메뉴 건너뛰기




Volumn 5, Issue 9, 2005, Pages 1193-1210

Immunotherapy for gynaecological malignancies

Author keywords

Cervical cancer; Cytokine; HPV; Immunotherapy; Lymphocyte; Ovarian cancer; Tumour infiltrating; Vaccine development

Indexed keywords

BRCA1 PROTEIN; CANCER VACCINE; CYTOCHROME P450 1B1; DENDRITIC CELL VACCINE; DNA VACCINE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FOLATE BINDING PROTEIN; HEAT SHOCK PROTEIN 65; LIPOPROTEIN; LIVE VACCINE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CA125; MUCIN 1; OREGOVOMAB; PLASMID DNA; PROTEIN E6; PROTEIN E7; PROTEIN P53; RECOMBINANT PROTEIN; TELOMERASE REVERSE TRANSCRIPTASE; TUMOR ANTIGEN; UNCLASSIFIED DRUG; VIRUS VACCINE; ZYC 101;

EID: 24144468941     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.5.9.1193     Document Type: Review
Times cited : (32)

References (215)
  • 2
    • 0033930463 scopus 로고    scopus 로고
    • The identification of cancer antigens: Impact on the development of cancer vaccines
    • ROSENBERG SA:The identification of cancer antigens: impact on the development of cancer vaccines. Cancer J. (2000) 6(Suppl. 2):S142-S149.
    • (2000) Cancer J. , vol.6 , Issue.SUPPL. 2
    • Rosenberg, S.A.1
  • 3
    • 0035018425 scopus 로고    scopus 로고
    • MHC class II-restricted tumor antigens recognized by CD4+ T cells: New strategies for cancer vaccine design
    • ZENG G:MHC class II-restricted tumor antigens recognized by CD4+ T cells: new strategies for cancer vaccine design. J. Immunother. (2001) 24:195-204.
    • (2001) J. Immunother. , vol.24 , pp. 195-204
    • Zeng, G.1
  • 4
    • 12944325331 scopus 로고    scopus 로고
    • A listing of human tumor antigens recognized by T cells: March 2004 update
    • NOVELLINO L, CASTELLI C, PARMIANI G:A listing of human tumor antigens recognized by T cells: March 2004 update. Cancer Immunol. Immunother. (2005) 54(3):187-207.
    • (2005) Cancer Immunol. Immunother. , vol.54 , Issue.3 , pp. 187-207
    • Novellino, L.1    Castelli, C.2    Parmiani, G.3
  • 5
    • 0037339508 scopus 로고    scopus 로고
    • HER2/neu overexpression: Has the Achilles' heel of uterine serous papillary carcinoma been exposed?
    • SANTIN AD:HER2/neu overexpression: has the Achilles' heel of uterine serous papillary carcinoma been exposed? Gynecol Oncol. (2003) 88:263-265.
    • (2003) Gynecol Oncol. , vol.88 , pp. 263-265
    • Santin, A.D.1
  • 6
    • 0037830009 scopus 로고    scopus 로고
    • Cervical cancer
    • WAGGONER SE:Cervical cancer. Lancet (2003) 361:2217-2225.
    • (2003) Lancet , vol.361 , pp. 2217-2225
    • Waggoner, S.E.1
  • 7
    • 0036559896 scopus 로고    scopus 로고
    • Papillomaviruses and cancer: From basic studies to clinical application
    • ZUR HAUSEN H:Papillomaviruses and cancer: from basic studies to clinical application. Nat. Rev. Cancer (2002) 2:342-350.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 342-350
    • Zur Hausen, H.1
  • 8
    • 0029025444 scopus 로고
    • Immunization with viruslike particles from cottontail rabbit papillomavirus (CRPV) can protect against experimental CRPV infection
    • BREITBURD E KIRNBAUER R, HUBBERT NL et al:Immunization with viruslike particles from cottontail rabbit papillomavirus (CRPV) can protect against experimental CRPV infection. J. Virol. (1995) 69:3959-3963. This article reports that neutralising IgG mediate protection after rabbit VLP vaccination.
    • (1995) J. Virol. , vol.69 , pp. 3959-3963
    • Breitburd, E.1    Kirnbauer, R.2    Hubbert, N.L.3
  • 9
    • 0029610072 scopus 로고
    • Systemic immunization with papillomavirus L1 protein completely prevents the development of viral mucosal papillomas
    • SUZICH JA, GHIM SJ, PALMER-HILL FJ et al:Systemic immunization with papillomavirus L1 protein completely prevents the development of viral mucosal papillomas. Proc. Natl. Acad. Sci. USA (1995) 92:11553-11557. This article reports that neutralising IgG mediate protection after canine VLP vaccination.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 11553-11557
    • Suzich, J.A.1    Ghim, S.J.2    Palmer-Hill, F.J.3
  • 10
    • 0036776613 scopus 로고    scopus 로고
    • Protective immunity to rabbit oral and cutaneous papillomaviruses by immunization with short peptides of L2, the minor capsid protein
    • EMBERS ME, BUDGEON LR, PICKEL M, CHRISTENSEN ND: Protective immunity to rabbit oral and cutaneous papillomaviruses by immunization with short peptides of L2, the minor capsid protein. J. Virol. (2002) 76:9798-9805.
    • (2002) J. Virol. , vol.76 , pp. 9798-9805
    • Embers, M.E.1    Budgeon, L.R.2    Pickel, M.3    Christensen, N.D.4
  • 11
    • 0028109547 scopus 로고
    • Immunology of the human papilloma virus in relation to cancer
    • WU TC: Immunology of the human papilloma virus in relation to cancer. Curr. Opin. Immunol. (1994) 6:746-754.
    • (1994) Curr. Opin. Immunol. , vol.6 , pp. 746-754
    • Wu, T.C.1
  • 13
    • 0026500817 scopus 로고
    • Genital papillomavirus infection and cervical dysplasia-opportunistic complications of HIV infection
    • LAGA M, ICENOGLE JP, MARSELLA R et al.:Genital papillomavirus infection and cervical dysplasia-opportunistic complications of HIV infection. Int. J. Cancer (1992) 50:45-48.
    • (1992) Int. J. Cancer , vol.50 , pp. 45-48
    • Laga, M.1    Icenogle, J.P.2    Marsella, R.3
  • 14
    • 0025975287 scopus 로고
    • The increased frequency of cervical dysplasia-neoplasia in women infected with the human immunodeficiency virus is related to the degree of immunosuppression
    • SCHAFER A, FRIEDMANN W, MIELKE M, SCHWARTLANDER B, KOCH MA:The increased frequency of cervical dysplasia-neoplasia in women infected with the human immunodeficiency virus is related to the degree of immunosuppression. Am. J. Obstet. Gynecol. (1991) 164:593-599.
    • (1991) Am. J. Obstet. Gynecol. , vol.164 , pp. 593-599
    • Schafer, A.1    Friedmann, W.2    Mielke, M.3    Schwartlander, B.4    Koch, M.A.5
  • 15
    • 0000191296 scopus 로고
    • Animal models for HPV vaccine development
    • BRANDSMA JL:Animal models for HPV vaccine development. Papillomavirus Rep. (1994) 5:105-111.
    • (1994) Papillomavirus Rep. , vol.5 , pp. 105-111
    • Brandsma, J.L.1
  • 16
    • 0028924786 scopus 로고
    • Immunization with nonstructural proteins E1 and E2 of cottontail rabbit papillomavirus stimulates regression of virus-induced papillomas
    • SELVAKUMAR R, BORENSTEIN LA, LIN YL, AHMED R, WETTSTEIN FO: Immunization with nonstructural proteins E1 and E2 of cottontail rabbit papillomavirus stimulates regression of virus-induced papillomas. J. Virol. (1995) 69:602-605.
    • (1995) J. Virol. , vol.69 , pp. 602-605
    • Selvakumar, R.1    Borenstein, L.A.2    Lin, Y.L.3    Ahmed, R.4    Wettstein, F.O.5
  • 17
    • 0021058264 scopus 로고
    • Regression phenomenon of numerous flat warts-an experiment on the nature of tumor immunity in man
    • TAGAMI H:Regression phenomenon of numerous flat warts-an experiment on the nature of tumor immunity in man. Int. J. Dermatol. (1983) 22:570-571.
    • (1983) Int. J. Dermatol. , vol.22 , pp. 570-571
    • Tagami, H.1
  • 19
    • 0000524075 scopus 로고
    • Growing human papillomaviruses and virus-like particles in the laboratory
    • HAGENSEE M, GALLOWAY D: Growing human papillomaviruses and virus-like particles in the laboratory. Papillomavirus Rep. (1993) 4:121-124.
    • (1993) Papillomavirus Rep. , vol.4 , pp. 121-124
    • Hagensee, M.1    Galloway, D.2
  • 20
    • 0026648295 scopus 로고
    • Definition of linear antigenic regions of the HPV16 L1 capsid protein using synthetic virion-like particles
    • ZHOU J, SUN XY, DAVIES H, CRAWFORD L, PARK D, FRAZER IH: Definition of linear antigenic regions of the HPV16 L1 capsid protein using synthetic virion-like particles. Virology (1992) 189:592-599.
    • (1992) Virology , vol.189 , pp. 592-599
    • Zhou, J.1    Sun, X.Y.2    Davies, H.3    Crawford, L.4    Park, D.5    Frazer, I.H.6
  • 21
    • 0027050013 scopus 로고
    • Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic
    • KIRNBAUER R, BOOY F, CHENG N, LOWY DR, SCHILLER JT:Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic. Proc. Natl. Acad. Sci. USA (1992) 89:12180-12184. This study demonstrates that L1 has an intrinsic capacity to assemble into empty capsid-like structures with immunogenicity similar to that of infectious virions. It provides a foundation for considering L1 preparations as candidates for a serological test for measuring antibodies to conformational virion epitopes and for a vaccine to prevent papillomavirus infection.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 12180-12184
    • Kirnbauer, R.1    Booy, F.2    Cheng, N.3    Lowy, D.R.4    Schiller, J.T.5
  • 22
    • 0028888362 scopus 로고
    • Synthesis and assembly of virus-like particles of human papillomaviruses Type 6 and Type 16 in fission yeast Schizosaccharomyces pombe
    • SASAGAWA T, PUSHKO P, STEERS G et al.:Synthesis and assembly of virus-like particles of human papillomaviruses Type 6 and Type 16 in fission yeast Schizosaccharomyces pombe. Virology (1995) 206:126-135.
    • (1995) Virology , vol.206 , pp. 126-135
    • Sasagawa, T.1    Pushko, P.2    Steers, G.3
  • 23
    • 0030808208 scopus 로고    scopus 로고
    • Human papillomavirus Type 16 virus-like particles expressed in attenuated Salmonella typhimurium elicit mucosal and systemic neutralizing antibodies in mice
    • NARDELLI-HAEFLIGER D, RODEN RB, BENYACOUB J et al: Human papillomavirus Type 16 virus-like particles expressed in attenuated Salmonella typhimurium elicit mucosal and systemic neutralizing antibodies in mice. Infect. Immun. (1997) 65:3328-3336.
    • (1997) Infect. Immun. , vol.65 , pp. 3328-3336
    • Nardelli-Haefliger, D.1    Roden, R.B.2    Benyacoub, J.3
  • 24
    • 0035841211 scopus 로고    scopus 로고
    • DNA microarray analysis of gene expression in endothelial cells in response to 24-h shear stress
    • CHEN BP, LI YS, ZHAO Y et al:DNA microarray analysis of gene expression in endothelial cells in response to 24-h shear stress. Physiol. Genomics (2001) 7:55-63.
    • (2001) Physiol. Genomics , vol.7 , pp. 55-63
    • Chen, B.P.1    Li, Y.S.2    Zhao, Y.3
  • 25
    • 0029841996 scopus 로고    scopus 로고
    • Papillomavirus-like particles for serology and vaccine development
    • KIRNBAUER R:Papillomavirus-like particles for serology and vaccine development. Intervirology (1996) 39:54-61.
    • (1996) Intervirology , vol.39 , pp. 54-61
    • Kirnbauer, R.1
  • 27
    • 0030759895 scopus 로고    scopus 로고
    • Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p2 IWAF1/CiP1
    • SOMASUNDARUM K, ZHANG H, ZENG YX et al.:Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p2 IWAF1/CiP1. Nature (1997) 389:187-190.
    • (1997) Nature , vol.389 , pp. 187-190
    • Somasundarum, K.1    Zhang, H.2    Zeng, Y.X.3
  • 28
    • 0035815517 scopus 로고    scopus 로고
    • Intra-epithelial vaccination with COPV L1 DNA by particle-mediated DNA delivery protects against mucosal challenge with infectious COPV in beagle dogs
    • STANLEY MA, MOORE RA, NICHOLLS PKetaL:Intra-epithelial vaccination with COPV L1 DNA by particle-mediated DNA delivery protects against mucosal challenge with infectious COPV in beagle dogs. Vaccine (2001) 19:2783-2792.
    • (2001) Vaccine , vol.19 , pp. 2783-2792
    • Stanley, M.A.1    Moore, R.A.2    Nicholls, P.K.3
  • 29
    • 0029897935 scopus 로고    scopus 로고
    • Salivary, nasal, genital, and systemic antibody responses in monkeys immunized intranasally with a bacterial protein antigen and the cholera toxin b subunit
    • RUSSELL MW, MOLDOVEANU Z, WHITE PL, SIBERT GJ, MESTECKY J, MICHALEK SM:Salivary, nasal, genital, and systemic antibody responses in monkeys immunized intranasally with a bacterial protein antigen and the cholera toxin b subunit. Infect. Immun. (1996) 64:1272-1283.
    • (1996) Infect. Immun. , vol.64 , pp. 1272-1283
    • Russell, M.W.1    Moldoveanu, Z.2    White, P.L.3    Sibert, G.J.4    Mestecky, J.5    Michalek, S.M.6
  • 30
    • 16944364476 scopus 로고    scopus 로고
    • Human papillomavirus Type 11 (HPV-11) neutralizing antibodies in the serum and genital mucosal secretions of African green monkeys immunized with HPV-11 virus-like particles expressed in yeast
    • LOWE RS, BROWN DR, BRYAN JT et al.:Human papillomavirus Type 11 (HPV-11) neutralizing antibodies in the serum and genital mucosal secretions of African green monkeys immunized with HPV-11 virus-like particles expressed in yeast. J. Infect. Dis. (1997) 176:1141-1145.
    • (1997) J. Infect. Dis. , vol.176 , pp. 1141-1145
    • Lowe, R.S.1    Brown, D.R.2    Bryan, J.T.3
  • 31
    • 0031668082 scopus 로고    scopus 로고
    • Nasal immunization of mice with human papillomavirus Type 16 virus-like particles elicits neutralizing antibodies in mucosal secretions
    • BALMELLI C, RODEN R, POTTS A, SCHILLER J, DE GRANDI P, NARDELLI-HAEFLIGER D:Nasal immunization of mice with human papillomavirus Type 16 virus-like particles elicits neutralizing antibodies in mucosal secretions. J. Virol. (1998) 72:8220-8229.
    • (1998) J. Virol. , vol.72 , pp. 8220-8229
    • Balmelli, C.1    Roden, R.2    Potts, A.3    Schiller, J.4    De Grandi, P.5    Nardelli-Haefliger, D.6
  • 32
    • 0032753468 scopus 로고    scopus 로고
    • Human ovarian cancer, cell lines, and primary ascites cells express the human Mullerian inhibiting substance (MIS) Type II receptor, bind, and are responsive to MIS
    • MASIAKOS PT, MACLAUGHLIN DT, MAHESWARAN S et al:Human ovarian cancer, cell lines, and primary ascites cells express the human Mullerian inhibiting substance (MIS) Type II receptor, bind, and are responsive to MIS. Clin. Cancer Res. (1999) 5:3488-3499.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 3488-3499
    • Masiakos, P.T.1    Maclaughlin, D.T.2    Maheswaran, S.3
  • 33
    • 0041920776 scopus 로고    scopus 로고
    • Specific antibody levels at the cervix during the menstrual cycle of women vaccinated with human papillomavirus 16 virus-like particles
    • NARDELLI-HAEFLIGER D1 WIRTHNER D, SCHILLER JT et al: Specific antibody levels at the cervix during the menstrual cycle of women vaccinated with human papillomavirus 16 virus-like particles. J. Natl. Cancer Inst. (2003) 95:1128-1137. This study reports the influence of the menstrual cycle and oral contraceptive use on the levels of total and specific antibodies in the cervical secretions of women who had been immunised with HPV-VLPs. Although such vaccination generated relatively high titres of anti-HPV-16 antibodies in the cervix, a decrease in neutralising antibody titres was obseved around ovulation.
    • (2003) J. Natl. Cancer Inst. , vol.95 , pp. 1128-1137
    • Nardelli-Haefliger, D.1    Wirthner, D.2    Schiller, J.T.3
  • 34
    • 0035925074 scopus 로고    scopus 로고
    • Safety and immunogenicity trial in adult volunteers of a human papillomavirus 16 L1 virus-like particle vaccine
    • HARRO CD, PANG YY, RODEN RB et al.:Safety and immunogenicity trial in adult volunteers of a human papillomavirus 16 L1 virus-like particle vaccine. J. Natl. Cancer Inst. (2001) 93:284-292.
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 284-292
    • Harro, C.D.1    Pang, Y.Y.2    Roden, R.B.3
  • 35
    • 0035873682 scopus 로고    scopus 로고
    • A Phase I study of a recombinant viruslike particle vaccine against human papillomavirus Type 11 in healthy adult volunteers
    • EVANS TG, BONNEZ W, ROSE RC et al.:A Phase I study of a recombinant viruslike particle vaccine against human papillomavirus Type 11 in healthy adult volunteers. J. Infect, Dis. (2001) 183:1485-1493.
    • (2001) J. Infect, Dis. , vol.183 , pp. 1485-1493
    • Evans, T.G.1    Bonnez, W.2    Rose, R.C.3
  • 36
    • 0037153042 scopus 로고    scopus 로고
    • A controlled trial of a human papillomavirus Type 16 vaccine
    • KOUTSKY LA, AULT KA, WHEELER CM et al:A controlled trial of a human papillomavirus Type 16 vaccine. N. Engl. J. Med. (2002) 347:1645-1651. This paper describes a HPV-L1 VLP trial that produced 100% effective protection from persistent HPV infection. This trial was the first to demonstrate protection against natural transmission of oncogenic HPV after vaccination with L1 VLPs.
    • (2002) N. Engl. J. Med. , vol.347 , pp. 1645-1651
    • Koutsky, L.A.1    Ault, K.A.2    Wheeler, C.M.3
  • 37
    • 0035500950 scopus 로고    scopus 로고
    • Neutralization of human papillomavirus Type 11 (HPV-11) by serum from women vaccinated with yeast-derived HPV-11 L1 virus-like particles: Correlation with competitive radioimmunoassay titer
    • BROWN DR, BRYAN JT, SCHROEDER JM et al:Neutralization of human papillomavirus Type 11 (HPV-11) by serum from women vaccinated with yeast-derived HPV-11 L1 virus-like particles: correlation with competitive radioimmunoassay titer. J. Infect. Dis. (2001) 184:1183-1186.
    • (2001) J. Infect. Dis. , vol.184 , pp. 1183-1186
    • Brown, D.R.1    Bryan, J.T.2    Schroeder, J.M.3
  • 38
    • 0029841214 scopus 로고    scopus 로고
    • In vitro generation and type-specific neutralization of a human papillomavirus Type 16 virion pseudotype
    • RODEN RB, GREENSTONE HL, KIRNBAUER R et al.:In vitro generation and type-specific neutralization of a human papillomavirus Type 16 virion pseudotype. J. Virol. (1996) 70:5875-5883.
    • (1996) J. Virol. , vol.70 , pp. 5875-5883
    • Roden, R.B.1    Greenstone, H.L.2    Kirnbauer, R.3
  • 39
    • 0035915996 scopus 로고    scopus 로고
    • NHPV16 VLP vaccine induces human antibodies that neutralize divergent variants of HPV16
    • PASTRANA DV, VASS WC, LOWY DR, SCHILLER JT:NHPV16 VLP vaccine induces human antibodies that neutralize divergent variants of HPV16. Virology (2001) 279:361-369.
    • (2001) Virology , vol.279 , pp. 361-369
    • Pastrana, D.V.1    Vass, W.C.2    Lowy, D.R.3    Schiller, J.T.4
  • 40
  • 41
    • 0034630951 scopus 로고    scopus 로고
    • Minor capsid protein of human genital papillomaviruses contains subdominant, cross-neutralizing epitopes
    • RODEN RB, YUTZY WH 4TH, FALLON R, INGLIS S, LOWY DR, SCHILLER JT:Minor capsid protein of human genital papillomaviruses contains subdominant, cross-neutralizing epitopes. Virology (2000) 270:254-257. This study presents evidence of crossreactive neutralising epitopes in L2, providing a rationale for developing L2-specific vaccines.
    • (2000) Virology , vol.270 , pp. 254-257
    • Roden, R.B.1    Yutzy IV, W.H.2    Fallon, R.3    Inglis, S.4    Lowy, D.R.5    Schiller, J.T.6
  • 44
    • 0025755278 scopus 로고
    • The open reading frame L2 of cottontail rabbit papillomavirus contains antibody-inducing neutralizing epitopes
    • CHRISTENSEN ND, KREIDER JW, KAN NC, DIANGELO SL:The open reading frame L2 of cottontail rabbit papillomavirus contains antibody-inducing neutralizing epitopes. Virology (1991) 181:572-579. This paper and [45] report an early demonstration of the protective efficacy of L2 vaccination in animal models.
    • (1991) Virology , vol.181 , pp. 572-579
    • Christensen, N.D.1    Kreider, J.W.2    Kan, N.C.3    Diangelo, S.L.4
  • 45
    • 0026559988 scopus 로고
    • Effective vaccination against papilloma development by immunization with L1 or L2 structural protein of cottontail rabbit papillomavirus
    • See [44]
    • LIN YL, BORENSTEIN LA, SELVAKUMAR R, AHMED R, WETTSTEIN FO:Effective vaccination against papilloma development by immunization with L1 or L2 structural protein of cottontail rabbit papillomavirus. Virology (1992) 187:612-619. See [44].
    • (1992) Virology , vol.187 , pp. 612-619
    • Lin, Y.L.1    Borenstein, L.A.2    Selvakumar, R.3    Ahmed, R.4    Wettstein, F.O.5
  • 46
    • 0032989277 scopus 로고    scopus 로고
    • Common neutralization epitope in minor capsid protein L2 of human papillomavirus types 16 and 6
    • KAWANA K, YOSHIKAWA H, TAKETANI Y, YOSHIIKE K, KANDA T: Common neutralization epitope in minor capsid protein L2 of human papillomavirus types 16 and 6. J. Virol. (1999) 73:6188-6190. This paper reports a common cross-neutralisation epitope for HPV-6 and -16 (located within amino acids 108 - 120 of L2 in HPV-16), suggesting that this epitope may be shared by other genital HPVs. Thus, this paper provides evidence of crossreactive neutralising epitopes in L2.
    • (1999) J. Virol. , vol.73 , pp. 6188-6190
    • Kawana, K.1    Yoshikawa, H.2    Taketani, Y.3    Yoshiike, K.4    Kanda, T.5
  • 47
    • 0035130055 scopus 로고    scopus 로고
    • Human papillomavirus Type 16 minor capsid protein L2 N-terminal region containing a common neutralization epitope binds to the cell surface and enters the cytoplasm
    • KAWANA Y, KAWANA K, YOSHIKAWA H, TAKETANI Y, YOSHIIKE K, KANDA T:Human papillomavirus Type 16 minor capsid protein L2 N-terminal region containing a common neutralization epitope binds to the cell surface and enters the cytoplasm. J. Virol. (2001) 75:2331-2336.
    • (2001) J. Virol. , vol.75 , pp. 2331-2336
    • Kawana, Y.1    Kawana, K.2    Yoshikawa, H.3    Taketani, Y.4    Yoshiike, K.5    Kanda, T.6
  • 48
    • 0033372829 scopus 로고    scopus 로고
    • Phase IIa safety and immunogenicity of a therapeutic vaccine, TA-GW, in persons with genital warts
    • LACEY CJ, THOMPSON HS, MONTEIRO EF et al:Phase IIa safety and immunogenicity of a therapeutic vaccine, TA-GW, in persons with genital warts. J. Infect. Dis. (1999) 179:612-618.
    • (1999) J. Infect. Dis. , vol.179 , pp. 612-618
    • Lacey, C.J.1    Thompson, H.S.2    Monteiro, E.F.3
  • 49
    • 0032374338 scopus 로고    scopus 로고
    • Enhanced immunogenicity of a recombinant genital warts vaccine adjuvanted with monophosphoryl lipid a
    • THOMPSON HS, DAVIES ML, WATTS MJ et al.:Enhanced immunogenicity of a recombinant genital warts vaccine adjuvanted with monophosphoryl lipid A. Vaccine (1998) 16:1993-1999.
    • (1998) Vaccine , vol.16 , pp. 1993-1999
    • Thompson, H.S.1    Davies, M.L.2    Watts, M.J.3
  • 50
    • 0037019901 scopus 로고    scopus 로고
    • Enhancement of human papillomavirus (HPV) Type 16 E6 and E7-specific T-cell immunity in healthy volunteers through vaccination with TA-CIN, an HPV16 L2E7E6 fusion protein vaccine
    • DE JONG A, O'NEILL T, KHAN AY et al.:Enhancement of human papillomavirus (HPV) Type 16 E6 and E7-specific T-cell immunity in healthy volunteers through vaccination with TA-CIN, an HPV16 L2E7E6 fusion protein vaccine. Vaccine (2002) 20:3456-3464.
