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Volumn 12, Issue 3, 2005, Pages 217-225

Novel therapies for rheumatoid arthritis

Author keywords

Biologic agents; Cytokine; Rheumatoid arthritis; Therapy; Tumor necrosis factor (TNF)

Indexed keywords

ADALIMUMAB; AMG 714; ANTIINFLAMMATORY AGENT; ATLIZUMAB; BIOLOGICAL FACTOR; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DISEASE MODIFYING ANTIRHEUMATIC DRUG; ETANERCEPT; IMMUNOLOGIC AGENT; INFLIXIMAB; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1 TRAP; INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR ANTAGONIST; INTERLEUKIN 18; INTERLEUKIN 18 ANTIBODY; INTERLEUKIN 18 BINDING PROTEIN; INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; LEA 29 Y; METHOTREXATE; PRALNACASAN; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RITUXIMAB; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 25444464091     PISSN: 09284680     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pathophys.2005.07.008     Document Type: Article
Times cited : (7)

References (98)
  • 1
    • 0025697332 scopus 로고
    • Epidemiology of rheumatoid arthritis: update
    • M.C. Hochberg, and T.D. Spector Epidemiology of rheumatoid arthritis: update Epidemiol. Rev. 12 1990 247 252
    • (1990) Epidemiol. Rev. , vol.12 , pp. 247-252
    • Hochberg, M.C.1    Spector, T.D.2
  • 3
    • 0029032756 scopus 로고
    • Work disability in early rheumatoid arthritis
    • D. Dougados, T. Suurmeiher, and B. Krol Work disability in early rheumatoid arthritis Ann. Rheum. Dis. 54 1995 445 460
    • (1995) Ann. Rheum. Dis. , vol.54 , pp. 445-460
    • Dougados, D.1    Suurmeiher, T.2    Krol, B.3
  • 4
    • 0022626173 scopus 로고
    • Survival, prognosis and causes of death in rheumatoid arthritis
    • D.M. Mitchell, P.W. Spitz, and D.Y. Yound Survival, prognosis and causes of death in rheumatoid arthritis Arthritis Rheum. 29 1986 706 714
    • (1986) Arthritis Rheum. , vol.29 , pp. 706-714
    • Mitchell, D.M.1    Spitz, P.W.2    Yound, D.Y.3
  • 5
    • 0030970556 scopus 로고    scopus 로고
    • The role of T cells in the immunopathogenesis of rheumatoid arthritis: new perspectives
    • D.A. Fox The role of T cells in the immunopathogenesis of rheumatoid arthritis: new perspectives Arthritis Rheum. 40 1997 598 609
    • (1997) Arthritis Rheum. , vol.40 , pp. 598-609
    • Fox, D.A.1
  • 7
    • 0029044362 scopus 로고
    • The American College of Rheumatology preliminary definition of improvement in rheumatoid arthritis
    • D.T. Felson, J.J. Anderson, and M. Boers The American College of Rheumatology preliminary definition of improvement in rheumatoid arthritis Arthritis Rheum. 38 1995 727 735
    • (1995) Arthritis Rheum. , vol.38 , pp. 727-735
    • Felson, D.T.1    Anderson, J.J.2    Boers, M.3
  • 8
    • 25444530297 scopus 로고
    • The dimensions of health outcomes: the health assessment questionnaire, disability, and pain scales
    • J.F. Fries, P.W. Spitz, and D.Y. Young The dimensions of health outcomes: the health assessment questionnaire, disability, and pain scales J. Rheumatol. 20 1993 557 560
    • (1993) J. Rheumatol. , vol.20 , pp. 557-560
    • Fries, J.F.1    Spitz, P.W.2    Young, D.Y.3
  • 9
    • 0017658738 scopus 로고
    • Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films
    • A. Larsen, K. Dale, and M. Eek Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films Acta Radiol. Diagn. 18 1977 481 491
    • (1977) Acta Radiol. Diagn. , vol.18 , pp. 481-491
    • Larsen, A.1    Dale, K.2    Eek, M.3
  • 10
    • 0015151774 scopus 로고
    • Methods of scoring the progression of radiographic changes in rheumatoid arthritis: correlation of radiographic, clinical, and laboratory abnormalities
    • T.J. Sharp, M.D. Lidsky, and L.C. Collins Methods of scoring the progression of radiographic changes in rheumatoid arthritis: correlation of radiographic, clinical, and laboratory abnormalities Arthritis Rheum. 14 1971 706 720
    • (1971) Arthritis Rheum. , vol.14 , pp. 706-720
    • Sharp, T.J.1    Lidsky, M.D.2    Collins, L.C.3
  • 11
    • 0038011833 scopus 로고    scopus 로고
    • Evolving concepts of rheumatoid arthritis
    • G.S. Firestein Evolving concepts of rheumatoid arthritis Nature 423 2003 356 361
    • (2003) Nature , vol.423 , pp. 356-361
    • Firestein, G.S.1
  • 12
    • 0023712236 scopus 로고    scopus 로고
    • Detection of tumor necrosis factor α but not tumor necrosis factor β in rheumatoid arthritis synovial fluid and serum
