The structure - Inhibitory activity relationships study in a series of cyclooxygenase-2 inhibitors: A combined electronic-topological and neural networks approach

Mini-Reviews in Medicinal Chemistry

Volumn 5, Issue 10, 2005, Pages 879-892

  Dimoglo, A ^a,b   Kovalishyn, V ^c   Shvets, N ^a,d   Ahsen, V ^a  

^a GEBZE TECHNICAL UNIVERSITY   (Turkey)

^b Institute of Chemistry   (Moldova)

^c INSTITUTE OF BIOORGANIC CHEMISTRY AND PETROCHEMISTRY   (Ukraine)

^d INSTITUTE OF MATHEMATICS AND COMPUTER SCIENCE   (Moldova)

Author keywords

COX 2 inhibitors; Electronic topological method; Neural networks; Structure activity relationships

Indexed keywords

CELECOXIB; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT;

ALGORITHM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTIFICIAL NEURAL NETWORK; COMPUTER PROGRAM; DRUG CLASSIFICATION; DRUG CONFORMATION; DRUG DESIGN; DRUG IDENTIFICATION; DRUG RESEARCH; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; MATHEMATICAL COMPUTING; METHODOLOGY; NONHUMAN; PHARMACOPHORE; PREDICTION; PROGNOSIS; RAT; REVIEW; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

CHEMISTRY, PHARMACEUTICAL; CLINICAL TRIALS; CYCLOOXYGENASE 2 INHIBITORS; DRUG EVALUATION, PRECLINICAL; ELECTRONICS; NEURAL NETWORKS (COMPUTER); STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 24944476674     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955705774329537     Document Type: Review

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