    • (2002) Vaccine , vol.20 , pp. 3456-3464
    • De Jong, A.1    O'Neill, T.2    Khan, A.Y.3
  • 52
    • 0024422238 scopus 로고
    • Differentiation-linked human papillomavirus types 6 and 11 transcription in genital condylomata revealed by in situ hybridization with message-specific RNA probes
    • STOLER MH, WOLINSKY SM, WHITBECKA, BROKERTR, CHOW LT:Differentiation- linked human papillomavirus types 6 and 11 transcription in genital condylomata revealed by in situ hybridization with message-specific RNA probes. Virology (1989) 172:331-340.
    • (1989) Virology , vol.172 , pp. 331-340
    • Stoler, M.H.1    Wolinsky, S.M.2    Whitbeck, A.3    Broker, T.R.4    Chow, L.T.5
  • 53
    • 0032970892 scopus 로고    scopus 로고
    • Induction of HPV16 capsid protein-specific human T cell responses by virus-like particles
    • RUDOLF MP, NIELAND JD, DASILVA DM et al:Induction of HPV16 capsid protein-specific human T cell responses by virus-like particles. Biol. Chem. (1999) 380:335-340.
    • (1999) Biol. Chem. , vol.380 , pp. 335-340
    • Rudolf, M.P.1    Nieland, J.D.2    Dasilva, D.M.3
  • 54
    • 0344406986 scopus 로고    scopus 로고
    • Human papillomavirus Type 16 L1 capsomeres induce L1-specific cytotoxic T lymphocytes and tumor regression in C57BL/6mice
    • OHLSCHLAGER P, OSEN W, DELL K et al.:Human papillomavirus Type 16 L1 capsomeres induce L1-specific cytotoxic T lymphocytes and tumor regression in C57BL/6mice. J. Virol. (2003) 77:4635-4645.
    • (2003) J. Virol. , vol.77 , pp. 4635-4645
    • Ohlschlager, P.1    Osen, W.2    Dell, K.3
  • 55
    • 0024412885 scopus 로고
    • Continued expression of HPV-16 E7 protein is required for maintenance of the transformed phenorype of cells co-transformed by HPV-16 plus EJ-ras
    • CROOK T, MORGENSTERN JP, CRAWFORD L, BANKS L:Continued expression of HPV-16 E7 protein is required for maintenance of the transformed phenorype of cells co-transformed by HPV-16 plus EJ-ras. EMBO J. (1989)8:513-519.
    • (1989) EMBO J. , vol.8 , pp. 513-519
    • Crook, T.1    Morgenstern, J.P.2    Crawford, L.3    Banks, L.4
  • 56
    • 0036894973 scopus 로고    scopus 로고
    • Safety and immunogenicity of TA-HPV, a recombinant vaccinia virus expressing modified human papillomavirus (HPV)-16 and HPV-18 E6 and E7 genes, in women with progressive cervical cancer
    • KAUFMANN AM, STERN PL, RANKIN EM et al.:Safety and immunogenicity of TA-HPV, a recombinant vaccinia virus expressing modified human papillomavirus (HPV)-16 and HPV-18 E6 and E7 genes, in women with progressive cervical cancer. Clin. Cancer Res. (2002) 8:3676-3685.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 3676-3685
    • Kaufmann, A.M.1    Stern, P.L.2    Rankin, E.M.3
  • 57
    • 0035925582 scopus 로고    scopus 로고
    • Clinical studies of human papilloma vaccines in pre-invasive and invasive cancer
    • ADAMS M, BORYSIEWICZ L, FIANDER A et al.:Clinical studies of human papilloma vaccines in pre-invasive and invasive cancer. Vaccine (2001) 19:2549-2556.
    • (2001) Vaccine , vol.19 , pp. 2549-2556
    • Adams, M.1    Borysiewicz, L.2    Fiander, A.3
  • 58
    • 15844365301 scopus 로고    scopus 로고
    • A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer
    • BORYSIEWICZ LK, FIANDER A, FIANDER A, NIMAKO M et al.:A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer. Lancet (1996) 347:1523-1527. This is the first paper to describe a clinical trial of an HPV vaccine utilising a vaccinia virus vector.
    • (1996) Lancet , vol.347 , pp. 1523-1527
    • Borysiewicz, L.K.1    Fiander, A.2    Fiander, A.3    Nimako, M.4
  • 59
    • 10744220391 scopus 로고    scopus 로고
    • Vaccinia-expressed human papillomavirus 16 and 18 e6 and e7 as a therapeutic vaccination for vulval and vaginal intraepithelial neoplasia
    • BALDWIN PJ, VAN DER BURG SH, BOSWELL CM et al.:Vaccinia-expressed human papillomavirus 16 and 18 e6 and e7 as a therapeutic vaccination for vulval and vaginal intraepithelial neoplasia. Clin. Cancer Res. (2003) 9:5205-5213.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 5205-5213
    • Baldwin, P.J.1    Van Der Burg, S.H.2    Boswell, C.M.3
  • 60
    • 0037439692 scopus 로고    scopus 로고
    • Association between human leukocyte antigen polymorphism and human papillomavirus 16-positive vulval intraepithelial neoplasia in British women
    • DAVIDSON EJ, DAVIDSON JA, STERLING JC, BALDWIN PJ, KITCHENER HC, STERN PL: Association between human leukocyte antigen polymorphism and human papillomavirus 16-positive vulval intraepithelial neoplasia in British women. Cancer Res. (2003) 63:400-403.
    • (2003) Cancer Res. , vol.63 , pp. 400-403
    • Davidson, E.J.1    Davidson, J.A.2    Sterling, J.C.3    Baldwin, P.J.4    Kitchener, H.C.5    Stern, P.L.6
  • 61
    • 0030880412 scopus 로고    scopus 로고
    • Listeria monocytogenes: A potent vaccine vector for neoplastic and infectious disease
    • WEISKIRCH LM, PATERSON Y: Listeria monocytogenes: a potent vaccine vector for neoplastic and infectious disease. Immunol. Rev. (1997) 158:159-169.
    • (1997) Immunol. Rev. , vol.158 , pp. 159-169
    • Weiskirch, L.M.1    Paterson, Y.2
  • 62
    • 18044393408 scopus 로고    scopus 로고
    • What is needed for effective antitumor immunotherapy? Lessons learned using Listeria monocytogenes as a live vector for HPV-associated tumors
    • HUSSAIN SF, PATERSON Y:What is needed for effective antitumor immunotherapy? Lessons learned using Listeria monocytogenes as a live vector for HPV-associated tumors. Cancer Immunol. Immunother. (2005) 54(6):577-586.
    • (2005) Cancer Immunol. Immunother. , vol.54 , Issue.6 , pp. 577-586
    • Hussain, S.F.1    Paterson, Y.2
  • 63
    • 0033813525 scopus 로고    scopus 로고
    • A Phase I trial of a human papillomavirus (HPV) peptide vaccine for women with high-grade cervical and vulvar intraepithelial neoplasia who are HPV 16 positive
    • MUDERSPACH L, WILCZYNSKI S, ROMAN L et al:A Phase I trial of a human papillomavirus (HPV) peptide vaccine for women with high-grade cervical and vulvar intraepithelial neoplasia who are HPV 16 positive. Clin. Cancer Res. (2000) 6:3406-3416.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 3406-3416
    • Muderspach, L.1    Wilczynski, S.2    Roman, L.3
  • 64
    • 0031712034 scopus 로고    scopus 로고
    • Cell-mediated immunological responses in cervical and vaginal cancer patients immunized with a lipidated epitope of human papillomavirus Type 16 E7
    • STELLER MA, GURSKI KJ, MURAKAMI M et al:Cell-mediated immunological responses in cervical and vaginal cancer patients immunized with a lipidated epitope of human papillomavirus Type 16 E7. Clin. Cancer Res. (1998) 4:2103-2109.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 2103-2109
    • Steller, M.A.1    Gurski, K.J.2    Murakami, M.3
  • 65
    • 2442540185 scopus 로고    scopus 로고
    • Effect of TA-CIN (HPV 16 L2E6E7) booster immunisation in vulval intraepithelial neoplasia patients previously vaccinated with TA-HPV (vaccinia virus encoding HPV 16/18 E6E7)
    • DAVIDSON EJ, FAULKNER RL, SEHR P et al.:Effect of TA-CIN (HPV 16 L2E6E7) booster immunisation in vulval intraepithelial neoplasia patients previously vaccinated with TA-HPV (vaccinia virus encoding HPV 16/18 E6E7). Vaccine (2004) 22:2722-2729.
    • (2004) Vaccine , vol.22 , pp. 2722-2729
    • Davidson, E.J.1    Faulkner, R.L.2    Sehr, P.3
  • 66
    • 3042723816 scopus 로고    scopus 로고
    • Phase I/II trial of immunogenicity of a human papillomavirus (HPV) Type 16 E7 protein-based vaccine in women with oncogenic HPV-positive cervical intraepithelial neoplasia
    • HALLEZ S, SIMON P, MAUDOUX F et al.:Phase I/II trial of immunogenicity of a human papillomavirus (HPV) Type 16 E7 protein-based vaccine in women with oncogenic HPV-positive cervical intraepithelial neoplasia. Cancer Immunol. Immunother. (2004) 53:642-650.
    • (2004) Cancer Immunol. Immunother. , vol.53 , pp. 642-650
    • Hallez, S.1    Simon, P.2    Maudoux, F.3
  • 67
    • 0037526586 scopus 로고    scopus 로고
    • Therapeutic vaccination for the treatment of mucosotropic human papillomavirus-associated disease
    • CHU NR:Therapeutic vaccination for the treatment of mucosotropic human papillomavirus-associated disease. Expert Opin. Biol. Ther. (2003) 3:477-486.
    • (2003) Expert Opin. Biol. Ther. , vol.3 , pp. 477-486
    • Chu, N.R.1
  • 68
    • 0034627197 scopus 로고    scopus 로고
    • Spontaneous regression of CIN and delayed-type hypersensitivity to HPV-16 oncoprotein E7
    • HOPFL R, HEIM K, CHRISTENSEN N et al.:Spontaneous regression of CIN and delayed-type hypersensitivity to HPV-16 oncoprotein E7. Lancet (2000) 356:1985-1986.
    • (2000) Lancet , vol.356 , pp. 1985-1986
    • Hopfl, R.1    Heim, K.2    Christensen, N.3
  • 69
    • 0036091223 scopus 로고    scopus 로고
    • Encapsulated plasmid DNA treatment for human papillomavirus 16-associated anal dysplasia: A Phase I study of ZYC101
    • KLENCKE B, MATIJEVIC M, URBAN RG et al:Encapsulated plasmid DNA treatment for human papillomavirus 16-associated anal dysplasia: a Phase I study of ZYC101. Clin. Cancer Res. (2002) 8:1028-1037. This study represents the first therapeutic HPV DNA vaccine clinical trial in patients with anal dysplasia. Ten out of twelve patients demonstrated an increased immune response to the peptide epitopes encoded by the DNA vaccine, and three patients experienced partial histological responses. The DNA vaccine was well-tolerated in all of the patients.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 1028-1037
    • Klencke, B.1    Matijevic, M.2    Urban, R.G.3
  • 70
    • 0038405322 scopus 로고    scopus 로고
    • Immunotherapy of human cervical high-grade cervical intraepithelial neoplasia with microparticle-delivered human papillomavirus 16 E7 plasmid DNA
    • SHEETS EE, URBAN RG, CRUM CP et al:Immunotherapy of human cervical high-grade cervical intraepithelial neoplasia with microparticle-delivered human papillomavirus 16 E7 plasmid DNA. Am. J. Obstet. Gynecol. (2003) 188:916-926.
    • (2003) Am. J. Obstet. Gynecol. , vol.188 , pp. 916-926
    • Sheets, E.E.1    Urban, R.G.2    Crum, C.P.3
  • 71
    • 1442305202 scopus 로고    scopus 로고
    • ZYC101a for treatment of high-grade cervical intraepithelial neoplasia: A randomized controlled trial
    • GARCIA F, PETRY KU, MUDERSPACH L et al:ZYC101a for treatment of high-grade cervical intraepithelial neoplasia: a randomized controlled trial. Obstet. Gynecol. (2004) 103:317-326.
    • (2004) Obstet. Gynecol. , vol.103 , pp. 317-326
    • Garcia, F.1    Petry, K.U.2    Muderspach, L.3
  • 72
    • 0035838981 scopus 로고    scopus 로고
    • Regulation of T cell immunity by dendritic cells
    • LANZAVECCHIA A, SALLUSTO F: Regulation of T cell immunity by dendritic cells. Cell (2001) 106:263-266.
    • (2001) Cell , vol.106 , pp. 263-266
    • Lanzavecchia, A.1    Sallusto, F.2
  • 74
    • 0037198442 scopus 로고    scopus 로고
    • Vaccination with HPV-18 E7-pulsed dendritic cells in a patient with metastatic cervical cancer
    • SANTIN AD, BELLONE S, GOKDEN M, CANNON MJ, PARHAM GP:Vaccination with HPV-18 E7-pulsed dendritic cells in a patient with metastatic cervical cancer. N. Engl. J. Med. (2002) 346:1752-1753.
