Prime site binding inhibitors of a serine protease: NS3/4A of hepatitis C virus

Biochemistry

Volumn 41, Issue 17, 2002, Pages 5483-5492

  Ingallinella, Paolo ^a   Pessi, Antonello ^a   Fattori, Daniela ^b   Altamura, Sergio ^a   Steinkühler, Christian ^a   Koch, Uwe ^a   Cicero, Daniel ^a   Bazzo, Renzo ^a   Cortese, Riccardo ^a   Bianchi, Elisabetta ^a  

^a IRBM   (Italy)

^b Menarini Ricerche Sud ^*  (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COMBINATORIAL LIBRARIES;

AMINO ACIDS; BINDING ENERGY; BIOASSAY; DRUG PRODUCTS; NUCLEAR MAGNETIC RESONANCE; VIRUSES;

ENZYMES;

ANTIVIRUS AGENT; CARBROMAL; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR;

ARTICLE; BINDING AFFINITY; BINDING SITE; CIRCULAR DICHROISM; COMBINATORIAL LIBRARY; DRUG POTENCY; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; HEPATITIS C VIRUS; MOLECULAR WEIGHT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; BINDING SITES; CARRIER PROTEINS; CIRCULAR DICHROISM; COMBINATORIAL CHEMISTRY TECHNIQUES; COMPUTER SIMULATION; DICARBOXYLIC ACIDS; ENDOPEPTIDASES; EVOLUTION, MOLECULAR; GLYCINE; HEPACIVIRUS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OLIGOPEPTIDES; PEPTIDE LIBRARY; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS; VIRAL PROTEINS;

HEPATITIS C VIRUS; RNA VIRUSES;

EID: 0037197701     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi025603x     Document Type: Article

References (52)

1. Hepatitis C Viruses