Comparative molecular modeling study of the three-dimensional structures of prostaglandin endoperoxide H2 synthase 1 and 2 (COX-1 and COX-2)

Journal of Molecular Graphics and Modelling

Volumn 15, Issue 5, 1997, Pages 290-300

  Filizola, Marta ^a,b   Perez, Juan J ^a   Palomer, Albert ^c   Mauleón, David ^c  

^a UNIVERSITAT POLITÈCNICA DE CATALUNYA   (Spain)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c Laboratorios Menarini   (Spain)

Author keywords

AMBER force field; COX; Homology modeling; NSAIDs; PGHS

Indexed keywords

ISOENZYME; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN ENDOPEROXIDE; PROSTAGLANDIN SYNTHASE;

ARTICLE; DIELECTRIC CONSTANT; GENETIC CONSERVATION; HUMAN; LIGAND BINDING; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; X RAY DIFFRACTION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; HUMANS; ISOENZYMES; LIGANDS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SHEEP; THERMODYNAMICS; X-RAY DIFFRACTION;

OVIS;

EID: 0031251727     PISSN: 10933263     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1093-3263(97)00107-1     Document Type: Article

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