    • (2002) N. Engl. J. Med. , vol.346 , pp. 1752-1753
    • Santin, A.D.1    Bellone, S.2    Gokden, M.3    Cannon, M.J.4    Parham, G.P.5
  • 75
    • 0037472447 scopus 로고    scopus 로고
    • Dendritic cell (DC) based therapy for cervical cancer: Use of DC pulsed with tumour lysate and matured with a novel synthetic clinically non-toxic double stranded RNA analogue poly [I]:poly [C(12)U] (Ampligen®)
    • ADAMS M, NAVABI H, JASANI B et al: Dendritic cell (DC) based therapy for cervical cancer: use of DC pulsed with tumour lysate and matured with a novel synthetic clinically non-toxic double stranded RNA analogue poly [I]:poly [C(12)U] (Ampligen®). Vaccine (2003) 21:787-790.
    • (2003) Vaccine , vol.21 , pp. 787-790
    • Adams, M.1    Navabi, H.2    Jasani, B.3
  • 76
    • 0037174674 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
    • DUDLEY ME, WUNDERLICH JR, ROBBINS PF et al.:Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science (2002) 298:850-854. This influential report represents the first successful use of adoptive cell transfer with TILs following non-myeloablative chemotherapy for the treatment of patients with melanoma.
    • (2002) Science , vol.298 , pp. 850-854
    • Dudley, M.E.1    Wunderlich, J.R.2    Robbins, P.F.3
  • 77
    • 4644324025 scopus 로고    scopus 로고
    • Cancer immunotherapy: Moving beyond current vaccines
    • ROSENBERG SA, YANG JC, RESTIFO NP:Cancer immunotherapy: moving beyond current vaccines. Nat. Med. (2004) 10:909-915. A critical evaluation of cancer vaccine approaches available at present, which emphasise alternative strategies that mediate cancer regression in clinical models.
    • (2004) Nat. Med. , vol.10 , pp. 909-915
    • Rosenberg, S.A.1    Yang, J.C.2    Restifo, N.P.3
  • 78
    • 17844402971 scopus 로고    scopus 로고
    • Phenotypic and functional analysis of tumor-infiltrating lymphocytes compared with tumor-associated lymphocytes from ascitic fluid and peripheral blood lymphocytes in patients with advanced ovarian cancer
    • SANTIN AD, HERMONAT PL, RAVAGGI A et al:Phenotypic and functional analysis of tumor-infiltrating lymphocytes compared with tumor-associated lymphocytes from ascitic fluid and peripheral blood lymphocytes in patients with advanced ovarian cancer. Gynecol. Obstet. Invest. (2001) 51:254-261.
    • (2001) Gynecol. Obstet. Invest. , vol.51 , pp. 254-261
    • Santin, A.D.1    Hermonat, P.L.2    Ravaggi, A.3
  • 79
    • 0030944928 scopus 로고    scopus 로고
    • Quantitative assessment of the leukocyte infiltrate in ovarian cancer and its relationship to the expression of C-C chemokines
    • NEGUS RP, STAMP GW, HADLEY J, BALKWILL FR:Quantitative assessment of the leukocyte infiltrate in ovarian cancer and its relationship to the expression of C-C chemokines. Am. J. Pathol. (1997) 150:1723-1734.
    • (1997) Am. J. Pathol. , vol.150 , pp. 1723-1734
    • Negus, R.P.1    Stamp, G.W.2    Hadley, J.3    Balkwill, F.R.4
  • 80
    • 0032030587 scopus 로고    scopus 로고
    • Immunologic features of tumor-infiltrating lymphocytes and peripheral blood lymphocytes in ovarian cancer patients. J
    • SCHONDORF T, ENGEL H, KURBACHER CM et al:Immunologic features of tumor-infiltrating lymphocytes and peripheral blood lymphocytes in ovarian cancer patients. J. Soc. Gynecol. Investig. (1998) 5:102-107.
    • (1998) Soc. Gynecol. Investig. , vol.5 , pp. 102-107
    • Schondorf, T.1    Engel, H.2    Kurbacher, C.M.3
  • 81
    • 17044446935 scopus 로고    scopus 로고
    • HLA class I expression on human ovarian carcinoma cells correlates with T-cell infiltration in vivo and T-cell expansion in vitro in low concentrations of recombinant interleukin-2
    • KOOI S, ZHANG HZ, PATENIA R, EDWARDS CL, PLATSOUCAS CD, FREEDMAN RS:HLA class I expression on human ovarian carcinoma cells correlates with T-cell infiltration in vivo and T-cell expansion in vitro in low concentrations of recombinant interleukin-2. Cell. Immunol. (1996) 174:116-128.
    • (1996) Cell. Immunol. , vol.174 , pp. 116-128
    • Kooi, S.1    Zhang, H.Z.2    Patenia, R.3    Edwards, C.L.4    Platsoucas, C.D.5    Freedman, R.S.6
  • 82
    • 0032793847 scopus 로고    scopus 로고
    • Clonal expansion of T cells that are specific for autologous ovarian tumor among tumor-infiltrating T cells in humans
    • HAYASHI K, YONAMINE K, MASUKO-HONGO K et al.:Clonal expansion of T cells that are specific for autologous ovarian tumor among tumor-infiltrating T cells in humans. Gynecol. Oncol. (1999) 74:86-92.
    • (1999) Gynecol. Oncol. , vol.74 , pp. 86-92
    • Hayashi, K.1    Yonamine, K.2    Masuko-Hongo, K.3
  • 83
    • 0027528759 scopus 로고
    • Restricted T cell receptor V-beta and J-beta usage in T cells from interleukin-2-cultured lymphocytes of ovarian and renal carcinomas
    • HALAPI E, YAMAMOTO Y, JUHLIN C et al:Restricted T cell receptor V-beta and J-beta usage in T cells from interleukin-2-cultured lymphocytes of ovarian and renal carcinomas. Cancer Immunol. Immunother. (1993) 36:191-197.
    • (1993) Cancer Immunol. Immunother. , vol.36 , pp. 191-197
    • Halapi, E.1    Yamamoto, Y.2    Juhlin, C.3
  • 84
    • 0029053749 scopus 로고
    • Identification of an immunodominant peptide of HER-2/neu protooncogene recognized by ovarian tumor-specific cytotoxic T lymphocyte lines
    • FISK B, BLEVINS TL, WHARTON JT, IOANNIDES CG:Identification of an immunodominant peptide of HER-2/neu protooncogene recognized by ovarian tumor-specific cytotoxic T lymphocyte lines. J. Exp. Med. (1995) 181:2109-2117.
    • (1995) J. Exp. Med. , vol.181 , pp. 2109-2117
    • Fisk, B.1    Blevins, T.L.2    Wharton, J.T.3    Ioannides, C.G.4
  • 85
    • 0027787511 scopus 로고
    • Cytokine production by T-cell lines derived from tumor-infiltrating lymphocytes from patients with ovarian carcinoma: Tumor-specific immune responses and inhibition of antigen-independent cytokine production by ovarian tumor cells
    • KOOI S, FREEDMAN RS, RODRIGUEZ-VILLANUEVA J, PLATSOUCAS CD:Cytokine production by T-cell lines derived from tumor-infiltrating lymphocytes from patients with ovarian carcinoma: tumor-specific immune responses and inhibition of antigen-independent cytokine production by ovarian tumor cells. Lymphokine Cytokine Res. (1993) 12:429-437.
    • (1993) Lymphokine Cytokine Res. , vol.12 , pp. 429-437
    • Kooi, S.1    Freedman, R.S.2    Rodriguez-Villanueva, J.3    Platsoucas, C.D.4
  • 88
    • 0000052318 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes from human ovarian cancer patients recognize autologous tumor in an MHC class II-restricted fashion
    • DADMARZ RD, ORDOUBADI A, MIXON A et al:Tumor-infiltrating lymphocytes from human ovarian cancer patients recognize autologous tumor in an MHC class II-restricted fashion. Cancer J. Sci. Am. (1996) 2:263.
    • (1996) Cancer J. Sci. Am. , vol.2 , pp. 263
    • Dadmarz, R.D.1    Ordoubadi, A.2    Mixon, A.3
  • 89
    • 0034734986 scopus 로고    scopus 로고
    • Induction of ovarian tumor-specific CD8+ cytotoxic T lymphocytes by acid-eluted peptide-pulsed autologous dendritic cells
    • SANTIN AD, BELLONE S, RAVAGGI A, PECORELLI S, CANNON MJ, PARHAM GP:Induction of ovarian tumor-specific CD8+ cytotoxic T lymphocytes by acid-eluted peptide-pulsed autologous dendritic cells. Obstet. Gynecol. (2000) 96:422-430.
    • (2000) Obstet. Gynecol. , vol.96 , pp. 422-430
    • Santin, A.D.1    Bellone, S.2    Ravaggi, A.3    Pecorelli, S.4    Cannon, M.J.5    Parham, G.P.6
  • 91
    • 0025979950 scopus 로고
    • Cytotoxic T cell clones isolated from ovarian tumor-infiltrating lymphocytes recognize multiple antigenic epitopes on autologous tumor cells
    • IOANNIDES CG, FREEDMAN RS, PLATSOUCAS CD, RASHED S, KIM YP: Cytotoxic T cell clones isolated from ovarian tumor-infiltrating lymphocytes recognize multiple antigenic epitopes on autologous tumor cells. J. Immunol. (1991) 146:1700-1707.
    • (1991) J. Immunol. , vol.146 , pp. 1700-1707
    • Ioannides, C.G.1    Freedman, R.S.2    Platsoucas, C.D.3    Rashed, S.4    Kim, Y.P.5
  • 93
    • 0028069489 scopus 로고
    • Large-scale expansion in interleukin-2 of tumor-infiltrating lymphocytes from patients with ovarian carcinoma for adoptive immunotherapy
    • FREEDMAN RS, TOMASOVIC B, TEMPLIN S et al:Large-scale expansion in interleukin-2 of tumor-infiltrating lymphocytes from patients with ovarian carcinoma for adoptive immunotherapy. j. Immunol. Methods (1994) 167:145-160.
    • (1994) J. Immunol. Methods , vol.167 , pp. 145-160
    • Freedman, R.S.1    Tomasovic, B.2    Templin, S.3
  • 94
    • 0037388367 scopus 로고    scopus 로고
    • TRANCE- And CD40 ligand-matured dendritic cells reveal MHC class I-restricted T cells specific for autologous tumor in late-stage ovarian cancer patients
    • SCHLIENGER K, CHU CS, WOO EY et al:TRANCE- and CD40 ligand-matured dendritic cells reveal MHC class I-restricted T cells specific for autologous tumor in late-stage ovarian cancer patients. Clin. Cancer Res. (2003) 9:1517-1527.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 1517-1527
    • Schlienger, K.1    Chu, C.S.2    Woo, E.Y.3
  • 95
    • 0037448353 scopus 로고    scopus 로고
    • Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer
    • ZHANG L, CONEJO-GARCIA JR, KATSAROS D et al:Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N. Engl. J. Med. (2003) 348:203-213.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 203-213
    • Zhang, L.1    Conejo-Garcia, J.R.2    Katsaros, D.3
  • 96
    • 0035872423 scopus 로고    scopus 로고
    • Prognostic significance of activated CD8(+) T cell infiltrations within esophageal carcinomas
    • SCHUMACHER K, HAENSCH W, ROEFZAAD C, SCHLAG PM:Prognostic significance of activated CD8(+) T cell infiltrations within esophageal carcinomas. Cancer Res. (2001) 61:3932-3936.
    • (2001) Cancer Res. , vol.61 , pp. 3932-3936
    • Schumacher, K.1    Haensch, W.2    Roefzaad, C.3    Schlag, P.M.4
  • 97
    • 0028032388 scopus 로고
    • Histological grade, perineural infiltration, tumour-infiltrating lymphocytes and apoptosis as determinants of long-term prognosis in prostatic adenocarcinoma
    • VESALAINEN S, LIPPONEN P, TALJA M, SYRJANEN K:Histological grade, perineural infiltration, tumour-infiltrating lymphocytes and apoptosis as determinants of long-term prognosis in prostatic adenocarcinoma. Eur. J. Cancer (1994) 30A:1797-1803.
    • (1994) Eur. J. Cancer , vol.30 A , pp. 1797-1803
    • Vesalainen, S.1    Lipponen, P.2    Talja, M.3    Syrjanen, K.4
  • 98
    • 0030659077 scopus 로고    scopus 로고
    • Study of tumor infiltrating lymphocytes and transforming growth factor-beta as prognostic factors in breast carcinoma
    • MARROGI AJ, MUNSHI A, MEROGI AJ et al:Study of tumor infiltrating lymphocytes and transforming growth factor-beta as prognostic factors in breast carcinoma. Int. J. Cancer (1997) 74:492-501.