    • T. Saxne, M.A. Palladino Jr., D. Heinegärd, N. Talal, and F.A. Wollheim Detection of tumor necrosis factor α but not tumor necrosis factor β in rheumatoid arthritis synovial fluid and serum Arthritis Rheum. 31 2003 1041 1045
    • (2003) Arthritis Rheum. , vol.31 , pp. 1041-1045
    • Saxne, T.1    Palladino Jr., M.A.2    Heinegärd, D.3    Talal, N.4    Wollheim, F.A.5
  • 13
    • 0028957263 scopus 로고
    • Peripheral blood and synovial fluid monocyte expression of interleukin 1α and 1β during active rheumatoid arthritis
    • I.C. Chikanza, G. Kingsley, and G.S. Panayi Peripheral blood and synovial fluid monocyte expression of interleukin 1α and 1β during active rheumatoid arthritis J. Rheumatol. 22 1995 600 606
    • (1995) J. Rheumatol. , vol.22 , pp. 600-606
    • Chikanza, I.C.1    Kingsley, G.2    Panayi, G.S.3
  • 14
    • 0034544946 scopus 로고    scopus 로고
    • Combination benefit of treatment with the cytokine inhibitors interleukin-1 receptor antagonist and PEGylated soluble tumor necrosis factor receptor type I in animal models of rheumatoid arthritis
    • A.M. Bendele, E.S. Chlipala, and J. Scherrer Combination benefit of treatment with the cytokine inhibitors interleukin-1 receptor antagonist and PEGylated soluble tumor necrosis factor receptor type I in animal models of rheumatoid arthritis Arthritis Rheum. 43 2000 2648 2659
    • (2000) Arthritis Rheum. , vol.43 , pp. 2648-2659
    • Bendele, A.M.1    Chlipala, E.S.2    Scherrer, J.3
  • 15
    • 8044257704 scopus 로고    scopus 로고
    • A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells
    • R.A. Black, C.T. Rauch, and C.J. Kozlosky A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells Nature 385 1997 729 733
    • (1997) Nature , vol.385 , pp. 729-733
    • Black, R.A.1    Rauch, C.T.2    Kozlosky, C.J.3
  • 16
    • 0035932519 scopus 로고    scopus 로고
    • Cytokine pathways and joint inflammation in rheumatoid arthritis
    • E.H. Choy, and G.S. Panayi Cytokine pathways and joint inflammation in rheumatoid arthritis New Engl. J. Med. 344 2001 907 916
    • (2001) New Engl. J. Med. , vol.344 , pp. 907-916
    • Choy, E.H.1    Panayi, G.S.2
  • 17
    • 0022648104 scopus 로고
    • Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors
    • D.R. Bertolini, G.E. Nedwin, T.S. Bringman, D.D. Smith, and G.R. Mundy Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors Nature 319 1986 516 518
    • (1986) Nature , vol.319 , pp. 516-518
    • Bertolini, D.R.1    Nedwin, G.E.2    Bringman, T.S.3    Smith, D.D.4    Mundy, G.R.5
  • 18
    • 0033524159 scopus 로고    scopus 로고
    • Infliximab (chimeric anti-tumour necrosis factor α monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomized phase II trial
    • R.N. Maini, E.W. St. Clair, F. Breedveld, D. Furst, J. Kalden, and M. Weisman Infliximab (chimeric anti-tumour necrosis factor α monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomized phase II trial Lancet 354 1999 1932 1939
    • (1999) Lancet , vol.354 , pp. 1932-1939
    • Maini, R.N.1    St. Clair, E.W.2    Breedveld, F.3    Furst, D.4    Kalden, J.5    Weisman, M.6
  • 19
    • 0034735842 scopus 로고    scopus 로고
    • Infliximab and methotrexate in the treatment of rheumatoid arthritis
    • P.E. Lipsky, D.M.F.M. van der Heijde, and E.W. St. Clair Infliximab and methotrexate in the treatment of rheumatoid arthritis New Engl. J. Med. 343 2000 1594 1602
    • (2000) New Engl. J. Med. , vol.343 , pp. 1594-1602
    • Lipsky, P.E.1    Van Der Heijde, D.M.F.M.2    St. Clair, E.W.3
  • 20
    • 4944256984 scopus 로고    scopus 로고
    • Infliximab inhibits radiographic joint damage in patients with early rheumatoid arthritis regardless of clinical response after 54 weeks treatment
    • J. Smolen, D. van der Heijde, and P. Emery Infliximab inhibits radiographic joint damage in patients with early rheumatoid arthritis regardless of clinical response after 54 weeks treatment Ann. Rheum. Dis. 63 Suppl. I 2004 260
    • (2004) Ann. Rheum. Dis. , vol.63 , Issue.1 SUPPL. , pp. 260
    • Smolen, J.1    Van Der Heijde, D.2    Emery, P.3
  • 21
    • 0033611472 scopus 로고    scopus 로고
    • A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate
    • M.E. Weinblatt, J.M. Kremer, A.D. Bankhurst, K.J. Bulpitt, R.M. Fleischmann, and R.I. Rox A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate New Engl. J. Med. 340 1999 253 259
    • (1999) New Engl. J. Med. , vol.340 , pp. 253-259
    • Weinblatt, M.E.1    Kremer, J.M.2    Bankhurst, A.D.3    Bulpitt, K.J.4    Fleischmann, R.M.5    Rox, R.I.6
  • 24
