The role of T cells in the immunopathogenesis of rheumatoid arthritis

Arthritis and Rheumatism

Volumn 40, Issue 4, 1997, Pages 598-609

  Fox, David A ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYTOKINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; RECEPTOR SUBTYPE; T LYMPHOCYTE RECEPTOR;

CELL INTERACTION; HUMAN; IMMUNOPATHOGENESIS; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; SYNOVIUM; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ARTHRITIS, RHEUMATOID; BIOLOGICAL MARKERS; CELL COMMUNICATION; CYTOKINES; HUMANS; MAJOR HISTOCOMPATIBILITY COMPLEX; SYNOVIAL MEMBRANE; T-LYMPHOCYTES;

EID: 0030970556     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.1780400403     Document Type: Review

References (131)

1. Janossy G, Panayi GS, Duke O, Bofill M, Poulter LW: Goldstein G: Rheumatoid arthritis: a disease of T-lymphocyte/macrophage immunoregulation. Lancet 2:839-842, 1981
2. Stamenkovic I, Stegagno M, Wright KA, Krane SM, Amento EP, Colvin RB, Duquesnoy RJ, Kurnick JT: Clonal dominance among T-lymphocyte infiltrates in arthritis. Proc Natl Acad Sci U S A 85:1179-1183, 1988
3. Duby AD, Sinclair AK, Osborne-Lawrence SL, Zeldes W, Kan L, Fox DA: Clonal heterogeneity of synovial fluid T lymphocytes from patients with rheumatoid arthritis. Proc Natl Acad Sci U S A 86:6206-6210, 1989
4. Cooper SM, Dier DL, Roessner KP, Budd RC, Nicklas JA: Diversity of rheumatoid synovial tissue T cells by T cell receptor analysis: oligoclonal expansion in interleukin-2-responsive cells. Arthritis Rheum 34:537-546, 1991
5. Korthäuer U, Hennerkes B, Menninger H, Mages HW, Zacher J, Potocnik AJ, Emmrich F, Kroczek RA: Oligoclonal T cells in rheumatoid arthritis: identification strategy and molecular characterization of a clonal T-cell receptor. Scand J Immunol 36:855-863, 1992
6. Fox DA, Millard JA, Kan L, Zeldes WS, Davis W, Higgs J, Emmrich F, Kinne R: Activation pathways of synovial T lymphocytes: expression and function of the UM4D4/CDw60 antigen. J Clin Invest 86:1124-1136, 1990
7. Struyk L, Hawes GE, Chatila MK, Breedveld FC, Kurnick JT, van den Elsen PJ: T cell receptors in rheumatoid arthritis. Arthritis Rheum 38:577-589, 1995
8. Williams WV, Fang Q, Demarco D, VonFeldt J, Zurier RB, Weiner DB: Restricted heterogeneity of T cell receptor transcripts in rheumatoid synovium. J Clin Invest 90:326-333, 1992
9. Howell MD, Diveley JP, Lundeen KA, Esty A, Winters ST, Carlo DJ, Brostoff SW: Limited T-cell receptor β-chain heterogeneity among interleukin 2 receptor-positive synovial T cells suggests a role for superantigen in rheumatoid arthritis. Proc Natl Acad Sci U S A 88:10921-10925, 1991
10. Davey MP, Munkirs DD: Patterns of T cell receptor variable β gene expression by synovial fluid and peripheral blood T cells in rheumatoid arthritis. Clin Immunol Immunopathol 68:79-87, 1993
11. Lunardi C, Marguerie C, So AK: An altered repertoire of T cell receptor V gene expression by rheumatoid synovial fluid T lymphocytes. Clin Exp Immunol 90:440-446, 1992
12. Jenkins RN, Nikaein A, Zimmerman A, Meek K, Lipsky PE: T cell receptor Vβ gene bias in rheumatoid arthritis. J Clin Invest 92:2688-2701, 1993
13. β6 in rheumatoid synovial fluid T cells. Arthritis Rheum 37:1627-1636, 1994
