IL-6 and its soluble receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage

Matrix Biology

Volumn 19, Issue 6, 2000, Pages 549-553

  Flannery, Carl R ^a   Little, Chris B ^a   Hughes, Clare E ^a   Curtis, Clare L ^a   Caterson, Bruce ^a   Jones, Simon A ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

ADAMTS; Aggrecan; Arthritis; Cytokines; Synovial joint

Indexed keywords

AGGRECAN; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTHRITIS; ARTICLE; ARTICULAR CARTILAGE; CONTROLLED STUDY; COW; ENZYME DEGRADATION; EXPLANT; IMMUNOBLOTTING; JOINT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ANIMAL; CARTILAGE, ARTICULAR; CATTLE; ENDOPEPTIDASES; GENE EXPRESSION; INTERLEUKIN-6; METALLOENDOPEPTIDASES; ORGAN CULTURE; PROTEOGLYCANS; RECEPTORS, INTERLEUKIN-6; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T;

BOVINAE;

EID: 0033783333     PISSN: 0945053X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0945-053X(00)00111-6     Document Type: Article

References (17)

1. Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family
2. Interleukin 6 is required for the development of collagen-induced arthritis
3. Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase
4. Interleukin-1beta induces synthesis and secretion of interleukin-6 in human chondrocytes
5. Interleukin 6 knock-out mice are resistant to antigen-induced experimental arthritis
6. Mechanisms involved in cartilage proteoglycan catabolism
7. n-3 fatty acids specifically modulate catabolic factors involved in articular cartilage degradation
8. Concentrations and origins of soluble interleukin 6 receptor-alpha in serum and synovial fluid
9. Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes
10. IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro
11. Effects of interleukin-6 on proliferation and proteoglycan metabolism in articular chondrocyte cultures
12. Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro
13. Comparative and combined effects of interleukin 6, interleukin 1 beta, and tumor necrosis factor alpha on proteoglycan metabolism of human articular chondrocytes cultured in agarose
14. The role of IL-4 and IL-6 in IL-1-dependent cartilage matrix degradation
15. Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins
16. Soluble interleukin 6 (IL-6) receptor and IL-6 levels in serum and synovial fluid of patients with different arthropathies