    • 0036274944 scopus 로고    scopus 로고
    • Etanercept versus methotrexate in patients with early rheumatoid arthritis two year radiographic and clinical outcomes
    • M.C. Genovese, J.M. Bathon, R.W. Martin, R.M. Fleischmann, J.R. Tesser, and M.H. Schiff Etanercept versus methotrexate in patients with early rheumatoid arthritis two year radiographic and clinical outcomes Arthritis Rheum. 46 2002 1443 1450
    • (2002) Arthritis Rheum. , vol.46 , pp. 1443-1450
    • Genovese, M.C.1    Bathon, J.M.2    Martin, R.W.3    Fleischmann, R.M.4    Tesser, J.R.5    Schiff, M.H.6
  • 25
    • 0037231533 scopus 로고    scopus 로고
    • Adalimumab, a fully human monoclonal antibody for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trial
    • M.E. Weinblatt, E.C. Keystone, D.E. Furst, L.W. Moreland, M.H. Weisman, and C.A. Birbara Adalimumab, a fully human monoclonal antibody for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trial Arthritis Rheum. 48 2003 35 45
    • (2003) Arthritis Rheum. , vol.48 , pp. 35-45
    • Weinblatt, M.E.1    Keystone, E.C.2    Furst, D.E.3    Moreland, L.W.4    Weisman, M.H.5    Birbara, C.A.6
  • 26
    • 2342658406 scopus 로고    scopus 로고
    • Radiographic, clinical, and functional outcomes with adalimumab (a human anti-TNF alpha monoclonal antibody) in the treatment of patients with active rheumatoid arthritis on concomitant methorexate theapy: a randomized, controlled 52 week-trial
    • E. Keystone, A. Kavanaugh, J. Sharp, H. Tennenbaum, Y. Hua, L. Teoh, S. Fischkoff, and E. Chartash Radiographic, clinical, and functional outcomes with adalimumab (a human anti-TNF alpha monoclonal antibody) in the treatment of patients with active rheumatoid arthritis on concomitant methorexate theapy: a randomized, controlled 52 week-trial Arthritis Rheum. 50 2004 1400 1411
    • (2004) Arthritis Rheum. , vol.50 , pp. 1400-1411
    • Keystone, E.1    Kavanaugh, A.2    Sharp, J.3    Tennenbaum, H.4    Hua, Y.5    Teoh, L.6    Fischkoff, S.7    Chartash, E.8
  • 27
    • 10744223002 scopus 로고    scopus 로고
    • Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial
    • L. Klareskog, D. van der Heijde, and J.P. de Jager Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial Lancet 363 2004 675 681
    • (2004) Lancet , vol.363 , pp. 675-681
    • Klareskog, L.1    Van Der Heijde, D.2    De Jager, J.P.3
  • 28
    • 0142124925 scopus 로고    scopus 로고
    • The safety of biologic agents in early rheumatoid arthritis
    • A. Kavanaugh, and E. Keystone The safety of biologic agents in early rheumatoid arthritis Clin. Exp. Rheumatol. 21 Suppl. 31 2003 71 76
    • (2003) Clin. Exp. Rheumatol. , vol.21 , Issue.31 SUPPL. , pp. 71-76
    • Kavanaugh, A.1    Keystone, E.2
  • 30
    • 0036351226 scopus 로고    scopus 로고
    • Effects of a PEGylated soluble TNF receptor type 1 (PEG s TNF-R1) on cytokine expression in adjuvant arthritis
    • K.A. Bush, J.S. Walker, and J. Frazier Effects of a PEGylated soluble TNF receptor type 1 (PEG s TNF-R1) on cytokine expression in adjuvant arthritis Scand. J. Rheumatol. 31 2002 198 204
    • (2002) Scand. J. Rheumatol. , vol.31 , pp. 198-204
    • Bush, K.A.1    Walker, J.S.2    Frazier, J.3
  • 31
    • 0023694150 scopus 로고
    • Correlation of plasma interleukin 1 levels with disease activity in rheumatoid arthritis
    • J.A. Eastgate, J.A. Symons, and N.C. Wood Correlation of plasma interleukin 1 levels with disease activity in rheumatoid arthritis Lancet 2 8613 1988 706 709
    • (1988) Lancet , vol.2 , Issue.8613 , pp. 706-709
    • Eastgate, J.A.1    Symons, J.A.2    Wood, N.C.3
  • 32
    • 0029979369 scopus 로고
    • Biologic basis for interleukin-1 in disease
    • C.A. Dinarello Biologic basis for interleukin-1 in disease Blood 87 1993 2095 2147
    • (1993) Blood , vol.87 , pp. 2095-2147
    • Dinarello, C.A.1
  • 33
    • 0027287950 scopus 로고
    • Interleukin-1 signaling occurs exclusively via the type I receptor
    • J.E. Sims, M.A. Gayle, and J.L. Slack Interleukin-1 signaling occurs exclusively via the type I receptor Proc. Natl. Acad. Sci. USA 90 1993 6155 6159
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6155-6159
    • Sims, J.E.1    Gayle, M.A.2    Slack, J.L.3
  • 34
    • 18244425295 scopus 로고    scopus 로고
    • The pivotal role of interleukin-1 in the clinical manifestations of rheumatoid arthritis
    • J.M. Dayer The pivotal role of interleukin-1 in the clinical manifestations of rheumatoid arthritis Rheumatology 42 Suppl. 2 2003 ii3 ii10
    • (2003) Rheumatology , vol.42 , Issue.2 SUPPL.
