메뉴 건너뛰기




Volumn 2, Issue 1, 2004, Pages 37-48

Metabolic fate of endocannabinoids

Author keywords

2 AG; Anandamide; Cannabinoid; Cyclooxygenase; Fatty acid amide hydrolase; Lipoxygenase; Mono acyl glycerol lipase; Prostamide

Indexed keywords

2 ARACHIDONOYLGLYCEROL; ACYLGLYCEROL LIPASE; AMIDE; ANANDAMIDE; BIMATOPROST; CANNABINOID; CANNABINOID DERIVATIVE; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; CYCLOHEXYLCARBAMIC ACID 3' CARBAMOYLBIPHENYL 3 YL ESTER; DOPAMINE 2 RECEPTOR; ESTER; FATTY ACID AMIDASE; FUNCTIONAL GROUP; GLYCEROL; HYDROLASE INHIBITOR; LIPOXYGENASE; N (3 FURYLMETHYL)ARACHIDONAMIDE; N (4 HYDROXY 2 METHYLPHENYL)ARACHIDONAMIDE; N (4 HYDROXYPHENYL)ARACHIDONAMIDE; N METHYL DEXTRO ASPARTIC ACID; NEUROTRANSMITTER; O 1624; PRESYNAPTIC RECEPTOR; PRODRUG; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE; UNCLASSIFIED DRUG; UNINDEXED DRUG; URB 532; VANILLOID RECEPTOR;

EID: 2442715648     PISSN: 1570159X     EISSN: None     Source Type: Journal    
DOI: 10.2174/1570159043476864     Document Type: Review
Times cited : (7)

References (100)
  • 2
    • 12244313878 scopus 로고    scopus 로고
    • Chronic ethanol inhibits the anandamide transport and increases extracellular anandamide levels in cerebellar granule neurons
    • Basavarajappa, B.S., Saito, M., Cooper, T.B. and Hungund, B.L. (2003) Chronic ethanol inhibits the anandamide transport and increases extracellular anandamide levels in cerebellar granule neurons. Eur. J. Pharmacol., 466, 73-83.
    • (2003) Eur. J. Pharmacol. , vol.466 , pp. 73-83
    • Basavarajappa, B.S.1    Saito, M.2    Cooper, T.B.3    Hungund, B.L.4
  • 4
    • 0030865871 scopus 로고    scopus 로고
    • Functional role of high-affinity anandamide transport, as revealed by selective inhibition
    • Beltramo, M., Stella, N., Calignano, A., Lin, S.Y., Makriyannis, A. and Piomelli, D. (1997) Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science, 277, 1094-1097.
    • (1997) Science , vol.277 , pp. 1094-1097
    • Beltramo, M.1    Stella, N.2    Calignano, A.3    Lin, S.Y.4    Makriyannis, A.5    Piomelli, D.6
  • 5
    • 0034463227 scopus 로고    scopus 로고
    • Investigation of structural analogs of prostaglandin amides for binding to and activation of CB1 and CB2 cannabinoid receptors in rat brain and human tonsils
    • Berglund, B.A., Boring, D.L. and Howlett, A.C. (1999) Investigation of structural analogs of prostaglandin amides for binding to and activation of CB1 and CB2 cannabinoid receptors in rat brain and human tonsils. Adv. Exp. Med. Biol., 469, 527-533.
    • (1999) Adv. Exp. Med. Biol. , vol.469 , pp. 527-533
    • Berglund, B.A.1    Boring, D.L.2    Howlett, A.C.3
  • 7
    • 0027731850 scopus 로고
    • The effect of cannabidiol on mouse hepatic microsomal cytochrome P450- dependent anandamide metabolism
    • Bornheim, L.M., Kim, K.Y., Chen, B. and Correia, M.A. (1993) The effect of cannabidiol on mouse hepatic microsomal cytochrome P450- dependent anandamide metabolism. Biochem. Biophys. Res. Commun., 197, 740-746.
