Synthesis and biological activity of macrocyclic inhibitors of hepatitis C virus (HCV) NS3 protease

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 20, 2005, Pages 4475-4478

  Chen, Kevin X ^a   Njoroge, F George ^a   Prongay, Andrew ^a   Pichardo, John ^a   Madison, Vincent ^a   Girijavallabhan, Viyyoor ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Hepatitis C virus; Inhibitor; Macrocycle; Protease

Indexed keywords

3 IODOPHENYLALANINE; ACID; ALKENE PHENYLIODIDE; AMIDE; ESTER DERIVATIVE; IODINE DERIVATIVE; MACROCYCLIC COMPOUND; PALLADIUM; PHENYLALANINE DERIVATIVE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CATALYSIS; CONTROLLED STUDY; CYCLIZATION; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; HECK REACTION; HEPATITIS C VIRUS; NONHUMAN;

CRYSTALLOGRAPHY, X-RAY; MOLECULAR STRUCTURE; PROTEASE INHIBITORS; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 24344504516     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.07.033     Document Type: Article

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