    • Dayer, J.M.1
  • 35
    • 0034677123 scopus 로고    scopus 로고
    • Development of chronic inflammatory arthroplasty resembling rheumatoid arthritis in interleukin 1 receptor antagonist deficient mice
    • R. Horai, S. Saijo, and H. Tanioka Development of chronic inflammatory arthroplasty resembling rheumatoid arthritis in interleukin 1 receptor antagonist deficient mice J. Exp. Med. 191 2 2000 313 320
    • (2000) J. Exp. Med. , vol.191 , Issue.2 , pp. 313-320
    • Horai, R.1    Saijo, S.2    Tanioka, H.3
  • 36
    • 0035306510 scopus 로고    scopus 로고
    • Uncoupling of inflammatory and destructive mechanisms in arthritis
    • W.B. van den Berg Uncoupling of inflammatory and destructive mechanisms in arthritis Semin. Arthritis Rheum. 30 5 Suppl. 2 2001 7 16
    • (2001) Semin. Arthritis Rheum. , vol.30 , Issue.5 SUPPL. 2 , pp. 7-16
    • Van Den Berg, W.B.1
  • 37
    • 17444394445 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist
    • B. Bresnihan, J.M. Alvaro-Garcia, and M. Cobby Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist Arthritis Rheum. 41 12 1998 2196 2204
    • (1998) Arthritis Rheum. , vol.41 , Issue.12 , pp. 2196-2204
    • Bresnihan, B.1    Alvaro-Garcia, J.M.2    Cobby, M.3
  • 38
    • 0036190776 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: results of a twenty-four week, multicenter, randomized, double-blind, placebo-controlled trial
    • S. Cohen, E. Hurd, and J. Cush Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: results of a twenty-four week, multicenter, randomized, double-blind, placebo-controlled trial Arthritis Rheum. 46 3 2002 614 624
    • (2002) Arthritis Rheum. , vol.46 , Issue.3 , pp. 614-624
    • Cohen, S.1    Hurd, E.2    Cush, J.3
  • 39
    • 0034083128 scopus 로고    scopus 로고
    • A multicenter, double-blind, dose-ranging, randomized, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis: radiologic progression and correlation of Genant and Larsen scores
    • Y. Jiang, H.K. Genant, and I. Watt A multicenter, double-blind, dose-ranging, randomized, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis: radiologic progression and correlation of Genant and Larsen scores Arthritis Rheum. 43 2000 1001 1009
    • (2000) Arthritis Rheum. , vol.43 , pp. 1001-1009
    • Jiang, Y.1    Genant, H.K.2    Watt, I.3
  • 40
    • 0036845130 scopus 로고    scopus 로고
    • Long-term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis: extension phase of a randomized double-blind, placebo-controlled trial
    • G. Nuki, B. Bresnihan, and M.B. Bear Long-term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis: extension phase of a randomized double-blind, placebo-controlled trial Arthritis Rheum. 46 11 2002 2838 2846
    • (2002) Arthritis Rheum. , vol.46 , Issue.11 , pp. 2838-2846
    • Nuki, G.1    Bresnihan, B.2    Bear, M.B.3
  • 41
    • 0142205811 scopus 로고    scopus 로고
    • A randomized double blind controlled study evaluating the safety and efficacy of etanercept versus etanercept plus anakinra in patients with rheumatoid arthritis
    • M. Genovese, S. Cohen, and L. Moreland A randomized double blind controlled study evaluating the safety and efficacy of etanercept versus etanercept plus anakinra in patients with rheumatoid arthritis Ann. Rheum. Dis. 62 Suppl. 1 2003 66
    • (2003) Ann. Rheum. Dis. , vol.62 , Issue.1 SUPPL. , pp. 66
    • Genovese, M.1    Cohen, S.2    Moreland, L.3
  • 42
    • 0034544946 scopus 로고    scopus 로고
    • Combination benefit of treatment with the cytokine inhibitors interleukin-1 receptor antagonist and PEGylated soluble tumor necrosis factor receptor type I in animal models with rheumatoid arthritis
    • A.M. Bendele, E.S. Chlipala, and J. Scherrer Combination benefit of treatment with the cytokine inhibitors interleukin-1 receptor antagonist and PEGylated soluble tumor necrosis factor receptor type I in animal models with rheumatoid arthritis Arthritis Rheum. 43 12 2000 2648 2659
    • (2000) Arthritis Rheum. , vol.43 , Issue.12 , pp. 2648-2659
    • Bendele, A.M.1    Chlipala, E.S.2    Scherrer, J.3
  • 43
    • 0037231664 scopus 로고    scopus 로고
    • Cytokine traps: multi-componenet, high-affinity blockers of cytokine action
    • A.N. Economides, L.R. Carpenter, and J.S. Rudge Cytokine traps: multi-componenet, high-affinity blockers of cytokine action Nat. Med. 9 2003 47 52
    • (2003) Nat. Med. , vol.9 , pp. 47-52
    • Economides, A.N.1    Carpenter, L.R.2    Rudge, J.S.3
  • 45
    • 0029971948 scopus 로고    scopus 로고
    • Interleukin-1β converting enzyme inhibition blocks progression of Type II collagen-induced arthritis in mice
    • G. Ku, T. Faust, and L.L. Lauffer Interleukin-1β converting enzyme inhibition blocks progression of Type II collagen-induced arthritis in mice Cytokine 8 1996 377 386
    • (1996) Cytokine , vol.8 , pp. 377-386
    • Ku, G.1    Faust, T.2    Lauffer, L.L.3
  • 47
