Characterization of NovP and NovN: Completion of Novobiocin Biosynthesis by Sequential Tailoring of the Noviosyl Ring

Angewandte Chemie - International Edition

Volumn 43, Issue 1, 2004, Pages 67-70

  Meyers, Caren L Freel ^a   Oberthür, Markus ^b   Xu, Hui ^c   Heide, Lutz ^c   Kahne, Daniel ^b   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b PRINCETON UNIVERSITY   (United States)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Antibiotics; Biosynthesis; Enzymes; Novobiocin; Transferases

Indexed keywords

SEQUENTIAL TAILORING;

BIOSYNTHESIS; ENZYMES; ESCHERICHIA COLI; SUGARS;

ANTIBIOTICS;

CARBAMOYLTRANSFERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); METHYLTRANSFERASE; NOVOBIOCIN; PROTEIN; PROTEIN NOVN; PROTEIN NOVP; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; DRUG SYNTHESIS; STREPTOMYCES; STREPTOMYCES SPHEROIDES; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

BASE SEQUENCE; DNA PRIMERS; KINETICS; MOLECULAR STRUCTURE; NOVOBIOCIN;

EID: 77349086625     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200352626     Document Type: Article

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