Phenethyl amides as novel noncovalent inhibitors of hepatitis C virus NS3/4A protease: Discovery, initial SAR, and molecular modeling

Journal of Medicinal Chemistry

Volumn 46, Issue 3, 2003, Pages 345-348

  Colarusso, Stefania ^a   Koch, Uwe ^a   Gerlach, Benjamin ^a   Steinkühler, Christian ^a   De Francesco, Raffaele ^a   Altamura, Sergio ^a   Matassa, Victor G ^a,b   Narjes, Frank ^a  

^a IRBM   (Italy)

^b Graffinity Pharmaceuticals AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ANTIVIRUS AGENT; BENZYL HYDROXAMATE; CYSTEINE PROTEINASE; HYDROXAMIC ACID DERIVATIVE; PHENETHYLAMINE DERIVATIVE; PROTEINASE INHIBITOR; RIBAVIRIN; SERINE PROTEINASE INHIBITOR; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; VIRUS ENZYME;

AMINO ACID SUBSTITUTION; ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HEPATITIS C VIRUS; IC 50; MOLECULAR MODEL; NONHUMAN; PROTEIN DOMAIN; PROTEINASE INHIBITION; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

AMIDES; BENZENE DERIVATIVES; MODELS, MOLECULAR; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

EID: 0037472688     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm025594q     Document Type: Article

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