Molecular biology of cannabinoid receptors

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 66, Issue 2-3, 2002, Pages 123-142

  Lutz, B ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 2 ARACHIDONOYLGLYCEROL ETHER; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; ANANDAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR AGONIST; DRONABINOL; KAPPA OPIATE RECEPTOR AGONIST; LIGAND; RIMONABANT; UNCLASSIFIED DRUG; CANNABINOID; DRUG RECEPTOR; ENDOCANNABINOID; ICOSANOID;

BRAIN ELECTROPHYSIOLOGY; CAENORHABDITIS ELEGANS; CELLULAR DISTRIBUTION; CEREBELLUM; DNA MODIFICATION; DROSOPHILA; ENZYME ACTIVITY; HIPPOCAMPUS; HUMAN; IMMUNOCOMPETENT CELL; INVERTEBRATE; MOLECULAR BIOLOGY; MOLECULAR CLONING; MOLECULAR GENETICS; MOLTING; NEUROBIOLOGY; NEUROMODULATION; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEFECT; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR GENE; RETROGRADE NERVE FIBER TRANSPORT; REVIEW; AMINO ACID SEQUENCE; ANIMAL; ANTIBODY SPECIFICITY; ENZYME SPECIFICITY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALIA; CAENORHABDITIS; CAENORHABDITIS ELEGANS; INVERTEBRATA; MAMMALIA; VERTEBRATA;

AMINO ACID SEQUENCE; ANIMALS; CANNABINOIDS; EICOSANOIDS; ENDOCANNABINOIDS; GENE EXPRESSION REGULATION; HUMANS; MOLECULAR BIOLOGY; MOLECULAR SEQUENCE DATA; ORGAN SPECIFICITY; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

EID: 0036019383     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1054/plef.2001.0342     Document Type: Article

References (212)

