Minocycline partially inhibits caspase-3 activation and photoreceptor degeneration after photic injury

Ophthalmic Research

Volumn 37, Issue 4, 2005, Pages 202-213

  Chang, Cheng Jong ^a,b   Cherng, Chen Hwan ^b   Liou, Wen Shyong ^a   Liao, Ching Len ^b  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Apoptosis; Caspase 3; Light damage; Minocycline; Photoreceptor; Retinal degeneration

Indexed keywords

CASPASE 3; MINOCYCLINE; ANTIINFECTIVE AGENT; CASP3 PROTEIN, RAT; CASPASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIGHT DAMAGE; MALE; MORPHOMETRICS; NICK END LABELING; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; RETINA DEGENERATION; RETINA INJURY; STAINING; STATISTICAL SIGNIFICANCE; WESTERN BLOTTING; ANIMAL; APOPTOSIS; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; LEWIS RAT; LIGHT; METABOLISM; PATHOLOGY; RADIATION EXPOSURE; RADIATION INJURY; UPREGULATION;

ANIMALS; ANTI-BACTERIAL AGENTS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASES; ENZYME ACTIVATION; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INJECTIONS, INTRAPERITONEAL; LIGHT; MALE; MINOCYCLINE; PHOTORECEPTORS, VERTEBRATE; POLY(ADP-RIBOSE) POLYMERASES; RADIATION INJURIES, EXPERIMENTAL; RATS; RATS, INBRED LEW; RETINAL DEGENERATION; UP-REGULATION;

EID: 25144448771     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000086610     Document Type: Article

References (45)