14. Alam A, Lulé J, Coppin H, Lambert N, Maziéres B, de Préval C, Cantagrel A: T-cell receptor variable region of the β-chain gene use in peripheral blood and multiple synovial membranes during rheumatoid arthritis. Hum Immunol 42:331-339, 1995
15. β transcripts in synovial fluid T cells in early stages of rheumatoid arthritis. Arthritis Rheum 39:454- 462, 1996
16. Paliard X, West SG, Lafferty FA, Clements JR, Kappler JW, Marrack P, Kotzin BL: Evidence for the effects of a superantigen in rheumatoid arthritis. Science 253:325-329, 1991
17. α2 genes in synovial fluid but not in peripheral blood. Arthritis Rheum 36:1234-1243, 1993
18. Zagon G, Tumang JR, Li Y, Friedman SM, Crow MK: Increased frequency of Vβl7-positive T cells in patients with rheumatoid arthritis. Arthritis Rheum 37:1431-1440, 1994
19. Travaglio-Encinoza A, Chaouni I, Dersimonian H, Jorgensen C, Simony-Lafontaine J, Romagné F, Sany J, Dupuy d'Angeac A, Brenner MB, Rème T: T cell receptor distribution in rheumatoid synovial follicles. J Rheumatol 22:394-399, 1995
20. Ikeda Y, Masuko K, Nakai Y, Kato T, Hasanuma T, Yoshino S-I, Mizushima Y, Nishioka K, Yamamoto K: High frequencies of identical T cell clonotypes in synovial tissues of rheumatoid arthritis patients suggest the occurrence of common antigen-driven immune responses. Arthritis Rheum 39:446-453. 1996
21. Alam A, Lambert N, Lulé J, Coppin H, Mazières B, de Préval C, Cantagrel A: Persistence of dominant T cell clones in synovial tissues during rheumatoid arthritis. J Immunol 156:3480-3485, 1996
22. + T cells in rheumatoid arthritis. J Clin Invest 94:2068-2076, 1994
23. González-Quintial R, Baccalà R, Pope RM, Theofilopoulos AN: Identification of clonally expanded T cells in rheumatoid arthritis using a sequence enrichment nuclease assay. J Clin Invest 97:1335-1343, 1996
24. + T cell population of rheumatoid arthritis patients. J Immunol 156:852-858, 1996
25. Kohsaka H, Taniguchi A, Chen PP, Oilier WER, Carson DA: The expressed T cell receptor V gene repertoire of rheumatoid arthritis monozygotic twins: rapid analysis by anchored polymerase chain reaction and enzyme-linked immunosorbent assay. Eur J Immunol 23:1895-1901, 1993
26. Jendro MC, Ganten T, Matteson EL, Weyand CM, Goronzy JJ: Emergence of oligoclonal T cell populations following therapeutic T cell depletion in rheumatoid arthritis. Arthritis Rheum 38:1242-1251, 1995
27. Mima T, Saeki Y, Ohshima S, Nishimoto N, Matsushita M, Shimizu M, Kobayashi Y, Nomura T, Kishimoto T: Transfer of rheumatoid arthritis into severe combined immunodeficient mice: the pathogenetic implications of T cell population oligoclonally expanding in the rheumatoid joints. J Clin Invest 96: 1746-1758, 1995
28. Fox DA, Smith BR: Evidence for oligoclonal B cell expansion in the peripheral blood of patients with rheumatoid arthritis. Ann Rheum Dis 45:991-995, 1986
29. McGee B, Small RE, Singh R, Han J, Carlson PL, Ruddy S, Moxley G: B lymphocytic clonal expansion in rheumatoid arthritis. J Rheumatol 23:36-43, 1996
30. Gause A, Gundlach K, Zdichavsky M, Jacobs G, Koch B, Hopf T, Pfreundschuh M: The B lymphocyte in rheumatoid arthritis: analysis of rearranged Vκ genes from B cells infiltrating the synovial membrane. Eur J Immunol 25:2775-2782, 1995