1. Isolation, structure and partial synthesis of an active constituent of hashish
2. Isolation and structure of a brain constituent that binds to the cannabinoid receptor
3. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
4. 2-Arachidonoylglycerol: A possible endogenous cannabinoid receptor ligand in brain
5. Endocannabinoids: Endogenous cannabinoid receptor ligands with neuromodulatory action
6. Molecular cloning of a human cannabinoid receptor which is also expressed in testis
7. Structure of a cannabinoid receptor and functional expression of the cloned cDNA
8. 2 peripheral cannabinoid receptor
9. 1 cannabinoid receptor gene
10. 2+ channel current
11. Zebra finch CB1 cannabinoid receptor: Pharmacology and in vivo and in vitro effects of activation
12. Behavioral, pharmacological, and molecular characterization of an amphibian cannabinoid receptor
13. Molecular cloning of two cannabinoid type 1-like receptor genes from the puffer fish fugu rubripes
14. Molecular characterization of a peripheral receptor for cannabinoids
15. 2 cannabinoid receptor
16. Molecular phylogenetics and the origins of placental mammals
17. The neurobiology and evolution of cannabinoid signalling
18. Association study of a cannabinoid receptor gene (CNR1) polymorphism and schizophrenia
19. Association study of cannabinoid receptor gene (CNR1) alleles and drug dependence
20. 1 cannabinoid receptor gene coding exon: No structural mutations in individuals exhibiting extreme responses to cannabis
21. Finding of the endocannabinoid signalling system in Hydra, a very primitive organism: Possible role in the feeding response
22. Evidence for an endocannabinoid system in the central nervous system of the leech Hirudo medicinalis
23. Anandamide amidase inhibition enhances anandamide-stimulated nitric oxide release in invertebrate neural tissues
24. Occurrence and metabolism of anandamide and related acyl-ethanolamides in ovaries of the sea urchin paracentrotus lividus
25. Identification and characterization of the leech CNS cannabinoid receptor: Coupling to nitric oxide release
26. An invertebrate G-protein coupled receptor is a chimeric cannabinoid/melanocortin receptor
27. Invertebrate molecular neuroimmune processes
28. Cannabinoid receptors are absent in insects
29. GCRBd: A G-protein-coupled receptor database
30. An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing
31. 1 cannabinoid receptor isoforms
32. 1-cannabinoid receptors in the caudate-putamen
33. 1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation
34. 9-tetrahydrocannabinol treatment produces a time-dependent loss of cannabinoid receptors and cannabinoid receptor-activated G proteins in rat brain
35. Changes in the cannabinoid receptor binding, G protein coupling, and cyclic AMP cascade in the CNS of rats tolerant to and dependent on the synthetic cannabinoid compound CP55,940
36. 35S]thiotriphosphate) binding without receptor down-regulation in brain regions of anandamide-tolerant rats
37. 1 receptors in striatal and cortical regions of rats with experimental allergic encephalomyelitis, an animal model of multiple sclerosis
38. 35S]GTP gamma S binding in synaptic plasma membrane from chronic ethanol exposed mouse
39. Modulation of rat brain cannabinoid receptors after chronic morphine treatment
40. Functional interaction between opioid and cannabinoid receptors in drug self-administration
41. Glucocorticoid regulation of cannabinoid receptor messenger RNA levels in the rat caudateputamen. An in situ hybridization study
42. 1 receptor upregulation in a rat model of chronic neuropathic pain
43. The pattern of neurodegeneration in Huntington's disease: A comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease
44. Cannabinoid receptor messenger RNA levels decrease in a subset of neurons of the lateral striatum, cortex and hippocampus of transgenic Huntington's disease mice
45. Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease
46. 1 receptor mRNA expression is decreased in the reserpine-treated rat model of Parkinson's disease
47. Towards a cannabinoid hypothesis of schizophrenia: Cognitive impairments due to dysregulation of the endogenous cannabinoid system
48. 1 cannabinoid receptor induction in experimental stroke
49. Genome-wide expression analysis reveals dysregulation of myelination- related genes in chronic schizophrenia
50. Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex
51. Normal human pituitary gland and pituitary adenomas express cannabinoid receptor type 1 and synthesize endogenous cannabinoids: First evidence for a direct role of cannabinoids on hormone modulation at the human pituitary level
52. 9-THC-induced central nervous system effects in the mouse
53. Cannabinoid inhibition of adenylate cyclase. Pharmacology of the response in neuroblastoma cell membranes
54. Dual activation and inhibition of adenylyl cyclase by cannabinoid receptor agonists: Evidence for agonist-specific trafficking of intracellular responses
55. Cannabinoids modulate voltage sensitive potassium A-current in hippocampal neurons via a cAMP-dependent process
56. Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells
57. 2+ current in NG108-15 neuroblastoma cells via a pertussis toxin-sensitive mechanism
58. 2 receptors
59. Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor
60. Activation of inwardly rectifying potassium channels (GIRK1) by co- expressed rat brain cannabinoid receptors in Xenopus oocytes
61. 1 cannabinoid receptor mediate desensitization and internalization
62. 1 receptors in hippocampal neurons
63. Rat brain cannabinoid receptors are N-linked glycosylated proteins