    • (1993) Biochem. Biophys. Res. Commun. , vol.197 , pp. 740-746
    • Bornheim, L.M.1    Kim, K.Y.2    Chen, B.3    Correia, M.A.4
  • 8
    • 0028978057 scopus 로고
    • Microsomal cytochrome P450-mediated liver and brain anandamide metabolism
    • Bornheim, L.M., Kim, K.Y., Chen, B. and Correia, M.A. (1995) Microsomal cytochrome P450-mediated liver and brain anandamide metabolism. Biochem. Pharmacol., 50, 677-686.
    • (1995) Biochem. Pharmacol. , vol.50 , pp. 677-686
    • Bornheim, L.M.1    Kim, K.Y.2    Chen, B.3    Correia, M.A.4
  • 9
    • 2242490907 scopus 로고    scopus 로고
    • Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling
    • Bracey, M.H., Hanson, M.A., Masuda, K.R., Stevens, R.C. and Cravatt, B.F. (2002) Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling. Science, 298, 1793-1796.
    • (2002) Science , vol.298 , pp. 1793-1796
    • Bracey, M.H.1    Hanson, M.A.2    Masuda, K.R.3    Stevens, R.C.4    Cravatt, B.F.5
  • 13
    • 0034846861 scopus 로고    scopus 로고
    • A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus
    • Craib, S.J., Ellington, H.C., Pertwee, R.G. and Ross, R.A. (2001) A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus. Br. J. Pharmacol., 134, 30-37.
    • (2001) Br. J. Pharmacol. , vol.134 , pp. 30-37
    • Craib, S.J.1    Ellington, H.C.2    Pertwee, R.G.3    Ross, R.A.4
  • 15
    • 0029904838 scopus 로고    scopus 로고
    • Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
    • Cravatt, B.F., Giang, D.K., Mayfield, S.P., Boger, D.L., Lerner, R.A. and Gilula, N.B. (1996) Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature, 384, 83-87.
    • (1996) Nature , vol.384 , pp. 83-87
    • Cravatt, B.F.1    Giang, D.K.2    Mayfield, S.P.3    Boger, D.L.4    Lerner, R.A.5    Gilula, N.B.6
  • 17
    • 0034986485 scopus 로고    scopus 로고
    • Role of fatty acid amide hydrolase in the transport of the endogenous cannabinoid anandamide
    • Day, T.A., Rakhshan, F., Deutsch, D.G. and Barker, E.L. (2001) Role of fatty acid amide hydrolase in the transport of the endogenous cannabinoid anandamide. Mol. Pharmacol., 59, 1369-1375.
    • (2001) Mol. Pharmacol. , vol.59 , pp. 1369-1375
    • Day, T.A.1    Rakhshan, F.2    Deutsch, D.G.3    Barker, E.L.4
  • 18
    • 0034644842 scopus 로고    scopus 로고
    • Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: Inhibitors of anandamide uptake with negligible capsaicin-like activity
    • De Petrocellis, L., Bisogno, T., Davis, J.B., Pertwee, R.G. and Di Marzo, V. (2000) Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity. FEBS Lett., 483, 52-56.
    • (2000) FEBS Lett. , vol.483 , pp. 52-56
    • De Petrocellis, L.1    Bisogno, T.2    Davis, J.B.3    Pertwee, R.G.4    Di Marzo, V.5
  • 19
    • 0035918311 scopus 로고    scopus 로고
    • The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism
    • De Petrocellis, L., Bisogno, T., Maccarrone, M., Davis, J.B., Finazzi-Agro, A. and Di Marzo, V. (2001) The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism. J. Biol. Chem., 276, 12856-12863.
    • (2001) J. Biol. Chem. , vol.276 , pp. 12856-12863
    • De Petrocellis, L.1    Bisogno, T.2    Maccarrone, M.3    Davis, J.B.4    Finazzi-Agro, A.5    Di Marzo, V.6
  • 21
    • 0029071194 scopus 로고
    • Cannabinoids modulate voltage sensitive potassium A-current in hippocampal neurons via a cAMP-dependent process
    • Deadwyler, S.A., Hampson, R.E., Mu, J., Whyte, A. and Childers, S. (1995) Cannabinoids modulate voltage sensitive potassium A-current in hippocampal neurons via a cAMP-dependent process. J. Pharmacol. Exp. Ther., 273, 734-743.
