A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus

British Journal of Pharmacology

Volumn 134, Issue 1, 2001, Pages 30-37

  Craib, S J ^a   Ellington, H C ^a   Pertwee, R G ^a   Ross, R A ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Anandamide; Bronchus; Cannabinoid; Cyclooxygenase; ETI; ETYA; Lipoxygenase; Vanilloid

Indexed keywords

5,8,11 ICOSATRIENOIC ACID; ANANDAMIDE; ARACHIDONIC ACID; BENZYLSULFONYL FLUORIDE; CAPSAICIN; CAPSAZEPINE; INDOMETACIN; LIPOXYGENASE; N (4 HYDROXYPHENYL)ARACHIDONAMIDE; RIMONABANT; SUBSTANCE P; THIORPHAN; VANILLOID RECEPTOR;

ANIMAL TISSUE; ARTICLE; BRONCHOSPASM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; GUINEA PIG; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING;

EID: 0034846861     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704223     Document Type: Article

References (22)

1. Oxidative metabolism of anandamide
2. Bidirectional control of airway responsiveness by endogenous cannabinoids
3. 2 antagonists
4. Selective inhibition of platelet n-8 lipoxygenase by 5,8,11-eicosatriynoic acid
5. Capsaicin: Cellular targets, mechanisms of action, and selectivity for thin sensory neurones
6. Direct activation of capsaicin receptors by products of lipoxygenase: Endogenous capsaicin-like substances
7. The anandamide transport inhibitor AM404 is an agonist at the rat vanilloid receptor (VRI)
8. Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel
9. The mammalian tachykinin receptors
10. Involvement of capsaicin-sensitive nerves in the bronchomotor effects of arachidonic acid and melittin: A possible role for lipoxin A4
11. Effect of ETYA and BW 755c on arachidonate-induced contractions in the guinea-pig isolated trachea
12. Antihyperalgesic effects of spinal cannabinoids
13. 1 receptors
14. Structure-activity relationship for the endogenous cannabinoid, anandamide and certain of its analogues at vanilloid receptors in transfected cells and vas deferens
15. Lipoxins and novel aspirin-triggered 15-epilipoxins: A jungle of cell-cell interactions or a therapeutic opportunity?
16. The endogenous lipid anandamide is a full agonist at the human, vanilloid receptor (hVR1)
17. Effect of the putative vanilloid receptor agonist, anandamide on the baseline tone in the guinea-pig bronchus
18. Vanilloid (capsaicin) receptors and mechanisms
19. The effect of 5,8,11,14-eicosatetraynoic acid on lipid metabolism
20. The endogenous cannabinoid agonist, anandamide stimulates sensory nerves in guinea-pig airways
21. The anandamide transport inhibitor AM404 activates vanilloid receptors
22. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide