-
2
-
-
0342679949
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo
-
Borchelt DR, Thinakaran G, Eckman CB et al. (1996). Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron 17:105-113.
-
(1996)
Neuron
, vol.17
, pp. 105-113
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
-
3
-
-
0035103358
-
The multiple paradoxes of presenilins
-
Checler F (2001). The multiple paradoxes of presenilins. J Neurochem 76:1621-1627.
-
(2001)
J Neurochem
, vol.76
, pp. 1621-1627
-
-
Checler, F.1
-
4
-
-
0034896955
-
Nicastrin binds to membrane-tethered Notch
-
Chen F, Yu G, Arawaka S et al. (2001). Nicastrin binds to membrane-tethered Notch. Nature Cell Biol 3:751-754.
-
(2001)
Nature Cell Biol
, vol.3
, pp. 751-754
-
-
Chen, F.1
Yu, G.2
Arawaka, S.3
-
5
-
-
0035204206
-
Nicastrin is required for presenilin-mediated transmembrane cleavage in Drosophila
-
Chung HM, Struhl G (2001). Nicastrin is required for presenilin-mediated transmembrane cleavage in Drosophila. Nature Cell Biol 3:1129-1132.
-
(2001)
Nature Cell Biol
, vol.3
, pp. 1129-1132
-
-
Chung, H.M.1
Struhl, G.2
-
6
-
-
16944362157
-
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
-
Citron M, Westaway D, Xia W et al. (1997). Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med 3:67-72.
-
(1997)
Nat Med
, vol.3
, pp. 67-72
-
-
Citron, M.1
Westaway, D.2
Xia, W.3
-
7
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
De Strooper B, Saftig P, Craessaerts K et al. (1998). Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391:387-390.
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
-
8
-
-
0033535504
-
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
-
De Strooper B, Annaeret W, Cupers P et al. (1999). A presenilin-1- dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 398:518-522.
-
(1999)
Nature
, vol.398
, pp. 518-522
-
-
De Strooper, B.1
Annaeret, W.2
Cupers, P.3
-
9
-
-
0033562741
-
Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies
-
Diehlmann A, Ida N, Weggen S et al. (1999). Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies. J Neurosci Res 56:405-419.
-
(1999)
J Neurosci Res
, vol.56
, pp. 405-419
-
-
Diehlmann, A.1
Ida, N.2
Weggen, S.3
-
10
-
-
0037022644
-
Activity-dependent isolation of the presenilin- Gamma-secretase complex reveals nicastrin and a gamma substrate
-
Esler WP, Kimberly WT, Ostaszewski BL et al. (2002). Activity-dependent isolation of the presenilin- gamma-secretase complex reveals nicastrin and a gamma substrate. Proc Natl Acad Sci USA 99:2720-2725.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 2720-2725
-
-
Esler, W.P.1
Kimberly, W.T.2
Ostaszewski, B.L.3
-
11
-
-
0029762447
-
Alzheimer's disease and apolipoprotein E genotype in Western Australia: An autopsy-verified series
-
Fabian VA, Jones TM, Wilton SD et al. (1996). Alzheimer's disease and apolipoprotein E genotype in Western Australia: an autopsy-verified series. Med J Aust 165:77-80.
-
(1996)
Med J Aust
, vol.165
, pp. 77-80
-
-
Fabian, V.A.1
Jones, T.M.2
Wilton, S.D.3
-
12
-
-
0031017150
-
Presenilin-1 immunoreactive neurons are preserved in late onset Alzheimer's disease
-
Giannakopoulos P, Bouras C, Kovari E et al. (1997). Presenilin-1 immunoreactive neurons are preserved in late onset Alzheimer's disease. Am J Pathol 150:429-436.
-
(1997)
Am J Pathol
, vol.150
, pp. 429-436
-
-
Giannakopoulos, P.1
Bouras, C.2
Kovari, E.3
-
13
-
-
0021256895
-
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
-
Glenner GG, Wong CW (1984). Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Comm 120:885-890.