    • (1995) J. Pharmacol. Exp. Ther. , vol.273 , pp. 734-743
    • Deadwyler, S.A.1    Hampson, R.E.2    Mu, J.3    Whyte, A.4    Childers, S.5
  • 23
    • 0028903996 scopus 로고
    • Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization
    • Desarnaud, F., Cadas, H. and Piomelli, D. (1995) Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization. J. Biol. Chem., 270, 6030-6035.
    • (1995) J. Biol. Chem. , vol.270 , pp. 6030-6035
    • Desarnaud, F.1    Cadas, H.2    Piomelli, D.3
  • 24
    • 0027180394 scopus 로고
    • Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist
    • Deutsch, D.G. and Chin, S.A. (1993) Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist. Biochem. Pharmacol., 46, 791-796.
    • (1993) Biochem. Pharmacol. , vol.46 , pp. 791-796
    • Deutsch, D.G.1    Chin, S.A.2
  • 28
    • 0033856581 scopus 로고    scopus 로고
    • Endocannabinoids: New targets for drug development
    • Di Marzo, V., Bisogno, T. and De Petrocellis, L. (2000) Endocannabinoids: new targets for drug development. Curr. Pharm. Des., 6, 1361-1380.
    • (2000) Curr. Pharm. Des. , vol.6 , pp. 1361-1380
    • Di Marzo, V.1    Bisogno, T.2    De Petrocellis, L.3
  • 29
    • 0033567190 scopus 로고    scopus 로고
    • Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages
    • Di Marzo, V., Bisogno, T., De Petrocellis, L., Melck, D., Orlando, P., Wagner, J.A. and Kunos, G. (1999) Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages. Eur. J. Biochem., 264, 258-267.
    • (1999) Eur. J. Biochem. , vol.264 , pp. 258-267
    • Di Marzo, V.1    Bisogno, T.2    De Petrocellis, L.3    Melck, D.4    Orlando, P.5    Wagner, J.A.6    Kunos, G.7
  • 30
    • 0032055496 scopus 로고    scopus 로고
    • The novel endogenous cannabinoid 2-arachidonoylglycerol is inactivated by neuronal- and basophil-like cells: Connections with anandamide
    • Di Marzo, V., Bisogno, T., Sugiura, T., Melck, D. and De Petrocellis, L. (1998) The novel endogenous cannabinoid 2-arachidonoylglycerol is inactivated by neuronal- and basophil-like cells: connections with anandamide. Biochem. J., 331, 15-19.
    • (1998) Biochem. J. , vol.331 , pp. 15-19
    • Di Marzo, V.1    Bisogno, T.2    Sugiura, T.3    Melck, D.4    De Petrocellis, L.5
  • 32
    • 0032401036 scopus 로고    scopus 로고
    • Endocannabinoids: Endogenous cannabinoid receptor ligands with neuromodulatory action
    • Di Marzo, V., Melck, D., Bisogno, T. and De Petrocellis, L. (1998) Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action. Trends Neurosci., 21, 521-528.
    • (1998) Trends Neurosci. , vol.21 , pp. 521-528
    • Di Marzo, V.1    Melck, D.2    Bisogno, T.3    De Petrocellis, L.4
  • 34
    • 0031820286 scopus 로고    scopus 로고
    • Human platelets and polymorphonuclear leukocytes synthesize oxygenated derivatives of arachidonylethanolamide (anandamide): Their affinities for cannabinoid receptors and pathways of inactivation
    • Edgemond, W.S., Hillard, C.J., Falck, J.R., Kearn, C.S. and Campbell, W.B. (1998) Human platelets and polymorphonuclear leukocytes synthesize oxygenated derivatives of arachidonylethanolamide (anandamide): their affinities for cannabinoid receptors and pathways of inactivation. Mol. Pharmacol., 54, 180-188.
