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Zein NN: Experimental and emerging therapies for chronic hepatitis C virus infection. Expert Opin Invest Drugs (2001) 10:1457-1469. An excellent review of experimental and emerging therapies for HCV infection.
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Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
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In vivo analysis of the 3′ untranslated region of the hepatitis C virus after in vitro mutagenesis of an infectious cDNA clone
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Peginterferon alfa-2a in patients with chronic hepatitis C
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Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
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Lohmann V, Korner F, Koch JO, Herian U, Theilmann L, Bartenschlager R: Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science (1999) 285:110-113. This paper describes the first stable cell-based assay for HCV.
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The conformation of hepatitis C virus NS3 proteinase with and without NS4A: A structural basis for the activation of the enzyme by its cofactor
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The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site
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A personal account of the role of peptide research in drug discovery: The case of hepatitis C
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Crystal structure of hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide
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WO-00009558
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Boehringer Ingelheim (Canada) Ltd (Llinas-Brunet M, Bailey MD, Cameron D, Ghiro E, Goudreau N, Poupart M-A, Rancourt J, Tsantrizos YS): Hepatitis C inhibitor peptides. WO-00009558 (2000).
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Boehringer Ingelheim (Canada) Ltd (Tsantrizos YS, Cameron DR, Faucher A-M, Ghiro E, Goudreau N, Halmos T, Llinas-Brunet M): Macrocyclic peptides active against the hepatitis C virus. WO-00059929 (2000).
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Macrocyclic NS3-serine protease inhibitors of hepatitis C virus comprising n-cyclic p2 moieties
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Schering Corp (Chen KX, Arasappan A, Venkatraman S, Parekh TN, Gu H, Njoroge FG, Girijavallabhan VM, Ganguly A, Saksena A, Jao E, Yao NH, Prongay AJ, Madison VS, Vibulbhan B): Macrocyclic NS3-serine protease inhibitors of hepatitis C virus comprising n-cyclic p2 moieties. WO-00177113 (2001).
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Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease
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Schering Corp (Zhang R): Azapeptides useful in the treatment of hepatitis C. WO-00158929 (2001).
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Compounds, compositions and methods for treatment of hepatitis C
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Method for the treatment or prevention of flavivirus infections using nucleoside analogues
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Japan Tobacco Inc (Hashimoto H, Mizutani K, Yoshida A): Fused-ring compounds and use thereof as drugs. WO-00147883 (2001)
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