-
(1984)
Biochem Biophys Res Comm
, vol.120
, pp. 885-890
-
-
Glenner, G.G.1
Wong, C.W.2
-
14
-
-
0034966874
-
Presenilins as therapeutic targets for the treatment of Alzheimer's disease
-
Golde TE, Younkin SG (2001). Presenilins as therapeutic targets for the treatment of Alzheimer's disease. Trends Mol Med 7:264-269.
-
(2001)
Trends Mol Med
, vol.7
, pp. 264-269
-
-
Golde, T.E.1
Younkin, S.G.2
-
15
-
-
0034080403
-
APH-2 encodes a novel extracellular protein required for GLP-1-mediated signaling
-
Goutte C, Hepler W, Mickey KM, Priess JR (2000). APH-2 encodes a novel extracellular protein required for GLP-1-mediated signaling. Development 127:2481-2492.
-
(2000)
Development
, vol.127
, pp. 2481-2492
-
-
Goutte, C.1
Hepler, W.2
Mickey, K.M.3
Priess, J.R.4
-
16
-
-
0032005524
-
Immunoreactivity of presenilin-1 and tau in Alzheimer's disease brain
-
Hendriks L, De Jonghe C, Ursula Lübke Woodrow S et al. (1998). Immunoreactivity of presenilin-1 and tau in Alzheimer's disease brain. Exp Neurol 149:341-348.
-
(1998)
Exp Neurol
, vol.149
, pp. 341-348
-
-
Hendriks, L.1
De Jonghe, C.2
Ursula Lübke Woodrow, S.3
-
17
-
-
0036007117
-
Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor
-
Hu Y, Ye Y, Fortini ME (2002). Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor. Develop Cell 2:69-78.
-
(2002)
Develop Cell
, vol.2
, pp. 69-78
-
-
Hu, Y.1
Ye, Y.2
Fortini, M.E.3
-
18
-
-
0030984042
-
Neuronal expression and intracellular localization of presenilins in normal and Alzheimer disease brains
-
Huynh DP, Vinters HV, Ho DHD, Ho VV, Pulst S-M (1997). Neuronal expression and intracellular localization of presenilins in normal and Alzheimer disease brains. J Neuropathol Exp Neurol 56:1009-1017.
-
(1997)
J Neuropathol Exp Neurol
, vol.56
, pp. 1009-1017
-
-
Huynh, D.P.1
Vinters, H.V.2
Ho, D.H.D.3
Ho, V.V.4
Pulst, S.-M.5
-
19
-
-
0034966352
-
Autopsy-confirmed familial early-onset Alzheimer disease caused by the L153V presenilin 1 mutation
-
Janssen JC, Lantos PL, Fox NC et al. (2001). Autopsy-confirmed familial early-onset Alzheimer disease caused by the L153V presenilin 1 mutation. Arch Neurol 58:963-968.
-
(2001)
Arch Neurol
, vol.58
, pp. 963-968
-
-
Janssen, J.C.1
Lantos, P.L.2
Fox, N.C.3
-
20
-
-
0342601539
-
Immunoreactivity of presenilin-1 in human, rat and mouse brain
-
Kim KS, Wegiel J, Sapienza V, Chen J, Hong H, Wisniewski HM (1997). Immunoreactivity of presenilin-1 in human, rat and mouse brain. Brain Res 757:159-163.
-
(1997)
Brain Res
, vol.757
, pp. 159-163
-
-
Kim, K.S.1
Wegiel, J.2
Sapienza, V.3
Chen, J.4
Hong, H.5
Wisniewski, H.M.6
-
21
-
-
16044365171
-
The E280A presenilin 1 Alzheimer mutation produces increased a beta 42 deposition and severe cerebellar pathology
-
Lemere CA, Lopera F, Kosik KS et al. (1996). The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology. Nat Med 2:1146-1150.
-
(1996)
Nat Med
, vol.2
, pp. 1146-1150
-
-
Lemere, C.A.1
Lopera, F.2
Kosik, K.S.3
-
22
-
-
15444350008
-
Presenilin-1 protein expression in familial and sporadic Alzheimer's disease
-
Levey AI, Heilman CJ, Lah JJ et al. (1997). Presenilin-1 protein expression in familial and sporadic Alzheimer's disease. Ann Neurol 41:742-753.