31. Waase I, Kayser C, Carison PJ, Goronzy JJ, Weyand CM: Oligoclonal T cell proliferation in patients with rheumatoid arthritis and their unaffected siblings. Arthritis Rheum 39:904-913, 1996
32. Nepom BS, Nepom GT: Polyglot and polymorphism: an HLA update. Arthritis Rheum 38:17l5-1721, 1995
33. Gregersen PK, Silver J, Winchester RJ: The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 30: 1205-1213, 1987
34. Weyand CM, McCarthy TG, Goronzy JJ: Correlation between disease phenotype and genetic heterogeneity in rheumatoid arthritis. J Clin Invest 95:2120-2126, 1995
35. Woulfe SL, Bono CP, Zacheis ML, Kirschmann DA, Baudino TA, Swearingen C, Karr RW, Schwartz BD: Negatively charged residues interacting with the p4 pocket confer binding specificity to DRB1*0401. Arthritis Rheum 38:1744-1753, 1995
36. Hammer J, Gallazzi F, Bono E, Karr RW, Guenot J, Valsasnini P, Nagy ZA, Sinigagiia F: Peptide binding specificity of HLA- DR4 molecules: correlation with rheumatoid arthritis association. J Exp Med 181:1847-1855. 1995
37. Kirschmann DA, Duff in KL, Smith CE, Welply JK, Howard SC, Schwartz BD, Woulfe SL: Naturally processed peptides from rheumatoid arthritis associated and non-associated HLA-DR alleles. J Immunol 155:5655-5662, 1995
38. Weyand CM, Xie C, Goronzy JJ: Homozygosity for the HLA-DRB1 allele selects for extra-articular manifestations in rheumatoid arthritis. J Clin Invest 89:2033-2039, 1992
39. Weyand CM, Hicok C, Conn D, Goronzy JJ: The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis. Ann Intern Med 117:801-806, 1992
40. Evans TI, Han J, Singh R, Moxley G: The genotypic distribution of shared-epitope DRB1 alleles suggests a recessive mode of inheritance of the rheumatoid arthritis disease-susceptibility gene. Arthritis Rheum 38:1754-1761, 1995
41. Moreno I, Valenzuela A, García A, Yélamos J, Sánchez B, Hernánz W: Association of the shared epitope with radiological severity of rheumatoid arthritis. J Rheumatol 23:6-9, 1996
42. Zanelli E, Gonzalez-Gay MA, David C: Could HLA-DRB1 be the protective locus in rheumatoid arthritis? Immunol Today 16:274-278, 1995
43. Albani S, Keystone EC, Nelson JL, Oilier WER, la Cava A, Montemayor AC, Weber DA, Montecucco C, Martini A, Carson DA: Positive selection in autoimmunity: abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis. Nature Med 1:448-452, 1995
44. Walser-Kuntz DR, Weyand CM, Weaver AJ, O'Fallon WM, Goronzy JJ: Mechanisms underlying the formation of the T cell receptor repertoire in rheumatoid arthritis. Immunity 2:597-605, 1995
45. Mu H, Charmley P, King M-C, Criswell LA: Synergy between T cell receptor β gene polymorphism and HLA-DR4 in susceptibility to rheumatoid arthritis. Arthritis Rheum 39:931-937, 1996
46. Auger I, Escola JM, Gorvel JP, Roudier J: HLA-DR4 and HLA-DR10 motifs that carry susceptibility to rheumatoid arthritis bind 70-kD heat shock proteins. Nature Med 2:306-310, 1996
47. Morimoto C, Romain PL, Fox DA, Anderson P, DiMaggio M, Levine H, Schlossman SF: Abnormalities in CD4+ T lymphocyte subsets in inflammatory rheumatic diseases. Am J Med 84:817-825, 1988
48. dim, CD27- memory T cells in the peripheral blood, synovial fluid, and synovial tissue of patients with rheumatoid arthritis. Arthritis Rheum 39:844-854, 1996