64. The cannabinoid receptor: Biochemical and cellular properties in neuroblastoma cells
65. 1 cannabinoid receptor
66. Induction of vanilloid receptor channel activity by protein kinase C
67. 2 phosphorylation by the inverse agonist SR 144528. Implications for receptor biological responses
68. 1 receptor selectively disrupts G protein signaling and prevents receptor internalization
69. 2, disrupts G-protein coupling
70. 1 cannabinoid receptors using receptor peptide fragments and site-directed antibodies
71. 2 receptor
72. 2: Evidence for subtype specificity
73. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
74. The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR)
75. Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human
76. Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel
77. The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism
78. Anandamide: Some like it hot
79. + channel TASK-1
80. Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery
81. CNS distribution of members of the two-pore-domain (KCNK) potassium channel family
82. 1 cannabinoid receptors in cultured astrocytes
83. 2 receptors
84. Assessment of anandamide interaction with the cannabinoid brain receptor: SR 141716A antagonism studies in mice and autoradiographic analysis of receptor binding in rat brain
85. 2 receptor-mediated actions of anandamide in mouse brain
86. Evidence for a new G protein-coupled cannabinoid receptor in mouse brain
87. Control of pain initiation by endogenous cannabinoids
88. 2-like cannabinoid receptors on peripheral nerve terminals
89. Novel cannabinoid-sensitive receptor mediates inhibition of glutamatergic synaptic transmission in the hippocampus
90. Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances
91. 2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor
92. Cannabinoid receptor localization in brain
93. Characterization and localization of cannabinoid receptors in rat brain: A quantitative in vitro autoradiographic study
94. Distribution of neuronal cannabinoid receptor in the adult rat brain: A comparative receptor binding radioautography and in situ hybridization histochemistry
95. 1 receptor in rat brain
96. Immunohistochemical localization of the neural cannabinoid receptor in rat brain
97. 1 receptors in the rat central nervous system
98. 1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons
99. 1
100. 1 cannabinoid receptor in the rat brain. An immunohistochemical study
101. Cannabinoids inhibit hippocampal GABAergic transmission and network oscillations
102. 1 in distinct neuronal subpopulations in the adult mouse forebrain
103. Coexpression of the cannabinoid receptor type 1 with dopamine and serotonin receptors in distinct neuronal subpopulations of the adult mouse forebrain
104. 1 cannabinoid receptor expression in brain regions associated with zebra finch song control
105. 1 cannabinoid receptor in primate brain
106. Distribution of cannabinoid receptor messenger RNA in the human brain: An in situ hybridization histochemistry with oligonucleotides
107. Cannabinoid receptor binding and messenger RNA expression in human brain: An in vitro receptor autoradiography and in situ hybridization histochemistry study of normal aged and Alzheimer's brains
108. Cannabinoid receptors in the human brain: A detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain
109. GABAergic interneurons are the targets of cannabinoid actions in the human hippocampus
110. 1 receptor expression in rat spinal cord
111. 1 cannabinoid receptor in the primate spinal cord
112. 1 receptors and ligands in vertebrate retina: Localization and function of an endogenous signaling system
113. 1 receptor and fatty acid amide hydrolase in rat retina
114. 1 cannabinoid receptor mRNA and protein
115. 1 cannabinoid receptor in macrophage-like cells from brain tissue: Immunochemical characterization by fusion protein antibodies
116. 9-tetrahydrocannabinol-induced stimulation of glucose metabolism in primary astrocytes
117. 1 cannabinoid receptor in μ-opioid receptor patches of the rat caudate putamen nucleus
118. 1 cannabinoid receptors in the anterior lobe of the pituitary gland
119. 1 receptor mRNA in the pituitary gland
120. Cannabinoid ligand-receptor signaling in the mouse uterus
121. Pharmacological analysis of cannabinoid receptor activity in the rat vas deferens
122. Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human
123. 1 receptors on peripheral sympathetic nerves
124. Bidirectional control of airway responsiveness by endogenous cannabinoids
125. Cannabinoids and the gastrointestinal tract
126. Identification of genes differentially expressed by nerve growth factor- and neurotrophin-3-dependent sensory neurons
127. Actions of cannabinoid receptor ligands on rat cultured sensory neurons: Implications for antinociception
128. Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons
129. 1 in alveolar Type II cells in the lung: Regulation by hydrocortisone
130. 2: A characterization of expression and adenylate cyclase modulation within the immune system
131. The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling
132. 2 receptor messenger RNAs during embryonic development in the rat
133. Localization of mRNA expression and activation of signal transduction mechanisms for cannabinoid receptor in rat brain during fetal development
134. Analysis of cannabinoid receptor binding and mRNA expression and endogenous cannabinoid contents in the developing rat brain during late gestation and early postnatal period
135. The effects of cannabinoids on the brain
