A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 22, 1999, Pages 3181-3186

  Li, Chun Sing ^a   Black, W Cameron ^a   Brideau, Christine ^a   Chan, Chi Chung ^a   Charleson, Stella ^a   Cromlish, Wanda A ^a   Claveau, David ^a   Yves Gauthier, Jacques ^a   Gordon, Robert ^a   Greig, Gillian ^a   Grimm, Erich ^a   Guay, Jocelyne ^a   Lau, Cheuk K ^a   Riendeau, Denis ^a   Thérien, Michel ^a   Visco, Denise M ^a   Wong, Elizabeth ^a   Xu, Lijing ^a   Prasit, Petpiboon ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5,5 DIMETHYL 3 (3 FLUOROPHENYL) 4 (4 METHANESULFONYLPHENYL) 2 (5H) FURANONE DERIVATIVE; ANISOLE; ANTIINFLAMMATORY AGENT; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DIMETHYL SULFIDE; DIMETHYL SULFONE; INDOMETACIN; ROFECOXIB; SULFONE DERIVATIVE; UNCLASSIFIED DRUG;

ADJUVANT ARTHRITIS; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BLOOD; CHEMICAL MODIFICATION; CHO CELL; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; GASTROINTESTINAL TOXICITY; HUMAN; HUMAN TISSUE; HYPERALGESIA; INFLAMMATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PAW EDEMA; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

EID: 0033571415     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00559-4     Document Type: Article

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