., Jen J., Merlo A., Baylin S. B. Hypermethylation-associated inactivation indicates a tumor suppressor role for p15 INK4B. Cancer Res. 1996; 56: 722 – 727
13. Hannon G. J., Beach D. p15INK4B is a potential effector of TGF-(5-induced cell cycle arrest. Nature 1994; 371: 257 – 261
14. Sherr C. J., Roberts J. M. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 1995; 9275: 1149 – 1163
15. Kamb A., Gruis N. A., Weaver-Feldhaus J., Liu Q., Harshman K., Tavtigian S. V., Stockert E., Day R. S., III, Johnson B. E., Skolnick M. H. A cell cycle regulator potentially involved in genesis of many tumor types. Science 1994; 264: 436 – 440
16. Nobori T., Miura K., Wu D. J., Lois A., Takabayashi K., Carson D. A. Deletions of the cyclin-dependent kinases inhibitor gene in multiple human cancers. Nature 1994; 368: 753 – 756
17. Hirama T., Koeffler H. P. Role of the cyclin-dependent kinase inhibitors in the development of cancer. Blood 1995; 86: 841 – 854
18. Malumbres M., De Castro I. P., Santos J., Melendez B., Mangues R., Serrano M., Pellicer A., Fernan-Dez-Piqueras J. Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo, methylation with independence of p16INK4a alterations in murine T-cell lymphomas. Oncogene 1997; 14: 1361 – 1370
19. Freiberg A. P., Gehrke C. W., Kuo K. C., Ehrlich M. Reduced genomic 5-methylcytosine content in human colonic neoplasia. Cancer Res. 1988; 48: 1159 – 1161
20. Freiberg A. P., Vogelstein B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 1983; 301: 89 – 91
21. Kautianian T. L., Jones P. A. DNA methyltransferase levels in tumorigenic and nontumorigenic cells in culture. J. Biol. Chem. 1986; 261: 1594 – 1598
22. Laird P. W., Jackson-Grusby L., Fazeli A., Dickinson S. L., Jung W. E., Li E., Weinberg R. A., Jaenisch R. Suppression of intestinal neoplasia by DNA hypomethylation. Cell 1995; 81: 197 – 205
23. Issa J. P. J., Vertino P. M., Wu I, Sazawal S., Celano P., Nelkin B. D., Hamliton S. R., Baylin S. B. Increased cytosine DNA-methyltransferase activity during colon cancer progression. J. Natl. Cancer inst 1993; 85: 1235 – 1240
24. Belinsky S. A., Nikula K. J., Baylin S. B., Issa J. P. J. Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer. Proc. Natl. Acad. Sci. USA 1996; 93: 4045 – 4050
25. Wu J., Issa J. P. J., Herman J., Bassett D. E., Jr, Nelkin B. D., Baylin S. B. Expression of exogenous eukaryotic DNA methyltransferase gene induces transformation of N1H 3T3 cells. Proc. Natl. Acad. Sci. USA 1993; 90: 8891 – 8895
26. Macleod A. R., Szyf M. Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis. J. Biol. Chem. 1995; 270: 8037 – 8043
27. Chuang L. S. H., Ian H. I., Koh T. W., Ng H. H., Xu G., Li B. F. L. Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAFI. Science 1997; 277: 1996 – 2000
28. Kondo M, Matsuoka S., Uchida K., Osada H., Nagatake M, Takagi K., Harper J. W., Takahashi T., Elledge S., Takahashi T. Selective maternal-allele loss in human lung cancers of the maternally expressed p57 kip2, gene at 11p15.5. Oncogene 1996; 12: 1365 – 1368
29. Caron H., Peter M., Van Sluis P., Speleman E, De Kraker J., Laureys G., Miction J., Brugieres L., Voute P. A., Westerveld A. Evidence for two tumour suppressor loci on chromosomal bands 1p35–36 involved in neuroblastoma: one probably imprinted, another associated with N-myc amplification. Hum. Mol. Genet. 1995; 4: 535 – 539
30. Kadhad M., Bonnet H., Yang A., Creancier L., Biscan J. C, Valent A., Minty A., Chalon P., Lelias J. M., Dumont X., Ferrara P., McKeon F., Caput D. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 1997; 90: 809 – 819
