Decreased skeletal muscle phosphotyrosine phosphatase (PTPase) activity towards insulin receptors in insulin-resistant Zucker rats measured by delayed Europium fluorescence

Diabetologia

Volumn 39, Issue 2, 1996, Pages 142-148

  Worm, D ^a   Handberg, A ^b   Hoppe, E ^c   Vinten, J ^b   Beck Nielsen, H ^a  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

Insulin receptor; Insulin resistance; Metformin; Phosphotyrosine phosphatases; Skeletal muscle; Zucker rats

Indexed keywords

ANTIDIABETIC AGENT; EUROPIUM; INSULIN RECEPTOR; METFORMIN; PROTEIN TYROSINE PHOSPHATASE;

ANIMAL TISSUE; ARTICLE; ENZYME ACTIVITY; FLUORESCENCE; GLUCOSE HOMEOSTASIS; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MUSCLE BIOPSY; NONHUMAN; OBESITY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE;

ADENOSINE TRIPHOSPHATE; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; EUROPIUM; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INSULIN; INSULIN RESISTANCE; KINETICS; METFORMIN; MUSCLE, SKELETAL; OBESITY; PROTEIN-TYROSINE-PHOSPHATASE; RATS; RATS, ZUCKER; RECEPTOR, INSULIN; REFERENCE VALUES; SPECTROMETRY, FLUORESCENCE;

EID: 0030051920     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00403956     Document Type: Article

References (40)