49. Lunardi C, Marguerie C, Walport MJ, So AK: Tγδ cells and their subsets in blood and synovial fluid from patients with rheumatoid arthritis. Br J Rheumatol 31:527-530, 1992
50. Bucht A, Soderstrom K, Hultman T, Uhlen M, Nilsson E, Kiessling R, Gronberg A: T cell receptor diversity and activation markers in the Vδ1 subset of rheumatoid synovial fluid and peripheral blood T lymphocytes. Eur J Immunol 22:567-574, 1992
51. Meliconi R, Ugucioni M, D'Errico A, Cassisa A, Frizziero L, Facchini A: T-cell receptor gamma-delta positive lymphocytes in synovial membrane. Br J Rheumatol 31:59-61, 1992
52. Holoshitz J, Koning F, Coligan JE, DeBruyn J, Strober S: Isolation of CD4-CD8- mycobacteria-reactive T lymphocyte clones from rheumatoid arthritis synovial fluid. Nature 339:226-229, 1989
53. Hoioshitz J, Vila LM, Keroack BJ, McKinley DR, Bayne NK: Dual antigenic recognition by cloned human γδ T cells. J Clin Invest 89:308-314, 1992
54. Tanaka Y, Morita CT, Tanaka Y, Nieves E, Brenner MB, Bloom BR: Natural and synthetic non-peptide antigens recognized by human γδ T cells. Nature 375:115-158, 1995
55. Haftel HM, Chang Y, Hinderer R, Hanash S, Holoshitz J: Induction of the autoantigen proliferating cell nuclear antigen in T lymphocytes by a mycobacterial antigen. J Clin Invest 94:1365-1372, 1994
56. Vila LM, Haftel HM, Park HS, Lin MS, Romzek NC, Hanash SM, Holoshitz J: Expansion of mycobacteria-reactive γδ T cells by a subset of memory helper T cells. Infect Immun 63:1211-1217, 1995
57. Olive C, Gatenby P, Serjeantson S: Evidence for oligoclonality of T cell receptor δ chain transcripts expressed in rheumatoid arthritis patients. Eur J Immunol 22:2587-2593, 1992
58. Doherty P, Inman R, Laxer R, Silverman E, Yang S, Suurmann I, Pan S: Analysis of T cell receptor γ transcripts in right and left knee synovial fluids of patients with rheumatoid arthritis. J Rheumatol 23:1143-1150, 1996
59. Peterman G, Spencer C, Sperling A, Bluestone J: Role of γδ T cells in murine collagen-induced arthritis. J Immunol 151:6546-6558, 1993
60. Pelegrí C, Kühnlein P, Buchner E, Schmidt CB, Franch A, Castell M, Hünig T, Emrnrich F, Kinne RW: Depletion of γ/δ T cells does not prevent or ameliorate, but rather aggravates, rai adjuvant arthritis. Arthritis Rheum 39:204-215, 1996
61. Verwilghen J, Lovis R, DeBoer M, Linsley P, Haines G, Koch A, Pope RM: Expression of functional B7 and CTLA4 on rheumatoid synovial T cells. J Immunol 153:1378-1385, 1994
62. Sfikakis PP, Zografou A, Viglis V, Iniotaki-Theodoraki A, Piskontaki I, Tsokos GC, Sfikakis P, Choremi-Papadopoulou H: CD28 expression on T cell subsets in vivo and CD28-mediated T cell response in vitro in patients with rheumatoid arthritis. Arthritis Rheum 38:649-654, 1995
63. Liu M, Kohsaka H, Sakurai H, Azuma M, Okumura K, Saito I, Miyasaka N: The presence of costimulatory molecules CD86 and CD28 in rheumatoid arthritis synovium. Arthritis Rheum 39:110-114, 1996
64. - T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity. J Clin Invest 97:2027-2037, 1996
65. Bott CM, Doshi JB, Morimoto C, Romain PL, Fox DA: Functional effects of a novel anti-CD6 monoclonal antibody and definition of four epitopes of the CD6 glycoprotein. Int Immunol 5:783-792, 1993
