The Cellular Uptake of Anandamide is Coupled to its Breakdown by Fatty-acid Amide Hydrolase

Journal of Biological Chemistry

Volumn 276, Issue 10, 2001, Pages 6967-6973

  Deutsch, Dale G ^a   Glaser, Sherrye T ^a   Howell, Judy M ^a   Kunz, Jeffrey S ^a   Puffenbarger, Robyn A ^a   Hillard, Cecilia J ^b   Abumrad, Nada ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODEGRADATION; BIOLOGICAL MEMBRANES; ENZYMES; FATTY ACIDS; ORGANIC COMPOUNDS; PHOSPHOLIPIDS;

EXTRACELLULAR CONCENTRATION;

CELLS;

ANANDAMIDE; ANTINOCICEPTIVE AGENT; ARACHIDONIC ACID; CANNABINOID RECEPTOR AGONIST; ENZYME INHIBITOR; ETHANOLAMINE; FATTY ACID AMIDASE; FATTY ACID AMIDASE INHIBITOR; METHYLARACHIDONYLFLUOROPHOSPHONATE; PALMITYLSULFONYL FLUORIDE; PHOSPHOLIPID; SERINE; UNCLASSIFIED DRUG; AMIDASE; AMIDE; ARACHIDONIC ACID DERIVATIVE; FATTY-ACID AMIDE HYDROLASE; METHYL ARACHIDONYLFLUOROPHOSPHONATE; PHOSPHONIC ACID DERIVATIVE;

ARTICLE; CELL LEVEL; CELL TYPE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DEGRADATION; DRUG MECHANISM; DRUG UPTAKE; ENZYME ACTIVE SITE; ENZYME INHIBITION; GLIOMA CELL; HUMAN; HUMAN CELL; HYDROLYSIS; LARYNX CARCINOMA; NEUROBLASTOMA CELL; PRIORITY JOURNAL; THIN LAYER CHROMATOGRAPHY; BINDING SITE; BIOLOGICAL MODEL; CELL CULTURE; CHEMISTRY; GENETIC TRANSFECTION; KINETICS; METABOLISM; TIME;

AMIDOHYDROLASES; ARACHIDONIC ACIDS; BINDING SITES; CHROMATOGRAPHY, THIN LAYER; ENZYME INHIBITORS; HUMANS; HYDROLYSIS; KINETICS; MODELS, BIOLOGICAL; PHOSPHONIC ACIDS; POLYUNSATURATED ALKAMIDES; TIME FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0035831508     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M003161200     Document Type: Article

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