    • (1998) Mol. Pharmacol. , vol.54 , pp. 180-188
    • Edgemond, W.S.1    Hillard, C.J.2    Falck, J.R.3    Kearn, C.S.4    Campbell, W.B.5
  • 36
    • 0027407655 scopus 로고
    • Effect of glutamate and its analogs on diacylglycerol and monoacylglycerol lipase activities of neuron-enriched cultures
    • Farooqui, A.A., Anderson, D.K. and Horrocks, L.A. (1993) Effect of glutamate and its analogs on diacylglycerol and monoacylglycerol lipase activities of neuron-enriched cultures. Brain Res., 604, 180-184.
    • (1993) Brain Res. , vol.604 , pp. 180-184
    • Farooqui, A.A.1    Anderson, D.K.2    Horrocks, L.A.3
  • 37
    • 0037181180 scopus 로고    scopus 로고
    • Noladin ether, a putative novel endocannabinoid: Inactivation mechanisms and a sensitive method for its quantification in rat tissues
    • Fezza, F., Bisogno, T., Minassi, A., Appendino, G., Mechoulam, R. and Di Marzo, V. (2002) Noladin ether, a putative novel endocannabinoid: inactivation mechanisms and a sensitive method for its quantification in rat tissues. FEBS Lett., 513, 294-298.
    • (2002) FEBS Lett. , vol.513 , pp. 294-298
    • Fezza, F.1    Bisogno, T.2    Minassi, A.3    Appendino, G.4    Mechoulam, R.5    Di Marzo, V.6
  • 38
    • 0036019387 scopus 로고    scopus 로고
    • Cellular transport of anandamide, 2-arachidonoylglycerol and palmitoylethanolamide-targets for drug development?
    • Fowler, C.J. and Jacobsson, S.O. (2002) Cellular transport of anandamide, 2-arachidonoylglycerol and palmitoylethanolamide-targets for drug development? Prostaglandins Leukot. Essent. Fatty Acids, 66, 193-200.
    • (2002) Prostaglandins Leukot. Essent. Fatty Acids , vol.66 , pp. 193-200
    • Fowler, C.J.1    Jacobsson, S.O.2
  • 39
    • 0030903752 scopus 로고    scopus 로고
    • Molecular characterization of human and mouse fatty acid amide hydrolases
    • Giang, D.K. and Cravatt, B.F. (1997) Molecular characterization of human and mouse fatty acid amide hydrolases. Proc. Natl. Acad. Sci. USA, 94, 2238-2242.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2238-2242
    • Giang, D.K.1    Cravatt, B.F.2
  • 41
    • 0032559369 scopus 로고    scopus 로고
    • Anandamide amidohydrolase reacting with 2-arachidonoylglycerol, another cannabinoid receptor ligand
    • Goparaju, S.K., Ueda, N., Yamaguchi, H. and Yamamoto, S. (1998) Anandamide amidohydrolase reacting with 2-arachidonoylglycerol, another cannabinoid receptor ligand. FEBS Lett., 422, 69-73.
    • (1998) FEBS Lett. , vol.422 , pp. 69-73
    • Goparaju, S.K.1    Ueda, N.2    Yamaguchi, H.3    Yamamoto, S.4
  • 45
    • 0030852614 scopus 로고    scopus 로고
    • Accumulation of N-arachidonoylethanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion
    • Hillard, C.J., Edgemond, W.S., Jarrahian, A. and Campbell, W.B. (1997) Accumulation of N-arachidonoylethanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion. J. Neurochem., 69, 631-638.
    • (1997) J. Neurochem. , vol.69 , pp. 631-638
    • Hillard, C.J.1    Edgemond, W.S.2    Jarrahian, A.3    Campbell, W.B.4
  • 46
    • 0033666960 scopus 로고    scopus 로고
    • The movement of N-arachidonoylethanolamine (anandamide) across cellular membranes
    • Hillard, C.J. and Jarrahian, A. (2000) The movement of N-arachidonoylethanolamine (anandamide) across cellular membranes. Chem. Phys. Lipids, 108, 123-134.
