SAR in the alkoxy lactone series: The discovery of DFP, a potent and orally active COX-2 inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 15, 1999, Pages 2207-2212

  Leblanc, Y ^a   Roy, P ^a   Boyce, S ^b   Brideau, C ^a   Chan, C C ^a   Charleson, S ^a   Gordon, R ^a   Grimm, E ^a   Guay, J ^a   Leger S ^a   Li, C S ^a   Riendeau, D ^a   Visco, D ^b   Wang, Z ^a   Webb, J ^b   Xu, L J ^a   Prasit, P ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,5 DIMETHYL 3 (2 PROPOXY) 4 METHANESULFONYLPHENYL 2 (5H) FURANONE; 6 (2,4 DIFLUOROPHENYLTHIO) 5 METHANESULFONAMIDO 1 INDANONE; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; LACTONE; NONSTEROID ANTIINFLAMMATORY AGENT; ROFECOXIB; TILMACOXIB; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG EFFECT; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG MECHANISM; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

ADMINISTRATION, ORAL; ANIMALS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; HUMANS; ISOENZYMES; MACACA MULATTA; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; SAIMIRI; STRUCTURE-ACTIVITY RELATIONSHIP; U937 CELLS;

ANIMALIA;

EID: 0033517081     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00365-0     Document Type: Article

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