-
(1997)
Ann Neurol
, vol.41
, pp. 742-753
-
-
Levey, A.I.1
Heilman, C.J.2
Lah, J.J.3
-
23
-
-
0029116848
-
Facilitation of lin-12-mediated signalling by se1-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
-
Levitan D, Greenwald I (1995). Facilitation of lin-12-mediated signalling by se1-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377:351-354.
-
(1995)
Nature
, vol.377
, pp. 351-354
-
-
Levitan, D.1
Greenwald, I.2
-
24
-
-
0034621824
-
Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
-
Li YM, Lai MT, Xu M et al. (2000a). Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1. Nature 405:689-694.
-
(2000)
Nature
, vol.405
, pp. 689-694
-
-
Li, Y.M.1
Lai, M.T.2
Xu, M.3
-
25
-
-
0343819757
-
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
-
Li YM, Lai MT, Xu M et al. (2000b). Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. Proc Natl Acad Sci USA 97:6138-6143.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 6138-6143
-
-
Li, Y.M.1
Lai, M.T.2
Xu, M.3
-
26
-
-
0036007118
-
Drosophila nicastrin is essential for the intramembranous cleavage of notch
-
Lopez-Schier H, St Johnson D (2002). Drosophila nicastrin is essential for the intramembranous cleavage of notch. Develop Cell 2:79-89.
-
(2002)
Develop Cell
, vol.2
, pp. 79-89
-
-
Lopez-Schier, H.1
St. Johnson, D.2
-
27
-
-
9444276544
-
Amyloid beta protein (Abeta) deposition in chromosome 14-linked Alzheimer's disease: Predominance of Abeta42(43)
-
Mann DM, Iwatsubo T, Cairns NJ et al. (1996). Amyloid beta protein (Abeta) deposition in chromosome 14-linked Alzheimer's disease: predominance of Abeta42(43). Ann Neurol 40:149-156.
-
(1996)
Ann Neurol
, vol.40
, pp. 149-156
-
-
Mann, D.M.1
Iwatsubo, T.2
Cairns, N.J.3
-
28
-
-
0012510759
-
Amyloid plaque core protein in Alzheimer disease and Down syndrome
-
Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K (1985). Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci USA 82:4245-4249.
-
(1985)
Proc Natl Acad Sci USA
, vol.82
, pp. 4245-4249
-
-
Masters, C.L.1
Simms, G.2
Weinman, N.A.3
Multhaup, G.4
McDonald, B.L.5
Beyreuther, K.6
-
29
-
-
0021271971
-
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
-
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984). Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34:939-944.
-
(1984)
Neurology
, vol.34
, pp. 939-944
-
-
McKhann, G.1
Drachman, D.2
Folstein, M.3
Katzman, R.4
Price, D.5
Stadlan, E.M.6
-
30
-
-
0035123370
-
The functions of the amyloid precursor protein gene
-
Panegyres PK (2001). The functions of the amyloid precursor protein gene. Rev Neurosci 12:1-39.
-
(2001)
Rev Neurosci
, vol.12
, pp. 1-39
-
-
Panegyres, P.K.1
-
31
-
-
0034599585
-
Genetic testing for Alzheimer's disease
-
Panegyres PK, Goldblatt J, Walpole I, Connor C, Liebeck T, Harrop K (2000). Genetic testing for Alzheimer's disease. Med J Aust 172:339-343.
-
(2000)
Med J Aust
, vol.172
, pp. 339-343
-
-
Panegyres, P.K.1
Goldblatt, J.2
Walpole, I.3
Connor, C.4
Liebeck, T.5
Harrop, K.6
-
32
-
-
0035005101
-
New Protease inhibitors prevent γ-secretase-mediated production of Aβ40/42 without affecting Notch cleavage
-
Petit A, Bihel F, da Costa CA, Pourquie O, Checler F, Kraus J-L (2001). New Protease inhibitors prevent γ-secretase-mediated production of Aβ40/42 without affecting Notch cleavage. Nature Cell Biol 3:507-511.