    • (2000) Chem. Phys. Lipids , vol.108 , pp. 123-134
    • Hillard, C.J.1    Jarrahian, A.2
  • 47
    • 0037127252 scopus 로고    scopus 로고
    • Monoacylglycerol metabolism in human intestinal Caco-2 cells: Evidence for metabolic compartmentation and hydrolysis
    • Ho, S.Y., Delgado, L. and Storch, J. (2002) Monoacylglycerol metabolism in human intestinal Caco-2 cells: evidence for metabolic compartmentation and hydrolysis. J. Biol. Chem., 277, 1816-1823.
    • (2002) J. Biol. Chem. , vol.277 , pp. 1816-1823
    • Ho, S.Y.1    Delgado, L.2    Storch, J.3
  • 51
    • 0034070409 scopus 로고    scopus 로고
    • Structure-activity relationships among N-arachidonylethanolamine (Anandamide) head group analogues for the anandamide transporter
    • Jarrahian, A., Manna, S., Edgemond, W.S., Campbell, W.B. and Hillard, C.J. (2000) Structure-activity relationships among N-arachidonylethanolamine (Anandamide) head group analogues for the anandamide transporter. J. Neurochem., 74, 2597-2606.
    • (2000) J. Neurochem. , vol.74 , pp. 2597-2606
    • Jarrahian, A.1    Manna, S.2    Edgemond, W.S.3    Campbell, W.B.4    Hillard, C.J.5
  • 52
    • 0036729532 scopus 로고    scopus 로고
    • Characterization of the anandamide induced depolarization of guinea-pig isolated vagus nerve
    • Kagaya, M., Lamb, J., Robbins, J., Page, C.P. and Spina, D. (2002) Characterization of the anandamide induced depolarization of guinea-pig isolated vagus nerve. Br. J. Pharmacol., 137, 39-48.
    • (2002) Br. J. Pharmacol. , vol.137 , pp. 39-48
    • Kagaya, M.1    Lamb, J.2    Robbins, J.3    Page, C.P.4    Spina, D.5
  • 53
    • 0030767295 scopus 로고    scopus 로고
    • cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases
    • Karlsson, M., Contreras, J.A., Hellman, U., Tornqvist, H. and Holm, C. (1997) cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases. J. Biol. Chem., 272, 27218-27223.
    • (1997) J. Biol. Chem. , vol.272 , pp. 27218-27223
    • Karlsson, M.1    Contreras, J.A.2    Hellman, U.3    Tornqvist, H.4    Holm, C.5
  • 55
    • 3042605467 scopus 로고    scopus 로고
    • Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides
    • Kozak, K.R., Crews, B.C., Morrow, J.D., Wang, L.H., Ma, Y.H., Weinander, R., Jakobsson, P.J. and Marnett, L.J. (2002) Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. J. Biol. Chem., 19, 19.
    • (2002) J. Biol. Chem. , vol.19 , pp. 19
    • Kozak, K.R.1    Crews, B.C.2    Morrow, J.D.3    Wang, L.H.4    Ma, Y.H.5    Weinander, R.6    Jakobsson, P.J.7    Marnett, L.J.8
  • 56
    • 0035813139 scopus 로고    scopus 로고
    • Metabolism of prostaglandin glycerol esters and prostaglandin ethanolamides in vitro and in vivo
    • Kozak, K.R., Crews, B.C., Ray, J.L., Tai, H.H., Morrow, J.D. and Marnett, L.J. (2001) Metabolism of prostaglandin glycerol esters and prostaglandin ethanolamides in vitro and in vivo. J. Biol. Chem., 276, 36993-36998.