    • 0033783333 scopus 로고    scopus 로고
    • IL-6 and its soluble receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage
    • C.R. Flannery, C.B. Little, C.E. Hughes, C.L. Curtis, B. Caterson, and S.A. Jones IL-6 and its soluble receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage Matrix Biol. 19 2000 549 553
    • (2000) Matrix Biol. , vol.19 , pp. 549-553
    • Flannery, C.R.1    Little, C.B.2    Hughes, C.E.3    Curtis, C.L.4    Caterson, B.5    Jones, S.A.6
  • 48
    • 0025967588 scopus 로고
    • Reciprocal expression of NF-IL6 and C/EBP in hepatocytes: possible involvement of NF-IL6 in acute phase protein gene expression
    • H. Isshiki, S. Akira, T. Sugita, Y. Nishio, S. Hashimoto, and T. Pawlowski Reciprocal expression of NF-IL6 and C/EBP in hepatocytes: possible involvement of NF-IL6 in acute phase protein gene expression New Biol. 3 1991 63 70
    • (1991) New Biol. , vol.3 , pp. 63-70
    • Isshiki, H.1    Akira, S.2    Sugita, T.3    Nishio, Y.4    Hashimoto, S.5    Pawlowski, T.6
  • 49
    • 0034213975 scopus 로고    scopus 로고
    • Receptor recognition by gp130 cytokines
    • J. Bravo, and J.K. Heath Receptor recognition by gp130 cytokines EMBO J. 19 2000 2399 2411
    • (2000) EMBO J. , vol.19 , pp. 2399-2411
    • Bravo, J.1    Heath, J.K.2
  • 50
    • 0026527781 scopus 로고
    • Interleukin 6 levels in synovial fluids of patients with different arthritides: correlation with local IgM rheumatoid factor and systemic acute phase protein production
    • M. Brozik, I. Rosztoczy, K. Meretey, G. Balint, M. Gaal, and Z. Balogh Interleukin 6 levels in synovial fluids of patients with different arthritides: correlation with local IgM rheumatoid factor and systemic acute phase protein production J. Rheumatol. 19 1992 63 68
    • (1992) J. Rheumatol. , vol.19 , pp. 63-68
    • Brozik, M.1    Rosztoczy, I.2    Meretey, K.3    Balint, G.4    Gaal, M.5    Balogh, Z.6
  • 51
    • 0026537579 scopus 로고
    • Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis
    • B. Dasgupta, M. Corkill, B. Kirkham, T. Gibson, and G. Panayi Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis J. Rheumatol. 19 1992 22 25
    • (1992) J. Rheumatol. , vol.19 , pp. 22-25
    • Dasgupta, B.1    Corkill, M.2    Kirkham, B.3    Gibson, T.4    Panayi, G.5
  • 52
    • 13344250490 scopus 로고    scopus 로고
    • Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation
    • S. Kotake, K. Sato, K.J. Kim, N. Takahashi, N. Udagawa, and I. Nakamura Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation J. Bone Miner. Res. 11 1996 88 95
    • (1996) J. Bone Miner. Res. , vol.11 , pp. 88-95
    • Kotake, S.1    Sato, K.2    Kim, K.J.3    Takahashi, N.4    Udagawa, N.5    Nakamura, I.6
  • 54
    • 0032429668 scopus 로고    scopus 로고
    • Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis
    • N. Takagi, M. Mihara, Y. Moriya, N. Nishimoto, K. Yoshizaki, and T. Kishimoto Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis Arthritis Rheum. 41 1998 2117 2121
    • (1998) Arthritis Rheum. , vol.41 , pp. 2117-2121
    • Takagi, N.1    Mihara, M.2    Moriya, Y.3    Nishimoto, N.4    Yoshizaki, K.5    Kishimoto, T.6
  • 55
    • 0035090840 scopus 로고    scopus 로고
    • Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys
    • M. Mihara, M. Kotoh, N. Nishimoto, Y. Oda, E. Kumagai, and N. Takagi Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys Clin. Immunol. 98 2001 319 326
    • (2001) Clin. Immunol. , vol.98 , pp. 319-326
    • Mihara, M.1    Kotoh, M.2    Nishimoto, N.3    Oda, Y.4    Kumagai, E.5    Takagi, N.6
  • 56
    • 0036899812 scopus 로고    scopus 로고
    • Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial
    • E.H. Choy, D.A. Isenberg, T. Garrood, S. Farrow, Y. Ioannou, and H. Bird Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial Arthritis Rheum. 46 2002 3143 3150
    • (2002) Arthritis Rheum. , vol.46 , pp. 3143-3150
    • Choy, E.H.1    Isenberg, D.A.2    Garrood, T.3    Farrow, S.4    Ioannou, Y.5    Bird, H.6
  • 57
    • 2542441032 scopus 로고    scopus 로고
    • Anti-interleukin-6 receptor antibody therapy normalizes serum vascular endotherial growth factor (VEGF) in patients with rheumatoid arthritis (RA)
    • N. Nishimoto, K. Nakahara, and T. Kishimoto Anti-interleukin-6 receptor antibody therapy normalizes serum vascular endotherial growth factor (VEGF) in patients with rheumatoid arthritis (RA) Arthritis Rheum. 46 Suppl. 2002 250
    • (2002) Arthritis Rheum. , vol.46 , Issue.SUPPL. , pp. 250
    • Nishimoto, N.1    Nakahara, K.2    Kishimoto, T.3
  • 58
    • 0142132569 scopus 로고    scopus 로고
    • Charisma Study Group. A double-blind, randomised, parallel group, controlled, dose ranging study of the safety, tolerability, pharmacokinetics and efficacy of repeat doses of MRA given alone or in combination with methotrexate in patients with rheumatoid arthritis