-
(2001)
Nature Cell Biol
, vol.3
, pp. 507-511
-
-
Petit, A.1
Bihel, F.2
Da Costa, C.A.3
Pourquie, O.4
Checler, F.5
Kraus, J.-L.6
-
33
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D, Eckman C, Jensen M et al. (1996). Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 2:864-870.
-
(1996)
Nat Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
-
34
-
-
0035066332
-
Alzheimer's disease: Genes, proteins and therapy
-
Selkoe DJ (2001). Alzheimer's disease: genes, proteins and therapy. Physiol Rev 81:741-766.
-
(2001)
Physiol Rev
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
35
-
-
0035107460
-
The role of presenilins in γ-secretase activity: Catalyst or cofactor?
-
Small DH (2001). The role of presenilins in γ-secretase activity: catalyst or cofactor? J Neurochem 76:1612-1614.
-
(2001)
J Neurochem
, vol.76
, pp. 1612-1614
-
-
Small, D.H.1
-
36
-
-
0029843172
-
Widespread immunoreactivity of presenilin in neurons of normal and Alzheimer's disease brains: Double-Caboling immunohistochemical study
-
Uchihara T, el Hachini HK, Duyckaerts C et al. (1996). Widespread immunoreactivity of presenilin in neurons of normal and Alzheimer's disease brains: Double-Caboling immunohistochemical study. Acta Neuropathol (Berl) 92:325-330.
-
(1996)
Acta Neuropathol (Berl)
, vol.92
, pp. 325-330
-
-
Uchihara, T.1
El Hachini, H.K.2
Duyckaerts, C.3
-
37
-
-
0031024228
-
Presenilin-1 immunoreactivity is localized intracellularly in Alzheimer's disease brain, but not detected in amyloid plaques
-
Weber LL, Leissring MA, Yang AJ, Glabe CG, Cribbs DH, LaFeria FM (1997). Presenilin-1 immunoreactivity is localized intracellularly in Alzheimer's disease brain, but not detected in amyloid plaques. Exp Neurol 143:37-44.
-
(1997)
Exp Neurol
, vol.143
, pp. 37-44
-
-
Weber, L.L.1
Leissring, M.A.2
Yang, A.J.3
Glabe, C.G.4
Cribbs, D.H.5
Laferia, F.M.6
-
38
-
-
0032487575
-
Prominent expression of presenilin-1 in senile plaques and reactive astrocytes in Alzheimer's disease brain
-
Weggen S, Diehlmann A, Buslei R, Beyreuther K, Bayer TA (1998). Prominent expression of presenilin-1 in senile plaques and reactive astrocytes in Alzheimer's disease brain. Clin Neurosci 9:3279-3283.
-
(1998)
Clin Neurosci
, vol.9
, pp. 3279-3283
-
-
Weggen, S.1
Diehlmann, A.2
Buslei, R.3
Beyreuther, K.4
Bayer, T.A.5
-
39
-
-
0030789895
-
Presenilin-1 is associated with Alzheimer's disease amyloid
-
Wisniewski T, Dowjat WK, Permanne B et al. (1997). Presenilin-1 is associated with Alzheimer's disease amyloid. Am J Pathol 151:601-610.
-
(1997)
Am J Pathol
, vol.151
, pp. 601-610
-
-
Wisniewski, T.1
Dowjat, W.K.2
Permanne, B.3
-
40
-
-
0035937153
-
The role of presenilins in γ-secretase activity
-
Wolfe MS, Haass C (2001). The role of presenilins in γ-secretase activity. J Biol Chem 276:5413-5416.
-
(2001)
J Biol Chem
, vol.276
, pp. 5413-5416
-
-
Wolfe, M.S.1
Haass, C.2
-
41
-
-
0034618715
-
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing
-
Yu G, Nishimura M, Arakawa S et al. (2000). Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature 407:48-54.
-
(2000)
Nature
, vol.407
, pp. 48-54
-
-
Yu, G.1
Nishimura, M.2
Arakawa, S.3
|