    • (2001) J. Biol. Chem. , vol.276 , pp. 36993-36998
    • Kozak, K.R.1    Crews, B.C.2    Ray, J.L.3    Tai, H.H.4    Morrow, J.D.5    Marnett, L.J.6
  • 57
    • 0037189536 scopus 로고    scopus 로고
    • 15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist
    • Kozak, K.R., Gupta, R.A., Moody, J.S., Ji, C., Boeglin, W.E., DuBois, R.N., Brash, A.R. and Marnett, L.J. (2002) 15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist. J. Biol. Chem., 277, 23278-23286.
    • (2002) J. Biol. Chem. , vol.277 , pp. 23278-23286
    • Kozak, K.R.1    Gupta, R.A.2    Moody, J.S.3    Ji, C.4    Boeglin, W.E.5    DuBois, R.N.6    Brash, A.R.7    Marnett, L.J.8
  • 59
    • 0034721794 scopus 로고    scopus 로고
    • Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2
    • Kozak, K.R., Rowlinson, S.W. and Marnett, L.J. (2000) Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2. J. Biol. Chem., 275, 33744-33749.
    • (2000) J. Biol. Chem. , vol.275 , pp. 33744-33749
    • Kozak, K.R.1    Rowlinson, S.W.2    Marnett, L.J.3
  • 60
    • 0032766027 scopus 로고    scopus 로고
    • The palmitoylethanolamide and oleamide enigmas: Are these two fatty acid amides cannabimimetic?
    • Lambert, D.M. and Di Marzo, V. (1999) The palmitoylethanolamide and oleamide enigmas: are these two fatty acid amides cannabimimetic? Curr. Med. Chem., 6, 757-773.
    • (1999) Curr. Med. Chem. , vol.6 , pp. 757-773
    • Lambert, D.M.1    Di Marzo, V.2
  • 61
    • 0037341020 scopus 로고    scopus 로고
    • Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease
    • Lastres-Becker, I., de Miguel, R., De Petrocellis, L., Makriyannis, A., Di Marzo, V. and Fernandez-Ruiz, J. (2003) Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease. J. Neurochem., 84, 1097-1109.
    • (2003) J. Neurochem. , vol.84 , pp. 1097-1109
    • Lastres-Becker, I.1    de Miguel, R.2    De Petrocellis, L.3    Makriyannis, A.4    Di Marzo, V.5    Fernandez-Ruiz, J.6
  • 62
    • 0242585423 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: Comparison with effects on fatty acid amidohydrolase
    • Lopez-Rodriguez, M.L., Viso, A., Ortega-Gutierrez, S., Fowler, C.J., Tiger, G., de Lago, E., Fernandez-Ruiz, J. and Ramos, J.A. (2003) Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase. J. Med. Chem., 46, 1512-1522.
    • (2003) J. Med. Chem. , vol.46 , pp. 1512-1522
    • Lopez-Rodriguez, M.L.1    Viso, A.2    Ortega-Gutierrez, S.3    Fowler, C.J.4    Tiger, G.5    de Lago, E.6    Fernandez-Ruiz, J.7    Ramos, J.A.8
  • 63
    • 0035924218 scopus 로고    scopus 로고
    • Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors
    • Lopez-Rodriguez, M.L., Viso, A., Ortega-Gutierrez, S., Lastres-Becker, I., Gonzalez, S., Fernandez-Ruiz, J. and Ramos J.A. (2001) Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors. J. Med. Chem., 44, 4505-4508.
    • (2001) J. Med. Chem. , vol.44 , pp. 4505-4508
    • Lopez-Rodriguez, M.L.1    Viso, A.2    Ortega-Gutierrez, S.3    Lastres-Becker, I.4    Gonzalez, S.5    Fernandez-Ruiz, J.6    Ramos, J.A.7
  • 65
    • 3042512645 scopus 로고    scopus 로고
    • Estrogen stimulates arachidonoylethanolamide release from human endothelial cells and platelet activation
    • Maccarrone, M., Bari, M., Battista, N. and Finazzi-Agro, A. (2002) Estrogen stimulates arachidonoylethanolamide release from human endothelial cells and platelet activation. Blood, 1, 1.