    • R. Maini Charisma Study Group. A double-blind, randomised, parallel group, controlled, dose ranging study of the safety, tolerability, pharmacokinetics and efficacy of repeat doses of MRA given alone or in combination with methotrexate in patients with rheumatoid arthritis Ann. Rheum. Dis. 62 Suppl. 2003 64
    • (2003) Ann. Rheum. Dis. , vol.62 , Issue.SUPPL. , pp. 64
    • Maini, R.1
  • 59
    • 3342897676 scopus 로고    scopus 로고
    • Interleukin-15: a new cytokine target for the treatment of inflammatory diseases
    • I.B. McInnes, and J.A. Gracie Interleukin-15: a new cytokine target for the treatment of inflammatory diseases Curr. Opin. Pharmacol. 4 2004 392 397
    • (2004) Curr. Opin. Pharmacol. , vol.4 , pp. 392-397
    • McInnes, I.B.1    Gracie, J.A.2
  • 60
    • 0141987785 scopus 로고    scopus 로고
    • Increased serum levels of interleukin-15 in rheumatoid arthritis with long-term disease
    • I. Gonzalez-Alvaro, A.M. Ortiz, and R. Garcia-Vicuna Increased serum levels of interleukin-15 in rheumatoid arthritis with long-term disease Clin. Exp. Rheumatol. 21 2003 639 642
    • (2003) Clin. Exp. Rheumatol. , vol.21 , pp. 639-642
    • Gonzalez-Alvaro, I.1    Ortiz, A.M.2    Garcia-Vicuna, R.3
  • 61
    • 0030900454 scopus 로고    scopus 로고
    • In vivo gene expression of type 1 and type 2 cytokines in synovial tissues from patients in early stages of rheumatoid, reactive, and undifferentiated arthritis
    • S. Kotake, H.R. Schumacher Jr., and C.H. Yarboro In vivo gene expression of type 1 and type 2 cytokines in synovial tissues from patients in early stages of rheumatoid, reactive, and undifferentiated arthritis Proc. Assoc. Am. Phys. 109 1997 286
    • (1997) Proc. Assoc. Am. Phys. , vol.109 , pp. 286
    • Kotake, S.1    Schumacher Jr., H.R.2    Yarboro, C.H.3
  • 62
    • 0036839148 scopus 로고    scopus 로고
    • Role of interleukin 15 and interleukin 18 in inflammatory response
    • F.Y. Liew, and I.B. McInnes Role of interleukin 15 and interleukin 18 in inflammatory response Ann. Rheum. Dis. 61 Suppl. 2 2002 ii100 ii102
    • (2002) Ann. Rheum. Dis. , vol.61 , Issue.2 SUPPL.
    • Liew, F.Y.1    McInnes, I.B.2
  • 63
    • 0032103993 scopus 로고    scopus 로고
    • Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunopathology
    • H. Ruchatz, B.P. Leung, and X. Wei Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunopathology J. Immunol. 160 1998 5654 5660
    • (1998) J. Immunol. , vol.160 , pp. 5654-5660
    • Ruchatz, H.1    Leung, B.P.2    Wei, X.3
  • 64
    • 6344269986 scopus 로고    scopus 로고
    • Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis
    • S. Ferrari-Lacraz, E. Zanelli, and M. Neuberg Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis J. Immunol. 173 2004 5818 5826
    • (2004) J. Immunol. , vol.173 , pp. 5818-5826
    • Ferrari-Lacraz, S.1    Zanelli, E.2    Neuberg, M.3
  • 65
    • 14844289358 scopus 로고    scopus 로고
    • Safety and efficacy of a human monoclonal antibody to IL-15 (AMG 714) in patients with rheumatoid arthritis: results from a multicenter, randomized, double-blind, placebo-controlled trial
    • San Antonio, Texas, abstract 527.
    • I.B. McInnes, R. Martin, I. Zimmerman-Gorska, et al. Safety and efficacy of a human monoclonal antibody to IL-15 (AMG 714) in patients with rheumatoid arthritis: results from a multicenter, randomized, double-blind, placebo-controlled trial, in: Proceedings of the 68th Annual Scientific Meeting of American College of Rheumatology, San Antonio, Texas, 2004, abstract 527.
    • (2004) Proceedings of the 68th Annual Scientific Meeting of American College of Rheumatology
    • McInnes, I.B.1    Martin, R.2    Zimmerman-Gorska, I.3
  • 66
    • 0031987322 scopus 로고    scopus 로고
    • Interleukin-18 (IFNγ-inducing factor) induces IL-8 and IL-1β via TNFα production from non-CD14+ human blood mononuclear cells
    • A.J. Puren, G. Fantuzzi, Y. Gu, M.S.-S. Su, and C.A. Dinarello Interleukin-18 (IFNγ-inducing factor) induces IL-8 and IL-1β via TNFα production from non-CD14+ human blood mononuclear cells J. Clin. Invest. 101 1998 711 724
    • (1998) J. Clin. Invest. , vol.101 , pp. 711-724
    • Puren, A.J.1    Fantuzzi, G.2    Gu, Y.3    Su, M.S.-S.4    Dinarello, C.A.5
  • 67
    • 0031004174 scopus 로고    scopus 로고
    • Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production
    • T. Ghayur, S. Bannerjee, and M. Hugunin Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production Nature 386 1997 619 623
    • (1997) Nature , vol.386 , pp. 619-623
    • Ghayur, T.1    Bannerjee, S.2    Hugunin, M.3
  • 68
    • 0037331297 scopus 로고    scopus 로고
    • Association of interleukin-18 expression with enhanced levels of both interleukin-1 beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritis
    • L.A. Joosten, T.R. Radstake, and E. Lubberts Association of interleukin-18 expression with enhanced levels of both interleukin-1 beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritis Arthritis Rheum. 48 2003 339 347