1. Grimm C, Wenzel A, Hafezi F, et al: Gene expression in the mouse retina: The effect of damaging light. Mol Vis 2000;6:252-260.
2. Wu T, Chen Y, Chiang SK, et al: NF-kappaB activation in light-induced retinal degeneration in a mouse model. Invest Ophthalmol Vis Sci 2002;43:2834-2840.
3. Edward DP, Lam TT, Shahinfar S, et al: Amelioration of light-induced retinal degeneration by a calcium overload blocker. Flunarizine. Arch Ophthalmol 1991;109:554-562.
4. Rosner M, Lam TT, Fu J, et al: Methylprednisolone ameliorates retinal photic injury in rats. Arch Ophthalmol 1992;110:857-861.
5. Lam TT, Abler AS, Kwong JM, et al: N-methyl-D-aspartate (NMDA)-induced apoptosis in rat retina. Invest Ophthalmol Vis Sci 1999;40:2391-2397.
6. Organisciak DT, Darrow RA, Barsalou L, et al: Light-induced damage in the retina: Differential effects of dimethylthiourea on photoreceptor survival, apoptosis and DNA oxidation. Photochem Photobiol 1999;70:261-268.
7. Yu X, Rajala RV, McGinnis JF, et al: Involvement of insulin/ phosphoinositide 3-kinase/Akt signal pathway in 17 beta-estradiol-mediated neuroprotection. J Biol Chem 2004;279:13086-13094.
8. Cao W, Tombran-Tink J, Elias R, et al: In vivo protection of photoreceptors from light damage by pigment epithelium-derived factor. Invest Ophthalmol Vis Sci 2001;42:1646-1652.
9. Abler AS, Chang CJ, Ful J, et al: Photic injury triggers apoptosis of photoreceptor cells. Res Commun Mol Pathol Pharmacol 1996;92:177-189.
10. Li S, Chang CJ, Abler AS, et al: A comparison of continuous versus intermittent light exposure on apoptosis. Curr Eye Res 1996;15:914-922.
11. Chang CJ, Lai WW, Edward DP, et al: Apoptotic photoreceptor cell death after traumatic retinal detachment in humans. Arch Ophthalmol 1995;113:880-886.
12. Friedlander RM: Apoptosis and caspases in neurodegenerative diseases. N Engl J Med 2003;348:1365-1375.
13. Tezel G, Wax MB: Inhibition of caspase activity in retinal cell apoptosis induced by various stimuli in vitro. Invest Ophthalmol Vis Sci 1999;40:2660-2667.
14. Singh M, Savitz SI, Hoque R, et al: Cell-specific caspase expression by different neuronal phenotypes in transient retinal ischemia. J Neurochem 2001;77:466-475.
15. Wu J, Gorman A, Zhou X, et al: Involvement of caspase-3 in photoreceptor cell apoptosis induced by in vivo blue light exposure. Invest Ophthalmol Vis Sci 2002;43:3349-3354.
16. Kim DH, Kim JA, Choi JS, et al: Activation of caspase-3 during degeneration of the outer nuclear layer in the rd mouse retina. Ophthalmic Res 2002;34:150-157.
17. Lam TT, Abler AS, Tso MO: Apoptosis and caspases after ischemia-reperfusion injury in rat retina. Invest Ophthalmol Vis Sci 1999;40:967-975.
18. Katai N, Yoshimura N: Apoptotic retinal neuronal death by ischemia-reperfusion is executed by two distinct caspase family proteases. Invest Ophthalmol Vis Sci 1999;40:2697-2705.
19. Thomas M, Le WD, Jankovic J: Minocycline and other tetracycline derivatives: A neuroprotective strategy in Parkinson's disease and Huntington's disease. Clin Neuropharmacol 2003;26:18-23.
20. Bonelli RM, Heuberger C, Reisecker F: Minocycline for Huntington's disease: An open label study. Neurology 2003;60:883-884.
21. Yrjanheikki J, Keinanen R, Pellikka M, et al: Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Proc Natl Acad Sci USA 1998;95:15769-15774.
22. Yrjanheikki J, Tikka T, Keinanen R, et al: A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc Natl Acad Sci USA 1999;96:13496-13500.
23. Sanchez Mejia RO, Ona VO, Li M, et al: Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction. Neurosurgery 2001;48:1393-1399.
24. Kriz J, Nguyen MD, Julien JP: Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis. Neurobiol Dis 2002;10:268-278.
25. Du Y, Ma Z, Lin S, et al: Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Proc Natl Acad Sci USA 2001;98:14669-14674.
26. Erickson RP, Bernard O: Studies on neuronal death in the mouse model of Niemann-Pick C disease. J Neurosci Res 2002;68:738-744.
27. Tikka T, Fiebich BL, Goldsteins G, et al: Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J Neurosci 2001;21:2580-2588.
28. Chen M, Ona VO, Li M, et al: Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med 2000;6:797-801.
29. Shahinfar S, Edward DP, Tso MO: A pathologic study of photoreceptor cell death in retinal photic injury. Curr Eye Res 1991;10:47-59.
30. Arvin KL, Han BH, Du Y, et al: Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury. Ann Neurol 2002;52:54-61.
31. Seiler MJ, Liu OL, Cooper NG, et al: Selective photoreceptor damage in albino rats using continuous blue light. A protocol useful for retinal degeneration and transplantation research. Graefes Arch Clin Exp Ophthalmol 2000;238:599-607.
32. Hafezi F, Marti A, Munz K, et al: Light-induced apoptosis: Differential timing in the retina and pigment epithelium. Exp Eye Res 1997;64:963-970.
33. Enari M, Talanian RV, Wong WW, et al: Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 1996;380:723-726.
34. Kang SJ, Wang S, Hara H, et al: Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions. J Cell Biol 2000;149:613-622.
35. Hengartner MO: The biochemistry of apoptosis. Nature 2000;407:770-776.
36. Tewari M, Quan LT, O'Rourke K, et al: Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 1995;81:801-809.
37. Donovan M, Cotter TG: Caspase-independent photoreceptor apoptosis in vivo and differential expression of apoptotic protease activating factor-1 and caspase-3 during retinal development. Cell Death Differ 2002;9:1220-1231.
38. Donovan M, Carmody RJ, Cotter TG: Light-induced photoreceptor apoptosis in vivo requires neuronal nitric-oxide synthase and guanylate cyclase activity and is caspase-3-independent. J Biol Chem 2001;276:23000-23008.
39. Enochs WS, Nilges MJ, Swartz HM: The minocycline-induced thyroid pigment and several synthetic models: Identification and characterization by electron paramagnetic resonance spectroscopy. J Pharmacol Exp Ther 1993;266:1164-1176.
40. Bowles WH: Protection against minocycline pigment formation by ascorbic acid (vitamin C). J Esthet Dent 1998;10:182-186.
41. Miyachi Y, Yoshioka A, Imamura S, et al: Effect of antibiotics on the generation of reactive oxygen species. J Invest Dermatol 1986;86:449-453.
42. Akamatsu H, Asada M, Komura J, et al: Effect of doxycycline on the generation of reactive oxygen species: A possible mechanism of action of acne therapy with doxycycline. Acta Derm Venereol 1992;72:178-179.
43. Kluck RM, Bossy-Wetzel E, Green DR, et al: The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis. Science 1997;275:1132-1136.
44. Kirsch DG, Doseff A, Chau BN, et al: Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c. J Biol Chem 1999;274:21155-21161.
45. Zhu S, Stavrovskaya IG, Drozda M, et al: Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature 2002;417:74-78.