    • (2002) Blood , vol.1 , pp. 1
    • Maccarrone, M.1    Bari, M.2    Battista, N.3    Finazzi-Agro, A.4
  • 67
    • 0035883892 scopus 로고    scopus 로고
    • Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes
    • Maccarrone, M., De Petrocellis, L., Bari, M., Fezza, F., Salvati, S., Di Marzo, V. and Finazzi-Agro, A. (2001) Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes. Arch. Biochem. Biophys., 393, 321-328.
    • (2001) Arch. Biochem. Biophys. , vol.393 , pp. 321-328
    • Maccarrone, M.1    De Petrocellis, L.2    Bari, M.3    Fezza, F.4    Salvati, S.5    Di Marzo, V.6    Finazzi-Agro, A.7
  • 68
    • 0035877059 scopus 로고    scopus 로고
    • Progesterone up-regulates anandamide hydrolase in human lymphocytes: Role of cytokines and implications for fertility
    • Maccarrone, M., Valensise, H., Bari, M., Lazzarin, N., Romanini, C. and Finazzi-Agro, A. (2001) Progesterone up-regulates anandamide hydrolase in human lymphocytes: role of cytokines and implications for fertility. J. Immunol., 166, 7183-7189.
    • (2001) J. Immunol. , vol.166 , pp. 7183-7189
    • Maccarrone, M.1    Valensise, H.2    Bari, M.3    Lazzarin, N.4    Romanini, C.5    Finazzi-Agro, A.6
  • 73
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • Matsuda, L.A., Lolait, S.J., Brownstein, M.J., Young, A.C. and Bonner, T.I. (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature, 346, 561-564.
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 75
    • 0035969952 scopus 로고    scopus 로고
    • Selective oxygenation of the endocannabinoid 2-arachidonylglycerol by leukocyte-type 12-lipoxygenase
    • Moody, J.S., Kozak, K.R., Ji, C. and Marnett, L.J. (2001) Selective oxygenation of the endocannabinoid 2-arachidonylglycerol by leukocyte-type 12-lipoxygenase. Biochemistry, 40, 861-866.
    • (2001) Biochemistry , vol.40 , pp. 861-866
    • Moody, J.S.1    Kozak, K.R.2    Ji, C.3    Marnett, L.J.4
  • 76
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • Munro, S., Thomas, K.L. and Abu-Shaar, M. (1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature, 365, 61-65.
    • (1993) Nature , vol.365 , pp. 61-65
    • Munro, S.1    Thomas, K.L.2    Abu-Shaar, M.3
  • 77
    • 0035050883 scopus 로고    scopus 로고
    • Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals
    • Ohno-Shosaku, T., Maejima, T. and Kano, M. (2001) Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals. Neuron, 29, 729-738.
    • (2001) Neuron. , vol.29 , pp. 729-738
    • Ohno-Shosaku, T.1    Maejima, T.2    Kano, M.3
  • 78
    • 0034705440 scopus 로고    scopus 로고
    • Clarifying the catalytic roles of conserved residues in the amidase signature family
    • Patricelli, M.P. and Cravatt, B.F. (2000) Clarifying the catalytic roles of conserved residues in the amidase signature family. J. Biol. Chem., 275, 19177-19184.
    • (2000) J. Biol. Chem. , vol.275 , pp. 19177-19184
    • Patricelli, M.P.1    Cravatt, B.F.2
  • 79
    • 0030611978 scopus 로고    scopus 로고
    • Pharmacology of cannabinoid CB1 and CB2 receptors
    • Pertwee, R.G. (1997) Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol. Ther., 74, 129-180.
    • (1997) Pharmacol. Ther. , vol.74 , pp. 129-180
    • Pertwee, R.G.1
  • 85
    • 0024312441 scopus 로고
    • The purification and properties of monoacylglycerol kinase from bovine brain
    • Shim, Y.H., Lin, C.H. and Strickland, K.P. (1989) The purification and properties of monoacylglycerol kinase from bovine brain. Biochem. Cell Biol., 67, 233-241.