66. Singer NG, Richardson BC, Powers D, Hooper F, Lialios F, Sanders J, Bott CM, Fox DA: Role of the CD6 glycoprotein in antigen-specific and autoreactive responses of cloned human T lymphocytes. Immunology 88:537-543, 1996
67. Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U, Haynes BF, Aruffo A: Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. J Exp Med 181:2213-2220, 1995
68. Singer NG, Mitra R, Lialios F, Richardson BC, Marks RM, Pesando JM, Fox DA, Nickoloff BJ: CD6 dependent interactions of T cells and keratinocytes: functional evidence for a second CD6 ligand on γ-interferon activated keratinocytes. Immunol Lett (in press)
69. Higgs JB, Zeldes W, Kozarsky K, Schteingart M, Kan L, Bohlke P, Krieger K, Davis W, Fox DA: A novel pathway of human T lymphocyte activation: identification by a monoclonal antibody generated against a rheumatoid synovial T cell line. J Immunol 140:3758-3765, 1988
70. Baadsgaard O, Tong P, Elder JT, Hansen ER, Ho V, Hammerberg C, Lange-Vejlsgaard G, Fox DA, Fisher G, Voorhees JJ, Cooper KD: UM4D4+ (CDw6O) T cells are compartmentalized into psoriatic skin and release lymphokines that induce a keratinocyte phenotype expressed in psoriatic lesions. J Invest Dermatol 95:275-282, 1990
71. Carr K, Lowry T, Li LL, Tsai C, Stoolman L, Fox D: Expression of CD60 on multiple cell lineages in inflammatory synovitis. Lab Invest 73:332-338, 1995
72. Fox DA, Chan LK, Kan L, Baadsgaard O, Cooper KD: Expression and function of the UM4D4 antigen in human thymus. J Immunol 143:2166-2175, 1989
73. Fox DA, Davis W, Zeldes W, Kan L, Higgs J, Duby AD, Holoshitz J: Activation of human T cell clones through the UM4D4/CDw60 surface antigen. Cell Immunol 128:480-489, 1990
74. + T cells. J Exp Med 180:2125-2135, 1994
75. Nojima Y, Humphries M, Mould A, Komoriya A, Yamada K, Schlossman S, Morimoto C: VLA-4 mediates CD3-dependent CD4+ T cell activation via the CS1 alternatively spliced domain of fibronectin. J Exp Med 172:1185-1192, 1990
76. Allen M, Young S, Michell R, Bacon P: Altered T lymphocyte signaling in rheumatoid arthritis. Eur J Immunol 25:1547-1554, 1995
77. Firestein GS, Yeo M, Zvaifler NJ: Apoptosis in rheumatoid arthritis synovium. J Clin Invest 96:1631-1638, 1995
78. Croft M, Bradley LM, Swain SL: Naive versus memory CD4 T cell response to antigen: memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells. J Immunol 152: 2675-2685, 1994
79. Liao HX, Haynes BF: Role of adhesion molecules in the pathogenesis of rheumatoid arthritis. Rheum Dis Clin North Am 21:715-740, 1995
80. Salmi M, Grantors K, Leirisalo-Repo M, Hämäläinen M, MacDermott R, Leino R, Havia T, Jalkanen S: Selective endothelial binding of interleukin-2-dependent human T-cell lines derived from different tissues. Proc Natl Acad Sci U S A 89:11436-11440, 1992
81. To SST, Newman PM, Hyland VJ, Robinson BG, Schrieber L: Regulation of adhesion molecule expression by human synovial microvascular endothelial cells in vitro. Arthritis Rheum 39:467-477, 1996
82. Halloran MM, Szekanecz Z, Barquin N, Haines GK, Koch AE: Cellular adhesion molecules in rat adjuvant arthritis. Arthritis Rheum 39:810-819, 1996
83. Mikecz K, Brennan FR, Kim JH, Giant TT: Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis. Nature Med 1:558-563, 1995
