Design, synthesis and biological evaluation of benzimidazole/benzothiazole and benzoxazole derivatives as cyclooxygenase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 4, 2003, Pages 657-660

  Paramashivappa, R ^a   Phani Kumar, P ^a   Subba Rao, P V ^a   Srinivasa Rao, A ^a  

^a JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[(2 METHOXY 6 PENTADECYLPHENYL)METHYL]THIO]BENZOTHIAZOLE; 5 (METHOXY) 2 [[(2 HYDROXY 6 PENTADECYLPHENYL)METHYL]THIO] 1H BENZIMIDAZOLE; ANACARDIC ACID; BENZIMIDAZOLE DERIVATIVE; BENZOTHIAZOLE DERIVATIVE; BENZOXAZOLE DERIVATIVE; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; PROSTAGLANDIN SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG DESIGN; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; IC 50; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE;

BENZIMIDAZOLES; BENZOTHIAZOLES; BENZOXAZOLES; BLOOD; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DRUG EVALUATION, PRECLINICAL; HETEROCYCLIC COMPOUNDS; HUMANS; INHIBITORY CONCENTRATION 50; ISOENZYMES; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 0037294820     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)01006-5     Document Type: Article

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