Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 22, 1999, Pages 3187-3192

  Lau, Cheuk K ^a   Brideau, Christine ^a   Chan, Chi Chung ^a   Charleson, Stella ^a   Cromlish, Wanda A ^a   Ethier, Diane ^a   Yves Gauthier, Jacques ^a   Gordon, Robert ^a   Guay, Jocelyne ^a   Kargman, Stacia ^a   Li, Chun Sing ^a   Prasit, Petpiboon ^a   Riendeau, Denis ^a   Thérien, Michel ^a   Visco, Denise M ^a   Xu, Lijing ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DERIVATIVE; ANTIINFLAMMATORY AGENT; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; FURANONE DERIVATIVE; INDOMETACIN; ROFECOXIB; UNCLASSIFIED DRUG;

ADJUVANT ARTHRITIS; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BLOOD; CHO CELL; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; GASTROINTESTINAL TOXICITY; HUMAN; HUMAN TISSUE; HYPERALGESIA; INFLAMMATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PAW EDEMA; RAT;

ANIMALIA;

EID: 0033571027     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00560-0     Document Type: Article

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