    • (2003) Arthritis Rheum. , vol.48 , pp. 339-347
    • Joosten, L.A.1    Radstake, T.R.2    Lubberts, E.3
  • 70
    • 0035173776 scopus 로고    scopus 로고
    • Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18
    • X.Q. Wei, B.P. Leung, H.M. Arthur, I.B. McInnes, and F.Y. Liew Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18 J. Immunol. 166 2001 517 521
    • (2001) J. Immunol. , vol.166 , pp. 517-521
    • Wei, X.Q.1    Leung, B.P.2    Arthur, H.M.3    McInnes, I.B.4    Liew, F.Y.5
  • 73
    • 0023811772 scopus 로고
    • Phenotypic analysis of synovial tissue and peripheral blood lymphocytes isolated from patients with rheumatoid arthritis
    • J.J. Cush, and P.E. Lipsky Phenotypic analysis of synovial tissue and peripheral blood lymphocytes isolated from patients with rheumatoid arthritis Arthritis Rheum. 31 1988 1230 1238
    • (1988) Arthritis Rheum. , vol.31 , pp. 1230-1238
    • Cush, J.J.1    Lipsky, P.E.2
  • 74
    • 0017878054 scopus 로고
    • Association of the B-cell alloantigen DRw4 with rheumatoid arthritis
    • P. Stastny Association of the B-cell alloantigen DRw4 with rheumatoid arthritis New Engl. J. Med. 298 1978 869 871
    • (1978) New Engl. J. Med. , vol.298 , pp. 869-871
    • Stastny, P.1
  • 75
    • 0025971681 scopus 로고
    • The CD28 ligand B7/BB1 provides costimulatory signal for alloactivation of CD4+ T cells
    • L. Koulova, E.A. Clark, G. Shu, and B. Dupont The CD28 ligand B7/BB1 provides costimulatory signal for alloactivation of CD4+ T cells J. Exp. Med. 173 1991 759 762
    • (1991) J. Exp. Med. , vol.173 , pp. 759-762
    • Koulova, L.1    Clark, E.A.2    Shu, G.3    Dupont, B.4
  • 76
    • 0028675006 scopus 로고
    • Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
    • P.S. Linsley, J.L. Greene, W. Brady, J. Bajorath, J.A. Ledbetter, and R. Peach Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors Immunity 1 1994 793 801
    • (1994) Immunity , vol.1 , pp. 793-801
    • Linsley, P.S.1    Greene, J.L.2    Brady, W.3    Bajorath, J.4    Ledbetter, J.A.5    Peach, R.6
  • 77
    • 0027397169 scopus 로고
    • Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1
    • P. Tan, C. Anasetti, J.A. Hansen, J. Melrose, M. Brunvand, and J. Bradshaw Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1 J. Exp. Med. 177 1993 165 173
    • (1993) J. Exp. Med. , vol.177 , pp. 165-173
    • Tan, P.1    Anasetti, C.2    Hansen, J.A.3    Melrose, J.4    Brunvand, M.5    Bradshaw, J.6
  • 78
    • 0028244233 scopus 로고
    • Expression of functional B7 and CTLA4 on rheumatoid synovial T cells
    • J. Verwilghen, R. Lovis, and M. De Boer Expression of functional B7 and CTLA4 on rheumatoid synovial T cells J. Immunol. 153 1994 1378 1385
    • (1994) J. Immunol. , vol.153 , pp. 1378-1385
    • Verwilghen, J.1    Lovis, R.2    De Boer, M.3
  • 80
    • 0029849012 scopus 로고    scopus 로고
    • Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: requirement for both B7-1 and B7-2
    • L.M.C. Webb, M.J. Walmsley, and M. Feldmann Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: requirement for both B7-1 and B7-2 Eur. J. Immunol. 26 1996 2320 2328
    • (1996) Eur. J. Immunol. , vol.26 , pp. 2320-2328
    • Webb, L.M.C.1    Walmsley, M.J.2    Feldmann, M.3
  • 81
    • 0033135564 scopus 로고    scopus 로고
    • CTLA4Ig-mediated blockade of T-cell costimulation in patients with Psoriasis vulgaris
    • J.R. Abrams, M.G. Lebwohl, and C.A. Guzzo CTLA4Ig-mediated blockade of T-cell costimulation in patients with Psoriasis vulgaris J. Clin. Invest. 103 1999 1243 1252
    • (1999) J. Clin. Invest. , vol.103 , pp. 1243-1252
    • Abrams, J.R.1    Lebwohl, M.G.2    Guzzo, C.A.3
  • 82
    • 0034605033 scopus 로고    scopus 로고
    • Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-iImmunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells
    • J.R. Abrams, S.L. Kelley, and E. Hayes Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-iImmunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells J. Exp. Med. 192 2000 681 694
    • (2000) J. Exp. Med. , vol.192 , pp. 681-694
    • Abrams, J.R.1    Kelley, S.L.2    Hayes, E.3
  • 83
    • 0036275436 scopus 로고    scopus 로고
    • Costimulatory blockade in patients with rheumatoid arthritis. A pilot, dose-finding, double-blind, placebo-controlled clinical trial evaluating CTLA-4 and LEA29Y eighty-five days after the first infusion
    • L.W. Moreland, R. Alten, F. Van den Bosch, T. Appelboom, M. Leon, and P. Emery Costimulatory blockade in patients with rheumatoid arthritis. A pilot, dose-finding, double-blind, placebo-controlled clinical trial evaluating CTLA-4 and LEA29Y eighty-five days after the first infusion Arthritis Rheum. 46 2002 1470 1479
    • (2002) Arthritis Rheum. , vol.46 , pp. 1470-1479
