A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1

Biochemical and Biophysical Research Communications

Volumn 303, Issue 1, 2003, Pages 91-97

  Nadav, Eran ^a   Shmueli, Ayelet ^a   Barr, Haim ^c   Gonen, Hedva ^b   Ciechanover, Aaron ^b   Reiss, Yuval ^c  

^a TEL AVIV UNIVERSITY   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^c Proteologics Ltd   (Israel)

Author keywords

Cystic fibrosis transmembrane conductance regulator; Endoplasmic reticulum associated degradation; hHrd1; HMG CoA reductase; Ubiquitin protein ligase

Indexed keywords

LIGASE; PROTEIN; PROTEIN HRD1; UBIQUITIN; UNCLASSIFIED DRUG; CFTR PROTEIN, HUMAN; COMPLEMENTARY DNA; HRD1 PROTEIN, S CEREVISIAE; RECOMBINANT PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN; TRANSMEMBRANE CONDUCTANCE REGULATOR; UBIQUITIN PROTEIN LIGASE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CLONING; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME ANALYSIS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; MAMMAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SEQUENCE HOMOLOGY; YEAST; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; CHO CELL; ENZYMOLOGY; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; HAMSTER; HELA CELL; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; TIME; TISSUE DISTRIBUTION; WESTERN BLOTTING;

MAMMALIA;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DNA, COMPLEMENTARY; ENDOPLASMIC RETICULUM; HELA CELLS; HUMANS; LIGASES; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TIME FACTORS; TISSUE DISTRIBUTION; TRANSFECTION; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 0037470838     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00279-1     Document Type: Article

References (26)

1. Hampton R.Y. ER-associated degradation in protein quality control and cellular regulation. Curr. Opin. Cell Biol. 14:2002;476-482.
2. Glickman M.H., Ciechanover A. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol. Rev. 82:2002;373-428.
3. Plemper R.K., Wolf D.H. Retrograde protein translocation: eradication of secretory proteins in health and disease. Trends Biochem. Sci. 24:1999;266-270.
4. Haas A.L., Siepmann T.J. Pathways of ubiquitin conjugation. FASEB J. 11:1997;1257-1268.
5. Freemont P.S. RING for destruction? Curr. Biol. 10:2000;R84-R87.
6. Jackson P.K., Eldridge A.G., Freed E., Furstenthal L., Hsu J.Y., Kaiser B.K., Reimann J.D. The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases. Trends Cell Biol. 10:2000;429-439.
7. Joazeiro C., Weissman A.M. RING finger proteins: mediators of ubiquitin ligase activity. Cell. 102:2000;549-552.
8. Goldstein J.L., Brown M.S. Regulation of the mevalonate pathway. Nature. 343:1990;425-430.
9. Hampton R.Y., Bhakta H. Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase. Proc. Natl. Acad. Sci. USA. 94:1997;12944-12948.
10. Ravid T., Doolman R., Avner R., Harats D., Roitelman J. The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J. Biol. Chem. 275:2000;35840-35847.
11. Deak P.M., Wolf D.H. Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation. J. Biol. Chem. 276:2001;10663-10669.
12. Bays N.W., Gardner R.G., Seelig L.P., Joazeiro C.A., Hampton R.Y. Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. Nat. Cell Biol. 3:2001;24-29.
13. Bordallo J., Wolf D.H. A RING-H2 finger motif is essential for the function of Der3/Hrd1 in endoplasmic reticulum associated protein degradation in the yeast Saccharomyces cerevisiae. FEBS Lett. 448:1999;244-248.
14. Kopito R.R. Biosynthesis and degradation of CFTR. Physiol. Rev. 79:1999;S167-S173.
15. Gelman M.S., Kannegaard E.S., Kopito R.R. A principal role for the proteasome in endoplasmic reticulum-associated degradation of misfolded intracellular cystic fibrosis transmembrane conductance regulator. J. Biol. Chem. 277:2002;11709-11714.
16. Kaneko M., Ishiguro M., Niinuma Y., Uesugi M., Nomura Y. Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation. FEBS Lett. 532:2002;147-152.
17. Gonen H., Bercovich B., Orian A., Carrano A., Takizawa C., Yamanaka K., Pagano M., Iwai K., Ciechanover A. Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IκBα J. Biol. Chem. 274:1999;14823-14830.
18. Handley P.M., Mueckler M., Siegel N.R., Ciechanover A., Schwartz A.L. Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1. Proc. Natl. Acad. Sci. USA. 88:1991;258-262.
19. Ciechanover A., Elias S., Heller H., Hershko A. "Covalent affinity" purification of ubiquitin-activating enzyme. J. Biol. Chem. 257:1982;2537-2542.
20. Van Oene M., Lukacs G.L., Rommens J.M. Cystic fibrosis mutations lead to carboxyl-terminal fragments that highlight an early biogenesis step of the cystic fibrosis transmembrane conductance regulator. J. Biol. Chem. 275:2000;19577-19584.
21. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
22. Fang D., Wang H.Y., Fang N., Altman Y., Elly C., Liu Y.C. Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells. J. Biol. Chem. 276:2001;4872-4878.
23. Fujita Y., Krause G., Scheffner M., Zechner D., Leddy H.E., Behrens J., Sommer T., Birchmeier W. Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat. Cell Biol. 4:2002;222-231.
24. Dai Z., Kerzic P., Schroeder W.G., McNiece I.K. Deletion of the Src homology 3 domain and C-terminal proline-rich sequences in Bcr-Abl prevents Abl interactor 2 degradation and spontaneous cell migration and impairs leukemogenesis. J. Biol. Chem. 276:2001;28954-28960.
25. Kamynina E., Staub O. Concerted action of ENaC, Nedd4-2, and Sgk1 in transepithelial Na(+) transport. Am. J. Physiol. Renal Physiol. 283:2002;F377-F387.
26. Lorick K.L., Jensen J.P., Fang S., Ong A.M., Hatakeyama S., Weissman A.M. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc. Natl. Acad. Sci. USA. 96:1999;11364-11369.