The movement of N-arachidonoylethanolamine (anandamide) across cellular membranes

Chemistry and Physics of Lipids

Volumn 108, Issue 1-2, 2000, Pages 123-134

  Hillard, Cecilia J ^a   Jarrahian, Abbas ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Cannabinoid; Endocannabinoid; Flux coupling; Transporter

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANANDAMIDE; CARRIER PROTEIN; SODIUM ION;

ACTIVE TRANSPORT; BIOACCUMULATION; CELL MEMBRANE TRANSPORT; CELL SPECIFICITY; CELLULAR DISTRIBUTION; COMPETITIVE INHIBITION; FATTY ACID TRANSPORT; HUMAN; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; REGULATORY MECHANISM; REVIEW; STRUCTURE ACTIVITY RELATION; TRANSPORT KINETICS;

ANIMALS; ARACHIDONIC ACIDS; BIOLOGICAL TRANSPORT; CELL MEMBRANE; HUMANS; POLYUNSATURATED ALKAMIDES;

BOVINAE;

EID: 0033666960     PISSN: 00093084     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-3084(00)00191-2     Document Type: Review

References (54)

1. Anandamide transport inhibition by the vanilloid agonist olvanil
2. Functional role of high-affinity anandamide transport, as revealed by selective inhibition
3. Brain regional distribution of endocannabinoids: Implications for their biosynthesis and biological function
4. Biosynthesis, uptake, and degradation of anandamide and palmitoylethanolamide in leukocytes
5. Biosynthesis of an endogenous cannabinoid precursor in neurons and its control by calcium and cAMP
6. Potentiation of anandamide hypotension by the transport inhibitor, AM404
7. The capsaicin receptor: A heat-activated ion channel in the pain pathway
8. Molecular characterization of an enzyme that degrades neuromodulatory fatty acid amides
9. Chemical characterization of a family of brain lipids that induce sleep
10. Protein kinases, nitric oxide and long-term depression of synapses in the cerebellum
11. Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist
12. Cellular uptake of anandamide is inhibited by blocking its degradation with FAAH inhibitors
13. Isolation and structure of a brain constituent that binds to the cannabinoid receptor
14. Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages
15. Interactions between synthetic vanilloids and the endogenous cannabinoid system
16. The novel endogenous cannabinoid 2-arachidonoylglycerol is inactivated by neuronal- and basophil-like cells: Connections with anandamide
17. Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells
18. Formation and inactivation of endogenous cannabinoid anandamide in central neurons
19. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction
20. Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat
21. Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent
22. Expression of central and peripheral cannabiniod receptors in human immune tissues and leukocyte subpopulations
23. Cannabinoid receptor localization in brain
24. Biochemistry and pharmacology of arachidonylethanolamine, a putative endogenous cannabinoid
25. Accumulation of N-arachidonoylethanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion
26. Effects of CB(1) cannabinoid receptor activation on cerebellar granule cell nitric oxide synthase activity
27. Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain
28. Cannabinoid inhibition of adenylate cyclase. Pharmacology of the response in neuroblastoma cell membranes
29. Structure activity relationships among anandamide head group analogs for the anandamide transporter
30. Identification and characterization of a prostaglandin transporter
31. Accumulation of various N-acylethanolamines including N-arachidonylethanolamine (anandamide) in cadmium chloride-administered rat testes
32. Cannabinoids decrease excitatory synaptic transmission and impair long-term depression in rat cerebellar Purkinje cells
33. Anandamide uptake by human endothelial cells and its regulation by nitric oxide
34. Anandamide hydrolysis by human cells in culture and brain
35. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
36. Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): Vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors
37. Synthesis and characterization of a fluorescent substrate for the anandamide transmembrane carrier
38. The modulation of long-term potentiation by Δ-9-tetrahydrocannabinol in the rat hippocampus, in vitro
39. Identification of cannabinoid receptors in cultures of rat cerebellar granule cells
40. Anandamide synthesis is induced by arachidonate mobilizing agonists in cells of the immune system
41. Structural determinants for recognition and translocation by the anandamide transporter
42. Carrier-mediated uptake of the endogenous cannabinoid anandamide in RBL-2H3 cells
43. Occurrence and postmortem generation of anandamide and other long-chain N-acylethanolamines in mammalian brain
44. Corrigendum to: Occurrence and postmortem generation of anandamide and other long chain N-acylethanolamines in mammalian brain
45. Changes in anandamide levels in mouse uterus are associated with uterine receptivity for embryo implantation
46. The intercellular messenger nitric oxide is required for long-term potentiation
47. 2-Arachidonoylglycerol: A possible endogenous cannabinoid receptor ligand in brain
48. Enzymatic synthesis of anandamide, an endogenous cannabinoid receptor ligand, through N-acylphosphatidylethanolamine pathway in testis: Involvement of Ca(2+)-dependent transacylase and phosphodiesterase activities
49. Inhibition of long-term potentiation in rat hippocampal slices by anandamide and WIN55212-2: Reversal by SR141716 A, a selective antagonist of CB1 cannabinoid receptors
50. Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
51. Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry
52. Partial purification and characterization of the porcine brain enzyme hydrolyzing and synthesizing anandamide
53. Platelet- and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension
54. GC/MS analysis of anandamide and quantification of N-arachidonoylphosphatidylethanolamides in various brain regions, spinal cord, testis, and spleen of the rat