    • Moreland, L.W.1    Alten, R.2    Van Den Bosch, F.3    Appelboom, T.4    Leon, M.5    Emery, P.6
  • 86
    • 0034843773 scopus 로고    scopus 로고
    • Ectopic lymphoid organogenesis: a fast track for autoimmunity
    • C.W. Weyand, P.J. Kurtin, and J.J. Goronzy Ectopic lymphoid organogenesis: a fast track for autoimmunity Am J. Pathol. 159 2001 787 793
    • (2001) Am J. Pathol. , vol.159 , pp. 787-793
    • Weyand, C.W.1    Kurtin, P.J.2    Goronzy, J.J.3
  • 88
    • 0026730111 scopus 로고
    • Clinical significance of rheumatoid factors in early rheumatoid arthritis: results of a follow up study
    • D. van Zeben, J.M. Hazes, and A.H. Zwinderman Clinical significance of rheumatoid factors in early rheumatoid arthritis: results of a follow up study Ann. Rheum. Dis. 51 1992 1029 1035
    • (1992) Ann. Rheum. Dis. , vol.51 , pp. 1029-1035
    • Van Zeben, D.1    Hazes, J.M.2    Zwinderman, A.H.3
  • 89
    • 0034757676 scopus 로고    scopus 로고
    • Specific presence of intracellular citrullinated proteins in rheumatoid arthritis synovium: relevance to antifilaggrin autoantibodies
    • D. Baeten, I. Peene, and A. Union Specific presence of intracellular citrullinated proteins in rheumatoid arthritis synovium: relevance to antifilaggrin autoantibodies Arthritis Rheum. 44 2001 2255 2262
    • (2001) Arthritis Rheum. , vol.44 , pp. 2255-2262
    • Baeten, D.1    Peene, I.2    Union, A.3
  • 90
    • 1542283760 scopus 로고    scopus 로고
    • Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study
    • F.A. van Gaalen, S.P. Linn-Rasker, and W.J. van Venrooij Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study Arthritis Rheum. 50 2004 709 715
    • (2004) Arthritis Rheum. , vol.50 , pp. 709-715
    • Van Gaalen, F.A.1    Linn-Rasker, S.P.2    Van Venrooij, W.J.3
  • 91
    • 0037732689 scopus 로고    scopus 로고
    • The role of B cells in rheumatoid arthritis: mechanisms and therapeutic targets
    • T. Dorner, and G.R. Burmester The role of B cells in rheumatoid arthritis: mechanisms and therapeutic targets Curr. Opin. Rheumatol. 15 2003 246 252
    • (2003) Curr. Opin. Rheumatol. , vol.15 , pp. 246-252
    • Dorner, T.1    Burmester, G.R.2
  • 92
    • 0033577903 scopus 로고    scopus 로고
    • A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus
    • O.T. Chan, L.G. Hannum, and A.M. Haberman A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus J. Exp. Med. 189 1999 1639 1648
    • (1999) J. Exp. Med. , vol.189 , pp. 1639-1648
    • Chan, O.T.1    Hannum, L.G.2    Haberman, A.M.3
  • 93
    • 0035888030 scopus 로고    scopus 로고
    • T cell activation in rheumatoid synovium is B cell dependent
    • S. Takemura, P.A. Klimiuk, and A. Braun T cell activation in rheumatoid synovium is B cell dependent J. Immunol. 167 2001 4710 4718
    • (2001) J. Immunol. , vol.167 , pp. 4710-4718
    • Takemura, S.1    Klimiuk, P.A.2    Braun, A.3
  • 94
    • 2542490265 scopus 로고    scopus 로고
    • B lymphocyte depletion therapy with rituximab in rheumatoid arthritis
    • J.C. Edwards, M.J. Leandro, and G. Cambridge B lymphocyte depletion therapy with rituximab in rheumatoid arthritis Rheum. Dis. Clin. N Am. 30 2004 393 403
    • (2004) Rheum. Dis. Clin. N Am. , vol.30 , pp. 393-403
    • Edwards, J.C.1    Leandro, M.J.2    Cambridge, G.3
  • 95
    • 0035093233 scopus 로고    scopus 로고
    • Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes
    • J.C. Edwards, and G. Cambridge Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes Rheumatology 40 2001 205 211
    • (2001) Rheumatology , vol.40 , pp. 205-211
    • Edwards, J.C.1    Cambridge, G.2
  • 96
    • 0036785351 scopus 로고    scopus 로고
    • Clinical outcome in 22 patients with rheumatoid arthritis treated with B lymphocyte depletion
    • M.J. Leandro, J.C. Edwards, and G. Cambridge Clinical outcome in 22 patients with rheumatoid arthritis treated with B lymphocyte depletion Ann. Rheum. Dis. 61 2002 883 888
    • (2002) Ann. Rheum. Dis. , vol.61 , pp. 883-888
    • Leandro, M.J.1    Edwards, J.C.2    Cambridge, G.3
  • 97
    • 0036676817 scopus 로고    scopus 로고
    • Efficacy of selective B cell blockade in the treatment of rheumatoid arthritis: evidence for a pathogenetic role of B cells
    • S. De Vita, F. Zaja, and S. Sacco Efficacy of selective B cell blockade in the treatment of rheumatoid arthritis: evidence for a pathogenetic role of B cells Arthritis Rheum. 46 2002 2029 2033
    • (2002) Arthritis Rheum. , vol.46 , pp. 2029-2033
    • De Vita, S.1    Zaja, F.2    Sacco, S.3
  • 98
    • 2942537697 scopus 로고    scopus 로고
    • Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis
    • J.C. Edwards, L. Szczepanski, and J. Szechinski Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis N Engl. J. Med. 350 2004 2572 2581
    • (2004) N Engl. J. Med. , vol.350 , pp. 2572-2581
    • Edwards, J.C.1    Szczepanski, L.2    Szechinski, J.3


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