The Activity of Anandamide at Vanilloid VR1 Receptors Requires Facilitated Transport across the Cell Membrane and Is Limited by Intracellular Metabolism

Journal of Biological Chemistry

Volumn 276, Issue 16, 2001, Pages 12856-12863

  De Petrocellis, Luciano ^b   Bisogno, Tiziana ^a   Maccarrone, Mauro ^d   Davis, John B ^c   Finazzi Agrò, Alessandro ^d   Di Marzo, Vincenzo ^a  

^a Istituto per la Chimica di Molecole di Interesse Biologico   (Italy)

^b CNR   (Italy)

^c GLAXOSMITHKLINE   (United Kingdom)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXATION; CYTOLOGY; DEGRADATION; ENZYMES; FATTY ACIDS; METABOLISM; TRANSPORT PROPERTIES;

ENDOGENOUS LIGANDS;

CELL MEMBRANES;

ANANDAMIDE; ANANDAMIDE HYDROLASE; BENZYLSULFONYL FLUORIDE; CALCIUM ION; CANNABINOID 1 RECEPTOR; CAPSAICIN; FATTY ACID AMIDASE; HORMONE INHIBITOR; METHYLARACHIDONOYL FLUOROPHOSPHONATE; N (2 METHYL 4 HYDROXYPHENYL)ARACHIDONAMIDE; N ARACHIDONOYL 5 METHOXYTRYPTAMINE; NITRIC OXIDE DONOR; NITROPRUSSIDE SODIUM; RESINIFERATOXIN; RIMONABANT; UNCLASSIFIED DRUG; VANILLOID RECEPTOR; VANILLOID RECEPTOR 1; AMIDE; ARACHIDONIC ACID DERIVATIVE; CALCIUM; CANNABINOID; DITERPENE; DRUG RECEPTOR; ENZYME INHIBITOR; METHYL ARACHIDONYLFLUOROPHOSPHONATE; N (2 (4 HYDROXYPHENYL)ETHYL)ARACHIDONAMIDE; N-(2-(4-HYDROXYPHENYL)ETHYL)ARACHIDONAMIDE; PHOSPHONIC ACID DERIVATIVE; RECOMBINANT PROTEIN;

ARTICLE; CALCIUM CELL LEVEL; CELL MEMBRANE TRANSPORT; CELL METABOLISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME MECHANISM; GENE OVEREXPRESSION; HORMONE ACTION; HORMONE METABOLISM; HORMONE RECEPTOR INTERACTION; HORMONE RECEPTOR TRANSLOCATION; HORMONE TRANSPORT; HUMAN; HUMAN CELL; HYDROLYSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; CELL LINE; CELL MEMBRANE; CYTOSOL; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; KINETICS; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSPORT AT THE CELLULAR LEVEL;

ARACHIDONIC ACIDS; BIOLOGICAL TRANSPORT; CALCIUM; CANNABINOIDS; CAPSAICIN; CELL LINE; CELL MEMBRANE; CYTOSOL; DITERPENES; ENZYME INHIBITORS; HUMANS; KINETICS; NITROPRUSSIDE; PHOSPHONIC ACIDS; POLYUNSATURATED ALKAMIDES; RECEPTORS, DRUG; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION;

EID: 0035918311     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008555200     Document Type: Article

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