Meta-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors

Journal of Medicinal Chemistry

Volumn 40, Issue 4, 1997, Pages 506-514

  Ksander, Gary M ^a   De Jesus, Reynalda ^a   Yuan, Andrew ^a   Ghai, Raj D ^a   McMartin, Colin ^a,b   Bohacek, Regine ^a,c  

^a NOVARTIS PHARMA AG   (Switzerland)

^b Thistlesoft   (United States)

^c Ariad Pharmaceutical   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [(ACETYLTHIO)METHYL] 4 OXO 5 AZABICYCLO[10.3.1]HEXADECA 1(16),12,14 TRIENE 6 CARBOXYLIC ACID METHYL ESTER; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; LACTAM DERIVATIVE; MACROCYCLIC COMPOUND; METALLOPROTEINASE INHIBITOR; THERMOLYSIN; UNCLASSIFIED DRUG; ZINC;

ARTICLE; CRYSTAL STRUCTURE; CYCLIZATION; DIASTEREOISOMER; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; MOLECULAR MODEL; PROTON NUCLEAR MAGNETIC RESONANCE;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; LACTAMS; MODELS, MOLECULAR; NEPRILYSIN; PROTEIN CONFORMATION; SOFTWARE; TEMPLATES, GENETIC;

EID: 0031042767     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960583g     Document Type: Article

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