    • (1989) Biochem. Cell Biol. , vol.67 , pp. 233-241
    • Shim, Y.H.1    Lin, C.H.2    Strickland, K.P.3
  • 87
    • 0031469972 scopus 로고    scopus 로고
    • Fatty acid amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central nervous system
    • Thomas, E.A., Cravatt, B.F., Danielson, P.E., Gilula, N.B. and Sutcliffe, J.G. (1997) Fatty acid amide hydrolase, the degradative enzyme for anandamide and oleamide, has selective distribution in neurons within the rat central nervous system. J. Neurosci. Res., 50, 1047-1052.
    • (1997) J. Neurosci. Res. , vol.50 , pp. 1047-1052
    • Thomas, E.A.1    Cravatt, B.F.2    Danielson, P.E.3    Gilula, N.B.4    Sutcliffe, J.G.5
  • 89
    • 0032974478 scopus 로고    scopus 로고
    • An acid amidase hydrolyzing anandamide as an endogenous ligand for cannabinoid receptors
    • Ueda, N., Yamanaka, K., Terasawa, Y. and Yamamoto, S. (1999) An acid amidase hydrolyzing anandamide as an endogenous ligand for cannabinoid receptors. FEBS Lett., 454, 267-270.
    • (1999) FEBS Lett. , vol.454 , pp. 267-270
    • Ueda, N.1    Yamanaka, K.2    Terasawa, Y.3    Yamamoto, S.4
  • 90
    • 0035929564 scopus 로고    scopus 로고
    • Purification and characterization of an acid amidase selective for N-palmitoylethanolamine, a putative endogenous anti-inflammatory substance
    • Ueda, N., Yamanaka, K. and Yamamoto, S. (2001) Purification and characterization of an acid amidase selective for N-palmitoylethanolamine, a putative endogenous anti-inflammatory substance. J. Biol. Chem., 276, 35552-35557.
    • (2001) J. Biol. Chem. , vol.276 , pp. 35552-35557
    • Ueda, N.1    Yamanaka, K.2    Yamamoto, S.3
  • 91
    • 0037103365 scopus 로고    scopus 로고
    • Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: Conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase
    • van der Stelt, M., van Kuik, J.A., Bari, M., van Zadelhoff, G., Leeflang, B.R., Veldink, G.A., Finazzi-Agro, A., Vliegenthart, J.F. and Maccarrone, M. (2002) Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase. J. Med. Chem., 45, 3709-3720.
    • (2002) J. Med. Chem. , vol.45 , pp. 3709-3720
    • van der Stelt, M.1    van Kuik, J.A.2    Bari, M.3    van Zadelhoff, G.4    Leeflang, B.R.5    Veldink, G.A.6    Finazzi-Agro, A.7    Vliegenthart, J.F.8    Maccarrone, M.9
  • 94
    • 0029745360 scopus 로고    scopus 로고
    • Inhibition of anandamide amidase activity in mouse brain microsomes by cannabinoids
    • Watanabe, K., Kayano, Y., Matsunaga, T., Yamamoto, I. and Yoshimura, H. (1996) Inhibition of anandamide amidase activity in mouse brain microsomes by cannabinoids. Biol. Pharm. Bull., 19, 1109-1111.
    • (1996) Biol. Pharm. Bull. , vol.19 , pp. 1109-1111
    • Watanabe, K.1    Kayano, Y.2    Matsunaga, T.3    Yamamoto, I.4    Yoshimura, H.5
  • 95
    • 0035967145 scopus 로고    scopus 로고
    • Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
    • Wilson, R.I. and Nicoll, R.A. (2001) Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses. Nature, 410, 588-592.
    • (2001) Nature , vol.410 , pp. 588-592
    • Wilson, R.I.1    Nicoll, R.A.2
  • 98
    • 0030611859 scopus 로고    scopus 로고
    • Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2
    • Yu, M., Ives, D. and Ramesha, C.S. (1997) Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2. J. Biol. Chem., 272, 21181-21186.
    • (1997) J. Biol. Chem. , vol.272 , pp. 21181-21186
    • Yu, M.1    Ives, D.2    Ramesha, C.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.