84. Jorgensen C, Couret I, Hellier I, Bologna C, Canovas F, Brochier J, Reme T, Sany J: In vivo migration of radiolabelled lymphocytes in rheumatoid synovial tissue engrafted in SCID mice: implication of β2 and β7-integrin. J Rheumatol 23:32-35, 1996
85. Wahl SM, Allen JB, Hines KL, Imamichi T, Wahl AM, Furcht LT, McCarthy JB: Synthetic fibronectin peptides suppress arthritis in rats by interrupting leukocyte adhesion and recruitment. J Clin Invest 94:655-662. 1994
86. Thomas R, Lipsky PE: Presentation of self peptides by dendritic cells: possible implications for the pathogenesis of rheumatoid arthritis. Arthritis Rheum 39:183-190, 1996
87. Firestein GS: Invasive fibroblast-like synoviocytes in rheumatoid arthritis: passive responders or transformed aegressors? Arthritis Rheum 39:1781-1790, 1996
88. Boots A, Wimmers-Bertens AJMM, Rijnders AWM: Antigen-presenting capacity of rheumatoid synovial fibroblasts. Immunology 82:268-274, 1994
89. Tsai C, Diaz LA Jr, Singer NG, Li LL, Kirsch AH, Mitra R, Nickoloff BJ, Crofford LJ, Fox DA: Responsiveness of human T lymphocytes to bacterial superantigens presented by cultured rheumatoid arthritis synoviocytes. Arthritis Rheum 39:125-136, 1996
90. Kraft M, Filsinger S, Kramer K-L, Kabelitz D, Hansch GM, Schoels M: Synovial fibroblasts as accessory cells for staphylococcal enterotoxin-mediated T-cell activation. Immunology 85: 461-466, 1995
91. Yokota A, Murata N, Saiki O, Shimizu M, Springer TA, Kishimoto T: High avidity state of leukocyte function-associated antigen-1 on rheumatoid synovial fluid T lymphocytes. J Immunol 155:4118-4124, 1995
92. 2. J Immunol 155:3570-3577, 1995
93. Scott S, Pandolfi F, Kurnick JT: Fibroblasts mediate T cell survival: a proposed mechanism for retention of primed T cells. J Exp Med 172:1873-1876, 1990
94. Tessier PA, Cattaruzzi P, McColl SR: Inhibition of lymphocyte adhesion to cytokine-activated synovial fibroblasts by glucocorticoids involves the attenuation of vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 gene expression. Arthritis Rheum 39:226-234, 1996
95. Feldmann M, Brennan FM, Maini RN: Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 14:397-440, 1996
96. Koch AE, Kunkel SL, Stricter RM: Cytokines in rheumatoid arthritis. J Invest Med 43:28-38, 1995
97. Wolley PH, Dutcher J, Widmer MB, Gillia S: Influence of a recombinant human soluble tumor necrosis factor Fc fusion protein on type II collagen-induced arthritis in mice. J Immunol 151:6602-6607, 1993
98. Elliott MJ, Maini RN, Feldmann M, Kalden JR, Antoni C, Smolen JS, Leeb B, Breedveld FC, Macfarlane JD, Biji H, Woody JN: Randomised double blind comparison of a chimaeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis. Lancet 344:1105-1110, 1994
99. Arend WP, Dayer J-M: Inhibition of the production and effects of interleukin-1 and tumor necrosis factor α in rheumatoid arthritis. Arthritis Rheum 38:151-160, 1995
100. Firestein GS, Zvaifler NJ: How important are T cells in chronic rheumatoid synovitis? (editorial). Arthritis Rheum 33:768-773, 1990
101. Al-Jandi M, Al-Balla S, Al-Dalaan A, Raziuddin S: Cytokine production by helper T cell populations from the synovial fluid and blood in patients with rheumatoid arthritis. J Rheumatol 20:1647-1653, 1993