31. Yang A. S., Shen J-C, Zingg J-M., Sha M., Jones P. A. Hhal and Hpall, DNA methyltransferases bind DNA mismatches, methylate uracil and block DNA repair. Nucleic Acids Res. 1995; 23: 1380 – 1387
32. Lengauer C, Kinzler K. W., Vogelstein B. DNA methylation and genetic instability in colorectal cancer cells. Pwc. Natl. Acad. Sci., USA 1997; 94: 2545 – 2550
33. Ahuja N., Mohan A. L., Li O., Stolker J. M., Herman J. G., Hamilton S. R., Baylin S. B., Issa J. P. J. Association between CpG island methylation and microsatellite instability in colorectal cancer. Cancer Res. 1997; 57: 3370 – 3374
34. Denissenko M. E, Chen J. T., Tang M., Pfeifer G. P. Cytosine methylation determines hot spots of DNA damage in the human P53, gene. Proc. Natl. Acad. Sci. USA 1997; 94: 3893 – 3898
35. Wales M. M., Biel M. A., El Deiry W., Nelkin B. D., Issa J. P. J., Cavenee W. K., Kuerbitz S. J., Baylin S. B. activates expression of HIC-1, a new candidate tumor suppressor gene on 17p1 3.3. Nature Med. 1995; 1: 53, 570–577
36. Herman J. G., Civin C. I, Issa J. P. J., Collector M. I., Sharkis S. J., Baylin S. B. Distinct patterns of inactivation of p15 INK4B, and p16 INK4A, characterize the major types of hematological malignancies. Cancer Res. 1997; 57: 837 – 841
37. Batova A., Diccianni M. B., Yu J. C., Nobori T., Link M. P., Pullen J., Yu A. L. Frequent and selective methylation of p/5and deletion of both p15, and p16, in T-cell acute lymphoblastic leukemia. Cancer Res. 1997; 57: 832 – 836
38. Ng M. H. L., Chung Y E, Lo K. W., Wickham N. W. R., Lee J. C. K., Huang D. P. Frequent hypermethylation of p16 INK4A and p15 INK4B, genes in multiple myeloma. Blood 1997; 89: 2500 – 2506
39. Baylin S. B., Fearon E. R., Vogelstein B, De Bustros A., Sharkis S. J., Burke P. J., Staal S. P., Nelkin B. D. Hypermethylation of the 5′ region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies. Blood 1987; 70: 412 – 417
40. Issa J. P. J., Kopecky K. J., Applebaum E, Willman C., Baylin S. B. Estrogen receptor methylation is a favorable prognostic factor in AML. Proc. Am. Sot: Clin. Oncol. 1996; 15: 357
41. Issa J. P. J., Zehnbauer B. A., Kaufmann S. H., Biel M. A., Baylin S. B. HICl, hypermethylation is a late event in hematopoietic neoplasms. Cancer Res. 1997; 57: 1678 – 1681
42. Nelkin B. D., Przepiorka D., Burke P. J., Thomas E. D., Baylin S. B. Abnormal methylation of the carcilonin, gene marks progression of chronic myelogenous leukemia. Blood 1991; 77: 2431 – 2434
43. Issa J. P. J., Zehnbauer B. A., Civin C. I., Collector M. I., Sharkis S. J., Davidson N. E., Kaufmann S. H., Baylin S. B. The estrogen receptor CpG island is methylated in most hematopoietic neoplasms. Cancer Res. 1996; 56: 973 – 977
44. Zion M., Ben-Yehuda D., Avraham A., Cohen O., Wetzler M., Melloul D., Ben-Neriah Y. Progressive de novo, DNA methylation at the bcr-abl, locus in the course of chronic myelogenous leukemia. Proc. Natl. Acad. Sci. USA 1994; 91: 10722 – 10726
45. Bennett J. M., Catovsky D., Daniel M. T., Flandrin G., Galton D. A. G., Gralnick H. R., Sultan C. The French-American-British (FAB) cooperative group. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol. 1982; 51: 189 – 199
46. Greenberg P., Cox C, Lebeau M., Fenaux P., Morel P., Sanz G., Sanz M., Vallepsi T., Hamblin T., Oscier D., Ohyashiki K., Toyama K., Aul C, Multi G., Bennett J. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 1997; 89: 2079 – 2088
47. Uchida T, Kinoshita T., Nagai H., Nakahara Y, Saito H., Hotta T., Murate T. Hypermethylation of the p15 INK4B, gene in myelodysplastic syndromes. Blood 1997; 90: 1403 – 1409