1. Lau KHW, Farley JR, Baylink DJ (1989) Phosphotyrosyl protein phosphatases. Biochem J 257: 23-36
2. Schlessinger J, Ullrich A (1992) Growth factor signalling by receptor tyrosine kinases. Neuron 9: 383-391
3. Fischer EH, Charbonneau H, Tonks NK (1991) Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes. Science 253: 401-406
4. Hauguel-de Mouzon S, Peraldi P, Alengrin F, Van Obberghen E (1993) Alteration of phosphotyrosine phosphatase activity in tissues from diabetic and pregnant rats. Endocrinology 132: 67-74
5. Begum N, Sussman KE, Draznin B (1991) Differential effects of diabetes on adipocytes and liver phosphotyrosine and phosphoserine phosphatase activities. Diabetes 40: 1620-1629
6. Olichon-Berthe C, Hauguel-de Mouzon S, Péraldi P, Van Obberghen E, Le Marchand-Brustel Y (1994) Insulin receptor dephosphorylation by phosphotyrosine phosphatases obtained from insulin-resistant obese mice. Diabetologia 37: 56-60
7. McGuire MC, Fields RM, Nyomba BL et al. (1991) Abnormal regulation of protein tyrosine phosphatase activities in skeletal muscle of insulin-resistant humans. Diabetes 40: 939-942
8. Ullrich A, Schlessinger J (1990) Signal transduction by receptors with tyrosine kinase activity. Cell 61: 203-212
9. Rosen OM, Herrera R, Olowe Y, Petruzzelli LM, Cobb MH (1983) Phosphorylation activates the insulin receptor tyrosine kinase. Proc Natl Acad Sci USA 80: 3237-3240
10. Le Marchand-Brustel Y, Grémeaux T, Ballotti R, Van Obberghen E (1985) Insulin receptor tyrosine kinase is defective in skeletal muscle of insulin-resistant obese mice. Nature 315: 676-679
11. Caro JF, Sinha MK, Raju SM et al. (1987) Insulin receptor kinase in human skeletal muscle from obese subjects with and without non-insulin dependent diabetes. J Clin Invest 79: 1330-1337
12. Arner P, Pollare T, Lithell H, Livingston JN (1987) Defective insulin receptor tyrosine kinase in human skeletal muscle in obesity and type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 30: 437-440
13. Obermaier-Kusser B, White MF, Pongratz DE et al. (1989) A defective intramolecular autoactivation cascade may cause the reduced kinase activity of the skeletal muscle insulin receptor from patients with non-insulin-dependent diabetes mellitus. J Biol Chem 264: 9497-9504
14. Meyerovitch J, Backer JM, Kahn CR (1989) Hepatic phosphotyrosine phosphatase activity and its alterations in diabetic rats. J Clin Invest 84: 976-983
15. Gruppuso PA, Boylan JM, Posner BI, Faure R, Brautigan DL (1990) Hepatic protein phosphotyrosine phosphatase. Dephosphorylation of insulin and epidermal growth factor receptors in normal and alloxan diabetic rats. J Clin Invest 85: 1754-1760
16. Meyerovitch J, Rothenberg P, Shechter Y, Bonner-Weir S, Kahn CR (1991) Vanadate normalizes hyperglycemia in two mouse models of non-insulin-dependent diabetes mellitus. J Clin Invest 87: 1286-1294
17. Boylan JM, Brautigan DL, Madden J, Raven T, Ellis L, Gruppuso PA (1992) Differential regulation of multiple hepatic protein tyrosine phosphatases in alloxan diabetic rats. J Clin Invest 90: 174-179
18. Kusari J, Kenner KA, Suh K-I, Hill DE, Henry RR (1994) Skeletal muscle protein tyrosine phosphatase activity and tyrosine phosphatase 1B protein content are associated with insulin action and resistance. J Clin Invest 93: 1156-1162
19. Zucker LM, Antoniades HN (1972) Insulin and obesity in the Zucker genetically obese "fatty" rat. Endocrinology 90: 1320-1330
20. Becker-Zimmerman K, Berger M, Berchtold P, Gries FA, Herberg L, Schwenen M (1982) Treadmill training improves intravenous glucose tolerance and insulin sensitivity in fatty Zucker rats. Diabetologia 22: 468-474
21. Ionescu E, Sauter JF, Jeanrenaud B (1985) Abnormal oral glucose tolerance in genetically obese (fa/fa) rats. Am J Physiol 248: E500-E506
22. Debant A, Guerre-Millo M, Le Marchand-Brustel Y, Freychet P, Lavau M, Van Obberghen E (1987) Insulin receptor kinase is hyperresponsive in adipocytes of young obese Zucker rats. Am J Physiol 252: E273-E278
23. Häring H, Obermaier B, Ermel B et al (1987) Insulin receptor kinase defects as a possible cause of cellular insulin resistance. Diabete Metab 13: 284-293
24. Bailey CJ (1988) Metformin revisited: its actions and indications for use. Diabet Med 5: 315-320
25. Hother-Nielsen O, Schmitz O, Andersen PH, Beck-Nielsen H, Pedersen O (1989) Metformin improves peripheral but not hepatic insulin action in obese patients with type II diabetes. Acta Endocrinol 120: 257-265
26. Galuska D, Zierath J, Thorne A, Sonnenfield T, Wallberg-Henriksson H (1991) Metformin increases insulin-stimulated glucose transport in insulin-resistant human skeletal muscle. Diabete Metab 17: 159-163
27. Handberg A, Kayser L, Høyer PE, Voldstedlund M, Hansen HP, Vinten J (1993) Metformin ameliorates diabetes but does not normalize the decreased GLUT 4 content in skeletal muscle of obese (fa/fa) Zucker rats. Diabetologia 36: 481-486
28. Bradford M (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle protein dye bonding. Anal Biochem 72: 248-254
29. Prigent SA, Stanley KK, Siddle K (1990) Identification of epitopes on the human insulin receptor reacting with rabbit polyclonal antisera and mouse monoclonal antibodies. J Biol Chem 265: 9970-9977
30. Ganderton RH, Stanley KK, Field CE, Coghlan MP, Soos MA, Siddle K (1992) A monoclonal anti-peptide antibody reacting with the insulin receptor β-subunit. Biochem J 288: 195-205
31. Swarup G, Speeg KV, Cohen S, Garbers DL (1982) Phosphotyrosyl-protein phosphatase of TCRC-2 cells. J Biol Chem 257: 7298-7301
32. Shen S-H, Bastien L, Posner BI, Chrétien P (1991) A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases. Nature 352: 736-739
33. Sun XJ, Crimmins DL, Myers MG, Miralpeix M, White MF (1993) Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Mol Cell Biol 12: 7418-7428
34. Kuhné MR, Pawson T, Lienhard GE, Feng G-S (1993) The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp. J Biol Chem 268: 11479-11481
35. Lorch E (1971) Inhibition of intestinal absorption and improvement of oral glucose tolerance by biguanides in the normal and in the streptozotocin-diabetic rat. Diabetologia 7: 195-203
36. Jackson RA, Hawa MI, Jaspan JB et al. (1987) Mechanism of metformin action in non-insulin-dependent diabetes. Diabetes 36: 632-640
37. Meyer F, Ipaktchi M, Clauser H (1967) Specific inhibition of gluconeogenesis by biguanides. Nature (London) 213: 203-204
38. Fantus IG, Brosseau R (1986) Mechanism of action of metformin: insulin receptor and post-receptor effects in vitro and in vivo. J Clin Endocrinol Metab 54: 95-100
39. Bailey CJ, Puah JA (1986) Effect of metformin on glucose metabolism in mouse soleus muscle. Diabet Metab 12: 212-218
40. Molnar IG, Davidson MB (1988) Metformin has both insulin-like and anti-insulin effects in cultured muscle cells. Clin Res 36: 157A (Abstract)