102. Quayle AJ, Chomarat P, Miossec P, Kjeldsen-Krach J, Forre O, Natvig JB: Rheumatoid inflammatory T cell clones express mostly Th1 but also Th2 and mixed (Th0-like) cytokine patterns. Scand J Immunol 38:75-82, 1993
103. Chomarat P, Kjeldsen-Kragh J, Quayle AJ, Natvig JB, Miossec P: Different cytokine production profiles of γδ T cell clones: relation to inflammatory arthritis. Eur J Immunol 24:2087-2091, 1994
104. Kelso A: Th1 and Th2 subsets: paradigms lost? Immunol Today 16:374-379, 1995
105. Tagaya Y, Bamford R, DeFilippis AP, Waldmann TA: IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels. Immunity 4:329-336, 1996
106. McInnis I, Al-Mughales J, Field M, Leung BP, Huang F-P, Dixon R, Sturrock RD, Wilkinson PC, Liew FY: The role of interleukin-15 in T cell migration and activation in rheumatoid arthritis. Nature Med 2:175-182, 1996
107. Byrd V, Zhao X-M, McKeehan WL, Miller GG, Thomas JW: Expression and functional expansion of fibroblast growth factor receptor T cells in rheumatoid synovium and peripheral blood of patients with rheumatoid arthritis. Arthritis Rheum 39:914-922, 1996
108. Katsikis P, Chu C-Q, Brennan FM, Maini RN, Feldmann M: Immunoregulatory role of interleukin 10 in rheumatoid arthritis. J Exp Med 179:1517-1527, 1994
109. Cush JJ, Splawski JB, Thomas R, McFarlin JE, Schulze-Koops H, Davis LS, Fujita K, Lipsky PE: Elevated interleukin-10 levels in patients with rheumatoid arthritis. Arthritis Rheum 38:96-104, 1995
110. Llorente L, Richaud-Patin Y, Fior R, Alococer-Varela J, Wijdenes J, Fourrier BM, Galanaud P, Emilie D: In vivo production of interleukin-10 by non-T cells in rheumatoid arthritis, Sjögren's syndrome, and systemic lupus erythematosus: a potential mechanism of B lymphocyte hyperactivity and autoimmunity. Arthritis Rheum 37:1647-1655, 1994
111. Cohen SBA, Katsikis PD, Chu C-Q, Thomssen H, Webb LMC, Maini RN, Londei M, Feldmann M: High level of interleukin-10 production by the activated T cell population within the rheumatoid synovial membrane. Arthritis Rheum 38:946-952, 1995
112. Walmsley M, Katsikis PD, Abney E, Parry S, Williams RO, Maini RN, Feldmann M: Interleukin-10 inhibition of the progression of established collagen-induced arthritis. Arthritis Rheum 39:495-503, 1996
113. Isomäki P, Luukkainen R, Saario R, Toivanen P, Punnonen J: Interleukin-10 functions as an antiinflammatory cytokine in rheumatoid synovium. Arthritis Rheum 39:386-395, 1996
114. Fox DA: Biological therapies: a novel approach to the treatment of autoimmune disease. Am J Med 99:82-88, 1995
115. Weinblatt ME, Maddison PJ, Bulpitt KJ, Hazleman BL, Urowitz MB, Sturrock RD, Coblyn JS, Mater AL, Spreen WR, Manna VK, Johnston JM: CAMPATH-1H, a humanized monoclonal antibody, in refractory rheumatoid arthritis: an intravenous doseescalation study. Arthritis Rheum 38:1589-1594, 1995
116. Moreland LW, Pratt PW, Mayes MD, Postlethwaite A, Weisman MH, Schnitzer T, Lightfoot R, Calabrese L, Zelinger DJ, Woody JN, Koopman WJ: Double-blind, placebo-controlled multicenter trial using chimeric monoclonal anti-CD4 antibody, cM-T412, in rheumatoid arthritis patient receiving concomitant methotrexate. Arthritis Rheum 38:1581-1588, 1995
117. 486IL-2) in refractory rheumatoid arthritis: a double-blind, placebo-controlled trial with open-label extension. Arthritis Rheum 38:1177-1186, 1995