48. Nakamaki T., Kawamata N., Schwaller J., Tobler A., Fey M., Pakkala S., Lee Y. Y, Kim B. K., Fukuchi K., Tsu-Ruoka N., Kahan J., Miller C. W., Koeffler H. P. Structural integrity of the cyclin-dependent kinase inhibitor genes, p15, p16, p18, in myeloid leukaemias. Br. J. Haematol. 1995; 91: 139 – 149
49. Nakamaki T., Bartram C, Seriu T., Kahan J., Fukuchi K., Tsuruoka N., Janssen J. W. G., Miller C. W., Koeffler H. P. Molecular analysis of the cyclin-dependent kinase inhibitor genes, p15, p16, p18, and p 19, in the myelodysplastic syndromes. Leukemia Res. 1997; 21: 235 – 240
50. Issa J. P. J., Ottaviano Y L., Celano P., Hamilton S. R., Davidson N. E., Baylin S. B. Methylation of the oestrogen receptor CpG island links aging and neoplasia in human colon. Nat. Genet. 1994; 7: 536 – 540
51. Singer-Sam J., Grant M., Lebon J. M., Okuyama K., Chapman V., Monk M., Riggs A. D. Use of a Hpall-polymerase chain reaction assay to study DNA methylation in the Pgk-1 CpG island of mouse embryos at the time of X-chromosome inactivation. Mol. Cell Biol. 1990; 10: 4987 – 4989
52. Asano H., Ohashi H., Ichikawa M., Kinoshita T., Murate T., Kobayashi M., Saito H., Hotta T. Evidence for nonclonal hematopoietic progenitor cell populations in bone marrow of patients with myelodysplastic syndromes. Blood 1994; 84: 588 – 594
53. Ito T, Ohashi H., Kagami Y., Ichikawa A., Saito H., Hotta T. Recovery of polyclonal hematopoiesis in patients with myelodysplastic syndromes following successful chemotherapy. Leukemia 1994; 8: 839 – 843
54. Delforge M., Demuynck H., Vandenberghe P., Verhoef G., Zachée P., Duppen V. V., Marijnen P., Berghe H. V., Boogaerts M. A. Polyclonal primitive hematopoietic progenitors can be detected in mobilized peripheral blood from patients with high-risk myelodysplastic syndromes. Blood 1995; 86: 3660 – 3667
55. Herman J. G., Graff J. R., Myöhänsen S., Nelkin B. D., Baylin S. B. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands. Proc. Natl. Acad. Sci. USA 1996; 93: 9821 – 9826
56. Gonzalgo M. L., Jones P. A. Rapid quantitation of methylation differences at specific sites using methylation-sensitive single nucleotide primer extention (Ms-SNuPE). Nucleic Acids Res. 1997; 25: 2529 – 2531
57. Xiong Z., Laird P. W. COBRA: a sensitive and quantitative DNA methylation assay. Nucleic Acids Res. 1997; 25: 2532 – 2534
58. Wijermans P. W., Krulder J. W. M, Huijgens P. C., Neve P. Continuous infusion of low-dose 5-aza-2′-deoxycytidine in elderly patients with high-risk myelodysplastic syndrome. Leukemia 1997; 11: S19 – S23, Supplement 1
59. Kantarjian H. M, O'Brien S. M., Estey E., Giralt S., Beran M., Rios M. B., Keating M., De Vos D., Talpaz M. Decitabine studies in chronic and acute myelogenous leukemia. Leukemia 1997; 11: S35 – S36, Supplement 1
60. Giralt S., Davis M., O'Brien S., Van Besien K., Champlin R., De Vos D., Kantarjian H. M. Studies of decitabine with allogeneic progenitor cell transplantation. Leukemia 1997; 11: S32 – S34, Supplement 1
61. Tsubari M., Tiihonen E., Laiho M. Cloning and characterization of p10, an alternatively spliced form of p15 cyclin-dependent kinase inhibitor. Cancer Res. 1997; 57: 2966 – 2973
62. Quelle D. E., Zindy R, Ashmun R. A., Sherr C. J. Alternative reading frames of the lNK4a, tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 1995; 83: 993 – 1000
63. Rideout W. M., III, Eversole-Cure P., Spruck C. H., III, Hustad C. M., Coetzee G. A., Gonzales F., Jones P. A. Progressive increases in the methylation status and heterochromatinization of the MyoD, CpG island during oncogenic transformation. Mol. Cell Biol 1994; 14: 6143 – 6152
64. Yoshiura K., Kanai Y., Ochiai A., Shimoyama Y., Sugiura T., Hirohashi S. Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. Proc. Natl. Acad. Sci. USA 1995; 92: 7416 – 7419