    • (1997) Int. J. Cancer , vol.74 , pp. 492-501
    • Marrogi, A.J.1    Munshi, A.2    Merogi, A.J.3
  • 99
    • 0032529466 scopus 로고    scopus 로고
    • CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer
    • NAITO Y, SAITO K, SHIIBA K et al: CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer. Cancer Res. (1998) 58:3491-3494.
    • (1998) Cancer Res. , vol.58 , pp. 3491-3494
    • Naito, Y.1    Saito, K.2    Shiiba, K.3
  • 100
    • 0035394233 scopus 로고    scopus 로고
    • Proliferative activity of intratumoral CD8(+) T-lymphocytes as a prognostic factor in human renal cell carcinoma: Clinicopathologic demonstration of antitumor immunity
    • NAKANO O, SATO M, NAITO Y et al: Proliferative activity of intratumoral CD8(+) T-lymphocytes as a prognostic factor in human renal cell carcinoma: clinicopathologic demonstration of antitumor immunity. Cancer Res. (2001) 61:5132-5136.
    • (2001) Cancer Res. , vol.61 , pp. 5132-5136
    • Nakano, O.1    Sato, M.2    Naito, Y.3
  • 102
    • 0033405438 scopus 로고    scopus 로고
    • Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma
    • THURNER B, HAENDLE I, RODER C et al:Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma. J. Exp. Med. (1999) 190:1669-1678.
    • (1999) J. Exp. Med. , vol.190 , pp. 1669-1678
    • Thurner, B.1    Haendle, I.2    Roder, C.3
  • 103
    • 0034100896 scopus 로고    scopus 로고
    • Regression of human metastatic renal cell carcinoma after vaccination with tumor cell-dendritic cell hybrids
    • KUGLER A, STUHLER G, WALDEN P et al:Regression of human metastatic renal cell carcinoma after vaccination with tumor cell-dendritic cell hybrids. Nat. Med. (2000) 6:332-336.
    • (2000) Nat. Med. , vol.6 , pp. 332-336
    • Kugler, A.1    Stuhler, G.2    Walden, P.3
  • 104
    • 10744230275 scopus 로고    scopus 로고
    • Adjuvant autologous renal tumour cell vaccine and risk of tumour progression in patients with renal-cell carcinoma after radical nephrectomy: Phase III, randomised controlled trial
    • JOCHAM D, RICHTER A, HOFFMANN L et al:Adjuvant autologous renal tumour cell vaccine and risk of tumour progression in patients with renal-cell carcinoma after radical nephrectomy: Phase III, randomised controlled trial. Lancet (2004) 363:594-599.
    • (2004) Lancet , vol.363 , pp. 594-599
    • Jocham, D.1    Richter, A.2    Hoffmann, L.3
  • 105
    • 0037089672 scopus 로고    scopus 로고
    • Adjuvant immunotherapy of resected, intermediate-thickness, node-negative melanoma with an allogeneic tumor vaccine: Impact of HLA class I antigen expression on outcome
    • SOSMAN JA, UNGER JM, LIU PY et al: Adjuvant immunotherapy of resected, intermediate-thickness, node-negative melanoma with an allogeneic tumor vaccine: impact of HLA class I antigen expression on outcome. J. Clin. Oncol. (2002) 20:2067-2075.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 2067-2075
    • Sosman, J.A.1    Unger, J.M.2    Liu, P.Y.3
  • 106
    • 11344251911 scopus 로고    scopus 로고
    • Persistence of multiple tumor-specific T-cell clones is associated with complete tumor regression in a melanoma patient receiving adoptive cell transfer therapy
    • ZHOU J, DUDLEY ME, ROSENBERG SA, ROBBINS PF: Persistence of multiple tumor-specific T-cell clones is associated with complete tumor regression in a melanoma patient receiving adoptive cell transfer therapy. J. Immunother. (2005) 28:53-62.
    • (2005) J. Immunother. , vol.28 , pp. 53-62
    • Zhou, J.1    Dudley, M.E.2    Rosenberg, S.A.3    Robbins, P.F.4
  • 107
    • 10344261422 scopus 로고    scopus 로고
    • Cutting edge: Persistence of transferred lymphocyte clonotypes correlates with cancer regression in patients receiving cell transfer therapy
    • ROBBINS PF, DUDLEY ME, WUNDERLICH J et al:Cutting edge: Persistence of transferred lymphocyte clonotypes correlates with cancer regression in patients receiving cell transfer therapy. J. Immunol. (2004) 173:7125-7130.
    • (2004) J. Immunol. , vol.173 , pp. 7125-7130
    • Robbins, P.F.1    Dudley, M.E.2    Wunderlich, J.3
  • 109
    • 0033542437 scopus 로고    scopus 로고
    • The importance of defining the paraneoplastic neurologic disorders
    • DARNELL RB:The importance of defining the paraneoplastic neurologic disorders. N. Engl. J. Med. (1999) 340:1831-1833.
    • (1999) N. Engl. J. Med. , vol.340 , pp. 1831-1833
    • Darnell, R.B.1
  • 110
    • 0034471993 scopus 로고    scopus 로고
    • Clinical trials of HER-2/neu-specific vaccines
    • discussion 92-100
    • MURRAY JL, PRZEPIORKA D, IOANNIDES CG:Clinical trials of HER-2/neu-specific vaccines. Semin. Oncol. (2000) 27:71-75; discussion 92-100.
    • (2000) Semin. Oncol. , vol.27 , pp. 71-75
    • Murray, J.L.1    Przepiorka, D.2    Ioannides, C.G.3
  • 111
    • 0035683821 scopus 로고    scopus 로고
    • Cancer vaccines targeting the HER2/neu oncogenic protein
    • DISIS ML, SCHIFFMAN K:Cancer vaccines targeting the HER2/neu oncogenic protein. Semin. Oncol. (2001) 28:12-20.
    • (2001) Semin. Oncol. , vol.28 , pp. 12-20
    • Disis, M.L.1    Schiffman, K.2
  • 112
    • 0037440042 scopus 로고    scopus 로고
    • Evaluation of monoclonal humanized anti-HER2 antibody, trastuzumab, in patients with recurrent or refractory ovarian or primary peritoneal carcinoma with overexpression of HER2: A Phase II trial of the Gynecologic Oncology Group
    • BOOKMAN MA, DARCY KM, CLARKE-PEARSON D, BOOTHBY RA, HOROWITZ IR:Evaluation of monoclonal humanized anti-HER2 antibody, trastuzumab, in patients with recurrent or refractory ovarian or primary peritoneal carcinoma with overexpression of HER2: a Phase II trial of the Gynecologic Oncology Group. J. Clin. Oncol. (2003) 21:283-290.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 283-290
    • Bookman, M.A.1    Darcy, K.M.2    Clarke-Pearson, D.3    Boothby, R.A.4    Horowitz, I.R.5
  • 114
    • 3042745485 scopus 로고    scopus 로고
    • Effect of dose on immune response in patients vaccinated with an her-2/neu intracellular domain protein-based vaccine
    • DISIS ML, SCHIFFMAN K, GUTHRIE K et al:Effect of dose on immune response in patients vaccinated with an her-2/neu intracellular domain protein-based vaccine. J. Clin. Oncol. (2004) 22:1916-1925. This report shows that a HER-2/neu ICD protein vaccine was effective in eliciting HER-2/neu-specific T cell immunity in the majority of ovarian cancer patients who completed the vaccine regimen.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 1916-1925
    • Disis, M.L.1    Schiffman, K.2    Guthrie, K.3
  • 115
    • 4544252430 scopus 로고    scopus 로고
    • Humoral epitope-spreading following immunization with a HER-2/neu peptide based vaccine in cancer patients
    • DISIS ML, GOODELL V, SCHIFFMAN K, KNUTSON KL: Humoral epitope-spreading following immunization with a HER-2/neu peptide based vaccine in cancer patients. J. Clin. Immunol. (2004) 24:571-578.
    • (2004) J. Clin. Immunol. , vol.24 , pp. 571-578
    • Disis, M.L.1    Goodell, V.2    Schiffman, K.3    Knutson, K.L.4
  • 116
    • 0032429418 scopus 로고    scopus 로고
    • Ovarian and breast cytotoxic T lymphocytes can recognize peptides from the amino enhancer of split protein of the Notch complex
    • BABCOCK B, ANDERSON BW, PAPAYANNOPOULOS I et al:Ovarian and breast cytotoxic T lymphocytes can recognize peptides from the amino enhancer of split protein of the Notch complex. Mol. Immunol. (1998) 35:1121-1133.
    • (1998) Mol. Immunol. , vol.35 , pp. 1121-1133
    • Babcock, B.1    Anderson, B.W.2    Papayannopoulos, I.3
  • 117
    • 0346364653 scopus 로고    scopus 로고
    • Rationale for the clinical development of STn-KLH (Theratope(R)) and anti-MUC-1 vaccines in breast cancer
    • MILES D, PAPAZISIS K:Rationale for the clinical development of STn-KLH (Theratope(R)) and anti-MUC-1 vaccines in breast cancer. Clin. Breast Cancer (2003) 3(Suppl. 4):S134-S138.
    • (2003) Clin. Breast Cancer , vol.3 , Issue.SUPPL. 4
    • Miles, D.1    Papazisis, K.2
  • 118
    • 0033935785 scopus 로고    scopus 로고
    • Clinical outcome of breast and ovarian cancer patients treated with high-dose chemotherapy, autologous stem cell rescue and THERATOPE STn-KLH cancer vaccine
    • HOLMBERG LA, OPARIN DV, GOOLEY T et al:Clinical outcome of breast and ovarian cancer patients treated with high-dose chemotherapy, autologous stem cell rescue and THERATOPE STn-KLH cancer vaccine. Bone Marrow Transplant. (2000) 25:1233-1241.
    • (2000) Bone Marrow Transplant. , vol.25 , pp. 1233-1241
    • Holmberg, L.A.1    Oparin, D.V.2    Gooley, T.3
  • 119
    • 0030796206 scopus 로고    scopus 로고
    • Mucin carbohydrate antigens (T, Tn, and sialyl-Tn) in human ovarian carcinomas: Relationship with histopathology and prognosis
    • GHAZIZADEH M, OGAWA H, SASAKI Y, ARAKI T, AIHARA K: Mucin carbohydrate antigens (T, Tn, and sialyl-Tn) in human ovarian carcinomas: relationship with histopathology and prognosis. Hum. Pathol. (1997) 28:960-966.
    • (1997) Hum. Pathol. , vol.28 , pp. 960-966
    • Ghazizadeh, M.1    Ogawa, H.2    Sasaki, Y.3    Araki, T.4    Aihara, K.5
  • 121
    • 0141507936 scopus 로고    scopus 로고
    • NY-ESO-1 and LAGE-1 cancer-testis antigens are potential targets for immunotherapy in epithelial ovarian cancer
    • JUNG BLUTH AA, JUNG BLUTH AA, STOCKERT E et al:NY-ESO-1 and LAGE-1 cancer-testis antigens are potential targets for immunotherapy in epithelial ovarian cancer. Cancer Res. (2003) 63:6076-6083.
    • (2003) Cancer Res. , vol.63 , pp. 6076-6083
    • Jung Bluth, A.A.1    Jung Bluth, A.A.2    Stockert, E.3
  • 122
    • 2642673605 scopus 로고    scopus 로고
    • A survey of the humoral immune response of cancer patients to a panel of human tumor antigens
    • STOCKERT E, JAGER E, CHEN YT et al:A survey of the humoral immune response of cancer patients to a panel of human tumor antigens. J. Exp. Med. (1998) 187:1349-1354.
    • (1998) J. Exp. Med. , vol.187 , pp. 1349-1354
    • Stockert, E.1    Jager, E.2    Chen, Y.T.3
  • 123
    • 12644276375 scopus 로고    scopus 로고
    • A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening
    • CHEN YT, SCANLAN MJ, SAHIN U et al:A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening. Proc. Natl. Acad. Sci. USA (1997) 94:1914-1918.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 1914-1918
    • Chen, Y.T.1    Scanlan, M.J.2    Sahin, U.3
  • 125
    • 1942469352 scopus 로고    scopus 로고
    • Ovarian tumorigenesis: A proposed model based on morphological and molecular genetic analysis
    • SHIH IEM, KURMAN RJ:Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis. Am. J. Pathol. (2004) 164:1511-1518.
    • (2004) Am. J. Pathol. , vol.164 , pp. 1511-1518
    • Shih, I.E.M.1    Kurman, R.J.2
  • 128
    • 0038756581 scopus 로고    scopus 로고
    • Induction of carcinogenesis by concurrent inactivation of p53 and Rb1 in the mouse ovarian surface epithelium
    • FLESKEN-NIKITIN A, CHOI KC, ENG JP, SHMIDT EN, NIKITIN AY: Induction of carcinogenesis by concurrent inactivation of p53 and Rb1 in the mouse ovarian surface epithelium. Cancer Res. (2003) 63:3459-3463.