118. Van der Lubbe PA, Dijkmans BAC, Markusse HM, Nässander U, Breedveld FC: A randomized, double-blind, placebo-controlled study of CD4 monoclonal antibody therapy in early rheumatoid arthritis. Arthritis Rheum 38:1097-1106, 1995
119. Olsen NJ, Brooks RH, Cush JJ, Lipsky PE, St. Clair EW, Matteson EL, Gold KN, Cannon GW, Jackson CG, McCune WJ, Fox DA, The Xoma RA Investigator Group, Nelson B, Lorenz T, Strand V: A double-blind, placebo-controlled study of anti-CD5 immunoconjugate in patients with rheumatoid arthritis. Arthritis Rheum 39:1102-1108, 1996
120. Tak PP, van der Lubbe PA, Cauli A, Dana MR, Smeets TJM, Kluin PM, Meinders AE, Yanni G, Panayi GS, Breedveld FC: Reduction of synovial inflammation after anti-CD4 monoclonal antibody treatment in early rheumatoid arthritis. Arthritis Rheum 38:1457-1465, 1995
121. Choy EHS, Pitzalis C, Cauli A, Bijl JA, Schantz A, Woody J, Kingsley GH, Panayi GS: Percentage of anti-CD4 monoclonal antibody-coated lymphocytes in the rheumatoid joint is associated with clinical improvement: implications for the development of immunotherapeutic dosing regimens. Arthritis Rheum 39:52-56, 1996
122. Ornstein MH, Kerr LD, Spiera H: A reexamination of the relationship between active rheumatoid arthritis and the acquired immunodeficiency syndrome. Arthritis Rheum 38:1701-1706, 1995
123. Yoshino S, Quattrocchi E, Weiner HL: Suppression of antigen-induced arthritis in Lewis rats by oral administration of type II collagen. Arthritis Rheum 38:1092-1096, 1995
124. Haqqi TM, Qu X-M, Anthony D, Ma J, Sy M-S: Immunization with T cell receptor Vβ chain peptides deletes pathogenic T cells and prevents the induction of collagen-induced arthritis in mice. J Clin Invest 97:2849-2858, 1996
125. Trentham DE, Dynesius-Trentham RA, Orav EJ, Combitchi D, Lorenzo C, Sewell KL, Hafler DA, Weiner HL; Effects of oral administration of type II collagen on rheumatoid arthritis. Science 261:1727-1730, 1993
126. Sieper J, Kary S, Sörensen H, Alten R, Eggens U, Hüge W, Hiepe F, Kühne A, Listing J, Ulbrich N, Braun J, Zink A, Mitchison NA: Oral type II collagen treatment in early rheumatoid arthritis: a double-blind, placebo-controlled, randomized trial. Arthritis Rheum 39:41-51, 1996
127. Smith JB, Fort JG: Treatment of rheumatoid arthritis by immunization with mononuclear white blood cells: results of a preliminary trial. J Rheumatol 23:220-224, 1996
128. Sato K, Maruyama I, Maruyama Y, Katajima I, Nakajima Y, Higaki M, Yamamoto K, Miyasaka N, Osame M, Nishioka K: Arthritis in patients infected with human T lymphotropic virus type I: clinical and immunopathologic features. Arthritis Rheum 34:714-721, 1991
129. Eguchi K, Origuchi T, Takashima H, Iwata K, Katamine S, Nagataki S: High seroprevalence of anti-HTLV-I antibody in rheumatoid arthritis. Arthritis Rheum 39:463-466, 1996
130. Sakai M, Eguchi K, Terada K, Nakashima M, Yamashita I, Ida H, Kawabe Y, Aoyagi T, Takino H, Nakamura T, Nagataki S: Infection of human synovial cells by human T cell lymphotropic virus type I. J Clin Invest 92:1957-1966, 1993
131. Iwakura Y, Tosu M, Yoshida E, Takiguchi M, Sato K, Katahma I, Nishioka K, Yamamoto K, Takeda T, Hatanaka M, Yamamoto H, Sekiguchi T: Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-1. Science 253:1026-1028, 1991