6-Dimethylamino 1H-pyrazolo[3,4-d]pyrimidine derivatives as new inhibitors of inflammatory mediators in intact cells

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 6, 2003, Pages 863-868

  Quintela, José M ^a   Peinador, Carlos ^a   González, Liliana ^a   Devesa, Isabel ^b   Ferrándiz, M Luisa ^b   Alcaraz, Maria J ^b   Riguera, Ricardo ^c  

^a UNIVERSITY OF A CORUÑA   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

^c Santiago de Compostela Spain   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

4 (3' AMINOMETHYLPYRIDINO) 6 DIMETHYLAMINO 1 PHENYL 1H PYRAZOLO[3,4 D]PYRIMIDINE; 4 (3' AMINOMETHYLPYRIDINO) 6 DIMETHYLAMINO 1 TERT BUTYL 1H PYRAZOLO[3,4 D]PYRIMIDINE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; PROSTAGLANDIN E2; PROSTAGLANDIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL FUNCTION; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; INFRARED SPECTROSCOPY; INHIBITION KINETICS; MACROPHAGE; MASS SPECTROMETRY; NEUTROPHIL; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CHEMILUMINESCENT MEASUREMENTS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; HUMANS; INFLAMMATION MEDIATORS; ISOENZYMES; LEUKOCYTES; LEUKOTRIENE B4; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE PROTEINS; MICE; PANCREATIC ELASTASE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

MURINAE;

EID: 0037334344     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00562-X     Document Type: Article

References (18)

1. Smith J. A. J. Leukoc. Biol. 56:1994;672.
2. Laskin D. L., Pendino J. K. Annu. Rev. Pharmacol. Toxicol. 35:1995;655.
3. Reddy S. T., Herschman H. R. J. Biol. Chem. 269:1994;15473.
4. Vane J. R., Mitchell J. A., Appleton I., Tomlison A., Bishop-Bailey D., Croxtall J., Willoughby D. A. Proc. Natl. Acad. Sci. U.S.A. 91:1994;2046.
5. Kang R. Y., Freire J., Sigal E., Chu C. Q. Br. J. Rheumatol. 35:1996;711.
6. Vidal A., Ferrándiz M. L., Ubeda A., Guillén I., Riguera R., Quintela J. M., Peinador C., Moreira M. J., Alcaraz M. J. Life Sci. 66:2000;125.
7. (a) Taylor, E. C.; McKillop, A. In The Chemistry of Cyclic Enaminonitriles and o-Aminonitriles; Interscience: New York, 1970.
8. (b) Wamhoff H. Adv. Heterocycl. Chem. 38:1985;357
9. (c) Erian A. W. Chem. Rev. 93:1993;1991.
10. Quintela J. M., Peinador C., Moreira M. J., Alvarez-Sarandés R. Recent Res. Dev. Org. Chem. 2:1998;409. and references therein.
11. Quintela J. M., Peinador C., Moreira M. J., Alfonso A., Botana L. M., Riguera R. Eur. J. Med. Chem. 36:2001;321.
12. Habib A., Bernard C., Lebret M., Créminon C., Esposito B., Tedgui A., Maclouf J. J. Immunol. 158:1997;3845.
13. Bustos G., Ferrándiz M. L., Sanz M. J., Payá M., Alcaraz M. J. Naunyn-Schmiedeberg's Arch. Pharmacol. 315:1995;298.
14. Gross S. S., Levy R. J. Biol. Chem. 267:1992;25722.
15. Barrett A. J. Methods Enzymol. 80:1981;581.
16. Escrig V., Úbeda A., Ferrándiz M. L., Darias J., Sánchez J., Alcaraz M. J., Payá M. J. Pharmacol. Exp. Ther. 282:1997;123.
17. Moroney M. A., Alcaraz M. J., Forder R. A., Carey F., Hoult J.R.S. J. Pharm. Pharmacol. 40:1998;787.
18. Misko T. P., Schilling R. J., Salvemini D., Moore W. M., Currie M. G. Anal. Biochem. 2314:1993;11.