Novel 1,2-diarylcyclobutenes: Selective and orally active COX-2 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 22, 1996, Pages 2677-2682

  Friesen, Richard W ^a   Dubé, Daniel ^a   Fortin, Rejean ^a   Frenette, Richard ^a   Prescott, Sylvie ^a   Cromlish, Wanda ^a   Greig, Gillian M ^a   Kargman, Stacia ^a   Wong, Elizabeth ^a   Chan, Chi Chung ^a   Gordon, Robert ^a   Xu, Li Jing ^a   Riendeau, Denis ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4,4 DIMETHYL 2 PHENYL 3 [4 (METHYLSULFONYL)PHENYL] 2 CYCLOBUTENONE; 5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; CYCLOBUTANE DERIVATIVE; INDOMETACIN; ISOENZYME; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; SC 58451; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG SYNTHESIS; EDEMA; ENZYME INHIBITION; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; REACTION ANALYSIS;

ANIMALIA;

EID: 16144363582     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(96)00501-X     Document Type: Article

References (31)

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31. 50 = 2.4 mg/kg).