    • (2003) Cancer Res. , vol.63 , pp. 3459-3463
    • Flesken-Nikitin, A.1    Choi, K.C.2    Eng, J.P.3    Shmidt, E.N.4    Nikitin, A.Y.5
  • 129
    • 12144287745 scopus 로고    scopus 로고
    • Vaccination of patients with advanced ovarian carcinoma with the anti-idiotype ACA125: Immunological response and survival (Phase Ib/II)
    • REINARTZ S, KOHLER S, SCHLEBUSCH H et al:Vaccination of patients with advanced ovarian carcinoma with the anti-idiotype ACA125: immunological response and survival (Phase Ib/II). Clin. Cancer Res. (2004) 10:1580-1587.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 1580-1587
    • Reinartz, S.1    Kohler, S.2    Schlebusch, H.3
  • 130
    • 3142750449 scopus 로고    scopus 로고
    • Immunotherapy of ovarian cancer with antibodies: A focus on oregovomab
    • BEREK JS:Immunotherapy of ovarian cancer with antibodies: a focus on oregovomab. Expert Opin. Biol. Ther. (2004) 4:1159-1165.
    • (2004) Expert Opin. Biol. Ther. , vol.4 , pp. 1159-1165
    • Berek, J.S.1
  • 131
    • 4444383336 scopus 로고    scopus 로고
    • Randomized, placebo-controlled study of oregovomab for consolidation of clinical remission in patients with advanced ovarian cancer
    • BEREK JS, TAYLOR PT, GORDON A et al:Randomized, placebo-controlled study of oregovomab for consolidation of clinical remission in patients with advanced ovarian cancer. J. Clin. Oncol. (2004) 22:3507-3516.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 3507-3516
    • Berek, J.S.1    Taylor, P.T.2    Gordon, A.3
  • 132
    • 0036384891 scopus 로고    scopus 로고
    • Universal tumor antigens as targets for immunotherapy
    • GORDAN JD, VONDERHEIDE RH: Universal tumor antigens as targets for immunotherapy. Cytotherapy (2002) 4:317-327.
    • (2002) Cytotherapy , vol.4 , pp. 317-327
    • Gordan, J.D.1    Vonderheide, R.H.2
  • 133
    • 0033151591 scopus 로고    scopus 로고
    • The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes
    • VONDERHEIDE RH, HAHN WC, SCHULTZE JL, NADLER LM:The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes. Immunity (1999) 10:673-679.
    • (1999) Immunity , vol.10 , pp. 673-679
    • Vonderheide, R.H.1    Hahn, W.C.2    Schultze, J.L.3    Nadler, L.M.4
  • 135
    • 0036604430 scopus 로고    scopus 로고
    • HER-2/neu and hTERT cryptic epitopes as novel targets for broad spectrum tumor immunotherapy
    • SCARDINO A, GROSS DA, ALVES P et al:HER-2/neu and hTERT cryptic epitopes as novel targets for broad spectrum tumor immunotherapy. J. Immunol. (2002) 168:5900-5906.
    • (2002) J. Immunol. , vol.168 , pp. 5900-5906
    • Scardino, A.1    Gross, D.A.2    Alves, P.3
  • 136
    • 2942661595 scopus 로고    scopus 로고
    • Repeated immunization with plasmid DNA formulated in poly(lactide-co- glycolide) microparticles is well tolerated and stimulates durable T cell responses to the tumor-associated antigen cytochrome P450 1B1
    • LUBY TM, COLE G, BAKER L, KORNHER JS, RAMSTEDT U, HEDLEY ML:Repeated immunization with plasmid DNA formulated in poly(lactide-co-glycolide) microparticles is well tolerated and stimulates durable T cell responses to the tumor-associated antigen cytochrome P450 1B1. Clin. Immunol. (2004) 112:45-53.
    • (2004) Clin. Immunol. , vol.112 , pp. 45-53
    • Luby, T.M.1    Cole, G.2    Baker, L.3    Kornher, J.S.4    Ramstedt, U.5    Hedley, M.L.6
  • 137
    • 10444267256 scopus 로고    scopus 로고
    • Lack of toxicity of therapy-induced T cell responses against the universal tumour antigen survivin
    • OTTO K, ANDERSEN MH, EGGERT A et al:Lack of toxicity of therapy-induced T cell responses against the universal tumour antigen survivin. Vaccine (2005) 23:884-889.
    • (2005) Vaccine , vol.23 , pp. 884-889
    • Otto, K.1    Andersen, M.H.2    Eggert, A.3
  • 139
    • 0033485264 scopus 로고    scopus 로고
    • Keyhole limpet hemocyanin (KLH): A biomedical review
    • HARRIS JR, MARKL J:Keyhole limpet hemocyanin (KLH): a biomedical review. Micron (1999) 30:597-623.
    • (1999) Micron , vol.30 , pp. 597-623
    • Harris, J.R.1    Markl, J.2
  • 140
  • 141
    • 0033589748 scopus 로고    scopus 로고
    • Disabled infectious single-cycle herpes simplex virus as an oncolytic vector for immunotherapy of colorectal cancer
    • TODRYK S, MCLEAN C, ALI S et al: Disabled infectious single-cycle herpes simplex virus as an oncolytic vector for immunotherapy of colorectal cancer. Hum. Gene Ther. (1999) 10:2757-2768.
    • (1999) Hum. Gene Ther. , vol.10 , pp. 2757-2768
    • Todryk, S.1    Mclean, C.2    Ali, S.3
  • 142
    • 0032816863 scopus 로고    scopus 로고
    • Dendritic cells transduced with wild-type p53 gene elicit potent anti-tumour immune responses
    • ISHIDA T, CHADA S, STIPANOV M et al:Dendritic cells transduced with wild-type p53 gene elicit potent anti-tumour immune responses. Clin. Exp. Immunol. (1999) 117:244-251.
    • (1999) Clin. Exp. Immunol. , vol.117 , pp. 244-251
    • Ishida, T.1    Chada, S.2    Stipanov, M.3
  • 143
    • 0032980749 scopus 로고    scopus 로고
    • Human PBMC-derived dendritic cells transduced with an adenovirus vector induce cytotoxic T-lymphocyte responses against a vector-encoded antigen in vitro
    • DIAO J, SMYTHE JA, SMYTH C, ROWE PB, ALEXANDER IE: Human PBMC-derived dendritic cells transduced with an adenovirus vector induce cytotoxic T-lymphocyte responses against a vector-encoded antigen in vitro. Gene Ther. (1999) 6:845-853.
    • (1999) Gene Ther. , vol.6 , pp. 845-853
    • Diao, J.1    Smythe, J.A.2    Smyth, C.3    Rowe, P.B.4    Alexander, I.E.5
  • 144
    • 4644253363 scopus 로고    scopus 로고
    • International meeting on cancer vaccines: How can we enhance efficacy of therapeutic vaccines?
    • BELARDELLI F, FERRANTINI M, PARMIANI G, SCHLOM J, GARACI E: International meeting on cancer vaccines: how can we enhance efficacy of therapeutic vaccines? Cancer Res. (2004) 64:6827-6830.
    • (2004) Cancer Res. , vol.64 , pp. 6827-6830
    • Belardelli, F.1    Ferrantini, M.2    Parmiani, G.3    Schlom, J.4    Garaci, E.5
  • 145
    • 0031798137 scopus 로고    scopus 로고
    • Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells
    • INABA K, TURLEY S, YAMAIDE F et al: Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells. J. Exp. Med. (1998) 188:2163-2173.
    • (1998) J. Exp. Med. , vol.188 , pp. 2163-2173
    • Inaba, K.1    Turley, S.2    Yamaide, F.3
  • 146
    • 0034181264 scopus 로고    scopus 로고
    • Phase I study in melanoma patients of a vaccine with peptide-pulsed dendritic cells generated in vitro from CD34(+) hematopoietic progenitor cells
    • MACKENSON A, HERBST B, CHEN JL et al:Phase I study in melanoma patients of a vaccine with peptide-pulsed dendritic cells generated in vitro from CD34(+) hematopoietic progenitor cells. Int. J. Cancer (2000) 86:385-392.
    • (2000) Int. J. Cancer , vol.86 , pp. 385-392
    • Mackenson, A.1    Herbst, B.2    Chen, J.L.3
  • 147
    • 0344076299 scopus 로고    scopus 로고
    • Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application
    • THURNER B, RODER C, DIECKMANN D et al:Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application. J. Immunol. Methods (1999) 223:1-15.
    • (1999) J. Immunol. Methods , vol.223 , pp. 1-15
    • Thurner, B.1    Roder, C.2    Dieckmann, D.3
  • 148
    • 0035879893 scopus 로고    scopus 로고
    • A comparison of two types of dendritic cell as adjuvants for the induction of melanoma-specific T-cell responses in humans following intranodal injection
    • JONULEIT H, GIESECKE-TUETTENBERG A, TUTING T et al:A comparison of two types of dendritic cell as adjuvants for the induction of melanoma-specific T-cell responses in humans following intranodal injection. Int. J. Cancer (2001) 93:243-251.
    • (2001) Int. J. Cancer , vol.93 , pp. 243-251
    • Jonuleit, H.1    Giesecke-Tuettenberg, A.2    Tuting, T.3
  • 149
    • 0142010678 scopus 로고    scopus 로고
    • Optimizing dendritic cell-based anticancer immunotherapy: Maturation state does have clinical impact
    • MCILROY D, GREGOIRE M: Optimizing dendritic cell-based anticancer immunotherapy: maturation state does have clinical impact. Cancer Immunol. Immunother. (2003) 52:583-591.
    • (2003) Cancer Immunol. Immunother. , vol.52 , pp. 583-591
    • Mcilroy, D.1    Gregoire, M.2
  • 150
    • 0035862333 scopus 로고    scopus 로고
    • Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells
    • DHODAPKAR MV, STEINMAN RM, KRASOVSKY J, MUNZ C, BHARDWAJ N:Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J. Exp. Med. (2001) 193:233-238. This article describes how immature DCs can inhibit the effector T cell function in vivo in humans, and urges caution with the use of immature DCs when trying to enhance tumour or microbial immunity.
    • (2001) J. Exp. Med. , vol.193 , pp. 233-238
    • Dhodapkar, M.V.1    Steinman, R.M.2    Krasovsky, J.3    Munz, C.4    Bhardwaj, N.5
  • 151
    • 4644345036 scopus 로고    scopus 로고
    • Tumor-infiltrating dendritic cell precursors recruited by a beta-defensin contribute to vasculogenesis under the influence of Vegf-A
    • CONEJO-GARCIA JR, BENENCIA F, COURREGES MC et al: Tumor-infiltrating dendritic cell precursors recruited by a beta-defensin contribute to vasculogenesis under the influence of Vegf-A. Nat. Med. (2004) 10:950-958. This seminal work describes the identification of a new population of myeloid DCs that turn into endothelial-like cells in the tumour microenvironment, thus contributing to tumour vascularisation. This subset, named vascular leukocytes, represents novel therapeutic targets.
    • (2004) Nat. Med. , vol.10 , pp. 950-958
    • Conejo-Garcia, J.R.1    Benencia, F.2    Courreges, M.C.3
  • 152
    • 11244332504 scopus 로고    scopus 로고
    • Vascular leukocytes contribute to tumor vascularization
    • CONEJO-GARCIA JR, BUCKANOVICH RJ, BENENCIA F et al:Vascular leukocytes contribute to tumor vascularization. Blood (2005) 105:679-681. This paper reports the identification of a high frequency of vascular leukocytes in human ovarian carcinoma specimens.
    • (2005) Blood , vol.105 , pp. 679-681
    • Conejo-Garcia, J.R.1    Buckanovich, R.J.2    Benencia, F.3
  • 153
    • 4143064951 scopus 로고    scopus 로고
    • Dendritic cell subsets differentially regulate angiogenesis in human ovarian cancer
    • CURIEL TJ, CHENG P, MOTTRAM P et al:Dendritic cell subsets differentially regulate angiogenesis in human ovarian cancer. Cancer Res. (2004) 64:5535-5538.
    • (2004) Cancer Res. , vol.64 , pp. 5535-5538
    • Curiel, T.J.1    Cheng, P.2    Mottram, P.3
  • 154
    • 0038273853 scopus 로고    scopus 로고
    • Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
    • CURIEL TJ, WEI S, DONG H et al: Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat. Med. (2003) 9:562-567.
    • (2003) Nat. Med. , vol.9 , pp. 562-567
    • Curiel, T.J.1    Wei, S.2    Dong, H.3
  • 155
    • 0034577943 scopus 로고    scopus 로고
    • IL-6 switches the differentiation of monocytes from dendritic cells to macrophages
    • CHOMARAT P, BANCHEREAU J, DAVOUST J, PALUCKA AK:IL-6 switches the differentiation of monocytes from dendritic cells to macrophages. Nat. Immunol. (2000) 1:510-514.
    • (2000) Nat. Immunol. , vol.1 , pp. 510-514
    • Chomarat, P.1    Banchereau, J.2    Davoust, J.3    Palucka, A.K.4
  • 156
    • 0032400862 scopus 로고    scopus 로고
    • Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo
    • GABRILOVICH D, ISHIDA T, OYAMA T et al:Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo. Blood (1998) 92:4150-4166. This work depicts the mechanism by which VEGF is responsible for the defective function of DCs in the tumour microenvironment.
    • (1998) Blood , vol.92 , pp. 4150-4166
    • Gabrilovich, D.1    Ishida, T.2    Oyama, T.3
  • 157
    • 0032741283 scopus 로고    scopus 로고
    • Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function
    • GABRILOVICH DI, ISHIDA T, NADAF S, OHM JE, CARBONE DP: Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. Clin. Cancer Res. (1999) 5:2963-2970.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 2963-2970
    • Gabrilovich, D.I.1    Ishida, T.2    Nadaf, S.3    Ohm, J.E.4    Carbone, D.P.5
  • 158
    • 0032442862 scopus 로고    scopus 로고
    • Interleukin-4 and interleukin-13: Their similarities and discrepancies
    • CHOMARAT P, BANCHEREAU J: Interleukin-4 and interleukin-13: their similarities and discrepancies. Int. Rev. Immunol. (1998) 17:1-52.
    • (1998) Int. Rev. Immunol. , vol.17 , pp. 1-52
    • Chomarat, P.1    Banchereau, J.2
  • 159
    • 1642362512 scopus 로고    scopus 로고
    • Combined TLR and CD40 triggering induces potent CD8+ T cell expansion with variable dependence on Type I IFN
    • AHONEN CL, DOXSEE CL, MCGURRAN SM et al:Combined TLR and CD40 triggering
    • (2004) J. Exp. Med. , vol.199 , pp. 775-784
    • Ahonen, C.L.1    Doxsee, C.L.2    Mcgurran, S.M.3
  • 160
    • 0034254702 scopus 로고    scopus 로고
    • Fusions of human ovarian carcinoma cells with autologous or allogeneic dendritic cells induce antitumor immunity
    • GONG J, NIKRUI N, CHEN D et al: Fusions of human ovarian carcinoma cells with autologous or allogeneic dendritic cells induce antitumor immunity. J. Immunol. (2000) 165:1705-1711.
    • (2000) J. Immunol. , vol.165 , pp. 1705-1711
    • Gong, J.1    Nikrui, N.2    Chen, D.3
  • 161
    • 0043245914 scopus 로고    scopus 로고
    • Synergy between tumor immunotherapy and antiangiogenic therapy
    • NAIR S, BOCZKOWSKI D, MOELLER B, DEWHIRST M, VIEWEG J, GILBOA E:Synergy between tumor immunotherapy and antiangiogenic therapy. Blood (2003) 102:964-971. This study shows that there is a strong synergy of antiangiogenic therapy combined with tumour immunotherapy of cancer.
    • (2003) Blood , vol.102 , pp. 964-971
    • Nair, S.1    Boczkowski, D.2    Moeller, B.3    Dewhirst, M.4    Vieweg, J.5    Gilboa, E.6
  • 162
    • 0031649505 scopus 로고    scopus 로고
    • Autologous, hapten-modified vaccine as a treatment for human cancers
    • BERD D, KAIRYS J, DUNTON C et al: Autologous, hapten-modified vaccine as a treatment for human cancers. Semin. Oncol. (1998) 25:646-653.
    • (1998) Semin. Oncol. , vol.25 , pp. 646-653
    • Berd, D.1    Kairys, J.2    Dunton, C.3
  • 163
    • 10744229445 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor gene-modified autologous tumor vaccines in non-small-cell lung cancer
    • NEMUNAITIS J, STERMAN D, JABLONS D et al:Granulocyte-macrophage colony-stimulating factor gene-modified autologous tumor vaccines in non-small-cell lung cancer. J. Natl. Cancer Inst. (2004) 96:326-331.
    • (2004) J. Natl. Cancer Inst. , vol.96 , pp. 326-331
    • Nemunaitis, J.1    Sterman, D.2    Jablons, D.3
  • 164
    • 0141576738 scopus 로고    scopus 로고
    • Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma
    • SOIFFER R, HODI FS, HALUSKA F et al:Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma. J. Clin. Oncol. (2003) 21:3343-3350.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 3343-3350
    • Soiffer, R.1    Hodi, F.S.2    Haluska, F.3
  • 165
    • 0031863853 scopus 로고    scopus 로고
    • Eradication of established murine tumors using a novel cell-free vaccine: Dendritic cell-derived exosomes
    • ZITVOGEL L, REGNAULT A, LOZIER A et al:Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat. Med. (1998) 4:594-600. This study shows how exosome-based cell-free vaccines represent a promising alternative to DC adoptive therapy for suppressing tumour growth.
    • (1998) Nat. Med. , vol.4 , pp. 594-600
    • Zitvogel, L.1    Regnault, A.2    Lozier, A.3
  • 166
    • 14844334129 scopus 로고    scopus 로고
    • Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects
    • TAYLOR DD, GERCEL-TAYLOR C: Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects. Br. J. Cancer (2005) 92(2):305-311.
    • (2005) Br. J. Cancer , vol.92 , Issue.2 , pp. 305-311
    • Taylor, D.D.1    Gercel-Taylor, C.2
  • 167
    • 3543053363 scopus 로고    scopus 로고
    • Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes
    • ALBERT ML, PEARCE SF, FRANCISCO LM et al:Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J. Exp. Med. (1998) 188:1359-1368.
    • (1998) J. Exp. Med. , vol.188 , pp. 1359-1368
    • Albert, M.L.1    Pearce, S.F.2    Francisco, L.M.3
  • 168
    • 0034614897 scopus 로고    scopus 로고
    • Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
    • SAUTER B, ALBERT ML, FRANCISCO L, LARSSON M, SOMERSAN S, BHARDWAJ N: Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J. Exp. Med. (2000) 191:423-434.
    • (2000) J. Exp. Med. , vol.191 , pp. 423-434
    • Sauter, B.1    Albert, M.L.2    Francisco, L.3    Larsson, M.4    Somersan, S.5    Bhardwaj, N.6
  • 169
    • 4644354179 scopus 로고    scopus 로고
    • Dendritic cell-tumor fusion vaccines for renal cell carcinoma
    • AVIGAN D:Dendritic cell-tumor fusion vaccines for renal cell carcinoma. Clin. Cancer Res. (2004) 10:6347S-6352S.
    • (2004) Clin. Cancer Res. , vol.10
    • Avigan, D.1
  • 170
    • 0025370889 scopus 로고
    • Active specific immunotherapy with vaccinia colon oncolysate enhances the immunomodulatory and antitumor effects of interleukin-2 and interferon alpha in a murine hepatic metastasis model
    • ARROYO PJ, BASH JA, WALLACK MK: Active specific immunotherapy with vaccinia colon oncolysate enhances the immunomodulatory and antitumor effects of interleukin-2 and interferon alpha in a murine hepatic metastasis model. Cancer Immunol. Immunother. (1990) 31:305-311.
    • (1990) Cancer Immunol. Immunother. , vol.31 , pp. 305-311
    • Arroyo, P.J.1    Bash, J.A.2    Wallack, M.K.3
  • 171
    • 0024153326 scopus 로고
    • Vaccinia virus oncolysates in the treatment of malignant melanoma
    • BASH JA, WALLACK MK:Vaccinia virus oncolysates in the treatment of malignant melanoma. Cancer Treat. Res. (1988) 43:177-190.
    • (1988) Cancer Treat. Res. , vol.43 , pp. 177-190
    • Bash, J.A.1    Wallack, M.K.2
  • 172
    • 0026268133 scopus 로고
    • Viral oncolysates as human tumor vaccines
    • SINKOVICS JG:Viral oncolysates as human tumor vaccines. Int. Rev. Immunol. (1991) 7:259-287.
    • (1991) Int. Rev. Immunol. , vol.7 , pp. 259-287
    • Sinkovics, J.G.1
  • 174
    • 0026248970 scopus 로고
    • Concepts in immunotherapy of cancer: Introduction
    • IOANNIDES CG, DEN OTTER W: Concepts in immunotherapy of cancer: introduction. In Vivo (1991) 5:551-552.
    • (1991) In Vivo , vol.5 , pp. 551-552
    • Ioannides, C.G.1    Den Otter, W.2
  • 175
    • 18144363557 scopus 로고    scopus 로고
    • Clinical trials of antitumor vaccination with an autologous tumor cell vaccine modified by virus infection: Improvement of patient survival based on improved antitumor immune memory
    • SCHIRRMACHER V:Clinical trials of antitumor vaccination with an autologous tumor cell vaccine modified by virus infection: improvement of patient survival based on improved antitumor immune memory. Cancer Immunol. Immunother. (2004) 54(6):587-598.
    • (2004) Cancer Immunol. Immunother. , vol.54 , Issue.6 , pp. 587-598
    • Schirrmacher, V.1
  • 177
    • 0018737217 scopus 로고
    • Virus augmentation of the antigenicity of tumor cell extracts
    • AUSTIN FC, BOONE CW:Virus augmentation of the antigenicity of tumor cell extracts. Adv. Cancer Res. (1979) 30:301-345.
    • (1979) Adv. Cancer Res. , vol.30 , pp. 301-345
    • Austin, F.C.1    Boone, C.W.2
  • 178
    • 0031836938 scopus 로고    scopus 로고
    • Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression
    • MELCHER A, TODRYK S, HARDWICK N, FORD M, JACOBSON M, VILE RG:Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression. Nat. Med. (1998) 4:581-587.
    • (1998) Nat. Med. , vol.4 , pp. 581-587
    • Melcher, A.1    Todryk, S.2    Hardwick, N.3    Ford, M.4    Jacobson, M.5    Vile, R.G.6
  • 179
    • 0031674910 scopus 로고    scopus 로고
    • Immunization with virus-modified tumor cells
    • SCHIRRMACHER V, AHLERT T, PROBSTLE T et al:Immunization with virus-modified tumor cells. Semin. Oncol. (1998) 25:677-696.
    • (1998) Semin. Oncol. , vol.25 , pp. 677-696
    • Schirrmacher, V.1    Ahlert, T.2    Probstle, T.3
  • 180
    • 0029682320 scopus 로고    scopus 로고
    • Immunotherapy for peritoneal ovarian carcinoma metastasis using ex vivo expanded tumor infiltrating lymphocytes
    • FREEDMAN RS, PLATSOUCAS CD: Immunotherapy for peritoneal ovarian carcinoma metastasis using ex vivo expanded tumor infiltrating lymphocytes. Cancer Treat. Res. (1996) 82:115-146.
    • (1996) Cancer Treat. Res. , vol.82 , pp. 115-146
    • Freedman, R.S.1    Platsoucas, C.D.2
  • 181
    • 0029117559 scopus 로고
    • Regression of advanced ovarian carcinoma by intraperitoneal treatment with autologous T lymphocytes retargeted by a bispecific monoclonal antibody
    • CANEVARI S, STOTER G, ARIENTI F et al:Regression of advanced ovarian carcinoma by intraperitoneal treatment with autologous T lymphocytes retargeted by a bispecific monoclonal antibody. J. Natl. Cancer Inst. (1995) 87:1463-1469.
    • (1995) J. Natl. Cancer Inst. , vol.87 , pp. 1463-1469
    • Canevari, S.1    Stoter, G.2    Arienti, F.3
  • 182
    • 0030796406 scopus 로고    scopus 로고
    • Local but no systemic immunomodulation by intraperitoneal treatment of advanced ovarian cancer with autologous T lymphocytes re-targeted by a bi-specific monoclonal antibody
    • LAMERS CH, BOLHUIS RL, WARNAAR SO, STOTER G, GRATAMA JW:Local but no systemic immunomodulation by intraperitoneal treatment of advanced ovarian cancer with autologous T lymphocytes re-targeted by a bi-specific monoclonal antibody. Int. J. Cancer (1997) 73:211-219.
    • (1997) Int. J. Cancer , vol.73 , pp. 211-219
    • Ch, L.1    Bolhuis, R.L.2    Warnaar, S.O.3    Stoter, G.4    Gratama, J.W.5
  • 183
    • 4444222734 scopus 로고    scopus 로고
    • Long-term intravenous administration of activated autologous lymphocytes for cancer patients does not induce antinuclear antibody and rheumatoid factor
    • YAMAGUCHI T, BAMBA K, KITAYAMA A et al:Long-term intravenous administration of activated autologous lymphocytes for cancer patients does not induce antinuclear antibody and rheumatoid factor. Anticancer Res. (2004) 24:2423-2429.
    • (2004) Anticancer Res. , vol.24 , pp. 2423-2429
    • Yamaguchi, T.1    Bamba, K.2    Kitayama, A.3
  • 185
    • 0028841784 scopus 로고
    • The Yin and Yang of T cell costimulation
    • ALLISON JP, KRUMMEL MF:The Yin and Yang of T cell costimulation. Science (1995) 270:932-933.
    • (1995) Science , vol.270 , pp. 932-933
    • Allison, J.P.1    Krummel, M.F.2
  • 186
    • 0027743537 scopus 로고
    • Tumor escape mechanisms from immunosurveillance: Induction of unresponsiveness in a specific MHC-restricted CD4+ human T cell clone by the autologous MHC class II+ melanoma
    • BECKER JC, BRABLETZ T, CZERNY C, TERMEER C, BROCKER EB:Tumor escape mechanisms from immunosurveillance: induction of unresponsiveness in a specific MHC-restricted CD4+ human T cell clone by the autologous MHC class II+ melanoma. Int. Immunol. (1993) 5:1501-1508.
    • (1993) Int. Immunol. , vol.5 , pp. 1501-1508
    • Becker, J.C.1    Brabletz, T.2    Czerny, C.3    Termeer, C.4    Brocker, E.B.5
  • 187
    • 0031573612 scopus 로고    scopus 로고
    • Effects of CD28 costimulation on long-term proliferation of CD4+ T cells in the absence of exogenous feeder cells
    • LEVINE BL, BERNSTEIN WB, CONNORS M et al:Effects of CD28 costimulation on long-term proliferation of CD4+ T cells in the absence of exogenous feeder cells. J. Immunol. (1997) 159:5921-5930.
    • (1997) J. Immunol. , vol.159 , pp. 5921-5930
    • Levine, B.L.1    Bernstein, W.B.2    Connors, M.3
  • 188
    • 0031737652 scopus 로고    scopus 로고
    • Large-scale production of CD4+ T cells from HIV-1-infected donors after CD3/CD28 costimulation
    • LEVINE BL, COTTE J, SMALL CC et al: Large-scale production of CD4+ T cells from HIV-1-infected donors after CD3/CD28 costimulation. J. Hematother. (1998) 7:437-448.
    • (1998) J. Hematother. , vol.7 , pp. 437-448
    • Levine, B.L.1    Cotte, J.2    Small, C.C.3
  • 189
    • 0036171757 scopus 로고    scopus 로고
    • Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB
    • MAUS MV, THOMAS AK, LEONARD DG et al:Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB. Nat. Biotechnol. (2002) 20:143-148.
    • (2002) Nat. Biotechnol. , vol.20 , pp. 143-148
    • Maus, M.V.1    Thomas, A.K.2    Leonard, D.G.3
  • 190
    • 12144289172 scopus 로고    scopus 로고
    • Ovarian carcinoma expresses the NKG2D ligand Letal and promotes the survival and expansion of CD28(-) antitumor T cells
    • CONEJO-GARCIA JR, BENENCIA F, COURREGES MC et al:Ovarian carcinoma expresses the NKG2D ligand Letal and promotes the survival and expansion of CD28(-) antitumor T cells. Cancer Res. (2004) 64:2175-2182.
    • (2004) Cancer Res. , vol.64 , pp. 2175-2182
    • Conejo-Garcia, J.R.1    Benencia, F.2    Courreges, M.C.3
  • 191
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • CURIEL TJ, COUKOS G, ZOU L et al: Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. (2004) 10:942-949. This paper conclusively demonstrates for the first time that tumour-associated regulatory T cells impair the function of T effector cells in tumour-bearing patients.
    • (2004) Nat. Med. , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3
  • 192
    • 0035874949 scopus 로고    scopus 로고
    • Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer
    • WOO EY, CHU CS, GOLETZ TJ et al: Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer. Cancer Res. (2001) 61:4766-4772.
    • (2001) Cancer Res. , vol.61 , pp. 4766-4772
    • Woo, E.Y.1    Chu, C.S.2    Goletz, T.J.3
  • 193
    • 0037364804 scopus 로고    scopus 로고
    • Natural versus adaptive regulatory T cells
    • BLUESTONE JA, ABBAS AK: Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. (2003) 3:253-257.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 253-257
    • Bluestone, J.A.1    Abbas, A.K.2
  • 194
    • 2442484053 scopus 로고    scopus 로고
    • Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses
    • SAKAGUCHI S:Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. (2004) 22:531-562.
    • (2004) Annu. Rev. Immunol. , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 195
  • 196
    • 0036569127 scopus 로고    scopus 로고
    • Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation
    • WOO EY, YEH H, CHU CS et al:Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation. J. Immunol. (2002) 168:4272-4276.
    • (2002) J. Immunol. , vol.168 , pp. 4272-4276
    • Woo, E.Y.1    Yeh, H.2    Chu, C.S.3
  • 197
    • 0038153907 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
    • PHAN GQ, YANG JC, SHERRY RM et al:Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc. Natl. Acad. Sci. USA (2003) 100:8372-8377.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 8372-8377
    • Phan, G.Q.1    Yang, J.C.2    Sherry, R.M.3
  • 198
    • 0344341626 scopus 로고    scopus 로고
    • Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
    • HODI FS, MIHM MC, SOIFFER RJ et al:Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Proc. Natl. Acad. Sci. USA (2003) 100:4712-4717.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 4712-4717
    • Hodi, F.S.1    Mihm, M.C.2    Soiffer, R.J.3
  • 199
    • 0141679441 scopus 로고    scopus 로고
    • A Phase II study of DT fusion protein denileukin diftitox in patients with fludarabine-refractory chronic lymphocytic leukemia
    • FRANKEL AE, FLEMING DR, HALL PD et al:A Phase II study of DT fusion protein denileukin diftitox in patients with fludarabine-refractory chronic lymphocytic leukemia. Clin. Cancer Res. (2003) 9:3555-3561.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 3555-3561
    • Frankel, A.E.1    Fleming, D.R.2    Hall, P.D.3
  • 200
    • 0036668242 scopus 로고    scopus 로고
    • Links between innate and adaptive immunity via Type I interferon
    • LE BON A, TOUGH DF:Links between innate and adaptive immunity via Type I interferon. Curr. Opin. Immunol. (2002) 14:432-436.
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 432-436
    • Le Bon, A.1    Tough, D.F.2
  • 201
    • 0041662272 scopus 로고    scopus 로고
    • Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence
    • TAKAOKA A, HAYAKAWA S, YANAI H et al:Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence. Nature (2003) 424:516-523.
    • (2003) Nature , vol.424 , pp. 516-523
    • Takaoka, A.1    Hayakawa, S.2    Yanai, H.3
  • 202
    • 0021813751 scopus 로고
    • Intraperitoneal administration of interferon beta in ovarian cancer patients
    • RAMBALDI A, INTRONA M, COLOTTA F et al:Intraperitoneal administration of interferon beta in ovarian cancer patients. Cancer (1985) 56:294-301.
    • (1985) Cancer , vol.56 , pp. 294-301
    • Rambaldi, A.1    Introna, M.2    Colotta, F.3
  • 203
    • 0032878097 scopus 로고    scopus 로고
    • Intraperitoneal interferon-alpha in residual ovarian carcinoma: A Phase II gynecologic oncology group study
    • FUJIWARA K, MARKMAN M, STONEBRAKER B et al:Intraperitoneal interferon-alpha in residual ovarian carcinoma: a Phase II gynecologic oncology group study. Gynecol. Oncol. (1999) 75:10-14.
    • (1999) Gynecol. Oncol. , vol.75 , pp. 10-14
    • Fujiwara, K.1    Markman, M.2    Stonebraker, B.3
  • 204
    • 0025806320 scopus 로고
    • A Phase I-II trial of intraperitoneal cisplatin and alpha-interferon in patients with persistent epithelial ovarian cancer
    • BEREK JS, WELANDER C, SCHINK JC, GROSSBERG H, MONTZ FJ, ZIGELBOIM J:A Phase I-II trial of intraperitoneal cisplatin and alpha-interferon in patients with persistent epithelial ovarian cancer. Gynecol. Oncol. (1991) 40:237-243.
    • (1991) Gynecol. Oncol. , vol.40 , pp. 237-243
    • Berek, J.S.1    Welander, C.2    Schink, J.C.3    Grossberg, H.4    Montz, F.J.5    Zigelboim, J.6
  • 205
    • 2942642267 scopus 로고    scopus 로고
    • Phase II trial of interferon-beta as second-line treatment of ovarian cancer, fallopian tube cancer, or primary carcinoma of the peritoneum
    • MARKMAN M, BELINSON J, WEBSTER K et al:Phase II trial of interferon-beta as second-line treatment of ovarian cancer, fallopian tube cancer, or primary carcinoma of the peritoneum. Oncology (2004) 66:343-346.
    • (2004) Oncology , vol.66 , pp. 343-346
    • Markman, M.1    Belinson, J.2    Webster, K.3
  • 206
    • 0031915601 scopus 로고    scopus 로고
    • Safety profile of interferon-alpha therapy
    • WEISS K:Safety profile of interferon-alpha therapy. Semin. Oncol. (1998) 25:9-13.
    • (1998) Semin. Oncol. , vol.25 , pp. 9-13
    • Weiss, K.1
  • 207
    • 0034938171 scopus 로고    scopus 로고
    • Evaluation of recombinant human interleukin-12 in patients with recurrent or refractory ovarian cancer: A gynecologic oncology group study
    • HURTEAU JA, BLESSING JA, DECESARE SL, CREASMAN WT: Evaluation of recombinant human interleukin-12 in patients with recurrent or refractory ovarian cancer: a gynecologic oncology group study. Gynecol. Oncol. (2001) 82:7-10.
    • (2001) Gynecol. Oncol. , vol.82 , pp. 7-10
    • Hurteau, J.A.1    Blessing, J.A.2    Decesare, S.L.3    Creasman, W.T.4
  • 208
    • 0036897227 scopus 로고    scopus 로고
    • Phase I study of intraperitoneal recombinant human interleukin 12 in patients with Mullerian carcinoma, gastrointestinal primary malignancies, and mesothelioma
    • LENZI R, ROSENBLUM M, VERSCHRAEGEN C et al:Phase I study of intraperitoneal recombinant human interleukin 12 in patients with Mullerian carcinoma, gastrointestinal primary malignancies, and mesothelioma. Clin. Cancer Res. (2002) 8:3686-3695.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 3686-3695
    • Lenzi, R.1    Rosenblum, M.2    Verschraegen, C.3
  • 209
    • 9044223660 scopus 로고    scopus 로고
    • Intraperitoneal recombinant interferon gamma in ovarian cancer patients with residual disease at second-look laparotomy
    • PUJADE-LAURAINE E, GUASTALLA JP, COLOMBO N et al:Intraperitoneal recombinant interferon gamma in ovarian cancer patients with residual disease at second-look laparotomy. J. Clin. Oncol. (1996) 14:343-350.
    • (1996) J. Clin. Oncol. , vol.14 , pp. 343-350
    • Pujade-Lauraine, E.1    Guastalla, J.P.2    Colombo, N.3
  • 210
    • 0034010642 scopus 로고    scopus 로고
    • Interferon-gamma in the first-line therapy of ovarian cancer: A randomized Phase III trial
    • WINDBICHLER GH, HAUSMANINGER H, STUMMVOLL W et al:Interferon-gamma in the first-line therapy of ovarian cancer: a randomized Phase III trial. Br. J. Cancer (2000) 82:1138-1144.
    • (2000) Br. J. Cancer , vol.82 , pp. 1138-1144
    • Windbichler, G.H.1    Hausmaninger, H.2    Stummvoll, W.3
  • 211
    • 9844256432 scopus 로고    scopus 로고
    • Comparison of toxicity and survival following intraperitoneal recombinant interleukin-2 for persistent ovarian cancer after platinum: Twenty-four-hour versus 7-day infusion
    • EDWARDS RP, GOODING W, LEMBERSKY BC et al:Comparison of toxicity and survival following intraperitoneal recombinant interleukin-2 for persistent ovarian cancer after platinum: twenty-four-hour versus 7-day infusion. J. Clin. Oncol. (1997) 15:3399-3407.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 3399-3407
    • Edwards, R.P.1    Gooding, W.2    Lembersky, B.C.3
  • 213
    • 18844483161 scopus 로고    scopus 로고
    • Clinical and biological effects of intraperitoneal injections of recombinant interferon-gamma and recombinant interleukin 2 with or without tumor-infiltrating lymphocytes in patients with ovarian or peritoneal carcinoma
    • FREEDMAN RS, KUDELKA AP, KAVANAGH JJ et al:Clinical and biological effects of intraperitoneal injections of recombinant interferon-gamma and recombinant interleukin 2 with or without tumor-infiltrating lymphocytes in patients with ovarian or peritoneal carcinoma. Clin. Cancer Res. (2000) 6:2268-2278.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2268-2278
    • Freedman, R.S.1    Kudelka, A.P.2    Kavanagh, J.J.3
  • 215
    • 0035881733 scopus 로고    scopus 로고
    • Eradication of intraperitoneal and distant tumor by adenovirus-mediated interferon-beta gene therapy is attributable to induction of systemic immunity
    • ODAKA M, STERMAN DH, WIEWRODT R et al:Eradication of intraperitoneal and distant tumor by adenovirus-mediated interferon-beta gene therapy is attributable to induction of systemic immunity. Cancer Res. (2001) 61:6201-6212.
    • (2001) Cancer Res. , vol.61 , pp. 6201-6212
    • Odaka, M.1    Sterman, D.H.2    Wiewrodt, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.