136. The endocannabinoid system as a target for therapeutic drugs
137. 2 receptor absence in the rat central nervous system
138. 2 peripheral cannabinoid receptors during B-cell differentiation
139. 2 cannabinoid receptor mRNA in adult rat retina
140. Cellular and molecular mechanisms underlying learning and memory impairments produced by cannabinoids
141. 9-tetrahydrocannabinol-induced memory impairment and reduction of hippocampal extracellular acetylcholine concentration
142. Cannabinoid and dopamine interaction in rodent brain: Effects on locomotor activity
143. 1 receptors are localized primarily on cholecystokinin-containing GABAergic interneurons in the rat hippocampal formation
144. 1 cannabinoid receptor antagonist-induced opiate withdrawal in morphine-dependent rats
145. Oligomerization of G-protein-coupled transmitter receptors
146. Neuronal localization of cannabinoid receptors in the basal ganglia of the rat
147. 1 receptors on presynaptic inhibitory terminals in cultured rat hippocampal neurons
148. Cannabinoid receptors undergo axonal flow in sensory nerves
149. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
150. Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase
151. Effects of the endogeneous cannabinoid, anandamide, on neuronal activity in rat hippocampal slices
152. 1 cannabinoid receptors inhibits neurotransmitter release from identified synaptic sites in rat hippocampal cultures
153. Mechanism of cannabinoid effects on long-term potentiation and depression in hippocampal CA1 neurons
154. Mechanisms of cannabinoid inhibition of GABA(A) synaptic transmission in the hippocampus
155. A-receptor synapses in the mammalian CNS
156. Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
157. Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals
158. Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells
159. Presynaptic specificity of endocannabinoid signaling in the hippocampus
160. + M-current in hippocampal CA1 neurons
161. The cannabinoid agonist Win55,212-2 inhibits calcium channels by receptor-mediated and direct pathways in cultured rat hippocampal neurons
162. Differences in G-protein activation by μ- and δ-opioid, and cannabinoid receptors in rat striatum
163. Large receptor reserve for cannabinoid actions in the central nervous system
164. 1 receptor knockout mice
165. Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice
166. Behavioral phenotypes of inbred mouse strains: Implications and recommendations for molecular studies
167. Strain-dependent differences in LTP and hippocampus-dependent memory in inbred mice
168. Strain-dependent effects of anandamide on memory consolidation in mice are antagonized by naltrexone
169. 35S]guanosine triphosphate gamma S binding in the brain of C57BL/6 and DBA/2 mice
170. Activation of brain-type cannabinoid receptors interferes with preimplantation mouse embryo development
171. Dysregulated cannabinoid signaling disrupts uterine receptivity for embryo implantation
172. Activational role of cannabinoids on movement
173. Biphasic effects of anandamide
174. 9-tetrahydrocannabinol-induced responses and apparent agonist activity
175. 1 receptors
176. 1 cannabinoid receptor knockout mice
177. Cannabinoid receptors and pain
178. SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
179. Analgesic, respiratory and heart rate effects of cannabinoid and opioid agonists in rhesus monkeys: Antagonist effects of SR 141716A
180. 1 receptor knockout mice fail to self-administer morphine but not other drugs of abuse
181. 1 receptor knockout mice
182. 1 knockout mice
183. 1 receptors
184. The motivation for beer in rats: Effects of ritanserin, naloxone and SR 141716
185. Cannabinoids, hippocampal function and memory
186. Learning impairment produced in rats by the cannabinoid agonist HU 210 in a water-maze task
187. SR141716A antagonizes the disruptive effects of cannabinoid ligands on learning in rats
188. 1 cannabinoid receptor antagonist, SR 141716
189. Long-term synaptic transformation of hippocampal CA1 γ-aminobutyric acid synapses and the effect of anandamide
190. SR 141716A enhances spatial memory as assessed in a radial-arm maze task in rats
191. 9-tetrahydrocannabinol or anandamide
192. 1 receptor antagonist SR141716A on the behavior of pigeons and rats
193. Molecular mechanisms of memory acquisition, consolidation and retrieval
194. 1 receptor knock-out mice
195. 1 receptors
196. 1 receptor-deficient mice
197. 1 receptor-mediated inhibition of noradrenaline release in the human and guinea-pig hippocampus
198. 1 receptor agonists increase rat cortical and hippocampal acetylcholine release in vivo
199. 1 receptors in hippocampus
200. +6,7 by cannabinoids in hippocampus
201. Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3-CA1 synapses
202. FAK and PYK2/CAKbeta in the nervous system: A link between neuronal activity, plasticity and survival?
203. 1 receptors
204. Appetite suppression and weight loss after the cannabinoid antagonist SR 141716
205. Leptin-regulated endocannabinoids are involved in maintaining food intake
206. The central cannabinoid receptor inactivation suppresses endocrine reproductive functions
207. 1 cannabinoid receptor knockout mice of different ages
208. 2 receptor
209. Abolition and reversal of strain differences in behavioral responses to drugs of abuse after a brief experience
210. Genetics of mouse behavior: Interactions with laboratory environment
211. 9-tetrahydrocannabinol exposure modifies proenkephalin gene expression in the fetal rat brain: Sex-dependent differences
212. Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting